PhilipTSagerMD

PubMed

• 1 citations
  SGK1 inhibition attenuates the action potential duration in reengineered heart cell models of drug-induced QT prolongation.
  Maengjo Kim, Philip T Sager, David J Tester, Sabindra Pradhananga, Samantha K Hamrick, Dinesh Srinivasan, Saumya Das, Michael J Ackerman> ;Heart Rhythm. 2023 Apr 1
• 15 citations
  First Randomized, Multicenter, Placebo-Controlled Study of Self-Administered Intranasal Etripamil for Acute Conversion of Spontaneous Paroxysmal Supraventricular Tachy...
  Bruce S Stambler, Francis Plat, Philip T Sager, Silvia Shardonofsky, Douglas Wight, Diane Potvin, A Shekhar Pandey, James E Ip, Benoit Coutu, Blandine Mondésert, Laure...> ;Circulation. Arrhythmia and Electrophysiology. 2022 Dec 1
• 3 citations
  A Phase 1 Clinical Study Evaluating the Effects of Cenobamate on the QT Interval.
  Borje Darpo, Philip T Sager, Hongqi Xue, Marc Kamin> ;Clinical Pharmacology in Drug Development. 2022 Apr 1
• 2 citations
  Electrophysiological and ECG Effects of Perhexiline, a Mixed Cardiac Ion Channel Inhibitor, Evaluated in Nonclinical Assays and in Healthy Subjects
  Mark G. Midei, Borje Darpo, Greg Ayers, Randy Brown, Jean-Philippe Couderc, William Daly, Georg Ferber, Philip T. Sager, A. John Camm> ;Journal of Clinical Pharmacology. 2021 Jul 20
• 25 citations
  Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it.
  Stanley Nattel, Philip T. Sager, Jörg Hüser, Jordi Heijman, Dobromir Dobrev> ;Cardiovascular Research. 2021 Jun 16
• 2 citations
  Methodological and Regulatory Considerations for Updated Guidance on the Pressor Effects of Drugs.
  Nicholas R Harrison, Philip T. Sager, Mitchell W. Krucoff, Michael A. Weber, William B. White> ;Therapeutic Innovation & Regulatory Science. 2020 Jun 4
• 43 citations
  Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms.
  Li Pang, Philip T. Sager, Xi Yang, Hong Shi, Frederick Sannajust, Mathew Brock, Joseph C. Wu, Najah Abi-Gerges, Beverly Lyn-Cook, Brian R. Berridge, Norman Stockbridge> ;Circulation Research. 2019 Oct 11
• 10 citations
  The Potential Role of the J-Tpeak Interval in Proarrhythmic Cardiac Safety: Current State of the Science From the American College of Clinical Pharmacology and the Car...
  Jose Vicente, David G. Strauss, Vijay V. Upreti, Michael J. Fossler, Philip T. Sager, Robert J. Noveck> ;Journal of Clinical Pharmacology. 2019 Jul 1
• 3 citations
  The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment.
  Najah Abi-Gerges, Carrie McMahon, Hugo M. Vargas, Philip T. Sager, Ray W. Chui, Dale Stevens, Jonathan Davila, Johanna R. Schaub, Joseph C. Wu, Carlos del Rio, Chris M...> ;Journal of Pharmacological and Toxicological Methods. 2019 Jul 1
• 62 citations
  Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting.
  David G. Strauss, Gary Gintant, Zhihua Li, Wendy W. Wu, Ksenia Blinova, Jose Vicente, J. Rick Turner, Philip T. Sager> ;Therapeutic Innovation & Regulatory Science. 2019 Jul 1
• 58 citations
  Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.
  Jose Vicente, Robbert Zusterzeel, Lars Johannesen, Roberto Ochoa‐Jimenez, Jay W. Mason, Carlos Sanabria, Sarah Kemp, Philip T. Sager, Vikram Patel, Murali K. Matta, Ji...> ;Clinical Pharmacology and Therapeutics. 2019 Apr 1
• 24 citations
  Cardiovascular Safety During and After Use of Phentermine and Topiramate.
  Mary E Ritchey, Abenah Harding, Shannon Hunter, Craig Peterson, Philip T. Sager, Peter R. Kowey, Lan Nguyen, Steven Thomas, Miguel Cainzos-Achirica, Kenneth J. Rothman...> ;The Journal of Clinical Endocrinology and Metabolism. 2019 Feb 1
• 24 citations
  Drug-induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy
  J. Rick Turner, Ignacio Rodriguez, Emily H Mantovani, Gary Gintant, Peter R. Kowey, Ralph J Klotzbaugh, Krishna Prasad, Philip T. Sager, Norman Stockbridge, Colette St...> ;Journal of Clinical Pharmacology. 2018 Aug 1
• 30 citations
  Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm.
  Bruce S. Stambler, Paul Dorian, Philip T. Sager, Douglas Wight, Philippe Douville, Diane Potvin, Pirouz Shamszad, Ronald J. Haberman, Richard S. Kuk, Dhanunjaya Lakkir...> ;Journal of the American College of Cardiology. 2018 Jul 31
• Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.
  Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss> ;Plos One. 2018 May 21
• 15 citations
  Effect of ulixertinib, a novel ERK1/2 inhibitor, on the QT/QTc interval in patients with advanced solid tumor malignancies.
  Boaz Mendzelevski, Georg Ferber, Filip Janku, Bob T. Li, Ryan J. Sullivan, Dean Welsch, Wei Chi, Jeanne Jackson, Onglee Weng, Philip T. Sager> ;Cancer Chemotherapy and Pharmacology. 2018 Mar 30
• 11 citations
  Correction to: Scientific white paper on concentration-QTc modeling.
  Christine Garnett, Peter L. Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan V. Mehrotra, Steve Riley, Philip T. Sager, Christoffer W. Tornøe, Yaning ...> ;Journal of Pharmacokinetics and Pharmacodynamics. 2018 Jan 12
• 88 citations
  Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study
  Jose Vicente, Robbert Zusterzeel, Lars Johannesen, Jay W. Mason, Philip T. Sager, Vikram Patel, Murali K. Matta, Zhihua Li, Jiang Liu, Christine Garnett, Norman Stockb...> ;Clinical Pharmacology and Therapeutics. 2018 Jan 1
• 137 citations
  Scientific white paper on concentration-QTc modeling
  Christine Garnett, Peter L. Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan V. Mehrotra, Steve Riley, Philip T. Sager, Christoffer W. Tornøe, Yaning ...> ;Journal of Pharmacokinetics and Pharmacodynamics. 2017 Dec 5
• 30 citations
  Is there a role for pharmacokinetic/pharmacodynamic-guided dosing for novel oral anticoagulants?
  Noel C. Chan, Philip T. Sager, Jack Lawrence, Thomas's Ortel, Paul A. Reilly, Scott D. Berkowitz, Dagmar Kubitza, John W. Eikelboom, Jeffry Florian, Norman Stockbridge...> ;American Heart Journal. 2017 Oct 1
• 17 citations
  Influence of Meals and Glycemic Changes on QT Interval Dynamics.
  Brenda Cirincione, Philip T. Sager, Donald E. Mager> ;Journal of Clinical Pharmacology. 2017 Aug 1
• 2 citations
  Model-Based Evaluation of Exenatide Effects on the QT Interval in Healthy Subjects Following Continuous IV Infusion.
  Brenda Cirincione, Frank LaCreta, Philip T. Sager, Donald E. Mager> ;Journal of Clinical Pharmacology. 2017 Aug 1
• 7 citations
  Long-term electrocardiographic safety monitoring in clinical drug development: A report from the Cardiac Safety Research Consortium.
  Jonathan P. Piccini, Richard Clark, Peter R. Kowey, Suneet Mittal, Preston Dunnmon, Norman Stockbridge, James A. Reiffel, Mintu P. Turakhia, Paul D. Ziegler, Robert Kl...> ;American Heart Journal. 2017 May 1
• 10 citations
  Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects
  Borje Darpo, Philip T. Sager, Prabhavathi Fernandes, Brian D. Jamieson, Kara Keedy, Meijian Zhou, David W. Oldach> ;The Journal of Antimicrobial Chemotherapy. 2017 Feb 1
• 28 citations
  Electrocardiographic biomarkers for detection of drug-induced late sodium current block
  Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss> ;Plos One. 2016 Dec 30
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