PriyaUdayKumthekarMD

Neurology • Chicago, IL

Instructor in Ken and Ruth Davee Department of Neurology

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Office
710 North Lake Shore Drive
Abbott Hall Room 1110
Chicago, IL 60611
Phone+1 312-695-0990
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Education & Training

McGaw Medical Center of Northwestern UniversityResidency, Neurology, 2008 - 2011
McGaw Medical Center of Northwestern UniversityInternship, Internal Medicine, 2007 - 2008
Northeast Ohio Medical UniversityClass of 2007

Certifications & Licensure

IL State Medical License 2008 - 2026
American Board of Psychiatry and Neurology Neurology

Clinical Trials

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Start of enrollment: 2009 Sep 01
Recruiting
Phase 3
Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Start of enrollment: 2010 Jun 17
Completed
Phase 2
Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2012 Nov 01
Completed
Phase 1, Phase 2
Bevacizumab in Pats w/ Recurrent ST Brain Metas Who Have Failed Whole Brain Radiation Therapy Start of enrollment: 2013 Nov 27
Completed
Phase 2
ANG1005 in Patients With Recurrent High-Grade Glioma Start of enrollment: 2013 Oct 01
Completed
Phase 2
Safety & Efficacy Study of TPI 287 + Avastin in Adults With Glioblastoma That Progressed Following Prior Avastin Therapy Start of enrollment: 2014 Jan 01
Terminated
Phase 2
ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases Start of enrollment: 2014 Apr 01
Completed
Phase 2
AGEN1884, an Anti-CTLA-4 Human Monoclonal Antibody in Subjects With Advanced or Refractory Cancer and Who Have Progressed With PD-1/PD-L1 Inhibitor as Their Most Recent Therapy Start of enrollment: 2016 Apr 01
Completed
Phase 1, Phase 2
Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma Start of enrollment: 2016 Aug 01
Recruiting
Phase 2
NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery Start of enrollment: 2017 May 25
Completed
Early Phase 1
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma Start of enrollment: 2020 Jun 08
Terminated
Phase 1, Phase 2
Roles: Principal Investigator, Contact
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease Start of enrollment: 2020 Dec 10
Recruiting
Phase 1, Phase 2
Roles: Principal Investigator, Contact
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers Start of enrollment: 2017 Jul 13
Recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

TIP24-199: Rhenium (Re-186) Obisbemeda {Re-186-Nanoliposome (186RNL)} in Leptomeningeal Metastases [LM] Phase 1/2A Dose Escalation Trial: Update of Initial Safety and ...
Norman LaFrance, Michael Youssef, Ande Bao, Melissa Moore, Joel Michalek, Marc Hedrick, William Phillips, Toral Patel, Jeffrey Weinberg, John Floyd, Andrew Brenner, Pr...> ;Journal of the National Comprehensive Cancer Network. 2024 Apr 5
CALGB 80802 (Alliance): Impact of Sorafenib with and without Doxorubicin on Hepatitis C Infection in Patients with Advanced Hepatocellular Carcinoma.
Abou-Alfa, G., Geyer, S., Nixon, A., Innocenti, F., Shi, Q., Kumthekar, P., Jacobson, S., El Dika, I., Yaqubie, A., Lopez, J., Huang, B., Tang, Y., Wen, Y., Schwartz, ...> ;Cancer Research Communications. 2024 Mar 7
1 citations
A multi-institutional phase I study of acetazolamide with temozolomide in adults with newly diagnosed-methylated malignant glioma.
Driscoll, R., Karrison, T., Merrell, R., Lyne, S., Voce, D., Maraka, S., Gondi, V., Chmura, S., Dixit, K., Kumthekar, P., Pytel, P., Collins, J., Stupp, R., Lukas, R.,...> ;Neuro-Oncology Advances. 2024 Feb 1
Pertuzumab plus high-dose trastuzumab for HER2-positive breast cancer with brain metastases: PATRICIA final efficacy data.
Nancy U Lin, Priya Kumthekar, Solmaz Sahebjam, Nuhad Ibrahim, Anita Fung, Anna Cheng, Alan Nicholas, Jesse Sussell, Mark Pegram> ;NPJ Breast Cancer. 2023 Nov 17
Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results.
Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings,...> ;Acta Neuropathologica Communications. 2023 Nov 2
1 citations
Novel approaches to treatment of leptomeningeal metastases.
Ditte Primdahl, Adam Cohen-Nowak, Priya Kumthekar> ;Current Opinion in Neurology. 2023 Dec 1
1 citations
Cerebrospinal fluid-administered therapies for leptomeningeal metastases from solid tumors.
Archit B Baskaran, Ankush Bhatia, Priya Kumthekar, Adrienne Boire, Rimas V Lukas> ;Future Oncology. 2023 Aug 1
6 citations
Correcting the drug development paradigm for glioblastoma requires serial tissue sampling.
Kirit Singh, Kelly M Hotchkiss, Ian F Parney, John De Groot, Solmaz Sahebjam, Nader Sanai, Michael Platten, Evanthia Galanis, Michael Lim, Patrick Y Wen, Giuseppe Minn...> ;Nature Medicine. 2023 Oct 1
Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance).
Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M Wolpin, Yin Zhang, Charles S Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A Guthrie, Fel...> ;Clinical Cancer Research. 2023 Jul 14
Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis.
Surbhi Warrior, Adam Cohen-Nowak, Priya Kumthekar> ;Cancers. 2023 May 25
40 citations
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.
Farshad Nassiri, Vikas Patil, Leeor S Yefet, Olivia Singh, Jeff Liu, Rachel M A Dang, Takafumi N Yamaguchi, Mariza Daras, Timothy F Cloughesy, Howard Colman, Priya U K...> ;Nature Medicine. 2023 Jun 1
Plasma 25-hydroxyvitamin D levels and survival in stage III colon cancer: Findings from CALGB/SWOG 80702 (Alliance).
Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M Wolpin, Yin Zhang, Charles S Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A Guthrie, Fel...> ;Clinical Cancer Research. 2023 May 11
1 citations
Neuro-Oncology in Women: Clinical Considerations.
Lauren Singer, Ditte Primdahl, Priya Kumthekar> ;Neurologic Clinics. 2023 May 1
26 citations
Repeated blood-brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 ...
Adam M Sonabend, Andrew Gould, Christina Amidei, Rachel Ward, Karyn A Schmidt, Daniel Y Zhang, Cristal Gomez, John F Bebawy, Benjamin P Liu, Guillaume Bouchoux, Carole...> ;The Lancet. Oncology. 2023 May 1
2 citations
A Phase II Single-arm Study of Palbociclib in Patients With HER2-positive Breast Cancer With Brain Metastases and Analysis of ctDNA in Patients With Active Brain Metas...
Ami N Shah, Cesar A Santa-Maria, Dhruvika Mukhija, Nikita Shah, Anthony K Kang, Priya Kumthekar, Kirsten Burdett, Shruti Chandra, Jenny Chang, Dean Tsarwhas, Jill Wood...> ;Clinical Breast Cancer. 2023 Apr 1
16 citations
Neurologic Manifestations of Long COVID Differ Based on Acute COVID-19 Severity.
Gina S Perez Giraldo, Sareen T Ali, Anthony K Kang, Tulsi R Patel, Shreya Budhiraja, Jordan I Gaelen, Grace K Lank, Jeffrey R Clark, Shreya Mukherjee, Tracey Singer, A...> ;Annals of Neurology. 2023 Jul 1
18 citations
Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With SomaticMutations.
Priscilla K Brastianos, Erin L Twohy, Elizabeth R Gerstner, Timothy J Kaufmann, A John Iafrate, Jochen Lennerz, Suriya Jeyapalan, David E Piccioni, Varun Monga, Camilo...> ;Journal of Clinical Oncology. 2023 Jan 20
8 citations
A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma.
Priya Kumthekar, Sean Aaron Grimm, Marc C Chamberlain, David Schiff, Patrick Y Wen, Fabio Massaiti Iwamoto, Demirkan Besim Gursel, David A Reardon, Benjamin Purow, Mas...> ;Neuro-Oncology Advances. 2022 Aug 19
22 citations
A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, effic...
Priya U Kumthekar, Michael J Avram, Andrew B Lassman, Nancy U Lin, Eudocia Lee, Sean A Grimm, Margaret Schwartz, Kirsten L Bell Burdett, Rimas V Lukas, Karan Dixit, Is...> ;Neuro-Oncology. 2023 Mar 14
5 citations
Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions.
Ayal A Aizer, Nayan Lamba, Manmeet S Ahluwalia, Kenneth Aldape, Adrienne Boire, Priscilla K Brastianos, Paul D Brown, D Ross Camidge, Veronica L Chiang, Michael A Davi...> ;Neuro-Oncology. 2022 Oct 3
Preclinical modeling in leptomeningeal disease: Starting at the foundation to tackle a difficult disease.
Priya Kumthekar, Seema Nagpal> ;Neuro-Oncology. 2022 Oct 3
Editorial commentary: Society for Neuro-Oncology 2021 Annual Meeting updates on primary central nervous system tumors.
Lauren Singer, Priya Kumthekar> ;Chinese Clinical Oncology. 2022 Jun 1
4 citations
Advances in the Diagnosis and Treatment of Leptomeningeal Disease.
Akanksha Sharma, Justin T Low, Priya Kumthekar> ;Current Neurology and Neuroscience Reports. 2022 Jul 1
3 citations
Phase I/randomized phase II trial of TRC105 plus bevacizumab versus bevacizumab in recurrent glioblastoma: North Central Cancer Treatment Group N1174 (Alliance).
Evanthia Galanis, S Keith Anderson, Erin Twohy, Nicholas A Butowski, Adilia Hormigo, David Schiff, Antonio Omuro, Kurt A Jaeckle, Shaji Kumar, Timothy J Kaufmann, Susa...> ;Neuro-Oncology Advances. 2022 Apr 4
10 citations
Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: A joint EORTC BTG and RANO effort.
Emilie Le Rhun, Patrick Devos, Sebastian Winklhofer, Hafida Lmalem, Dieta Brandsma, Priya Kumthekar, Antonella Castellano, Annette Compter, Frederic Dhermain, Enrico F...> ;Neuro-Oncology. 2022 Oct 3
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Lectures

A phase 0 first-in-human study using NU-0129: A gold base spherical nucleic acid (SNA) nanoconjugate targeting BCL2L12 in recurrent glioblastoma patients.
2019 ASCO Annual Meeting - 6/1/2019
A phase II trial of bevacizumab in patients with recurrent solid tumor brain metastases who have failed whole brain radiation therapy (WBRT).
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

Biocept to Host Key Opinion Leader Webinar on October 14 to Discuss Its Proprietary CNSide™ Assay to Detect and Quantify Cancer That Metastasized to the Central Nervous SystemOctober 6th, 2022
Top 5 Breakthroughs Podcasts of 2021January 7th, 2022
Northwestern’s SPORE Has Made Advances in Understanding the Genetic Basis of GlioblastomaOctober 3rd, 2021
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