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Paul Nghiem, MD, Dermatology, Seattle, WA

Paul Tuan-Xuan Nghiem MD PhD (He/Him)

[Pronunciation: NEE-em]

Dermatology•Seattle, WA

George F. Odland Professor and Founding Chair, Department of Dermatology, University of Washington; Director, Skin Oncology at Fred Hutchinson Cancer Center

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  • Uwmcroosevelt4225 Roosevelt Way NESeattle, WA 98105

  • Phone+1 206-598-4067

  • Fax+1 206-606-1025

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Summary

  • Dr. Paul Nghiem is a dermatologist based in Seattle, WA. He completed his medical education at Stanford University School of Medicine in 1994 and holds a Ph.D. in Cancer Biology from the same institution. He pursued residencies in Internal Medicine and Dermatology at Mass General Brigham hospitals. His areas of expertise include Merkel cell carcinoma (MCC), melanoma, and cutaneous malignancies. Dr. Nghiem has contributed to the field through fundamental studies of the nature of the immune response in MCC, and leading clinical trials that established immune therapy as the standard of care for MCC. He also serves as the Principal Investigator for the MATRiX clinical trial, focusing on the combination of anticancer drugs for MCC that is refractory to approved treatments.

Education & Training

  • Mass General Brigham/Massachusetts General Hospital/Beth Israel Deaconess Medical Center/Brigham and Women's Hosp
    Mass General Brigham/Massachusetts General Hospital/Beth Israel Deaconess Medical Center/Brigham and Women's HospResidency, Dermatology, 1995 - 1998
  • Mass General Brigham/Brigham and Women's Hospital
    Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 1994 - 1995
  • Stanford University
    Stanford UniversityPh.D., Program in Cancer Biology, 1994
  • Stanford University School of Medicine
    Stanford University School of MedicineClass of 1994
  • Harvard University
    Harvard UniversityA.B., Biological Sciences, 1986

Certifications & Licensure

  • FL State Medical License
    FL State Medical License 2021 - Present
  • CA State Medical License
    CA State Medical License 2022 - 2028
  • WA State Medical License
    WA State Medical License 2005 - 2028
  • MA State Medical License
    MA State Medical License 1998 - 2006
  • Dermatology
    American Board of Dermatology Dermatology

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • (P33) Case Report: Neutron Radiation Therapy for Refractory Merkel Cell Carcinoma in an Immunotherapy Primed Patient Potentiates the Immune Response  
    Schaub SK, Stewart RD, Sandison GA, Arbuckle T, Liao JJ, Laramore GE, Zeng J, Rengan R, Tseng YD, Mayr NA, Bhatia S, Nghiem P, Parvathaneni U, International Journal of Radiation Oncology, Biology, Physics, 1/1/2018
  • Case Report: Neutron Radiation Therapy for Refractory Merkel Cell Carcinoma in an Immunotherapy Primed Patient Potentiates the Immune Response  
    Schaub SK, Stewart RD, Sandison GA, Arbuckle T, Liao JJ, Laramore GE, Zeng J, Rengan R, Tseng YD, Mayr NA, Bhatia S, Nghiem P, Parvathaneni U, International Journal of Radiation Oncology, Biology, Physics, 1/1/2018
  • Merkel Cell Carcinoma Cell Death in Response to Single-Fraction Irradiation: Implications for Immune Therapy  
    Mullen TD, Nghiem P, Bhatia S, Parvathaneni U, Schwartz JL, Int J Radiat Oncol Biol Phys, 1/1/2016

Books/Book Chapters

  • Textbook of Aging Skin 
    Chapter: "Carcinogenesis: UV Radiation" 
    Douglas E. Brash, Timothy P. Heffernan, Paul Nghiem, Raymond J. Cho
  • Textbook of Aging Skin. Adapted with permission from Fitzpatrick�s Dermatology in General Medicine, 8th edition. 
    Chapter: Carcinogenesis: UV Radiation. 
    Page 1 - 17Douglas E. Brash, Timothy P. Heffernan, Paul Nghiem, Raymond J. ChoEditors: Goldsmith, Katz, Gilchrest et al.McGraw-Hill2015
  • Fitzpatrick�s Dermatology in General Medicine 
    Chapter: Merkel Cell Carcinoma. 
    Page 1362 - 1371Tegeder A, Afanasiev OK, Nghiem PEditors: Goldsmith, Katz, Gilchrest et al.McGraw-HillEdition 8th,2012

Abstracts/Posters

  • Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
    Lu YP, Lou YR, Bernard JJ, Peng QY, Li T, Lin Y, Shih WJ, Nghiem P, Shapses S, Wagner GC, Conney AH, Proc Natl Acad Sci U S A, 1/1/2012
  • Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.
    Huryn D, Brodsky J, Brummond K, Chambers P, Eyre B, Ireland A, Kawasumi M, LaPorte M, Lloyd K, Manteau B, Nghiem P, Quade B, Wipf P, Proc Natl Acad Sci USA, 1/1/2011
  • Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.
    Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP..., Proc Natl Acad Sci USA, 1/1/2011

Lectures

  • Late-breaking Research: Basic Science/Cutaneous Oncology/Pathology 
    American Academy of Dermatology - Annual Meeting 2019 - Washington, D.C. - 3/2/2019
  • Seattle Investigative Dermatology, MCC & the immunogenic principles transforming the care of all UV-induced skin cancers. 
    Oregon Convention Center, Portland, OR - 1/29/2017
  • MCC & the immunogenic principles transforming the care of all UV-induced skin cancers, Clinical scholars program session II: Emerging immunotherapies 
    Oregon Convention Center, Portland, OR - 1/29/2017

Other

  • Cancer: The Final Frontier. 
    Nghiem P, Atlantic Monthly
    1/25/2016
  • "Cancer: The Final Frontier." 
    Nghiem P, The Atlantic Monthly
    1/25/2016
  • The list of cancers that can be treated by immunotherapy keeps growing. 
    Nghiem P, Washington Post
    1/19/2016

Press Mentions

  • Tip Sheet: New Treatments for Graft-vs.-Host Disease, Updated Dosage for HPV Vaccines — and Fred Hutch Announces Awards for Graduate Students
    Tip Sheet: New Treatments for Graft-vs.-Host Disease, Updated Dosage for HPV Vaccines — and Fred Hutch Announces Awards for Graduate StudentsMarch 5th, 2025
  • UW Medicine, Fred Hutch Launch Skin Cancer Institute
    UW Medicine, Fred Hutch Launch Skin Cancer InstituteFebruary 3rd, 2025
  • New Institute Musters Forces Against Lethal Skin Cancer
    New Institute Musters Forces Against Lethal Skin CancerJanuary 30th, 2025

Grant Support

  • Immunobiology and Immune Therapy for Merkel Cell CarcinomaUNIVERSITY OF WASHINGTON2019–2030
  • The Replication Checkpoint And Genomic Fidelity In SkinNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2005–2012
  • Humoral And Cellular Immunity In Polyomavirus-Linked Merkel Cell CarcinomaNational Cancer Institute2011
  • Pathogenetic And Prognostic Studies For Improved Therapy Of Merkel Cell CarcinomaNational Cancer Institute2009–2011
  • Targeting Mcpyv To Overcome Immune Evasion In Merkel Cell CarcinomaNational Cancer Institute2009–2010

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