PrzemyslawTwardowskiMD

Genitourinary Oncology, Hematologic Oncology

Professor of Medical Oncology and Urologic Oncology , Director of Clinical Research, John Wayne Cancer Institute, Santa Monica , CA

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Office
2200 Santa Monica Boulevard
Santa Monica, CA 90404
Phone+1 310-829-8317

Fax+1 310-315-6143
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Education & Training

McGaw Medical Center of Northwestern UniversityFellowship, Hematology and Medical Oncology, 1994 - 1997
McGaw Medical Center of Northwestern UniversityFellowship, Hematology and Medical Oncology, 1993 - 1994
McGaw Medical Center of Northwestern UniversityResidency, Internal Medicine, 1990 - 1993
University of Missouri-Columbia School of MedicineClass of 1990

Certifications & Licensure

CA State Medical License 1998 - 2026
IL State Medical License 1990 - 1999
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
Top Doctors:LA Area Castle Connolly, 2013
America's Top Doctors for Cancer Castle Connolly, 2009-2013
Top Doctors:Southern California Castle Connolly, 2012
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Clinical Trials

SU5416 and Paclitaxel in Treating Patients With Advanced Cancer Start of enrollment: 2000 Nov 01
Completed
Phase 1
Arsenic Trioxide and Pamidronate in Treating Patients With Advanced Solid Tumors or Multiple Myeloma Start of enrollment: 2005 Apr 01
Completed
Phase 1
Eribulin Mesylate in Treating Patients With Locally Advanced or Metastatic Cancer of the Urothelium and Kidney Dysfunction Start of enrollment: 2006 Oct 23
Active, not recruiting
Phase 1, Phase 2
Hormone Therapy and Intensity-Modulated Radiation Therapy in Treating Patients With Metastatic Prostate Cancer Start of enrollment: 2006 Jul 18
Active, not recruiting
Phase 2
Etoposide and Celecoxib in Patients With Advanced Cancer Start of enrollment: 2001 Dec 01
Completed
Phase 1
Cyclophosphamide and Celecoxib in Treating Patients With Advanced Cancer Start of enrollment: 2001 Sep 01
Completed
Phase 1
White Button Mushroom Extract in Treating Patients With Recurrent Prostate Cancer After Local Therapy Start of enrollment: 2009 Jan 29
Completed
Phase 1
First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma Start of enrollment: 2012 Jan 01
Completed
Phase 2
Abiraterone Acetate and Prednisone With or Without Veliparib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Start of enrollment: 2012 Mar 30
Completed
Phase 2
Trebananib With or Without Bevacizumab, Pazopanib Hydrochloride, Sorafenib Tosylate, or Sunitinib Malate in Treating Patients With Advanced Kidney Cancer Start of enrollment: 2012 Aug 01
Completed
Phase 2
Sipuleucel-T With or Without Radiation Therapy in Treating Patients With Hormone-Resistant Metastatic Prostate Cancer Start of enrollment: 2013 Jun 07
Completed
Phase 2
S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer Start of enrollment: 2013 Mar 08
Active, not recruiting
Phase 3
Fluorine F 18 Sodium Fluoride PET/CT and Whole Body and Axial MRI in Finding Metastases in Patients With Recurrent Prostate Cancer Start of enrollment: 2013 Dec 01
Completed
Not Applicable
A Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Prostate Cancer Start of enrollment: 2014 Jun 01
Completed
Phase 2
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Publications & Presentations

PubMed

Markers of bone metabolism and overall survival in men with bone-metastatic hormone sensitive prostate cancer (HSPC): A subset analysis of SWOG S1216, a phase III tria...
Primo N Lara Jr, Edward Mayerson, Erik Gertz, Catherine Tangen, Amir Goldkorn, Marta van Loan, Maha Hussain, Shilpa Gupta, Jingsong Zhang, Mamta Parikh, Przemyslaw Twa...> ;Prostate Cancer and Prostatic Diseases. 2024 Feb 29
Reply by Authors.
Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Przemyslaw Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F Chapin, David M ...> ;The Journal of Urology. 2023 Aug 1
1 citations
Diagnostic Performance and Safety ofF-rhPSMA-7.3 Positron Emission Tomography in Men With Suspected Prostate Cancer Recurrence: Results From a Phase 3, Prospective, Mu...
Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Przemyslaw Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F Chapin, David M ...> ;The Journal of Urology. 2023 Sep 1
13 citations
Diagnostic Performance and Safety ofF-rhPSMA-7.3 Positron Emission Tomography in Men With Suspected Prostate Cancer Recurrence: Results From a Phase 3, Prospective, Mu...
Ashesh B Jani, Gregory C Ravizzini, Benjamin A Gartrell, Barry A Siegel, Przemyslaw Twardowski, Daniel Saltzstein, Mark T Fleming, Albert Chau, Phillip Davis, Brian F ...> ;The Journal of Urology. 2023 Aug 1
5 citations
Bone Biomarkers and Subsequent Survival in Men with Hormone-sensitive Prostate Cancer: Results from the SWOG S1216 Phase 3 Trial of Androgen Deprivation Therapy with o...
Primo N Lara Jr, Edward Mayerson, Erik Gertz, Catherine Tangen, Amir Goldkorn, Marta van Loan, Maha Hussain, Shilpa Gupta, Jingsong Zhang, Mamta Parikh, Przemyslaw Twa...> ;European Urology. 2024 Feb 1
3 citations
Mechanism-Driven and Clinically Focused Development of Botanical Foods as Multitarget Anticancer Medicine: Collective Perspectives and Insights from Preclinical Studie...
Xiaoqiang Wang, Yin S Chan, Kelly Wong, Ryohei Yoshitake, David Sadava, Timothy W Synold, Paul Frankel, Przemyslaw W Twardowski, Clayton Lau, Shiuan Chen> ;Cancers. 2023 Jan 23
2 citations
Long-Term Outcomes of Patients on a Phase II Prospective Trial of Oligometastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation and External Beam...
Claire Hao, Colton Ladbury, Yung Lyou, Saro Manoukian, Christopher Ruel, Paul Frankel, Tanya Dorff, Jeffrey Wong, Sumanta Pal, Przemyslaw Twardowski, Savita Dandapani> ;International Journal of Radiation Oncology, Biology, Physics. 2022 Nov 15
15 citations
Orteronel for Metastatic Hormone-Sensitive Prostate Cancer: A Multicenter, Randomized, Open-Label Phase III Trial (SWOG-1216).
Neeraj Agarwal, Catherine M Tangen, Maha H A Hussain, Shilpa Gupta, Melissa Plets, Primo N Lara, Andrea L Harzstark, Przemyslaw W Twardowski, Channing J Paller, Dylan ...> ;Journal of Clinical Oncology. 2022 Oct 1
13 citations
A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone-Sensitive Prostate Cancer
Phillip L. Palmbos, Stephanie Daignault-Newton, Scott A. Tomlins, Neeraj Agarwal, Przemyslaw Twardowski, Alicia K. Morgans, Wm. Kevin Kelly, Vivek K. Arora, Emmanuel S...> ;Clinical Cancer Research. 2021 Jun 1
58 citations
TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer.
Samuel R. Denmeade, Hao Wang, Neeraj Agarwal, David Smith, Michael T. Schweizer, Mark N. Stein, Vasileios J. Assikis, Przemyslaw Twardowski, Thomas W. Flaig, Russell Z...> ;Journal of Clinical Oncology. 2021 Feb 22
Impact of Late Dosing on Testosterone Suppression with 2 Different Leuprolide Acetate Formulations: In Situ Gel and Microsphere. An Analysis of United States Clinical ...
E. David Crawford, Jason Hafron, Scott T. Tagawa, Przemyslaw Twardowski, Richard G. Harris, Judd W. Moul, Thomas E. Keane, Raoul S. Concepcion, Celestia S. Higano, Luc...> ;The Journal of Urology. 2021 Feb 1
24 citations
An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth
Hubert Lam, Lisa K. McNeil, Hanna Starobinets, Victoria L. DeVault, Roger B. Cohen, Przemyslaw Twardowski, Melissa Lynne Johnson, Maura L. Gillison, Mark N. Stein, Ulk...> ;Cancer Discovery. 2021 Mar 1
3 citations
Cryopreserved placental tissue allograft accelerates time to continence following robot-assisted radical prostatectomy.
Peter A. Elliott, Stephanie Hsiang, Ramkishen Narayanan, James Bierylo, Shu-Ching Chang, Przemyslaw Twardowski, Timothy G. Wilson> ;Journal of Robotic Surgery. 2021 Jan 11
11 citations
Phase II study of the histone deacetylase inhibitor vorinostat (Suberoylanilide Hydroxamic Acid; SAHA) in recurrent or metastatic transitional cell carcinoma of the ur...
David I. Quinn, Denice D. Tsao-Wei, Przemyslaw Twardowski, Ana Aparicio, Paul Frankel, Gurkamal Chatta, John Wright, Susan Groshen, Stella Khoo, Heinz-Josef Lenz, Prim...> ;Investigational New Drugs. 2021 Jan 6
352 citations
Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.
Maha Hussain, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal D. Shore, Shahneen Sandhu, Kim N. Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin,...> ;The New England Journal of Medicine. 2020 Sep 20
8 citations
18F-Fluciclovine Positron Emission Tomography in Men With Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy and Planning to Undergo Salvage Radiati...
Abhishek A. Solanki, Bital Savir-Baruch, Stanley L. Liauw, Jeff M. Michalski, Jonathan D. Tward, Neha Vapiwala, Eugene J. Teoh, Lee P. Adler, Gerald L. Andriole, Laure...> ;Practical Radiation Oncology. 2020 Sep 1
4 citations
Review of Radium-223 and Metastatic Castration-Sensitive Prostate Cancer
S.V. Dandapani, Jeffrey Y.C. Wong, Przemyslaw Twardowski> ;Cancer Biotherapy & Radiopharmaceuticals. 2020 Aug 31
6 citations
The Impact of Late Luteinizing Hormone-Releasing Hormone Agonist Dosing on Testosterone Suppression in Patients with Prostate Cancer: An Analysis of United States Clin...
E. David Crawford, Przemyslaw Twardowski, Raoul S. Concepcion, Jason Hafron, Richard G. Harris, Judd W. Moul, Lucio N. Gordan, Daniel P. Petrylak, Stuart Atkinson, Deb...> ;The Journal of Urology. 2020 Apr 1
Time from definitive therapy to onset of metastatic disease predicts outcomes in men with metastatic hormone sensitive prostate cancer.
Andrew W. Hahn, David D. Stenehjem, Anitha Alex, David Gill, Heather H. Cheng, Elizabeth R. Kessler, Namita Chittoria, Przemyslaw Twardowski, Ulka N. Vaishampayan, Nee...> ;Urologic Oncology. 2019 Jun 1
26 citations
Understanding Caregiver Quality of Life in Caregivers of Hospitalized Older Adults With Cancer
Tina Hsu, Nitya Nathwani, Matthew Loscalzo, Vincent Chung, Joseph Chao, Chatchada Karanes, Marianna Koczywas, Stephen J. Forman, Dean Lim, Tanya Siddiqi, Anthony S. St...> ;Journal of the American Geriatrics Society. 2019 May 1
27 citations
Randomized phase II trial of sipuleucel-T immunotherapy preceded by sensitizing radiation therapy and sipuleucel-T alone in patients with metastatic castrate resistant...
Przemyslaw Twardowski, Jeffrey Y.C. Wong, Sumanta K. Pal, Benjamin L. Maughan, Paul Frankel, Kelly Franklin, Maribel Junqueira, Manisha R. Prajapati, Gayatri Nachaegar...> ;Cancer Treatment and Research Communications. 2019 Jan 1
13 citations
Randomized trial of oral cyclophosphamide versus oral cyclophosphamide with celecoxib for recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.
Rohan Gupta, Mihaela C. Cristea, Paul Frankel, Christopher Ruel, Chen Chen, Yingyu Wang, Robert J. Morgan, Lucille Leong, Warren Chow, Marianna Koczywas, Steve Koehler...> ;Cancer Treatment and Research Communications. 2019 Jan 1
50 citations
Identification of mechanisms of resistance to treatment with abiraterone acetate or enzalutamide in patients with castration-resistant prostate cancer (CRPC).
Sumanta K. Pal, Jaymala Patel, Miaoling He, Brad Foulk, Katherine Kraft, Denis Smirnov, Przemyslaw Twardowski, Marcin Kortylewski, Vipul Bhargava, Jeremy O. Jones> ;Cancer. 2018 Mar 15
7 citations
Effectiveness of Subcutaneously Administered Leuprolide Acetate to Achieve Low Nadir Testosterone in Prostate Cancer Patients.
Christopher Michael Pieczonka, Przemyslaw Twardowski, Joseph Renzulli, Jason Hafron, Deborah M. Boldt-Houle, Stuart Atkinson, Scott E. Eggener> ;Reviews in Urology. 2018 Jan 1
4 citations
Bone turnover biomarkers identify unique prognostic risk groups in men with castration resistant prostate cancer and skeletal metastases: Results from SWOG S0421.
Primo N. Lara, Melissa Plets, Catherine M. Tangen, E. Gertz, Nicholas J. Vogelzang, Maha Hussain, Przemyslaw Twardowski, Mark Garzotto, J. P. Monk, Michael A. Carducci...> ;Cancer Treatment and Research Communications. 2018 Jan 1
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Journal Articles

Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer
Maha Hussain, Neeraj Agarwal, Przemyslaw Twardowski, The New England Journal of Medicine

Press Mentions

Advanced Prostate Cancer: Experts Say This Double Therapy Can HelpMarch 30th, 2023
Prostate Cancer ADT Has Fewer Cardiovascular Risks Than ExpectedJanuary 12th, 2022
25 Warning Signs Your Kidneys Send YouJune 8th, 2020
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Grant Support

Biologic Markers Of Angiogenesis: A Companion Study To "Phase I Trial Of OralNational Center For Research Resources2005
Phase I Trial Of Oral Cyclophosphamide With CelecoxibNational Center For Research Resources2004
Phase I Trial Of Etoposide In Combination W/ CelecoxibNational Center For Research Resources2004