PaulALyleMD

PubMed

• Comparing hypertension guidelines. Guidelines are based on evidence from trials, not normal practice.
  Scanlon, T. J., Luben, R., Lyle, P.> ;BMJ. 1996 Nov 9
• A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily losartan 100 mg/hydrochlorothiazide 25 mg and ...
  Gradman, A. H., Brady, W. E., Gazdick, L. P., Lyle, P., Zeldin, R. K.> ;Clin Ther. 2002 Jul
• Clusters of metabolic risk factors predict cardiovascular events in hypertension with target-organ damage: the LIFE study.
  de Simone, G., Olsen, M. H., Wachtell, K., Hille, D. A., Dahlöf, B., Ibsen, H., Kjeldsen, S. E., Lyle, P. A., Devereux, R. B.> ;J Hum Hypertens. 2007 Aug
• First-dose effects of enalapril 2.5 mg and captopril 6.25 mg in patients with heart failure: a double-blind, randomized, multicenter study. The Enalapril-Captopril Inv...
  Lang, R. M., DiBianco, R., Broderick, G. T., Gottlieb, S. S., Kostis, J., Lyle, P. A., Makris, L., Rajfer, S. I., Rucinska, E. J.> ;Am Heart J. 1994 Sep
• The effect of losartan compared with atenolol on the incidence of revascularization in patients with hypertension and electrocardiographic left ventricular hypertrophy...
  Olsen, M. H., Wachtell, K., Dahlöf, B., Devereux, R. B., Ibsen, H., Kjeldsen, S. E., Lindholm, L. H., Lyle, P. A., Nieminen, M. S.> ;J Hum Hypertens. 2006 Jun
• A double-blind, randomized study evaluating losartan potassium monotherapy or in combination with hydrochlorothiazide versus placebo in obese patients with hypertension.
  Oparil, S., Abate, N., Chen, E., Creager, M. A., Galet, V., Jia, G., Julius, S., Lerman, A., Lyle, P. A., Pool, J., Tershakovec, A. M.> ;Curr Med Res Opin. 2008 Apr
• The effect of losartan on hemoglobin concentration and renal outcome in diabetic nephropathy of type 2 diabetes.
  Mohanram, A., Zhang, Z., Shahinfar, S., Lyle, P. A., Toto, R. D.> ;Kidney Int. 2008 Mar
• The effect of baseline physical activity on cardiovascular outcomes and new-onset diabetes in patients treated for hypertension and left ventricular hypertrophy: the L...
  Fossum, E., Gleim, G. W., Kjeldsen, S. E., Kizer, J. R., Julius, S., Devereux, R. B., Brady, W. E., Hille, D. A., Lyle, P. A., Dahlöf, B.> ;J Intern Med. 2007 Oct
• Effects of losartan in women with hypertension and left ventricular hypertrophy: results from the Losartan Intervention for Endpoint Reduction in Hypertension Study.
  Os, I., Franco, V., Kjeldsen, S. E., Manhem, K., Devereux, R. B., Gerdts, E., Hille, D. A., Lyle, P. A., Okin, P. M., Dahlöf, B., Oparil, S.> ;Hypertension. 2008 Apr
• ACE gene polymorphism and losartan treatment in type 2 diabetic patients with nephropathy.
  Parving, H. H., de Zeeuw, D., Cooper, M. E., Remuzzi, G., Liu, N., Lunceford, J., Shahinfar, S., Wong, P. H., Lyle, P. A., Rossing, P., Brenner, B. M.> ;J Am Soc Nephrol. 2008 Apr
• Effect of ACE insertion/deletion and 12 other polymorphisms on clinical outcomes and response to treatment in the LIFE study.
  Nordestgaard, B. G., Kontula, K., Benn, M., Dahlöf, B., de Faire, U., Edelman, J. M., Eliasson, E., Fyhrquist, F., Hille, D. A., Ibsen, H., Lyle, P. A., Berg, K., Sand...> ;Pharmacogenet Genomics. 2010 Feb
• Predictors of cardiovascular events in patients with hypertension and left ventricular hypertrophy: the Losartan Intervention for Endpoint reduction in hypertension st...
  Kjeldsen, S. E., Devereux, R. B., Hille, D. A., Lyle, P. A., Dahlöf, B., Julius, S., Edelman, J. M., Snapinn, S. M., de Faire, U., Fyhrquist, F., Ibsen, H., Lederballe...> ;Blood Press. 2009
• Effects of losartan compared with atenolol on lipids in patients with hypertension and left ventricular hypertrophy: the Losartan Intervention For Endpoint reduction i...
  Olsen, M. H., Wachtell, K., Beevers, G., Dahlöf, B., de Simone, G., Devereux, R. B., de Faire, U., Fyhrquist, F., Ibsen, H., Kjeldsen, S. E., Lederballe-Pedersen, O., ...> ;J Hypertens. 2009 Mar
• The left atrium, atrial fibrillation, and the risk of stroke in hypertensive patients with left ventricular hypertrophy.
  Wachtell, K., Devereux, R. B., Lyle, P. A., Okin, P. M., Gerdts, E.> ;Ther Adv Cardiovasc Dis. 2008 Dec 01
• Effect of LDL cholesterol and treatment with losartan on end-stage renal disease in the RENAAL study.
  Tershakovec, A. M., Keane, W. F., Zhang, Z., Lyle, P. A., Appel, G. B., McGill, J. B., Parving, H. H., Cooper, M. E., Shahinfar, S., Brenner, B. M.> ;Diabetes Care. 2008 Mar
• Effect of hemoglobin levels on cardiovascular outcomes in patients with isolated systolic hypertension and left ventricular hypertrophy (from the LIFE study).
  Smebye, M. L., Iversen, E. K., Høieggen, A., Flaa, A., Os, I., Kjeldsen, S. E., Olsen, M. H., Chattopadhyay, A., Hille, D. A., Lyle, P. A., Devereux, R. B., Dahlöf, B.> ;Am J Cardiol. 2007 Sep 1
• Fixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke.
  Kjeldsen, S. E., Lyle, P. A., Kizer, J. R., Oparil, S., Høieggen, A., Os, I.> ;Vasc Health Risk Manag. 2007
• Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy: the RENAAL study.
  Keane, W. F., Zhang, Z., Lyle, P. A., Cooper, M. E., de Zeeuw, D., Grunfeld, J. P., Lash, J. P., McGill, J. B., Mitch, W. E., Remuzzi, G., Shahinfar, S., Snapinn, S. M...> ;Clin J Am Soc Nephrol. 2006 Jul
• Atenolol as a comparator in outcome trials in hypertension: a correct choice in the past, but not for the future?
  Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Lyle, P. A., Zhang, Z., Edelman, J. M.> ;Blood Press. 2007
• A multicenter, randomized, double-blind, parallel-group trial of the antihypertensive efficacy and tolerability of a combination of once-daily losartan 100 mg/hydrochl...
  Gleim, G. W., Rubino, J., Zhang, H., Shahinfar, S., Soffer, B. A., Lyle, P. A., Littlejohn, T. W., Feig, P. U.> ;Clin Ther. 2006 Oct
• Use of beta-blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers to prevent atrial fibrillation.
  Wachtell, K., Devereux, R. B., Lyle, P. A.> ;Curr Cardiol Rep. 2006 Sep
• Losartan: lessons learned from the RENAAL study.
  Shahinfar, S., Lyle, P. A., Zhang, Z., Keane, W. F., Brenner, B. M.> ;Expert Opin Pharmacother. 2006 Apr
• Does albuminuria predict cardiovascular outcomes on treatment with losartan versus atenolol in patients with diabetes, hypertension, and left ventricular hypertrophy? ...
  Ibsen, H., Olsen, M. H., Wachtell, K., Borch-Johnsen, K., Lindholm, L. H., Mogensen, C. E., Dahlöf, B., Snapinn, S. M., Wan, Y., Lyle, P. A.> ;Diabetes Care. 2006 Mar
• Hospitalizations for new heart failure among subjects with diabetes mellitus in the RENAAL and LIFE studies.
  Carr, A. A., Kowey, P. R., Devereux, R. B., Brenner, B. M., Dahlöf, B., Ibsen, H., Lindholm, L. H., Lyle, P. A., Snapinn, S. M., Zhang, Z., Edelman, J. M., Shahinfar, S.> ;Am J Cardiol. 2005 Dec 1
• Targeting the renin-angiotensin system for the reduction of cardiovascular outcomes in hypertension: angiotensin-converting enzyme inhibitors and angiotensin receptor ...
  Kjeldsen, S. E., Lyle, P. A., Tershakovec, A. M., Devereux, R. B., Oparil, S., Dahlöf, B., de Faire, U., Fyhrquist, F., Ibsen, H., Kristianson, K., Lederballe-Pedersen...> ;Expert Opin Emerg Drugs. 2005 Nov
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