RahulManuKohliMDPhD

Infectious Disease • Philadelphia, PA

Assistant Professor, Medicine, Perelman School of Medicine

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Office
3400 Spruce Street
3 Silverstein Bldg, Suite D
Philadelphia, PA 19104
Phone+1 215-662-6932
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Education & Training

Johns Hopkins UniversityFellowship, Infectious Disease, 2006 - 2010
University of Pennsylvania Health SystemResidency, Internal Medicine, 2004 - 2006
Harvard Medical SchoolClass of 2004

Certifications & Licensure

PA State Medical License 2004 - 2024
MD State Medical License 2009 - 2010
American Board of Internal Medicine Infectious Disease

Publications & Presentations

PubMed

Mpox Evolution: Has the Current Outbreak Revealed a Pox on "U"?
Rahul M Kohli, Stuart N Isaacs> ;The Journal of Infectious Diseases. 2023 Mar 28
1 citations
Kinetic dissection of macromolecular complex formation with minimally perturbing fluorescent probes.
Michael B Cory, Zachary M Hostetler, Rahul M Kohli> ;Methods in Enzymology. 2022 Jan 1
42 citations
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma.
Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E Olander, Ramzi Adil, Amaya Pankaj, Krishna S. Tummala, Vajira Weere...> ;Cancer Discovery. 2021 Nov 30
24 citations
Controllable genome editing with split-engineered base editors.
Kiara N. Berríos, Niklaus H. Evitt, Rachel A. DeWeerd, Diqiu Ren, Meiqi Luo, Aleksia Barka, Tong Wang, Caroline Bartman, Yemin Lan, Abby M. Green, Junwei Shi, Rahul M....> ;Nature Chemical Biology. 2021 Oct 18
45 citations
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
Weimin Kong, Alexander Dimitri, Wenliang Wang, In-Young Jung, Christopher J. Ott, Maria Fasolino, Yan Wang, Irina Kulikovskaya, Minnal Gupta, Todd Yoder, Jamie E. DeNi...> ;The Journal of Clinical Investigation. 2021 Aug 17
11 citations
Enzymatic approaches for profiling cytosine methylation and hydroxymethylation.
Tong Wang, Christian E. Loo, Rahul M. Kohli> ;Molecular Metabolism. 2021 Aug 8
5 citations
Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.
Juan Alvarez-Gonzalez, Adam Yasgar, Robert W. Maul, Amanda E. Rieffer, Daniel J. Crawford, Daniel J. Salamango, Dorjbal Dorjsuren, Alexey V. Zakharov, Daniel J. Jansen...> ;ACS Pharmacology & Translational Science. 2021 May 7
12 citations
SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2.
Anna A. Kiseleva, Elizabeth M Troisi, Scott E. Hensley, Rahul M. Kohli, Jonathan A. Epstein> ;Journal of Biochemistry. 2021 Mar 27
17 citations
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
Jamie E. DeNizio, Blaine J. Dow, Juan C. Serrano, Uday Ghanty, Alexander C. Drohat, Rahul M. Kohli> ;Journal of Molecular Biology. 2021 Apr 16
4 citations
Bisulfite-Free Sequencing of 5-Hydroxymethylcytosine with APOBEC-Coupled Epigenetic Sequencing (ACE-Seq).
Tong Wang, Meiqi Luo, Kiara N. Berríos, Emily K Schutsky, Hao Wu, Rahul M. Kohli> ;Methods in Molecular Biology. 2021 Jan 1
3 citations
High-Resolution Analysis of 5-Hydroxymethylcytosine by TET-Assisted Bisulfite Sequencing.
Zhijun Huang, Yingying Meng, Piroska E. Szabó, Rahul M. Kohli, Gerd P. Pfeifer> ;Methods in Molecular Biology. 2021 Jan 1
Harnessing Alternative Substrates to Probe TET Family Enzymes.
Uday Ghanty, Juan C. Serrano, Rahul M. Kohli> ;Methods in Molecular Biology. 2021 Jan 1
5 citations
Discovery of an Unnatural DNA Modification Derived from a Natural Secondary Metabolite.
Tong Wang, Rahul M. Kohli> ;Cell Chemical Biology. 2021 Jan 21
24 citations
Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency.
Blake A. Caldwell, Monica Yun Liu, Rexxi D. Prasasya, Tong Wang, Jamie E. DeNizio, N. Adrian Leu, Nana Yaa A. Amoh, Christopher Krapp, Yemin Lan, Emily J. Shields, Rob...> ;Molecular Cell. 2021 Feb 18
Modular affinity-labeling of the cytosine demethylation base elements in DNA.
Fanny Wang, Osama K. Zahid, Uday Ghanty, Rahul M. Kohli, Adam R. Hall> ;Scientific Reports. 2020 Nov 20
25 citations
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation.
Hui Shen, Robert Jordan Ontiveros, Michael C Owens, Monica Yun Liu, Uday Ghanty, Rahul M Kohli, Kathy Fange Liu> ;The Journal of Biological Chemistry. 2020 Nov 23
48 citations
High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening.
Rodrigo A. Gier, Krista A. Budinich, Niklaus H. Evitt, Zhendong Cao, Elizabeth Freilich, Qingzhou Chen, Jun Qi, Yemin Lan, Rahul M. Kohli, Junwei Shi> ;Nature Communications. 2020 Jul 13
17 citations
Targeting evolution to inhibit antibiotic resistance.
Houra Merrikh, Rahul M. Kohli> ;The FEBS Journal. 2020 Oct 1
5 citations
Deciphering the Role of Colicins during Colonization of the Mammalian Gut by Commensal E. coli.
Amanda N. Samuels, Manuela Roggiani, Kathryn A. Smith, Jun Zhu, Mark Goulian, Rahul M. Kohli> ;Microorganisms. 2020 May 2
7 citations
Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation
Uday Ghanty, Tong Wang, Rahul M. Kohli> ;Angewandte Chemie. 2020 Jul 6
11 citations
The Kinetic and Molecular Basis for the Interaction of LexA and Activated RecA Revealed by a Fluorescent Amino Acid Probe.
Zachary M Hostetler, Michael B. Cory, Chloe M. Jones, E. James Petersson, Rahul M. Kohli> ;ACS Chemical Biology. 2020 Feb 5
52 citations
A vitamin-C-derived DNA modification catalysed by an algal TET homologue
Jian Huang Xue, Guo Dong Chen, Fuhua Hao, Hui Chen, Zhaoyuan Fang, Fangfang Chen, Bo Pang, Qing Lin Yang, Xinben Wei, Qiang Qiang Fan, Changpeng Xin, Jiaohong Zhao, Xu...> ;Nature. 2019 May 23
17 citations
Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response
Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Matthew J. Culyba, Zachary M Hostetler, Rahul M. Kohli, Allen B. Reitz, Simon D P Baugh> ;Frontiers in Microbiology. 2018 Dec 18
14 citations
Exploiting Substrate Promiscuity To Develop Activity-Based Probes for Ten-Eleven Translocation Family Enzymes
Uday Ghanty, Jamie E. DeNizio, Monica Yun Liu, Rahul M. Kohli> ;Journal of the American Chemical Society. 2018 Dec 6
14 citations
The SOS Response Mediates Sustained Colonization of the Mammalian Gut.
Amanda N. Samuels, Manuela Roggiani, Jun Zhu, Mark Goulian, Rahul M. Kohli> ;Infection and Immunity. 2019 Jan 24
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Journal Articles

Disruption of TET2 Promotes the Therapeutic Efficacy of CD19-Targeted T Cells
Shannon A Carty, Carl H June, David L Porter, Bruce L Levine, Rahul M Kohli, Nature

Press Mentions

Gene Editing Method Could Power New Cell Gene TherapiesApril 29th, 2023
Improved Gene Editing Method Could Power the Next Generation of Cell and Gene TherapiesApril 28th, 2023
DNA Deaminase-Based Hydroxymethyl–Seq: Nondestructive and Base-ResolutionJune 4th, 2019
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Hospital Affiliations

Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania