Peter Densen MD

PubMed

• A Point Mutation Creating a 3' Splice Site in C8A Is a Predominant Cause of C8α-γ Deficiency in African Americans.
  Peter Densen, Laynez W. Ackermann, Leslie J. Saucedo, Julio E. Figueroa, Zhi-Hai Si
  Journal of Immunology. 2020-08-07
• James A. Clifton, III, MD 1923-2014.
  Peter Densen
  Transactions of the American Clinical and Climatological Association. 2015-01-01
• 21 citations
  Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited
  Elizabeth C. Miller, Nicole M. Chase, Peter Densen, Mary Hintermeyer, James T. Casper
  Clinical Immunology. 2012-12-01

Journal Articles

• Multicenter Comparison of Neisseria meningitidis Serogroup C Anticapsular Polysaccharide Antibody Levels Measured by Using a Standardized Enzyme-Linked Immunosorbent A...  
  Gheesling, L.L., Carlone, G.M., Pais, L.B., Holder, P.F., Maslanka, S.E., Plikaytis, B.D., Achtman, M., Densen, P., Frasch, C.E., Käyhty, H. Mays, J.P., Nencioni, L., ..., J. Clin. Microbiol., 32:1475-1482
• Reduced C8? Messenger RNA Expression in Families with Hereditary C8? Deficiency.  
  Warnick, P.R., and Densen, P, J. Immunol., 146:1052-1056
• Infectious Consequences of Complement Deficiency States.  
  Densen, P, Clin. Immunol. Newsl., 11(1):5-10
• Infectious Diseases Associated with Complement Deficiency States.  
  Figueroa, J., and Densen, P, Clin. Microbiol. Rev., 4:359-395
• Is the AIDS Epidemic Ending?  
  Densen, P., and Stapleton, J, Iowa Med., 81:167-169
• Complement Deficiencies and Meningococcal Disease.  
  Densen, P, Clin. Exp. Immunol., 86(S1):57-62
• C4B Deficiency is Not Associated with Meningitis or Bac¬teremia with Encapsulated Bacteria.  
  Cates, K.L., Densen, P., Lockman, J.C., and Levine, R.P, J. Infect. Dis., 165:942-944
• Interactions of C3 and C4 with Haemophilus influenzae.  
  Cates, K.L., Lockman, J., Densen, P., and Levine, R.P, J. Infect. Dis., 165(S1):S70-S71
• Type I Human Complement C2 Deficiency. A 28-Base Pair Gene Deletion Causes Skipping of Exon 6 During RNA Splicing.  
  Johnson, C.A., Densen, P., Hurford, R.K., Jr., Colten, H.R., and Wetsel, R.A, J. Biol. Chem., 267:9347-9353
• Molecular Heterogeneity of C2 Defi¬ciency.  
  Johnson, C.A., Densen, P., Wetsel, R.A., Cole, F.S., Goeken, N.E., and Colten, H.R, N. Engl. J. Med., 326:871-874
• Activa¬tion of Leukocytes with Complement C5a is Associated with Prostanoid-Dependent Constriction of Large Arteries in Atherosclerotic Monkeys In Vivo.  
  Mügge, A., Heistad, D.D., Densen, P., Piegors, D.J., Armstrong, ML., Padgett, R.C., and Lopez, J.A.G, Atherosclerosis, 95:211-222
• Mechanisms of Contraction Induced by Human Leukocytes in Normal and Atherosclerotic Arteries.  
  Mügge, A., Heistad, D.D., Padgett, R.C., Waack, B.J., Densen, P., and Lopez, J.A.G, Circ. Res., 69:871-880
• Vascular Response to Activation of Leukocytes in Atherosclerotic Primates.  
  Heistad, D.D., Lopez, J.A.G., Mügge, A., Densen, P., Padgett, R.C., and Armstrong, M.L, Trans. Assoc. Am. Phys., CIV: 150-154
• Vaccination and the Role of Capsular Polysaccharide Antibody in Prevention of Recurrent Meningococcal Disease in Late Complement Component Deficient Individuals.  
  Andreoni, J., Käyhty, H., and Densen, P, J. Infect. Dis., 168:227-231
• Complement Deficiency States and Meningococcal Disease.  
  Figueroa, J., Andreoni, J., and Densen, P, Immunol. Res., 12(3):295-311
• Prevalence of Homozygous C4B Deficiency in Patients with Deficiencies of Terminal Complement Components and Meningococcemia.  
  Fasano, M.B., Densen, P., McLean, R.H., and Winkelstein, J.A, J. Infect. Dis., 162:1220-1221
• Recurrent Infections, Pericarditis and Renal Disease in a Patient with Total C2 Deficiency and Decreased NK Function Consistent with Acute Rheumatic Fever and Systemic...  
  Bittleman, D.B., Maves, K.K., Bertolatus, J.A., Bonsib, S.M., Densen, P., Ballas, Z.K., and Weiler, J.M, Ann. Rheum. Dis., 53:280-287
• A Teaching Rotation for Residents.  
  Mitchell, S., Cook, J., and Densen, P, Academic Medicine, 69(5):434
• A New Course for Medical Education.  
  Densen, P, Iowa Medicine, 85:164-65
• Cloning and Characterization of the cDNA Encoding Guinea Pig Properdin: A Comparison of Properdin from Three Species.  
  Maves, K.K., Guenthner, S.T., Densen, P., Moser, D.R., and Weiler, J.M, Immunology, 86(3):475-9
• Delineation of Additional Genetic Bases for C8? Deficiency.  
  Saucedo, L., Ackermann, L., Platonov, A.E., Gewurz, A., Rakita, R.M., and Densen, P, Journal of Immunology, 155:5022-5028
• Invasive Haemophilus Influenzae Type b Infection in a Child with Familial Deficiency of the Beta Subunit of the Eighth Component of Complement.  
  Pallares, D.E., Figueroa, J.E., Densen, P., Giclas, P.C., and Marshall, G.S, Journal of Pediatrics, 128(1):102-103
• Type II Human Complement C2 Deficiency - Allele-specific Amino Acid Substitutions (Ser 189--?Phe; Gly444--?Arg) Cause Impaired C2 Secretion.  
  Wetsel, R.A., Kulics, J., Lokki, M.L., Kiepiela, P., Akama, H., Johnson, C.A.C., Densen, P., and Colten, H.R, Journal of Biological Chemistry, 271(10):5824-5831
• Student Health Policies of United States Medical Schools.  
  Diekema, D.J., Albanese, M.A., Densen, P., and Doebbeling, B.N, Academic Medicine, 71(10):1090-1092
• Heterozygous C8 beta Complement Deficiency does not Predispose to Meningococcal Disease.  
  Platonov, A.E., Shipulin, G.A., Shipulina, O. J., Vershinina, I.V., Densen, P, Clin Exp Immunol. 108(3): 497-499
• Join now to see all

Books/Book Chapters

• Textbook of Internal Medicine. 
  Chapter: Meningococcal Infections 
  Page 1630 - 1632Densen, PEditors: Kelley, W.M.J. B. Lippincott Co, Philadelphia
• Neisseriae. 
  Chapter: Antibody Response to Meningococcal Infection in Late Complement Deficient Individuals 
  Page 671 - 677Densen, P., Zaleski, A., Sanford, M., and Frasch, CEditors: Achtman, M., Kohl, P., Marchal, C., Morelli, G., Seiler, A., Thiesen, B.Walter de Gruyter & Co, Berlin
• Complement in Health and Disease. 
  Chapter: Human Complement Deficiency States and Infection 
  Page 173 - 198Densen, PEditors: Whaley, K., Loos, M., Weiler, J.M.Kluwer Academic Publishers, Dordrecht, NetherlandsEdition 2,
• Internal Medicine 
  Chapter: Basic Principles of Infectious Diseases 
  Page 1788 - 1791Densen, P. and Sande, MEditors: Mosby, Stein, J.H., et al.Little, Brown and Co, BostonEdition 4,
• Internal Medicine. 
  Chapter: Host Defense Against Infection: The Roles of Antibody, Complement, and Phagocytic Cells 
  Page 1791 - 1800Densen, P., Weinbaum, D.L., and Mandell, G.LEditors: Mosby, Stein, J.H., et al.Little, Brown and Co, BostonEdition 4,
• Principles and Practice of Infectious Diseases. 
  Chapter: Complement 
  Page 58 - 77Densen, PEditors: Mandell, G.L., Douglas, G., Bennett, J.Churchill Livingstone, IncEdition 4,
• Principles and Practice of Infectious Diseases. 
  Chapter: Granulocytic Phagocytes 
  Page 78 - 101Densen, P., Clark, R.A., and Nauseef, W.MEditors: Mandell, G.L., Douglas, G., Bennett, J.Churchill Livingstone, IncEdition 4,
• Neisseria 94. 
  Chapter: Enhanced Immune Response to Meningococcal Antigens in C5 Deficient Mice 
  Page 236 - 240Andreoni, J., and Densen, PEditors: Evans, Yost, Maiden, Feavers.Merieux UK, Ltd, Winchester, England
• Neisseria 94. 
  Chapter: Effect of Gc LOS Sialylation on Antibody Deposition and Complement Activation 
  Page 241 - 242Zaleski, T., and Densen, PEditors: Evans, Yost, Maiden, Feavers.Merieux UK, Ltd, Winchester, England
• Abstracts of the Tenth International Pathogenic Neisseria Conference. 
  Chapter: The Lipooligosaccharides of the Pathogenic Neisseria 
  Page 63 - 70Apicella, M.A., Densen, P., Preston, A., Mandrell, R.E., Stephens, D.S., Stein, D.C., and Gibson, B.WEditors: Baltimore, MD, WD Zollinger, CE Frasch, CD Deal.
• Principles and Practice of Infectious Diseases. 
  Chapter: Granulocytic Phagocytes 
  Page 81 - 101Densen, P., and Mandell, G.LEditors: Mandell, G.L., Douglas, G., Bennett, J.Churchill Livingstone, IncEdition 3,
• Manual of Clinical Laboratory Immunology. 
  Chapter: Alternative Pathway and Late Complement Component Deficiencies 
  Page 850 - 854Densen, PEditors: Rose, N.R., Cunningham-Rundles, C., et al.ASM Press, Washington, DC
• Internal Medicine. 
  Chapter: Basic Principles of Infectious Disease 
  Page 1334 - 1336Densen, P. and Sande, MEditors: Mosby, Stein, J.H., et al.Little, Brown and Co, Boston, MAEdition 5,
• Internal Medicine. 
  Chapter: Host Defense Against Infection: The Roles of Antibody, Complement, and Phagocytic Cells 
  Page 1336 - 1343Densen, P., Weinbaum, D.L., and Mandell, G.LEditors: Mosby, Stein, J.II., et al.Little, Brown and Co, Boston, MAEdition 5,
• The Human Complement System in Health and Disease. 
  Chapter: Complement Deficiencies and Infection 
  Page 409 - 421Densen, PEditors: Frank, M., and Volanakis, J.Marcel Dekker, Inc, New York
• Principles and Practice of Infectious Diseases. 
  Chapter: Complement 
  Page 67 - 89Densen, PEditors: Mandell, G.L., Douglas, G., Bennett, J.Churchill Livingstone, Inc
• Textbook of Internal Medicine. 
  Chapter: Meningococcal Infections 
  Page 1986 - 1990Densen, PEditors: Kelley, W.M.J. B. Lippincott Co, Philadelphia
• Principles and Practice of Infectious Diseases. 
  Chapter: Complement 
  Page 77 - 98Densen, PEditors: Mandell, G.L., Bennet, J.E., Dolin, R.Churchill Livingstone, IncEdition 6,
• Principles and Practice of Infectious Diseases. 
  Chapter: Complement 
  Page 77 - 98Densen, PEditors: Mandell, G.L., Bennet, J.E., Dolin, R.Churchill Livingstone, IncEdition 7,
• Infectious Disease Reviews Vol. 5. 
  Chapter: Phagocytic Cells Versus Microbes 
  Page 43 - 62Densen, P., and Mandell, G.LEditors: Holloway, W.J.Futura Publ. Co, New York
• Funda¬mentals of Immunology and Allergy. 
  Chapter: Phagocytosis 
  Page 51 - 64Densen, P., and Mandell, G.LEditors: Lockey, R.F., and Bukantz, S.C.W.B. Saunders, New York
• Immunobiology of Neisseria Gonorrhoeae. 
  Chapter: Morphological Observations of Neutrophil-Gonococcus Interaction 
  Page 213 - 220Densen, P., Rein, M.F., Sullivan, J.A., and Mandell, G.LEditors: Brooks, G.F., Gotschlich, E.C., Holmes, K.K., Sawyer, W.D., and Young, F.E.Amer. Soc. Microbiol, Washington, DC
• Principles and Practice of Infectious Disease. 
  Chapter: Granulocytic Phagocytes 
  Page 63 - 82Densen, P., and Mandell, G.LEditors: Mandell, G.L., Douglas, G., and Bennett, J.John Wiley & Sons, New YorkEdition 1,
• Principles and Prac¬tice of Infectious Disease. 
  Chapter: Cat Scratch Disease 
  Page 1456 - 1457Densen, PEditors: Mandell, G.L., Douglas, G., and Bennett, J.John Wiley & Sons, New York
• Current Chemotherapy and Infectious Disease. 
  Chapter: Gonococci Causing Uncomplicated Gonorrhea or Disseminated Gonococcal Infection Differ in Stimulation of Neutrophil Chemotaxis 
  Page 1247 - 1249Densen, P., MacKeen, L., and Clark, R.AEditors: Nelson, J.D., and Grassi, C.Amer. Soc. Microbiol, Washington, DC
• Join now to see all

Abstracts/Posters

• Complement C5a Produces Vasoconstriction in Atherosclerotic but not in Normal Primates In Vivo.
  Lopez, J.A.G., Mügge, A., Densen, P., Piegors, D.J., Armstrong, M.L., and Heistad, D.D, Clin. Res., 38:830A
• Differential Expression of C8 Subunits: Primary Role of C8?
  Densen, P., and McRill, C, Clin. Res., 35:613A
• C5b-8 Promotes Alternative Pathway C3 Convertase Decay on Neisseria.
  Densen, P., and McRill, C.M, Fed. Proc., 46:1196
• Differential Expression of C8 Subunits: Primary Role of C8?
  Densen, P., and McRill, C.M, Complement, 4:149
• Biosynthesis of Human C8.
  Densen, P., and Nauseef, W.M, Complement, 4:150
• The Kinetics of C3 and Factor B Cleavage on Serum Sensitive and Serum Resistant Gonococci Differ in C8 Deficient and Normal Human Serum.
  McRill, C.M., and Densen, P, Sixth International Pathogenic Neisseria Conference, Pine Mountain, Georgia
• Activation of Complement by Neisseria gonorrhoeae and Neisseria meningitidis.
  Densen, P., McRill, C., and Sanford, M, Sixth International Pathogenic Neisseria Conference, Pine Mountain, Georgia
• Identification of Extrahepatic Sites of C8 Synthesis and Further Characterization of the Basis for C8 Deficiency.
  Warnick, P., and Densen, P, Complement, 6:412 (Abst. #275)
• Molecular Heterogeneity of Human C2 Deficiency.
  Johnson, C., Densen, P., Wetsel, R., and Colten, H.R, Complement, 6:351 (Abst. #117)
• Identification of Extrahepatic Sites of C8 Synthesis and Further Characterization of the Basis for C8 Deficiency.
  Warnick, P., and Densen, P, 29th Interscience Conference on Antimicrobial Agents and Chemotherapy, p. 242. (Abst. #844)
• C4B Deficiency is Not Associated with Meningitis or Bacteremia with Encapsulated Bacteria.
  Cates, K.L., Dodds, A.W., Lockman, J., Densen, P., and Levine, R.P, FASEB J
• Antibody Response to Meningococcal Infection in Late Complement Component Deficient Individuals.
  Densen, P., Sanford, M., and Frasch, C, Abstract for the 7th International Pathogenic Neisseriae Conference
• Molecular Basis of C8 Deficiency States.
  Warnick, P., and Densen, P, 3rd European Meeting on Complement in Human Disease
• Prospective Study of the Prevalence of Complement Deficiency in Meningitis.
  Densen, P., Sanford, M., Burke, T., Densen, E., and Wintermeyer, L, 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, p. 140, (Abst. #320)
• Mono- and Polymorphonuclear Leukocytes Produce Endothelium-Independent Vasoconstriction in Normal and Atherosclerotic Primates.
  Mügge, A., Lopez, J.A.G., Densen, P., Waack, B.J., and Heistad, D.D, 63rd Scientific Sessions of the American Heart Association
• Activated Human Leukocytes Produce Endothelium-Independent Vasoconstriction in Normal and Atherosclerotic Primates In Vitro.
  Mügge, A., Lopez, J.A.G., Densen, P., Waack, B., and Heistad, D.D, Clin. Res., 38:854A
• Specificity of Lipooligosaccharide Antibodies Against Neisseria gonorrhoeae that Stimulate Chemotaxis.
  Densen, P., Gulati, S., Zollinger, W., and Rice, P, Fifth International Pathogenic Neisseria Conference, Amsterdam
• Properdin cDNA Sequence Isolated from Guinea Pig Spleen Using Polymerase Chain Reaction.
  Maves, K.K., Moser, D.R., Densen, P., and Weiler, J.M, FASEB J., 5:A1 716
• Deficiency of Human Complement C2, Type I: A 28BP Gene Deletion Leads to a Splicing Defect.
  Johnson, C.A., Densen, P., Hurford, R., Colten, H.R., and Wetsel, R.A, Clin. Res., 39:304A
• Basis for Recurrent Meningococcal Disease in Complement Deficiency.
  Andreoni, J., Kähty, H., Bruch, B., and Densen, P, 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL
• Comparison of Properdin Sequence in Three Species Shows Conservation of Thrombospondin Repeats.
  Maves, K.K., Moser, D.R., Densen, P., and Weiler, J.M, Abst. XIVth Int. Complement Workshop, 1991. Complement Inflamm., 8:191
• C8 as an Acute Phase Reactant: Regulation and Coordinate Expression of the 3 C8 Genes.
  Ackerman, L., Warnick, P., and Densen, P, Abst. XIV International Complement Workshop, 1991. Complement Inflamm., 8:123
• The Influence of Growth Conditions on Complement Mediated Killing and LOS Expression of Neisseria meningitidis.
  Andreoni, J., Saucedo, L., and Densen, P, Eighth International Pathogenic Neisseria Conference, Cuernavaca, Mexico
• Low Molecular Weight Serum Factor Enhances Meningococcal Serum Resistance.
  Andreoni, J., Saucedo, L., Mandrell, R., and Densen, P, Clin. Res., 41:376A
• Glucose Modulates Meningococcal Susceptibility to Complement Dependent Killing.
  Andreoni, J., Saucedo, L., Figueroa, J., and Densen, P, Clin. Res., 41:376A
• Join now to see all

Lectures

• Meningococcal Disease: a collision between genomes. 
  Landspitali University Hospital
• Challenges in medical curricular assessment, revision and evaluation. 
  Amman, Jordan
• Medical Learning Communities: What are they and why now? 
  Amman, Jordan
• Ethical Issues in Health Policy: access and workforce issues. 
  University of Dubuque, Dubuque, IA
• Learning Communities and Beyond. 
  Iowa City, IA, 2005; Kansas City, MO, 2006
• Pathogenesis and Mechanisms of Host Immunity against Neisseria Meningitidis. 
  World Health Organization, Geneva, Switzerland
• Extended Academic Programs – Who Pays? An Associate Dean’s Perspective. 
  Annual AAMC, Washington, D.C
• Pathogenesis of Meningococcal Disease. 
  X International Meeting of Pathogenic Neisseria, Baltimore, MD
• Enhanced Immune Response to Meningococcal Antigens in C5 Deficient Mice. 
  IX International Meeting of Pathogenic Neisseria, Winchester, England
• Infectious Consequences of Complement Deficiency States. 
  The American Academy of Allergy and Immunology, San Francisco, California
• Antibody Response to Meningococcal Infection in Late Complement Component Deficient Individuals. 
  VII International Meeting of Pathogenic Neisseria, Berlin, Germany
• Activation of Complement by Neisseria gonorrhoeae and Neisseria meningitidis. 
  VI International Meeting of Pathogenic Neisseria, Pine Mountain, GA
• Complement Activation in the Pathogenesis of Neisserial Infections. 
  27th Interscience Conference on Antimicrobial Agents and Chemotherapy
• Regulation of Complement Activation by Bacterial Surfaces. 
  27th Interscience Conference on Antimicrobial Agents and Chemotherapy
• Atypical HUS and TTP: insights for microvascular integrity. 
  University of Missouri-Columbia
• Venting the Spleen, A Loss of Humor with Catastrophic Results. 
  University of Iowa
• Meningococcal Disease as an Epidemiologic and Pathogenetic Paradigm. 
  San Antonio, TX, 1995; Kalamazoo, MI, 1995
• New Insights into Old Diseases: emerging concepts in microvascular integrity. 
  University of Iowa
• Meningococcal Disease: Teens, Genes and Vaccines. 
  University of Iowa, 2003; University of Minnesota, 2003
• Running a Temperature – Having a Fever: What’s the Difference? 
  University of Iowa
• A Tale of Two Cities: downwind and downstream mechanisms. 
  University of Iowa
• Guts, Germs and Stool. 
  University of Iowa
• Observation of a Grand Rounds Absentee or Who Moved My Cheese? 
  University of Iowa
• Recurrent Infections. 
  Third Annual Update in Infectious Disease, Galena, Illinois
• Epidemiology and Disease Produced by E. coli. 
  Second Annual Update in Infectious Disease, Galena, Illinois
• Join now to see all

Other

• How Iowa Can Best Serve AIDS Patients. 
  Densen, P., Nauseef, W.M., Clark, R.A., Kirchhoff, L.V., Stapleton, J.T., Wilson, M.E., Britigan, B.E., Davis, K., and Herring, P, The Des Moines Register
• The Association of Inherited Defects of the Complement Cascade and Bacterial Infection in Iowa - 1984-1989. 
  Densen, P, Epi-Gram, 5(1):4-5
• Is the AIDS Epidemic Ending? 
  Densen, P., and Stapleton, J, Epi-Gram, 5(3):1-3