Priscilla Kaliopi Brastianos MD

PubMed

• Combination treatment with RAF/MEK inhibitor avutometinib and FAK inhibitor defactinib in preclinical models of meningioma.
  Nazanin Ijad, Katie L Waller, Erika Yamazawa, Naema Nayyar, Danielle Burgenske
  Neuro-Oncology Advances. 2026-08-12
• Germline determinants of risk and molecular subtype in young-onset lung cancer.
  Jaclyn LoPiccolo, Ryan L Collins, Noah Fields, Carter Nakagawa, Kodi Taraszka
  Medrxiv. 2026-07-10
• 1 citations
  Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model.
  Thijs J Hagenbeek, Jason Zbieg, Russell Smith, Sayantanee Paul, Luca Gerosa
  Nature Communications. 2026-06-27

Journal Articles

• Toward Precision Medicine in Brain Metastases  
  Priscilla Brastianos, MD, Thieme
• The Dual PI3K/mTOR-pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases  
  Priscilla K Brastianos, Daniel P Cahill, Clinical Cancer Research
• DMD Genomic Deletions Characterize a Subset of progressive/higher-grade Meningiomas with Poor Outcome  
  Ganesh M Shankar, Sandro Santagata, Priscilla K Brastianos, Daniel P Cahill, Acta Neuropathologica

Books/Book Chapters

• Central Nervous System Metastasis, the Biological Basis and Clinical Consideration 
  Chapter: Leptomeningeal Carcinomatosis 
  Page 187 - 201Brastianos, P.K., Brastianos, H.C., Eichler, AEditors: Palmieri, D..Springer, New York, NY2013
• Encyclopedia for Neurological Sciences 
  Chapter: Primary CNS Lymphoma 
  Page 971 - 977Brastianos, P.K., & Batchelor, T.T.Editors: Aminoff, M.J., and Daroff, R.B..2013
• Primary Central Nervous System Tumors: Pathogenesis and Therapy 
  Chapter: Pineal Region Tumors 
  Page 435 - 457Brastianos, H., Brastianos, P.K., Blakeley, JEditors: Norden, A., Reardon, D., Wen, P.Humana Press, New York, NY2011

Abstracts/Posters

• Genetic characterization demonstrates high frequency of clinically actionable mutations in SMO and AKT1 in skull base meningiomas
  Brastianos, P.K., Society for Neuro-Oncology International Meningioma Meeting, Toronto, ON, Canada, 1/1/2016
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Metastasis-specific Mutations
  Brastianos, P.K., Clonal Evolution Symposium, AACR National Meeting, Philadelphia, PA, 1/1/2015
• Modes of metastasis in human and murine cancer revealed by whole exome sequencing
  Carter, S.L., Brastianos, P.K., Mcfadden, D.G., Papagiannokopoulos, T., Taylor-Weiner, A., Cibulskis, K., Jacks, T., Hahn, W.C., Getz, G, American Association for Cancer Research, San Diego, CA, 1/1/2014

Lectures

• Will There Ever Be Progress for Leptomeningeal Carcinomatosis: An Update on the Multidisciplinary... 
  ASCO Annual Meeting 2019 - Chicago, IL - 6/4/2019
• How Can We Apply Precision Medicine to Craniopharyngioma and Meningioma? 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
• Phase II study of pembrolizumab in leptomeningeal carcinomatosis. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/1/2018

Other

• Identification of PIN1 inhibitors as possible therapeutic agents against Alzheimer’s disease (Thesis) 
  Brastianos, P.K, University of British Columbia
  1/2/2002