PaulEdwardMorinMDFACP

PubMed

• 17 citations
  Novel phenylalanine derived diamides as Factor XIa inhibitors.
  Leon M. Smith, Michael J. Orwat, Zilun Hu, Wei Han, Cailan Wang, Karen A. Rossi, Paul J. Gilligan, Pabbisetty Kumar Balashanmuga, Honey Osuna, James R. Corte, Alan R. ...> ;Bioorganic & Medicinal Chemistry Letters. 2016 Jan 15
• 27 citations
  Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
  Donald J. P. Pinto, Joanne M. Smallheer, James R. Corte, Erin J.D. Austin, Cailan Wang, Tianan Fang, Leon M. Smith, Karen A. Rossi, Alan R. Rendina, Jeffrey M. Bozarth...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Apr 1
• 27 citations
  Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics
  Roxana E. Iacob, Stanley R. Krystek, Richard Y.-C. Huang, Hui Wei, Li Tao, Zheng Lin, Paul E. Morin, Michael L. Doyle, Adrienne A. Tymiak, John R. Engen, Guodong Chen> ;Expert Review of Proteomics. 2015 Mar 20
• 13 citations
  Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening
  Daniel L. Cheney, Jeffrey M. Bozarth, William J. Metzler, Paul E. Morin, Luciano Mueller, John A. Newitt, Alexandra H. Nirschl, Alan R. Rendina, James K. Tamura, Anzhi...> ;Journal of Medicinal Chemistry. 2015 Mar 12
• 15 citations
  Pyridine and pyridinone-based factor XIa inhibitors.
  James R. Corte, Tianan Fang, Jon J. Hangeland, Todd J. Friends, Alan R. Rendina, Joseph M. Luettgen, Jeffrey M. Bozarth, Frank A. Barbera, Karen A. Rossi, Anzhi Wei, V...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Feb 15
• 28 citations
  Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.
  Jon J. Hangeland, Todd J. Friends, Karen A. Rossi, Joanne M. Smallheer, Cailan Wang, Zhong Sun, James R. Corte, Tianan Fang, Pancras C. Wong, Alan R. Rendina, Frank A....> ;Journal of Medicinal Chemistry. 2014 Dec 2
• 18 citations
  Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)
  Jun Li, Lawrence J. Kennedy, Haixia Wang, James J. Li, Steven J. Walker, Zhenqiu Hong, Stephen P. O'connor, Akbar Nayeem, Daniel M. Camac, Paul E. Morin, Steven Sherif...> ;ACS Medicinal Chemistry Letters. 2014 May 22
• 51 citations
  Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors.
  Mimi L. Quan, Pancras C. Wong, Cailan Wang, Francis J. Woerner, Joanne M. Smallheer, Frank A. Barbera, Jeffrey M. Bozarth, Randi L. Brown, Mark R. Harpel, Joseph M. Lu...> ;Journal of Medicinal Chemistry. 2014 Jan 17
• 53 citations
  Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
  Robert G. Gentles, Min Ding, Bender John A, Bergstrom Carl P, Katharine A. Grant-Young, Piyasena Hewawasam, Thomas W. Hudyma, Scott W. Martin, Andrew Nickel, Alicia Re...> ;Journal of Medicinal Chemistry. 2014 Jan 7
• 14 citations
  Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).
  Shung C. Wu, David S. Yoon, Janice Chin, Katy Van Kirk, Ramakrishna Seethala, Rajasree Golla, Bin He, Thomas Harrity, Lori Kunselman, Nathan Morgan, Randolph P. Pontic...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Nov 15
• 21 citations
  Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
  Xiaofan Zheng, Thomas W. Hudyma, Scott W. Martin, Bergstrom Carl P, Min Ding, Feng He, Jeffrey L. Romine, Michael A. Poss, John F. Kadow, Chong-Hwan Chang, John Wan, M...> ;Bioorganic & Medicinal Chemistry Letters. 2011 May 15
• 5 citations
  Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
  Robert G. Gentles, Steven Sheriff, Brett R. Beno, Changhong Wan, Kevin Kish, Min Ding, Xiaofan Zheng, Louis S. Chupak, Michael A. Poss, Mark R. Witmer, Paul E. Morin, ...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Apr 15
• 21 citations
  Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
  Lawrence R. Marcin, Mendi A. Higgins, F. Christopher Zusi, Yunhui Zhang, Michael F. Dee, Michael F. Parker, Jodi K. Muckelbauer, Daniel M. Camac, Paul E. Morin, Vidhya...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Jan 1
• 8 citations
  Phenyltriazolinones as potent factor Xa inhibitors.
  Mimi L. Quan, Donald J. P. Pinto, Karen A. Rossi, Steven Sheriff, Richard S. Alexander, Eugene Amparo, Kevin Kish, Robert M. Knabb, Joseph M. Luettgen, Paul E. Morin, ...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Feb 15
• 19 citations
  Pyridine amides as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
  Haixia Wang, Zheming Ruan, James J. Li, Ligaya M. Simpkins, Rebecca A. Smirk, Shung C. Wu, Robert D. Hutchins, David S. Nirschl, Katy Van Kirk, Cooper Christopher B, J...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Jun 1
• 23 citations
  Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
  James R. Corte, Tianan Fang, Donald J. P. Pinto, Wei Han, Zilun Hu, Xiang-Jun Jiang, Yun-Long Li, Jolicia F. Gauuan, Mark Hadden, Darren Orton, Alan R. Rendina, Joseph...> ;Bioorganic & Medicinal Chemistry Letters. 2008 May 1
• 22 citations
  SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
  Jennifer X. Qiao, C.-H. Chang, Daniel L. Cheney, Paul E. Morin, Gren Z. Wang, Sarah R. King, Tammy C. Wang, Alan R. Rendina, Joseph M. Luettgen, Robert M. Knabb, Ruth ...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Aug 15
• 14 citations
  Comparative studies of active site–ligand interactions among various recombinant constructs of human β-amyloid precursor protein cleaving enzyme
  Lisa M. Kopcho, Jianhong Ma, Jovita Marcinkeviciene, Zhihong Lai, Mark R. Witmer, Janet D. Cheng, Joseph Yanchunas, Jeffrey Tredup, Martin J. Corbett, Deepa Calambur, ...> ;Archives of Biochemistry and Biophysics. 2003 Feb 15
• New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased In vitro metabolic stability.
  Plobeck, N., Delorme, D., Wei, Z. Y., Yang, H., Zhou, F., Schwarz, P., Gawell, L., Gagnon, H., Pelcman, B., Schmidt, R., Yue, S. Y., Walpole, C., Brown, W., Zhou, E., ...> ;J Med Chem. 2000 Oct 19
• N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its anal...
  Wei, Z. Y., Brown, W., Takasaki, B., Plobeck, N., Delorme, D., Zhou, F., Yang, H., Jones, P., Gawell, L., Gagnon, H., Schmidt, R., Yue, S. Y., Walpole, C., Payza, K., ...> ;J Med Chem. 2000 Oct 19
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