PaulMischelMD

Pathology • La Jolla, CA

Neuropathology, Anatomic Pathology, Clinical Pathology

Physician

Join to view full profile

Dr. Mischel is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Mischel's full profile

Already have an account?

Office
9500 GIlman Drive
CMME 2051
La Jolla, CA 92093
Phone+1 858-534-6080

Fax+1 858-534-7750
Is this information wrong?

Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Pathology-Anatomic and Clinical, 1992 - 1996
UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Neuropathology, 1993 - 1995
UCLA/Stewart & Lynda Resnick Neuropsychiatric HospitalInternship, Transitional Year, 1991 - 1992
Weill Cornell MedicineClass of 1991

Certifications & Licensure

CA State Medical License 1993 - 2025
American Board of Pathology Anatomic Pathology
American Board of Pathology Neuropathology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
Top Doctors:San Diego Area Castle Connolly, 2013
America's Top Doctors for Cancer Castle Connolly, 2006-2013
Top Doctors:Southern California Castle Connolly, 2012
Elected Member The American Society for Clinical Investigation, 2007
Join now to see all

Publications & Presentations

PubMed

35 citations
Extrachromosomal DNA: An Emerging Hallmark in Human Cancer
Sihan Wu, Vineet Bafna, Howard Y. Chang, Paul S. Mischel> ;Annual Review of Pathology. 2022 Jan 24
53 citations
ecDNA hubs drive cooperative intermolecular oncogene expression.
King L. Hung, Kathryn E. Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T. Lange, Rocío Chamorro González, Natasha E. We...> ;Nature. 2021 Nov 24
33 citations
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug.
Junfeng Bi, Atif Ali Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro ...> ;Cell Reports. 2021 Nov 2
6 citations
BAP1 methylation: a prognostic marker of uveal melanoma metastasis.
Mathieu F. Bakhoum, Ellis J. Curtis, Michael H. Goldbaum, Paul S. Mischel> ;NPJ Precision Oncology. 2021 Sep 30
14 citations
Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.
, , , , , , , , , , , , , , , > ;Clinical Cancer Research. 2021 Sep 21
24 citations
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.
Mathieu F. Bakhoum, Jasmine H. Francis, Albert Agustinus, Ethan M. Earlie, Melody Di Bona, David H. Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander ...> ;Nature Communications. 2021 Sep 13
16 citations
Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer.
Mio Harachi, Kenta Masui, Webster K. Cavenee, Paul S. Mischel, Noriyuki Shibata> ;Metabolites. 2021 Apr 1
23 citations
Extrachromosomal DNA (ecDNA) in cancer pathogenesis.
Sihan Wu, Vineet Bafna, Paul S. Mischel> ;Current Opinion in Genetics & Development. 2021 Feb 1
4 citations
Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma.
Sihan Wu, Paul S. Mischel> ;Cancer Cell. 2020 Sep 14
40 citations
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
Jens Luebeck, Ceyda Coruh, Siavash R. Dehkordi, Joshua T. Lange, Kristen M. Turner, Viraj Deshpande, Dave A. Pai, Chao Zhang, Utkrisht Rajkumar, Julie A. Law, Paul S. ...> ;Nature Communications. 2020 Sep 1
194 citations
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Hoon Kim, Nam-Phuong Nguyen, Kristen M. Turner, Sihan Wu, Amit D. Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, Samirkumar B. Ami...> ;Nature Genetics. 2020 Aug 17
52 citations
Extrachromosomal DNA-relieving heredity constraints, accelerating tumour evolution.
Christopher Bailey, Massa J. Shoura, Paul S. Mischel, Charles Swanton> ;Annals of Oncology. 2020 Apr 7
10 citations
What Is Extrachromosomal Circular DNA and What Does It Do
Rossa W.K. Chiu, Anindya Dutta, Anton G Hensson, Y.M. Dennis Lo, Paul S. Mischel, Birgitte Regenberg> ;Clinical Chemistry. 2020 Jun 1
20 citations
Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM.
Mio Harachi, Kenta Masui, Hiroaki Honda, Yoshihiro Muragaki, Takakazu Kawamata, Webster K. Cavenee, Paul S. Mischel, Noriyuki Shibata> ;Molecular Cancer Research. 2020 Jan 1
1 citations
Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Tomoyuki Koga, Isaac A. Chaim, Jorge A. Benitez, Sebastian Markmiller, Alison Parisian, Robert F. Hevner, Kristen M. Turner, Florian M. Hessenauer, Matteo D’Antonio, N...> ;Nature Communications. 2020 Apr 20
24 citations
mTOR complex 2 is an integrator of cancer metabolism and epigenetics
Kenta Masui, Mio Harachi, Webster K. Cavenee, Paul S. Mischel, Noriyuki Shibata> ;Cancer Letters. 2020 May 28
17 citations
Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review.
Kenta Masui, Mio Harachi, Webster K. Cavenee, Paul S. Mischel, Noriyuki Shibata> ;Acta Histochemica Et Cytochemica. 2020 Feb 28
35 citations
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Tomoyuki Koga, Isaac A. Chaim, Jorge A. Benitez, Sebastian Markmiller, Alison Parisian, Robert F. Hevner, Kristen M. Turner, Florian M. Hessenauer, Matteo D’Antonio, N...> ;Nature Communications. 2020 Jan 28
151 citations
Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets.
Junfeng Bi, Sudhir Chowdhry, Sihan Wu, Wenjing Zhang, Kenta Masui, Paul S. Mischel> ;Nature Reviews. Cancer. 2020 Jan 1
23 citations
EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA
Utkrisht Rajkumar, Kristen M. Turner, Jens Luebeck, Viraj Deshpande, Manmohan Chandraker, Paul S. Mischel, Vineet Bafna> ;Iscience. 2019 Nov 22
249 citations
Circular ecDNA promotes accessible chromatin and high oncogene expression
Sihan Wu, Kristen M. Turner, Nam Nguyen, Ramya Raviram, Marcella L. Erb, Jennifer Santini, Jens Luebeck, Utkrisht Rajkumar, Yarui Diao, Bin Li, Wenjing Zhang, Nathan M...> ;Nature. 2019 Nov 1
21 citations
mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma
Kenta Masui, Mio Harachi, Shiro Ikegami, Huijun Yang, Hiromi Onizuka, William H. Yong, Timothy F. Cloughesy, Yoshihiro Muragaki, Takakazu Kawamata, Nobutaka Arai, Taka...> ;The Journal of Biological Chemistry. 2019 Dec 20
20 citations
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations
Pyoung Hwa Park, Tomomi M. Yamamoto, Hua Li, Allen L. Alcivar, Bing Xia, Yifan Wang, Andrea J. Bernhardy, Kristen M. Turner, Andrew V. Kossenkov, Zachary L. Watson, Ki...> ;Molecular Cancer Therapeutics. 2020 Feb 1
105 citations
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
Junfeng Bi, Taka-Aki Ichu, Ciro Zanca, Huijun Yang, Wei Zhang, Yuchao Gu, Sudhir Chowdhry, Alex Reed, Shiro Ikegami, Kristen M. Turner, Wenjing Zhang, Genaro R. Villa,...> ;Cell Metabolism. 2019 Sep 3
11 citations
Acyl-CoA-Binding Protein Fuels Gliomagenesis
Junfeng Bi, Paul S. Mischel> ;Cell Metabolism. 2019 Aug 6
Join now to see all

Press Mentions

PEACE Study Offers New Clues About How Cancer Resists TreatmentApril 26th, 2023
Esophageal Cancer, Precancer Study Points to Extrachromosomal DNA AppearanceApril 13th, 2023
UC San Diego Researchers Help Discover That Tiny DNA Circles Are Key Drivers of CancerApril 12th, 2023
Join now to see all

PaulMischelMD

Dr. Mischel is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Publications & Presentations

Press Mentions

Viewing the full profile is available to verified healthcare professionals only.