PratapSinghMDCMD

PubMed

• 23 citations
  Translational Pharmacokinetic/Pharmacodynamic Characterization and Target-Mediated Drug Disposition Modeling of an Anti-Tissue Factor Pathway Inhibitor Antibody, PF-06...
  Chuenlei Parng, Pratap Singh, Debra D. Pittman, Katherine Wright, Beth A. Leary, Sunita Patel-Hett, Swapnil Rakhe, James A. Stejskal, Marjorie A. Peraza, Dawn Dufield,...> ;Journal of Pharmaceutical Sciences. 2018 Jul 1
• 4 citations
  Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease.
  Xiaoying Chen, Vahid Farrokhi, Pratap Singh, Mireia Fernández Ocaña, Jenil Patel, Lih-Ling Lin, Hendrik Neubert, Joanne Brodfuehrer> ;Mabs. 2018 Jan 1
• 13 citations
  Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling
  Abhinav Tiwari, Anson K. Abraham, John M. Harrold, Anup Zutshi, Pratap Singh> ;The AAPS Journal. 2017 Mar 1
• Erratum to: Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling
  Abhinav Tiwari, Anson K. Abraham, John M. Harrold, Anup Zutshi, Pratap Singh> ;The AAPS Journal. 2017 Jan 17
• 8 citations
  Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions.
  Abhinav Tiwari, H Luo, Xiaoying Chen, Pratap Singh, Indranil Bhattacharya, P Jasper, JE Tolsma, Hannah M. Jones, Anup Zutshi, Anson K. Abraham> ;CPT. 2016 Oct 1
• 22 citations
  Translational Pharmacokinetic/Pharmacodynamic Analysis of MYO-029 Antibody for Muscular Dystrophy.
  Pratap Singh, H Rong, T Gordi, J Bosley, Indranil Bhattacharya> ;Clinical and Translational Science. 2016 Oct 4
• 9 citations
  Mathematical modeling of receptor occupancy data: A valuable technology for biotherapeutic drug development.
  Mary E. Spilker, Pratap Singh, Paolo Vicini> ;Cytometry. Part B, Clinical Cytometry. 2016 Mar 1
• 37 citations
  Quantitative prediction of human pharmacokinetics for mAbs exhibiting target-mediated disposition.
  Aman P. Singh, Wojciech Krzyzanski, Steven W. Martin, Gregory Weber, Alison Betts, Alaa Ahmad, Anson K. Abraham, Anup Zutshi, John C. Lin, Pratap Singh> ;The AAPS Journal. 2015 Mar 1
• 3 citations
  A Systems Pharmacology Model of Erythropoiesis in Mice Induced by Small Molecule Inhibitor of Prolyl Hydroxylase Enzymes.
  Indrajeet Singh, EE Nagiec, JM Thompson, Wojciech Krzyzanski, Pratap Singh> ;CPT. 2015 Feb 1
• 19 citations
  Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies
  Vaishali L. Chudasama, Anup Zutshi, Pratap Singh, Anson K. Abraham, Donald E. Mager, John M. Harrold> ;Journal of Pharmacokinetics and Pharmacodynamics. 2015 Jan 6
• 15 citations
  Quantitative analysis of target coverage and germinal center response by a CXCL13 neutralizing antibody in a T-dependent mouse immunization model.
  Joanne Brodfuehrer, Andrew L. Rankin, Jason Edmonds, Sean Keegan, Tatyana Andreyeva, Rosemary Lawrence-Henderson, Josef S. Ozer, Huilan Gao, Laird Bloom, Angela Boisve...> ;Pharmaceutical Research. 2014 Mar 1
• 15 citations
  Agonistic TAM-163 antibody targeting tyrosine kinase receptor-B: Applying mechanistic modeling to enable preclinical to clinical translation and guide clinical trial d...
  Yulia Vugmeyster, Cynthia M. Rohde, Mylene Perreault, Ruth E. Gimeno, Pratap Singh> ;Mabs. 2013 Mar 25
• 23 citations
  Polyscope: a new era in flexible ureterorenoscopy.
  Harbans Bansal, Samir Swain, Girish K. Sharma, Mikhil Mathanya, Sameer Trivedi, Udai S. Dwivedi, Pratap Singh> ;Journal of Endourology. 2011 Feb 25
• 55 citations
  Improved Extrapolation of Hepatobiliary Clearance from in Vitro Sandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters
  Na Li, Pratap Singh, Kathy M. Mandrell, Yurong Lai> ;Molecular Pharmaceutics. 2010 Jun 7
• 4 citations
  Multivitamin and micronutrient treatment improves semen parameters of azoospermic patients with maturation arrest.
  Amit Singh, Anil Kumar Tiwari, Pratap Singh, Udai S. Dwivedi, Sameer Trivedi, Surya Singh, Neeraj K. Agrawal, Shripad B. Deshpande> ;Indian Journal of Physiology and Pharmacology. 2010 Apr 1
• 20 citations
  Substitution urethroplasty for anterior urethral strictures: buccal versus lingual mucosal graft.
  Abhay Kumar, Suren K. Das, Sameer Trivedi, Udai S. Dwivedi, Pratap B. Singh> ;Urologia Internationalis. 2010 Feb 17
• 11 citations
  Molecular insights into substrate specificity of prostate specific antigen through structural modeling
  Pratap Singh, Aaron M. LeBeau, Hans Lilja, Samuel R. Denmeade, John T. Isaacs> ;Proteins. 2009 Dec 1
• 12 citations
  Prostate-specific antigen is a "chymotrypsin-like" serine protease with unique P1 substrate specificity.
  Aaron M LeBeau, Pratap Singh, John T Isaacs, Samuel R Denmeade> ;Biochemistry. 2009 Apr 21
• 26 citations
  Our experience with genitourinary fistulae.
  Abhay Kumar, Neeraj Kumar Goyal, Suren K. Das, Sameer Trivedi, Udai S. Dwivedi, Pratap B. Singh> ;Urologia Internationalis. 2009 Jan 1
• 6 citations
  Rational design of novel antiandrogens for neutralizing androgen receptor function in hormone refractory prostate cancer
  Pratap Singh, Gurulingappa Hallur, Ravi K. Anchoori, Oladapo Bakare, Yukio Kageyama, Saeed R. Khan, John T. Isaacs> ;The Prostate. 2008 Oct 1
• 49 citations
  Potent and Selective Peptidyl Boronic Acid Inhibitors of the Serine Protease Prostate-Specific Antigen
  Aaron M. LeBeau, Pratap Singh, John T. Isaacs, Samuel R. Denmeade> ;Chemistry & Biology. 2008 Jul 21
• 15 citations
  Mechanistic insights into the inhibition of prostate specific antigen by β‐lactam class compounds
  Pratap Singh, Simon A. Williams, Meha H. Shah, Thomas Lectka, Gareth J. Pritchard, John T. Isaacs, Samuel R. Denmeade> ;Proteins. 2007 Sep 25
• 26 citations
  Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.
  Masayasu Urushibara, Junichiro Ishioka, Nobuhiko Hyochi, Kazunori Kihara, Shuntaro Hara, Pratap Singh, John T. Isaacs, Yukio Kageyama> ;The Prostate. 2007 Jun 1
• 76 citations
  Does PSA play a role as a promoting agent during the initiation and/or progression of prostate cancer?
  Simon A. Williams, Pratap Singh, John T. Isaacs, Samuel R. Denmeade> ;The Prostate. 2007 Feb 15
• 73 citations
  A Dimeric Peptide That Binds Selectively to Prostate-Specific Membrane Antigen and Inhibits its Enzymatic Activity
  Saurabh Aggarwal, Pratap Singh, Ozlem Topaloglu, John T. Isaacs, Samuel R. Denmeade> ;Cancer Research. 2006 Sep 15
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