PaulWSperdutoMDFASTRO

Radiation Oncology • Waconia, MN

Central Nervous System Cancer

Co-Director, University of Minnesota Gamma Knife Center Medical Director, Ridgeview Regional Radiation Oncology

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Office
560 S Maple St
# 10
Waconia, MN 55387
Phone+1 952-442-6000

Fax+1 952-442-7851
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Education & Training

National Capital ConsortiumResidency, Radiation Oncology, 1988 - 1991
Duke University HospitalResidency, Internal Medicine, 1985 - 1987
Duke University School of MedicineClass of 1984

Certifications & Licensure

SC State Medical License 2022 - 2025
MN State Medical License 1991 - 2022
WI State Medical License 2010 - 2021
MD State Medical License 1987 - 1991
NC State Medical License 1987 - 1988
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
CMS Meaningful Use Stage 1 Certification ARIA Radiation Oncology EMR, Varian Medical Systems, 2013
Top MD Consumers Checkbook

Clinical Trials

Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer Start of enrollment: 2004 Oct 06
Terminated
Phase 3
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer Start of enrollment: 2008 Feb 01
Active, not recruiting
Phase 3
Paclitaxel, Cisplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Locally Advanced Esophageal Cancer Start of enrollment: 2008 Jun 01
Completed
Phase 3
Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Start of enrollment: 2009 Feb 01
Completed
Phase 1, Phase 2
Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer Start of enrollment: 2009 Sep 01
Active, not recruiting
Phase 3
Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer Start of enrollment: 2009 Nov 01
Active, not recruiting
Phase 3
Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Start of enrollment: 2010 Apr 05
Active, not recruiting
Phase 3
Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer Start of enrollment: 2011 Feb 14
Completed
Phase 3
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer Start of enrollment: 2011 Jun 01
Active, not recruiting
Phase 3
Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer Start of enrollment: 2012 May 01
Active, not recruiting
Phase 3
Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer Start of enrollment: 2012 Dec 06
Completed
Phase 2
Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer Start of enrollment: 2012 Nov 01
Completed
Phase 3
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Publications & Presentations

PubMed

Long-Term Intracranial Outcomes With Combination Dual Immune-Checkpoint Blockade and Stereotactic Radiosurgery in Patients With Melanoma and Non-Small Cell Lung Cancer...
Eugene J Vaios, Rachel F Shenker, Peter G Hendrickson, Zihan Wan, Donna Niedzwiecki, Sebastian F Winter, Helen A Shih, Jorg Dietrich, Chunhao Wang, April K S Salama, J...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
1 citations
Concurrent Lapatinib With Brain Radiation Therapy in Patients With HER2+ Breast Cancer With Brain Metastases: NRG Oncology-KROG/RTOG 1119 Phase 2 Randomized Trial.
In Ah Kim, Kathryn A Winter, Paul W Sperduto, Jennifer F De Los Santos, David M Peereboom, Tomi Ogunleye, Daniel Boulter, Joel M Fritz, Kwan Ho Cho, Kyung Hwan Shin, I...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
3 citations
National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities.
Michelle M Kim, Minesh P Mehta, DeeDee K Smart, Patricia S Steeg, Julie A Hong, Michael G Espey, Pataje G Prasanna, Laura Crandon, Christine Hodgdon, Niki Kozak, Terri...> ;The Lancet. Oncology. 2023 Aug 1
Progress for patients with melanoma brain metastases.
Paul W Sperduto, April K S Salama, Carey Anders> ;Neuro-Oncology. 2023 Jul 6
Graded Prognostic Assessment (GPA) for Patients With Lung Cancer and Brain Metastases: Initial Report of the Small Cell Lung Cancer GPA and Update of the Non-Small Cel...
Wang, T. J., Paul W Sperduto, Brian De, Jing Li, David Carpenter, John Kirkpatrick, Michael Milligan, Helen A Shih, Tugce Kutuk, Rupesh Kotecha, Hajime Higaki, Manami ...> ;International Journal of Radiation Oncology, Biology, Physics. 2022 Sep 1
2 citations
Targeted therapy strategies for melanoma brain metastasis.
Chantal Saberian, Paul Sperduto, Michael A. Davies> ;Neuro-Oncology Advances. 2021 Nov 1
8 citations
Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival.
Lari Wenzel, Kathryn Osann, Chelsea O. McKinney, David Cella, Giulia Fulci, Mary J Scroggins, Heather A. Lankes, Victoria Wang, Kenneth P. Nephew, George L. Maxwell, S...> ;Journal of the National Cancer Institute. 2021 Oct 1
6 citations
A radiomics-based model for predicting local control of resected brain metastases receiving adjuvant SRS
Kellen Mulford, Chuyu Chen, Kathryn E. Dusenbery, Jianling Yuan, Matthew A. Hunt, Clark C. Chen, Paul W. Sperduto, Yoichi Watanabe, Christopher Wilke> ;Clinical and Translational Radiation Oncology. 2021 May 8
1 citations
The past, present, and future management of brain metastases in EGFR-mutant non-small cell lung cancer.
Paul W. Sperduto, Emil Lou> ;Neuro-Oncology. 2021 Jun 1
38 citations
Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival
Paul W. Sperduto, Shane Mesko, Jing Li, Daniel N. Cagney, Ayal A. Aizer, Nan Lin, Eric Nesbit, Tim J. Kruser, Jason Chan, Steve Braunstein, Jessica W. Lee, John P. Kir...> ;Neuro-Oncology. 2020 Sep 29
181 citations
Survival in Patients with Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient
Paul W. Sperduto, Shane Mesko, Jing Li, Daniel N. Cagney, Ayal A. Aizer, Nan Lin, Eric Nesbit, Tim J. Kruser, Jason Chan, Steve Braunstein, Jessica W. Lee, John P. Kir...> ;Journal of Clinical Oncology. 2020 Sep 15
3 citations
Indirect cell death and the LQ model in SBRT and SRS.
Chang W. Song, Stephanie A. Terezakis, Bahman Emami, Robert J. Griffin, Paul W. Sperduto, Mi-Sook Kim, L. Chinsoo Cho> ;Journal of Radiosurgery and SBRT. 2020 Jan 1
72 citations
Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today
Paul W. Sperduto, Shane Mesko, Jing Li, Daniel N. Cagney, Ayal A. Aizer, Nan Lin, Eric Nesbit, Tim J. Kruser, Jason Chan, Steve Braunstein, Jessica W. Lee, John P. Kir...> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Jun 1
60 citations
Current multidisciplinary management of brain metastases.
Michael J. Moravan, Peter E. Fecci, Carey K. Anders, Jeffrey M. Clarke, April K.S. Salama, Justus Adamson, Scott R. Floyd, Jordan A. Torok, Joseph K. Salama, John H. S...> ;Cancer. 2020 Apr 1
8 citations
Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases (Sarcoma-GPA)
Anna Patrikidou, Loic Chaigneau, Nicolas Isambert, Kyriaki Kitikidou, Ryan Shanley, Isabelle Ray-Coquard, Thibaud Valentin, Bettina Malivoir, Maryline Laigre, Jacques-...> ;BMC Cancer. 2020 Feb 12
25 citations
Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA).
Paul W. Sperduto, Penny Fang, Jing Li, William G. Breen, Paul D. Brown, Daniel N. Cagney, Ayal A. Aizer, James B. Yu, Veronica Chiang, Supriya Jain, Laurie E. Gaspar, ...> ;Clinical and Translational Radiation Oncology. 2019 Sep 1
252 citations
Safety and Efficacy of a Five-Fraction Stereotactic Body Radiotherapy Schedule for Centrally Located Non-Small-Cell Lung Cancer: NRG Oncology/RTOG 0813 Trial.
Andrea Bezjak, Rebecca Paulus, Laurie E. Gaspar, Robert Timmerman, William L. Straube, William F. Ryan, Yolanda I. Garces, Anthony T. Pu, Anurag K. Singh, Gregory M.M....> ;Journal of Clinical Oncology. 2019 Apr 3
84 citations
Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death.
Chang W. Song, Eli Glatstein, Lawrence B. Marks, Bahman Emami, Jimm Grimm, Paul W. Sperduto, Mi-Sook Kim, Susanta K. Hui, Kathryn E. Dusenbery, L. Chinsoo Cho> ;International Journal of Radiation Oncology, Biology, Physics. 2021 May 1
6 citations
GOG 8020/210: Risk stratification of lymph node metastasis, disease progression and survival using single nucleotide polymorphisms in endometrial cancer: An NRG oncolo...
Rebecca A. Brooks, D. Tritchler, Kathleen M. Darcy, Heather A. Lankes, Ritu Salani, Paul Sperduto, Saketh R. Guntupalli, Paul DiSilvestro, Joshua Kesterson, Alexander ...> ;Gynecologic Oncology. 2019 May 1
12 citations
Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases: have we made progress?
Paul W. Sperduto, Penny Fang, Jing Li, William G. Breen, Paul D. Brown, Daniel N. Cagney, Ayal A. Aizer, James B. Yu, Veronica Chiang, Supriya Jain, Laurie E. Gaspar, ...> ;Translational Research. 2019 Feb 27
37 citations
Estimating survival for renal cell carcinoma patients with brain metastases: an update of the Renal Graded Prognostic Assessment tool
Paul W. Sperduto, Brian J. Deegan, Jing Li, Krishan R. Jethwa, Paul D. Brown, Natalie A. Lockney, Kathryn Beal, Nitesh Rana, Albert Attia, Chia-Lin Tseng, Arjun Sahgal...> ;Neuro-Oncology. 2018 Nov 12
10 citations
Prognostic models for patients with brain metastases after stereotactic radiosurgery with or without whole brain radiotherapy: a validation study
Stephanie R. Rice, Søren M. Bentzen, Andrew Hanna, Enid Choi, Drexell Hunter Boggs, Young Kwok, Jalal Hyder, Steven J. Feigenberg, William F. Regine, Graeme F. Woodwor...> ;Journal of Neuro-Oncology. 2018 Aug 21
8 citations
Omitting radiosurgery in melanoma brain metastases: a drastic and dangerous de-escalation.
Tim J. Kruser, Vinai Gondi, Paul W. Sperduto, Paul D. Brown, Minesh P. Mehta> ;The Lancet. Oncology. 2018 Aug 1
19 citations
Effect of Targeted Therapies on Prognostic Factors, Patterns of Care, and Survival in Patients With Renal Cell Carcinoma and Brain Metastases
Paul W. Sperduto, Brian J. Deegan, Jing Li, Krishan R. Jethwa, Paul D. Brown, Natalie A. Lockney, Kathryn Beal, Nitesh Rana, Albert Attia, Chia-Lin Tseng, Arjun Sahgal...> ;International Journal of Radiation Oncology, Biology, Physics. 2018 Jul 15
In Regard to Churilla et al.
Paul W. Sperduto> ;International Journal of Radiation Oncology, Biology, Physics. 2018 May 1
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Lectures

Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases from 1985 to Today
2019 ASCO Annual Meeting - 6/1/2019