QingDongMD

PubMed

• Mutant β-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.
  Qing Dong, Louis J Ptáček, Ying-Hui Fu> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr 11
• 7 citations
  Familial natural short sleep mutations reduce Alzheimer pathology in mice.
  Qing Dong, Nicholas W Gentry, Thomas McMahon, Maya Yamazaki, Lorena Benitez-Rivera, Tammy Wang, Li Gan, Louis Ptáček, Ying-Hui Fu> ;Iscience. 2022 Apr 15
• 38 citations
  Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
  Betty Lam, Yasuyoshi Arikawa, Joshua Cramlett, Qing Dong, Ron de Jong, Victoria A. Feher, Charles E. Grimshaw, Pamela Farrell, Isaac Hoffman, Andrew John Jennings, Jon...> ;Bioorganic & Medicinal Chemistry Letters. 2016 Dec 15
• Discovery of SHR1977: A highly potent and selective ROMK inhibitor.
  Li X, Zhang Y, Chen Y, He W, Wan H, Zhang L, Hu Q, Feng J, Yuan J, Dong Q, Cao G, Zhang L, He F, Bai C, Tao W> ;Bioorg. Med. Chem. Lett.. 2016-06-27
• Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model.
  Peng J, Hu Q, Gu C, Liu B, Jin F, Yuan J, Feng J, Zhang L, Lan J, Dong Q, Cao G> ;Bioorg. Med. Chem. Lett.. 2016-01-15
• Synthesis and biological evaluation of cyclopentyl-triazolol-pyrimidine (CPTP) based P2Y12 antagonists.
  Tu W, Fan J, Zhang H, Xu G, Liu Z, Qu J, Yang F, Zhang L, Luan T, Yuan J, Gong A, Feng J, Sun P, Dong Q> ;Bioorg. Med. Chem. Lett.. 2014-01-01
• Discovery of novel orally bioavailable GPR40 agonists.
  Lu H, Fei H, Yang F, Zheng S, Hu Q, Zhang L, Yuan J, Feng J, Sun P, Dong Q> ;Bioorg. Med. Chem. Lett.. 2013-05-15
• 10 citations
  Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy
  Mark E. Adams, Michael B. Wallace, Toufike Kanouni, Nicholas Scorah, Shawn M. O’Connell, Hiroshi Miyake, Lihong Shi, Petro Halkowycz, Lilly Zhang, Qing Dong> ;Bioorganic & Medicinal Chemistry Letters. 2012 Apr 1
• 85 citations
  Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer
  Qing Dong, Douglas R. Dougan, Xianchang Gong, Petro Halkowycz, Bohan Jin, Toufike Kanouni, Shawn M. O’Connell, Nicholas Scorah, Lihong Shi, Michael B. Wallace, Feng Zhou> ;Bioorganic & Medicinal Chemistry Letters. 2011 Mar 1
• 4 citations
  Naturally-Occurring Mutation in the Calcium-Sensing Receptor Reveals the Significance of Extracellular Domain Loop III Region for Class C G-Protein-Coupled Receptor Fu...
  Qing Dong, Zhiqiang Cheng, Wenhan Chang, Brigitte E. Blackman, Felix A. Conte, Jianxin Hu, Dolores M. Shoback, Walter L. Miller> ;The Journal of Clinical Endocrinology and Metabolism. 2010 Aug 1
• 33 citations
  Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
  Michael B. Wallace, Mark E. Adams, Toufike Kanouni, Clifford D. Mol, Douglas R. Dougan, Feher Victoria, Shawn M. O’Connell, Lihong Shi, Petro Halkowycz, Qing Dong> ;Bioorganic & Medicinal Chemistry Letters. 2010 Jul 15
• 39 citations
  Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis.
  Meng Kian Tee, Qing Dong, Walter L. Miller> ;Endocrinology. 2008 Jan 10
• 17 citations
  Vitamin D 25-hydroxylase deficiency.
  Qing Dong, Walter L. Miller> ;Molecular Genetics and Metabolism. 2004 Sep 1
• Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia.
  Chua EL, Wu WM, Tran KT, McCarthy SW, Lauer CS, Dubourdieu D, Packham N, O'Brien CJ, Turtle JR, Dong Q> ;J. Clin. Endocrinol. Metab.. 2000-08-01
• Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplas...
  Dong Q, Debelenko LV, Chandrasekharappa SC, Emmert-Buck MR, Zhuang Z, Guru SC, Manickam P, Skarulis M, Lubensky IA, Liotta LA, Collins FS, Marx SJ, Spiegel AM> ;J. Clin. Endocrinol. Metab.. 1997-05-01
• Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone ...
  Dong Q, Brucker-Davis F, Weintraub BD, Smallridge RC, Carr FE, Battey J, Spiegel AM, Shenker A> ;J. Clin. Endocrinol. Metab.. 1996-03-01
• Cloning and sequencing of a novel 64-kDa autoantigen recognized by patients with autoimmune thyroid disease.
  Dong Q, Ludgate M, Vassart G> ;J. Clin. Endocrinol. Metab.. 1991-06-01
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