RakeshKumarDixitMD

PubMed

• 15 citations
  Recent advances in trophoblast cell-surface antigen 2 targeted therapy for solid tumors.
  Shutan Liao, Bing Wang, Rong Zeng, Haifeng Bao, Xiaomin Chen, Rakesh Dixit, Xiaoyan Xing> ;Drug Development Research. 2021 Aug 30
• 8 citations
  The enhanced immunopharmacology of VIB4920, a novel Tn3 fusion protein and CD40L antagonist, and assessment of its safety profile in cynomolgus monkeys.
  Simone M. Nicholson, Kerry A. Casey, Michele Gunsior, Stacey Drabic, William O. Iverson, Halie Cook, Stephen Scott, Terry O'Day, Subramanya Karanth, Rakesh Dixit, Patr...> ;British Journal of Pharmacology. 2020 Mar 1
• 174 citations
  Antibody–Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index
  Steven R. Coats, Marna Williams, Benjamin Kebble, Rakesh Dixit, Leo Tseng, Nai-Shun Yao, David A. Tice, Jean-Charles Soria> ;Clinical Cancer Research. 2019 Sep 15
• 10 citations
  Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrr...
  Jason White, Ryan Fleming, Luke Masterson, Ben T Ruddle, Haihong Zhong, Christine Fazenbaker, Patrick Strout, Kim Rosenthal, Molly Reed, Vanessa Muniz-Medina, Philip H...> ;Mabs. 2019 Mar 5
• 5 citations
  Nonclinical safety and pharmacokinetics of Miglyol 812: A medium chain triglyceride in exenatide once weekly suspension.
  Nicholas Buss, Patricia C. Ryan, Todd Baughman, Denis Roy, Claire Patterson, Carolyn Gordon, Rakesh Dixit> ;Journal of Applied Toxicology. 2018 Oct 1
• 2 citations
  Monoclonal antibody targeting of fibroblast growth factor receptor 1c causes cardiac valvulopathy in rats
  Nicholas Buss, Jean-Martin Lapointe, Lolke de Haan, Sally Price, Andrea Ahnmark, Lorraine Irving, Andrew Buchanan, Feenagh Keyes, Pia Davidsson, Rakesh Dixit, Daniel L...> ;Toxicology and Applied Pharmacology. 2018 Sep 15
• 8 citations
  Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer.
  Emily E. Bosco, R. James Christie, Rosa A. Carrasco, Darrin Sabol, Jiping Zha, Karma Dacosta, Lee Brown, Maureen Kennedy, John Meekin, Sandrina Phipps, Joanne Ayriss, ...> ;Oncotarget. 2018 May 1
• 7 citations
  Effects of ICOS+ T cell depletion via afucosylated monoclonal antibody MEDI-570 on pregnant cynomolgus monkeys and the developing offspring
  Simone M Nicholson, Gianluca Carlesso, Lily Cheng, Halie Cook, Karma Dacosta, Joel Leininger, Kathleen McKeever, Stephen Weasel Scott, Devon K. Taylor, Katie Streicher...> ;Reproductive Toxicology. 2017 Dec 1
• 27 citations
  Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates
  Mary Jane Hinrichs, Pauline M. Ryan, Bo Zheng, Shameen Afif-Rider, Xiang Qing Yu, Michele Gunsior, Haihong Zhong, Jay Harper, Binyam Bezabeh, Kapil Vashisht, Marlon Re...> ;Clinical Cancer Research. 2017 Oct 1
• Special issue on electronic cigarettes.
  Rakesh Dixit> ;Toxicology Mechanisms and Methods. 2016 Sep 30
• 41 citations
  Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics
  Pamela Thompson, Ryan Fleming, Binyam Bezabeh, Fengying Huang, Shenlan Mao, Cui Chen, Jay Harper, Haihong Zhong, Xizhe Gao, Xiang-Qing Yu, Mary Jane Hinrichs, Molly Re...> ;Journal of Controlled Release. 2016 Aug 28
• 68 citations
  A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.
  John Y Li, Samuel R Perry, Vanessa Muniz-Medina, Xinzhong Wang, Leslie K Wetzel, Marlon C Rebelatto, Mary Jane Masson Hinrichs, Binyam Z Bezabeh, Ryan L Fleming, Nazza...> ;Cancer Cell. 2016 Jan 11
• 15 citations
  Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety.
  Patricia C. Ryan, Matthew A. Sleeman, Marlon Rebelatto, Bing Wang, Hong Lu, Xiaomin Chen, Chi-Yuan Wu, Mary Jane Hinrichs, Lorin Roskos, Heidi Towers, Kathleen McKeeve...> ;Toxicology and Applied Pharmacology. 2014 Sep 1
• 2 citations
  Nasal Turbinate Enlargement Due to Cartilage and Bone Proliferation: A Normal Developmental Finding in Young Ferrets
  Kathleen A. Funk, Christopher Frantz, Amy S. Dyke, Patricia C. Ryan, Hong Jin, George Kemble, Rakesh Dixit, Joel R. Leininger> ;Toxicologic Pathology. 2010 Sep 13
• 8 citations
  Challenges of general safety evaluations of biologics compared to small molecule pharmaceuticals in animal models.
  Rakesh Dixit, Laurie Iciek, Kathleen McKeever, Patricia C. Ryan> ;Expert Opinion on Drug Discovery. 2010 Jan 1
• 2 citations
  Preclinical efficacy and safety models for mAbs: the challenge of developing effective model systems.
  Rakesh Dixit, Steve Coats> ;Idrugs. 2009 Feb 1
• 70 citations
  Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies.
  Rakesh Dixit, Urs A. Boelsterli> ;Drug Discovery Today. 2007 Apr 1
• Cancer biomarkers. Preface.
  Rakesh Kumar Dixit, Sudhir Srivastava> ;Cancer Biomarkers. 2005 Jan 1
• 25 citations
  Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment.
  Rakesh Dixit, Jim E. Riviere, Kannan Krishnan, Melvin E. Andersen> ;Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 2003 Jan 1
• 48 citations
  Diet, caloric restriction, and the rodent bioassay.
  Kevin P. Keenan, Gordon C. Ballam, Keith A. Soper, Philippe Laroque, John B. Coleman, Rakesh Dixit> ;Toxicological Sciences. 1999 Dec 1
• 13 citations
  A method for estimating and testing area under the curve in serial sacrifice, batch, and complete data designs.
  Daniel J. Holder, Francis Hsuan, Rakesh Dixit, Keith A. Soper> ;Journal of Biopharmaceutical Statistics. 1999 Aug 1
• 34 citations
  Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies.
  Kevin P. Keenan, Philippe Laroque, Rakesh Dixit> ;Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 1998 Apr 1
• 61 citations
  The Effects of Diet, Overfeeding and Moderate Dietary Restriction on Sprague-Dawley Rat Survival, Disease and Toxicology
  Kevin P. Keenan, Gordon C. Ballam, Rakesh Dixit, Keith A. Soper, Philippe Laroque, Britta A. Mattson, Stephen P. Adams, John B. Coleman> ;The Journal of Nutrition. 1997 May 1
• 71 citations
  The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment.
  Kevin P. Keenan, Philippe Laroque, Gordon C. Ballam, Keith A. Soper, Rakesh Dixit, Britta A. Mattson, Stephen P. Adams, John B. Coleman> ;Toxicologic Pathology. 1996 Nov 1
• 16 citations
  The effects of overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, pathology, carcinogenicity, and the toxicity of pharmaceutical agents
  Kevin P. Keenan, Philippe Laroque, Keith A. Soper, R.E. Morrissey, Rakesh Dixit> ;Experimental and Toxicologic Pathology. 1996 Feb 1
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