PrestonCarpenterSprenkleMD

Surgical Oncology

Chief, Urology Service, VA Connecticut Healthcare Director, Urologic Oncology Fellowship Program Director, Prostate MR-US Fusion biopsy and Focal Therapy in Prostate Cancer Programs

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Office
330 Cedar St
Department Of Urology, Rm 315b
New Haven, CT 06520
Phone+1 203-785-2052

Fax+1 203-785-4043
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Complex General Surgical Oncology, 2009 - 2011
New York Presbyterian Hospital (Columbia Campus)Residency, Urology, 2005 - 2009
New York Presbyterian HospitalInternship, Transitional Year, 2004 - 2005
Columbia University Vagelos College of Physicians and SurgeonsClass of 2004
Stanford UniversityBA, Human Biology, 1998

Certifications & Licensure

CA State Medical License 2012 - Present
FL State Medical License 2022 - Present
CT State Medical License 2012 - 2025
PA State Medical License 2011 - 2014
NY State Medical License 2005 - 2013
American Board of Urology Urology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2014

Clinical Trials

Prostate Cancer Screening in Men With Germline BRCA2 Mutations Start of enrollment: 2014 May 01
Completed
MR-US Image Fusion Targeted Biopsy for Single-cell Prostate Cancer Research Start of enrollment: 2013 Jul 01
Recruiting
Active Surveillance in Prostate Cancer, Imaging to Detect Radiographic Progression as an Endpoint (ASPIRE) Start of enrollment: 2015 Apr 01
Active, not recruiting
Study to Evaluate 99mTc-MIP-1404 SPECT/CT Imaging in Men With Biopsy Proven Low-Grade Prostate Cancer Start of enrollment: 2015 Dec 01
Completed
Phase 3
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Publications & Presentations

PubMed

Association between sociodemographic factors and diagnosis of lethal prostate cancer in early life.
Shayan Smani, Madison Novosel, Ryan Sutherland, Farah Jeong, Michael Jalfon, Victoria Marks, Paweł Rajwa, José Ignacio Nolazco, Samuel L Washington, Joseph F Renzulli ...> ;Urologic Oncology. 2024 Feb 1
Prostate cancer risk stratification using magnetic resonance imaging-ultrasound fusion vs systematic prostate biopsy.
Ghazal Khajir, Benjamin Press, Soum Lokeshwar, Kamyar Ghabili, Syed Rahman, Mursal Gardezi, Samuel Washington, Matthew R Cooperberg, Preston Sprenkle, Michael S Leapman> ;JNCI Cancer Spectrum. 2023 Oct 31
Cytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with his...
Ghazal Khajir, Tong Sun, He Wang, Preston C Sprenkle, Adebowale J Adeniran, Guoping Cai, Angelique W Levi> ;Cytopathology. 2024 Mar 1
1 citations
Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning.
Nathan Paulson, Tal Zeevi, Maria Papademetris, Michael S Leapman, John A Onofrey, Preston C Sprenkle, Peter A Humphrey, Lawrence H Staib, Angelique W Levi> ;JCO Clinical Cancer Informatics. 2022 Sep 1
16 citations
Multi-institutional analysis of clinical and imaging risk factors for detecting clinically significant prostate cancer in men with PI-RADS 3 lesions.
Andrew M Fang, Luke A Shumaker, Kimberly D Martin, Jamaal C Jackson, Richard E Fan, Ghazal Khajir, Hiten D Patel, Nachiketh Soodana-Prakash, Srinivas Vourganti, Christ...> ;Cancer. 2022 Sep 15
Clinical utility of MR/ultrasound fusion-guided biopsy in patients with lower suspicion lesions on active surveillance for low-risk prostate cancer.
Soum D Lokeshwar, Justin Nguyen, Syed N Rahman, Ghazal Khajir, Richard Ho, Kamyar Ghabili, Michael S Leapman, Jeffrey C Weinreb, Preston C Sprenkle> ;Urologic Oncology. 2022 Sep 1
6 citations
Real-Time MRI-Guided Prostate Interventions.
Seyedeh Nina Masoom, Karthik M Sundaram, Pejman Ghanouni, Jurgen Fütterer, Aytekin Oto, Raj Ayyagari, Preston Sprenkle, Jeffrey Weinreb, Sandeep Arora> ;Cancers. 2022 Apr 7
Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer.
Matthew Buck, Eric Ghiraldi, Patrick Demkowicz, Henry S Park, Yi An, Benjamin H Kann, James B Yu, Preston C Sprenkle, Isaac Y Kim, Michael S Leapman, Park, H. S.> ;Urology Practice. 2022 Mar 1
8 citations
Association Between a 22-feature Genomic Classifier and Biopsy Gleason Upgrade During Active Surveillance for Prostate Cancer.
Benjamin H Press, Tashzna Jones, Olamide Olawoyin, Soum D Lokeshwar, Syed N Rahman, Ghazal Khajir, Daniel W Lin, Matthew R Cooperberg, Stacy Loeb, Burcu F Darst, Yingy...> ;European Urology Open Science. 2022 Mar 1
3 citations
Optimal Use of Tumor-Based Molecular Assays for Localized Prostate Cancer.
Soum D Lokeshwar, Jamil S Syed, Daniel Segal, Syed N Rahman, Preston C Sprenkle> ;Current Oncology Reports. 2022 Feb 1
25 citations
Changes in Prostate-Specific Antigen Testing Relative to the Revised US Preventive Services Task Force Recommendation on Prostate Cancer Screening.
Michael S. Leapman, Rong Wang, Henry Park, James B. Yu, Preston C. Sprenkle, Matthew R. Cooperberg, Cary P. Gross, Xiaomei Ma> ;JAMA Oncology. 2021 Nov 11
7 citations
Targeting prostate cancer with Clostridium perfringens enterotoxin functionalized nanoparticles co-encapsulating imaging cargo enhances magnetic resonance imaging spec...
Darryl T. Martin, Jung Seok Lee, Qiang Liu, Gigi Galiana, Preston C. Sprenkle, Peter A. Humphrey, Daniel P. Petrylak, Jeffery C. Weinreb, Peter G. Schulam, Robert M. W...> ;Nanomedicine. 2022 Feb 1
10 citations
Adoption of New Risk Stratification Technologies Within US Hospital Referral Regions and Association With Prostate Cancer Management.
Michael S. Leapman, Rong Wang, Henry S. Park, James B. Yu, Preston C. Sprenkle, Michaela A. Dinan, Xiaomei Ma, Cary P. Gross> ;JAMA Network Open. 2021 Oct 1
7 citations
The stanford prostate cancer calculator: Development and external validation of online nomograms incorporating PIRADS scores to predict clinically significant prostate...
Nancy Wang, Steve R. Zhou, Leo C Chen, Robert Tibshirani, Richard E. Fan, Pejman Ghanouni, Alan Thong, Katherine J. To'o, Kamyar Ghabili, Jeffrey W. Nix, Jennifer Gord...> ;Urologic Oncology. 2021 Jul 8
4 citations
Utility of PSA Density in Predicting Upgraded Gleason Score in Men on Active Surveillance With Negative MRI.
Benjamin Press, Ghazal Khajir, Kamyar Ghabili, Cynthia Leung, Richard E. Fan, Nancy Wang, Michael S. Leapman, Geoffrey A. Sonn, Preston C. Sprenkle> ;Urology. 2021 Jun 1
9 citations
International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer.
Andreas Wibmer, Michael W. Kattan, Francesco Alessandrino, Alexander D. J. Baur, Lars Boesen, Felipe Boschini Franco, David Bonekamp, Riccardo Campa, Hannes Cash, Viol...> ;Cancers. 2021 May 27
Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage.
Nathan Paulson, Robin T. Vollmer, Peter A. Humphrey, Preston C. Sprenkle, John A. Onofrey, Steffen Huber, Kamyar Ghabili Amirkhiz, Angelique Levi> ;Archives of Pathology & Laboratory Medicine. 2021 May 20
15 citations
The Prognostic Association of Prostate MRI PI-RADS™ v2 Assessment Category and Risk of Biochemical Recurrence after Definitive Local Therapy for Prostate Cancer: A Sys...
Pawel Rajwa, Keiichiro Mori, Nicolai A. Huebner, Darryl T. Martin, Preston C. Sprenkle, Jeffrey C. Weinreb, Guillaume Ploussard, Benjamin Pradere, Shahrokh F. Shariat,...> ;The Journal of Urology. 2021 Apr 27
Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy.
Kamyar Ghabili, Nathan Paulson, Jamil Syed, Cayce Nawaf, Ghazal Khajir, Darryl T. Martin, John A. Onofrey, Michael S. Leapman, Angelique Levi, Jeffrey C. Weinreb, Pete...> ;Case Reports in Urology. 2021 Mar 17
6 citations
Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology.
Richard Torres, Eben Olson, Robert J. Homer, Darryl T. Martin, Michael J. Levene, Sudhir Perincheri, Preston C. Sprenkle, Peter A. Humphrey> ;Archives of Pathology & Laboratory Medicine. 2021 May 1
Radiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy.
Daniel X. Yang, Vivek Verma, Yi An, James B. Yu, Preston C. Sprenkle, Michael S. Leapman, Henry S. Park> ;Advances in Radiation Oncology. 2020 Sep 15
1 citations
National trends in the management of patients with positive surgical margins at radical prostatectomy.
Kamyar Ghabili, Henry S. Park, James B. Yu, Preston C. Sprenkle, Simon P. Kim, Kevin A. Nguyen, Xiaomei Ma, Cary P. Gross, Michael S. Leapman> ;World Journal of Urology. 2021 Apr 1
8 citations
Effect of Diaphragmatic Breathing on Procedural Anxiety During Transrectal Prostate Biopsy.
Amy S. Grinberg, John J. Sellinger, Preston C. Sprenkle, Alexander J. Bandin, Cayce Nawaf, Jamil Syed, Michael S. Leapman> ;Urology. 2020 Mar 1
10 citations
When and How Should Active Surveillance for Prostate Cancer be De-Escalated?
Pawel Rajwa, Preston C. Sprenkle, Michael S. Leapman> ;European Urology Focus. 2021 Mar 1
3 citations
Association Between Tumor Multifocality on Multi-parametric MRI and Detection of Clinically-Significant Prostate Cancer in Lesions with Prostate Imaging Reporting and ...
Kamyar Ghabili, Matthew S. Swallow, Rachael L. Sherrer, Jamil Syed, Ghazal Khajir, Jennifer Gordetsky, Michael S. Leapman, Soroush Rais-Bahrami, Preston C. Sprenkle> ;Urology. 2019 Dec 1
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Press Mentions

Active Surveillance: Optimizing the Quality of Life in Men with Localized Prostate Cancer - Preston Sprenkle & Randy VinceApril 14th, 2023
Digital Rectal Exams Alone May Not Accurately Detect Prostate Cancer, Study ShowsApril 4th, 2023
Do You Really Need a Prostate Check?November 13th, 2017
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