RalphArouneGiannellaMD

Gastroenterology • Cincinnati, OH

Professor of Medicine

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Office
222 Piedmont Avenue
Suite 6300
Cincinnati, OH 45219
Phone+1 513-475-7505

Fax+1 513-475-7355
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Education & Training

Boston University Medical CenterResidency, Internal Medicine, 1968 - 1969
Boston VA Healthcare System (Brockton-West Roxbury)Residency, Internal Medicine, 1967 - 1968
Boston University Medical CenterResidency, Internal Medicine, 1965 - 1967
Albany Medical CollegeClass of 1965

Certifications & Licensure

OH State Medical License 1980 - 2023
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
Best Physicians in America 2011
Top 75 Gastroenterologists in America 2011
Top 25 physicians in Ohio 2010
Fellow (AGAF) American Gastroenterological Association, 2006
elected member Ameerican Clinical and Climatological Associstion, 2000
elected member Association of American Physicians, 1987
Elected Member The American Society for Clinical Investigation, 1982
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Publications & Presentations

PubMed

40 citations
Gastro 2013 APDW/WCOG Shanghai Working Party Report: Chronic diarrhea: Definition, classification, diagnosis
Lawrence R. Schiller, Darrell S. Pardi, Robin C. Spiller, Carol E. Semrad, Christina M. Surawicz, Ralph A. Giannella, Guenter J. Krejs, Michael J.G. Farthing, Joseph H...> ;Journal of Gastroenterology and Hepatology. 2014 Jan 1
53 citations
Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease
Ali Raza, Wajeeha Yousaf, Ralph A. Giannella, Mohamed T. Shata> ;Expert Review of Clinical Immunology. 2012 Feb 1
26 citations
Thinking beyond the colon-small bowel Involvement in clostridium difficile infection
Udayakumar Navaneethan, Ralph A. Giannella> ;Gut Pathogens. 2009 Mar 19
94 citations
Mechanisms of infectious diarrhea
Udayakumar Navaneethan, Ralph A. Giannella> ;Nature Clinical Practice. Gastroenterology & Hepatology. 2008 Sep 23
28 citations
Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3− secretion via a novel GC-C- and CFTR-independent pathway
Zachary M. Sellers, Elizabeth A. Mann, Anders Smith, Kwang Hyun Ko, Ralph A. Giannella, Mitchell B. Cohen, Kim E. Barrett, Hui Dong> ;FASEB Journal. 2008 May 1
1 citations
AGA PAC: an essential tool to advance gastroenterology.
Michael Roberts, Ralph A. Giannella> ;Gastroenterology. 2008 Apr 1
8 citations
Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells.
Fabio Albano, Giulio De Marco, Roberto Berni Canani, Pia Cirillo, Vittoria Buccigrossi, Ralph A. Giannella, Alfredo Guarino> ;Pediatric Research. 2005 May 18
15 citations
Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intes...
Elizabeth A. Mann, Kris A. Steinbrecher, Carmen Stroup, David P. Witte, Mitchell B. Cohen, Ralph A. Giannella> ;International Journal of Cancer. 2005 Sep 10
14 citations
Clinical application of polymerase chain reaction to diagnose Clostridium difficile in hospitalized patients with diarrhea.
Michael S. Morelli, Susan D. Rouster, Ralph A. Giannella, Kenneth E. Sherman> ;Clinical Gastroenterology and Hepatology. 2004 Aug 1
75 citations
Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor
Stephen L. Carrithers, C. E. Ott, Michael J. Hill, Brett R. Johnson, Weiyan Cai, Jason J. Chang, Rajesh G. Shah, Congmei Sun, Elizabeth A. Mann, Manassés C. Fonteles, ...> ;Kidney International. 2004 Jan 1
16 citations
A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion
S. P. Rao, Zachary M. Sellers, Diane L. Crombie, Daniel L. Hogan, Elizabeth A. Mann, Debbie Childs, Stephen J. Keely, M. Sheil-Puopolo, Ralph A. Giannella, Kim E. Barr...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2004 Jan 1
29 citations
E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions.
Ralph A. Giannella, Elizabeth A. Mann> ;Transactions of the American Clinical and Climatological Association. 2003 Jan 1
58 citations
Randomized, Controlled Human Challenge Study of the Safety, Immunogenicity, and Protective Efficacy of a Single Dose of Peru-15, a Live Attenuated Oral Cholera Vaccine
Mitchell B. Cohen, Ralph A. Giannella, Judy Bean, David N. Taylor, Susan Parker, Amy Hoeper, Stephen Wowk, Jennifer Hawkins, Sims K. Kochi, Gilbert M. Schiff, Kevin P....> ;Infection and Immunity. 2002 Apr 1
4 citations
Antibiotic-associated diarrhea and Clostridium difficile colitis: an update.
Ralph A. Giannella> ;Revista Espanola De Enfermedades Digestivas. 2001 Aug 1
16 citations
Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent
Kris A. Steinbrecher, Elizabeth A. Mann, Ralph A. Giannella, Mitchell B. Cohen> ;Gastroenterology. 2001 Nov 1
2 citations
Practical management of acute diarrhea.
Mark D. Scheidler, Ralph A. Giannella> ;Hospital Practice. 2001 Jul 15
12 citations
Colonocyte basolateral membranes contain Escherichia coli heat-stable enterotoxin receptors.
F Albano, Thomas A. Brasitus, Elizabeth A. Mann, Alfredo Guarino, Ralph A. Giannella> ;Biochemical and Biophysical Research Communications. 2001 Jun 8
92 citations
Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea.
Raj J. Shah, Cecilia M. Fenoglio-Preiser, Brian L. Bleau, Ralph A. Giannella> ;The American Journal of Gastroenterology. 2001 Apr 1
8 citations
Protein kinase C regulates transcription of the human guanylate cyclase C gene
Nivedita Roy, Medigeshi R. Guruprasad, Paturu Kondaiah, Elizabeth A. Mann, Ralph A. Giannella, Sandhya S. Visweswariah> ;European Journal of Biochemistry. 2001 Apr 1
25 citations
Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclase C receptor-deficient mice
Alan N. Charney, Richard W. Egnor, Jesline Alexander-Chacko, Valentin Zaharia, Elizabeth A. Mann, Ralph A. Giannella> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2001 Feb 1
29 citations
Effects of olestra and sorbitol consumption on objective measures of diarrhea: impact of stool viscosity on common gastrointestinal symptoms.
J. McRorie, Nora L. Zorich, Karen A. Riccardi, Lori J. Bishop, Thomas G. Filloon, S. Wason, Ralph A. Giannella> ;Regulatory Toxicology and Pharmacology. 2000 Feb 1
16 citations
Validation and characterization of a human volunteer challenge model for cholera by using frozen bacteria of the new Vibrio cholerae epidemic serotype, O139.
Mitchell B. Cohen, Ralph A. Giannella, Genevieve Losonsky, Dennis Lang, Susan Parker, Jennifer Hawkins, Carolyn Gunther, Gilbert A. Schiff> ;Infection and Immunity. 1999 Dec 1
118 citations
Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera follo...
Carol O. Tacket, Mitchell B. Cohen, Steven S. Wasserman, Genevieve Losonsky, Sofie Livio, Karen L. Kotloff, Robert R. Edelman, James B. Kaper, Stanley J. Cryz, Ralph A...> ;Infection and Immunity. 1999 Dec 1
Pediatric gastroenterology and the AGA.
Ralph A. Giannella> ;Journal of Pediatric Gastroenterology and Nutrition. 1999 Nov 1
47 citations
Renal effects of uroguanylin and guanylin in vivo.
Stephen L. Carrithers, M J Hill, B.R. Johnson, S M O'Hara, Brian A. Jackson, C. E. Ott, John N. Lorenz, Elizabeth A. Mann, Ralph A. Giannella, Leonard R. Forte, Richar...> ;Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas e Biologicas. 1999 Nov 1
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