R. JeffreyChangMD

Obstetrics & Gynecology • San Diego, CA

Reproductive Endocrinology & Infertility

Physician

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Office
9333 Genesee Ave
Ste 200
San Diego, CA 92121
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Summary

Dr. R. Jeffrey Chang is an obstetrician/gynecologist in San Diego, CA and is affiliated with UC San Diego Health Science Center. Dr. Chang received his medical degree from Oregon Health and Science University School of Medicine and has been in practice 49 years. Dr. Chang specializes in reproductive endocrinology & infertility. Dr. Chang has more than 100 publications and over 500 citings.

Education & Training

Oregon Health and Science University School of MedicineClass of 1969

Certifications & Licensure

CA State Medical License 1971 - 2021
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Reproductive Endocrinology/Infertility

Publications & Presentations

PubMed

1 citations
Ibuprofen Reduces Testosterone Level in Women With Polycystic Ovary Syndrome.
Beata Banaszewska, Katarzyna Ozegowska, Martyna Polska, Leszek Pawelczyk, R Jeffrey Chang, Antoni J Duleba> ;Journal of the Endocrine Society. 2022 Oct 1
4 citations
Ovarian response to follicle-stimulating hormone in women with polycystic ovary syndrome is diminished compared to ovulatory controls.
Tracy N H Harrison, R Jeffrey Chang> ;Clinical Endocrinology. 2022 Sep 1
3 citations
Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.
Christian Secchi, Martina Belli, Tracy N. H. Harrison, Joseph Swift, CheMyong Ko, Antoni J. Duleba, Dwayne G. Stupack, R. Jeffrey Chang, Shunichi Shimasaki> ;Journal of Translational Medicine. 2021 Oct 15
3 citations
Ibuprofen inhibits key genes involved in androgen production in theca–interstitial cells
Chelsea W. Fox, Lingzhi Zhang, Benjamin C. Moeller, V. Gabriel Garzo, R. Jeffrey Chang, Antoni J. Duleba> ;F&S Science. 2021 Aug 1
10 citations
Elevation of markers of endotoxemia in women with polycystic ovary syndrome.
Beata Banaszewska, Martyna Siakowska, Izabela Chudzicka-Strugała, R. Jeffrey Chang, Leszek Pawelczyk, Barbara Zwozdziak, Robert Z. Spaczynski, Antoni J. Duleba> ;Human Reproduction. 2020 Oct 1
3 citations
Androgens Modulate Rat Granulosa Cell Steroidogenesis.
Manuel Doblado, Lingzhi Zhang, Tannaz Toloubeydokhti, Gabriel T Garzo, R. Jeffrey Chang, Antoni J. Duleba> ;Reproductive Sciences. 2020 Jan 8
33 citations
Inflammatory Stimuli Trigger Increased Androgen Production and Shifts in Gene Expression in Theca-Interstitial Cells
Chelsea Webb Fox, Lingzhi Zhang, Abhishek Sohni, Manuel Doblado, Miles F. Wilkinson, R. Jeffrey Chang, Antoni J. Duleba> ;Endocrinology. 2019 Dec 1
3 citations
Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome.
Michael V. Homer, Tannaz Toloubeydokhti, Mark A. Lawson, Gabriel T Garzo, Antoni J. Duleba, R. Jeffrey Chang> ;Journal of the Endocrine Society. 2019 Feb 7
27 citations
The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond.
Brigid M. Smith, Francesca E. Duncan, Lauren M. Ataman, Kristin Smith, Gwendolyn P. Quinn, R. Jeffrey Chang, Courtney Finlayson, Kyle E. Orwig, Hanna Valli-Pulaski, Mo...> ;Future Oncology. 2018 Dec 1
115 citations
Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society
Kathryn A. Martin, R. Rox Anderson, R. Jeffrey Chang, David A. Ehrmann, Rogerio A. Lobo, M. Hassan Murad, Michel Pugeat, Robert L. Rosenfield> ;The Journal of Clinical Endocrinology and Metabolism. 2018 Apr 1
193 citations
An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
Lourdes Ibáñez, Sharon E. Oberfield, Selma F. Witchel, Richard J. Auchus, R. Jeffrey Chang, Ethel Codner, Preeti Dabadghao, Feyza Darendeliler, Nancy Samir Elbarbary, ...> ;Hormone Research in Paediatrics. 2017 Nov 13
64 citations
Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis.
Nozomi Takahashi, Miyuki Harada, Yasushi Hirota, Emi Nose, Jerilee Mk Azhary, Hiroshi Koike, Chisato Kunitomi, Osamu Yoshino, Gentaro Izumi, Tetsuya Hirata, Kaori Koga...> ;Scientific Reports. 2017 Sep 7
10 citations
PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-β and TNF-α in mononuclear cells by insulin-sensitizing drugs.
Kaori Yamada-Nomoto, Osamu Yoshino, Ikumi Akiyama, Akira Iwase, Yosuke Ono, Tomoko Nakamura, Miyuki Harada, Akitoshi Nakashima, Tomoko Shima, Akemi Ushijima, Yutaka Os...> ;American Journal of Reproductive Immunology. 2017 Jul 1
18 citations
MicroRNA-196 Regulates HOX Gene Expression in Human Gluteal Adipose Tissue.
Adeline Divoux, Hui Xie, Jian-Liang Li, Kalypso Karastergiou, Ranjan J. Perera, R. Jeffrey Chang, Susan K. Fried, Steven R. Smith> ;Obesity. 2017 Jun 25
14 citations
Increased Adrenal Androgens in Overweight Peripubertal Girls.
Christine M. Burt Solorzano, Kristin D. Helm, James T. Patrie, Rana F. Shayya, Heidi Cook-Andersen, R. Jeffrey Chang, Christopher R. McCartney, John C. Marshall> ;Journal of the Endocrine Society. 2017 Apr 12
15 citations
The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome.
Michael V. Homer, Marcus A. Rosencrantz, Rana F. Shayya, R. Jeffrey Chang> ;Reproductive Biology and Endocrinology. 2017 Feb 10
10 citations
Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome.
K.H. Maas, Sandy S. Chuan, Evan Harrison, Heidi Cook-Andersen, Antoni J. Duleba, R. Jeffrey Chang> ;Fertility and Sterility. 2016 Oct 1
2 citations
17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ova...
Jingwen Hou, Heidi Cook-Andersen, H. Irene Su, Rana F. Shayya, K.H. Maas, Christine M. Burt-Solorzano, Ajay Kumar, R. Jeffrey Chang> ;Journal of Pediatric Endocrinology & Metabolism. 2016 Jul 1
12 citations
Growth and differentiation factor 9 promotes oocyte growth at the primary but not the early secondary stage in three-dimensional follicle culture
Heidi Cook-Andersen, Kirsten J. Curnow, H. Irene Su, R. Jeffrey Chang, Shunichi Shimasaki> ;Journal of Assisted Reproduction and Genetics. 2016 May 7
10 citations
Relationship Between 17-Hydroxyprogesterone Responses to Human Chorionic Gonadotropin and Markers of Ovarian Follicle Morphology in Women With Polycystic Ovary Syndrome
K.H. Maas, Sandy S. Chuan, Heidi Cook-Andersen, H. Irene Su, Antoni J. Duleba, R. Jeffrey Chang> ;The Journal of Clinical Endocrinology and Metabolism. 2015 Jan 1
6 citations
Lack of Serum Anti-Mullerian Hormone Responses After Recombinant Human Chorionic Gonadotropin Stimulation in Women With Polycystic Ovary Syndrome
Heidi Cook-Andersen, Sandy S. Chuan, K.H. Maas, Marcus A. Rosencrantz, H. Irene Su, Mark A. Lawson, Helen D. Mason, R. Jeffrey Chang> ;The Journal of Clinical Endocrinology and Metabolism. 2015 Jan 1
68 citations
Anti-Mullerian hormone may be a useful adjunct in the diagnosis of polycystic ovary syndrome in nonobese adolescents.
Aviva B. Sopher, Galina Grigoriev, Diana Laura, Tamara Cameo, Jodi P. Lerner, R. Jeffrey Chang, Donald J. McMahon, Sharon E. Oberfield> ;Journal of Pediatric Endocrinology & Metabolism. 2014 Nov 1
17 citations
Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls With Obesity: the Potential Role of Hyperandrogenemia
Jessicah S. Collins, Jennifer P. Beller, Christine Burt Solorzano, James T. Patrie, R. Jeffrey Chang, John C. Marshall, Christopher R. McCartney> ;The Journal of Clinical Endocrinology and Metabolism. 2014 Apr 29
4 citations
Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome.
Rana F. Shayya, Marcus A. Rosencrantz, Sandy S. Chuan, Heidi Cook-Andersen, William E. Roudebush, H. Irene Su, Shunichi Shimasaki, R. Jeffrey Chang> ;Fertility and Sterility. 2014 Jan 1
38 citations
The impact of depot GnRH agonist on AMH levels in healthy reproductive-aged women.
H. Irene Su, K.H. Maas, Patrick M. Sluss, R. Jeffrey Chang, Janet E. Hall, Hadine Joffe> ;The Journal of Clinical Endocrinology and Metabolism. 2013 Sep 30
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