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Rama Mallampalli, MD, Pulmonology, Columbus, OH, Ohio State University Wexner Medical Center

RamaKMallampalliMD

Pulmonology • Columbus, OH

Critical Care Medicine, Pleural Disease

Chair of Internal Medicine, Physician in Chief of Medicine, The Ohio State University Wexner Medical Center

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  • Office

    395 W 12th Avenue, Room 392
    Department of Internal Medicine
    Columbus, OH 43210
    Phone+1 614-293-8724
    Fax+1 614-293-6656
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Summary

  • Dr. Mallampalli’s research in the area of pulmonary molecular and cell biology as it relates to acute lung injury (ALI) and the mechanisms of sepsis. He is an internationally recognized investigator in the area of ubiquitin-mediated proteolysis as it relates to inflammation and injury. His research program discovered a unique model for the molecular behavior of ubiquitin E3 ligase subunits that control inflammation. Dr. Mallampalli’s laboratory designed, synthesized, and tested the first-in-class genus of oral ubiquitin E3 ligase (F box) inhibitors that block inflammation in preclinical models of ALI and multi-organ failure that are FDA approved for Phase 1 studies. He currently leads an NIH Program Project grant in ALI and a Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage II (CADETII) award to develop drug therapies for inflammatory lung illness.

Education & Training

  • University of Iowa Hospitals and Clinics
    University of Iowa Hospitals and ClinicsFellowship, Pulmonary Disease and Critical Care Medicine, 1988 - 1991
  • Hennepin Healthcare
    Hennepin HealthcareChief Residency, Internal Medicine, 1987 - 1988
  • Hennepin Healthcare
    Hennepin HealthcareResidency, Internal Medicine, 1985 - 1988
  • Hennepin Healthcare
    Hennepin HealthcareInternship, Internal Medicine, 1984 - 1987
  • Hennepin Healthcare
    Hennepin HealthcareInternship, Transitional Year, 1984 - 1985
  • University of Wisconsin School of Medicine & Public Health
    University of Wisconsin School of Medicine & Public HealthClass of 1984

Certifications & Licensure

  • OH State Medical License
    OH State Medical License 2019 - 2026
  • PA State Medical License
    PA State Medical License 2009 - 2021
  • IA State Medical License
    IA State Medical License 1988 - 2014
  • MN State Medical License
    MN State Medical License 1985 - 1990
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Critical Care Medicine
  • American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

  • Distinguished Alumnus Award University of Iowa Carver College of Medicine, 2020
  • Permanent Member NHLBI Program Project Review Committee
  • Harrington Scholar-Innovator Harrington Discovery Institute, 2016
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Publications & Presentations

PubMed

Lectures

  • 2012 Pittsburgh International Lung Conference 
    UPMC Life Changing Medicine, Philadelphia, Pennsylvania - 10/5/2012

Press Mentions

  • Cleveland VA, Ohio State Join Clinical Trials Testing Experimental COVID-19 Vaccines in Humans
    Cleveland VA, Ohio State Join Clinical Trials Testing Experimental COVID-19 Vaccines in HumansSeptember 2nd, 2020
  • Tiny Coils Improve Quality of Life for Patients with Severe Emphysema
    Tiny Coils Improve Quality of Life for Patients with Severe EmphysemaMay 15th, 2016
  • The Ohio State University Wexner Medical Center
    The Ohio State University Wexner Medical CenterJuly 9th, 2023
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Grant Support

  • F box-Induced Acute Lung Injury and ParkinNational Heart, Lung, & Blood Institute2016–2020
  • Signaling Mechanisms by Which Mitochondria Regulates Fibrosis in the LungNational Heart, Lung, & Blood Institute2016–2020
  • Epigenetic Regulation in Acute Lung InjuryNational Heart, Lung, & Blood Institute2015–2019
  • Novel F Box Immunomodulator for Lung Allograft RejectionHarrington Discovery Institute2016–2018
  • Mechanisms of Lung Homeostatis by F box ProteinsNational Heart, Lung, & Blood Institute2014–2018
  • Cardiolipin as a Novel Mediator of Acute Lung Injury - Project 1National Heart, Lung, & Blood Institute2014–2018
  • Regulation of F Box Proteins in Acute Lung InjuryNational Heart, Lung, & Blood Institute2014–2018
  • Translational Training Program in Pulmonary Biology and MedicineNational Heart, Lung, & Blood Institute2013–2018
  • Regulation of Innate Immunity by F-Box ProteinsNational Heart, Lung, & Blood Institute2013–2018
  • A New Genus of Ubiquitin-Based Anti-Inflammatories for COPDNational Heart, Lung, & Blood Institute2014–2017
  • Novel F Box Anti-Inflammatories for COPDFlight Attendants Medical Research Institute2014–2017
  • Cardiolipin, Pneumonia, And A Novel Cardiolipin PUMPVeterans Affairs2010–2012
  • Septic Lung Injury And SurfactantNational Heart, Lung, And Blood Institute2010–2012
  • Cardiolipin Induced Lung Injury And FIC1National Heart, Lung, And Blood Institute2010–2012
  • Mechanisms Of Lung Phospholipid HomeostasisNational Heart, Lung, And Blood Institute2009–2011
  • Tnf-Alpha Control Of A Surfactant Enzyme In Lung InjuryNational Heart, Lung, And Blood Institute2009–2010
  • Adenoviral Induced Acute Lung Injury And SurfactantNational Heart, Lung, And Blood Institute2009–2010
  • Tnf-Alpha Control Of A Surfactant Enzyme In Lung InjuryNational Heart, Lung, And Blood Institute2006–2009
  • Adenoviral Induced Acute Lung Injury And SurfactantNational Heart, Lung, And Blood Institute2006–2009
  • Regulation Of Surfactant Synthesis In AsthmaNational Heart, Lung, And Blood Institute2005–2008
  • Transcriptional Regulation Of A Surfactant EnzymeNational Heart, Lung, And Blood Institute2002–2005
  • Regulation Of Cytidylytransferase In Fetal RAT LungNational Heart, Lung, And Blood Institute2002–2005
  • Tnfalpha-Lipoprotein Control Of A Surfactant EnzymeNational Heart, Lung, And Blood Institute2001–2004
  • Transcriptional Regulation Of A Surfactant EnzymeEunice Kennedy Shriver National Institute Of Child Health &Human Development2002–2003
  • Regulation Of Sufactant Synthesis By TNF In Adult LungNational Heart, Lung, And Blood Institute1998–2002
  • Regulation Of Cytidylyltransferase In Fetal RAT LungNational Heart, Lung, And Blood Institute1998–2000
  • Regulation Of Cytidylyltransferase In Fetal RAT LungNational Heart, Lung, And Blood Institute1996–1997

Professional Memberships

  • American Thoracic Society - ATS
    Member
  • The American Society for Clinical Investigation
    Member
  • American Society for Microbiology
    Member
  • American College of Chest Physicians, Fellow
    Member
  • Amercian Society for Biochemsitry and Molecular Biology
    Fellow
  • Society for Pediatric Research
    Member
  • Central Society for Clinical Research
    Member
  • American Federation for Medical Research
    Member
  • Iowa Medical society
    Member
  • Biochemical Society
    Member

Hospital Affiliations

Dr. Rama Mallampalli, Dr. Rama Mallampalli, MD, Dr. R Mallampalli, Dr. Rama K Mallampalli