RamaswamyGovindanMD

Oncology • Saint Louis, MO

Professor, Internal Medicine, Washington University School of Medicine

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Office
4921 Parkview Pl
Saint Louis, MO 63110
Phone+1 314-747-1171

Fax+1 314-362-3895
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Hematology and Medical Oncology, 1993 - 1996
University of Illinois College of Medicine at ChicagoResidency, Internal Medicine, 1991 - 1993
Stanley Medical College SMCClass of 1987

Certifications & Licensure

MO State Medical License 1995 - 2025
IL State Medical License 1996 - 1999

Awards, Honors, & Recognition

Alton Ochsner Award Related Smoking and Disease Alton Ochsner, 2016
Endowed Chair in Medical Oncology Anheuser Busch, 2016
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012

Clinical Trials

Gefitinib in Treating Patients With Malignant Mesothelioma Start of enrollment: 2001 Sep 01
Completed
Phase 2
Combination Chemotherapy and Exisulind in Treating Patients With Extensive-Stage Small Cell Lung Cancer Start of enrollment: 2002 Jun 01
Completed
Phase 2
Pemetrexed Disodium, Carboplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III Non-Small Cell Lung Cancer Start of enrollment: 2005 Sep 01
Completed
Phase 2
Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-small Cell Lung Cancer That Was Removed By Surgery Start of enrollment: 2007 Jun 01
Active, not recruiting
Phase 3
A Phase II Study of Radiation Therapy, Paclitaxel Poliglumex, and Carboplatin in Stage III Non-Small Cell Lung Cancer Start of enrollment: 2006 Apr 01
Terminated
Phase 2
FDG-PET/CT Scans in Patients With Stage IIIB or Stage IV NSCLC Undergoing Chemotherapy Start of enrollment: 2007 Mar 30
Terminated
Not Applicable
Differences in the Presentation Outcome and Response to Treatment Between Never- Smokers and Smokers With NSCLC Start of enrollment: 2006 Mar 01
Completed
Drug Delivery and Toxicities of Adjuvant Chemotherapy in Resected NCSLC Start of enrollment: 2006 Feb 01
Completed
A Phase I Study of SUNITINIB and Rapamycin in Advanced Non-Small Cell Lung Cancer (NSCLC) Start of enrollment: 2007 Nov 01
Completed
Phase 1
Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide Start of enrollment: 2008 Mar 01
Active, not recruiting
Phase 3
Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Start of enrollment: 2011 Jan 11
Terminated
Phase 3
Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer Start of enrollment: 2012 Mar 01
Completed
Combining MLN8237 With Nab-Paclitaxel in Patients With Advanced Solid Malignancies Start of enrollment: 2013 May 07
Completed
Phase 1
Immunotherapy Study in Progressive or Relapsed Non-Small Cell Lung Cancer Start of enrollment: 2013 Feb 01
Terminated
Phase 2, Phase 3
VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors Start of enrollment: 2013 May 03
Terminated
Phase 1, Phase 2
Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride in Treating Patient With Stage IV Non-Small Cell Lung Cancer Resistant to First-Line Therapy With Erlotinib Hydrochloride or Gefitinib Start of enrollment: 2014 Jun 01
Withdrawn
Phase 2
Hypofractionated Proton Beam Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Stage II-III Non-Small Cell Lung Cancer Start of enrollment: 2014 May 22
Completed
Phase 1
Pazopanib in Molecularly Selected Patients With Advanced NSCLC Start of enrollment: 2015 Apr 27
Terminated
Phase 2
Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) Start of enrollment: 2015 Feb 11
Active, not recruiting
Phase 3
A Study of Abemaciclib (LY2835219) in Participants With Stage IV Squamous Non-small Cell Lung Cancer Start of enrollment: 2015 Aug 06
Completed
Phase 2
Afatinib Genomic Landscape Start of enrollment: 2015 Jun 11
Terminated
Genomic Landscape of Ceritinib Start of enrollment: 2015 Sep 16
Terminated
MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors Start of enrollment: 2016 Sep 12
Terminated
Phase 2
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Publications & Presentations

PubMed

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer.
Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B Dodhiawala, Lin Li, Yutong G...> ;Nature Communications. 2024 Mar 20
The changing landscape of small cell lung cancer.
Giordano Fabricio Cittolin-Santos, Bharath Ganesh, Feng Gao, Saiama Waqar, Thomas Eldridge Stinchcombe, Ramaswamy Govindan, Daniel Morgensztern, Knapp, B., Brendan Knapp> ;Cancer. 2024 Mar 12
AI-guided histopathology predicts brain metastasis in lung cancer patients.
Haowen Zhou, Mark Watson, Cory T Bernadt, Steven Siyu Lin, Chieh-Yu Lin, Jon H Ritter, Alexander Wein, Simon Mahler, Sid Rawal, Ramaswamy Govindan, Changhuei Yang, Ric...> ;The Journal of Pathology. 2024 May 1
Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein.
Mark A Kroenke, Marta Starcevic Manning, Christina L Zuch de Zafra, Xinwen Zhang, Kevin D Cook, Michael Archer, Martijn P Lolkema, Jin Wang, Sarah Hoofring, Gurleen Sa...> ;Frontiers in Immunology. 2024 Jan 1
Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carc...
Lim, K., Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun,...> ;Cancer Research. 2023 Dec 15
Long-term benefit of sotorasib in patients with KRAS G12C-mutated non-small-cell lung cancer: plain language summary.
Grace K Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S Falchook, Antoine Italiano, Jürgen Wolf, Adrian G Sacher, Toshiaki Takahashi, Suresh S Ramalingam, Christo...> ;Future Oncology. 2024 Jan 1
Pre-radiotherapy ctDNA liquid biopsy for risk stratification of oligometastatic non-small cell lung cancer.
Nicholas P Semenkovich, Shahed N Badiyan, Pamela P Samson, Hayley B Stowe, Yun E Wang, Rachel Star, Siddhartha Devarakonda, Ramaswamy Govindan, Saiama N Waqar, Cliffor...> ;NPJ Precision Oncology. 2023 Oct 2
2 citations
Non-small Cell Lung Cancer Epigenomes Exhibit Altered DNA Methylation in Smokers and Never-smokers.
Jennifer A Karlow, Erica C Pehrsson, Xiaoyun Xing, Mark Watson, Siddhartha Devarakonda, Ramaswamy Govindan, Ting Wang> ;Genomics, Proteomics & Bioinformatics. 2023 Oct 1
Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data.
Prashanth Ashok Kumar, Maryam Karimi, Alina Basnet, Lesley Seymour, Robert Kratzke, Elizabeth Brambilla, Thierry Le-Chevalier, Jean-Charles Soria, Ken André Olaussen, ...> ;Clinical Lung Cancer. 2023 Sep 1
5 citations
Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer.
Brett H Herzog, John M Baer, Nicholas Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Y...> ;Science Translational Medicine. 2023 Jun 7
Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer.
Xiaoyan Wang, Ruiyi Tian, Xiaoyu Zong, Myung Sik Jeon, Jingqin Luo, Graham A Colditz, Jean S Wang, Konstantinos K Tsilidis, Yo-El S Ju, Ramaswamy Govindan, Varun Puri,...> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Aug 1
14 citations
Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With PretreatedG12C-Mutated Non-Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100.
Grace K Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S Falchook, Antoine Italiano, Jürgen Wolf, Adrian G Sacher, Toshiaki Takahashi, Suresh S Ramalingam, Christo...> ;Journal of Clinical Oncology. 2023 Jun 20
21 citations
Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.
Kelsy C Cotto, Yang-Yang Feng, Avinash Ramu, Megan Richters, Sharon L Freshour, Zachary L Skidmore, Huiming Xia, Joshua F McMichael, Jason Kunisaki, Katie M Campbell, ...> ;Nature Communications. 2023 Mar 22
1 citations
Pre-radiotherapy ctDNA liquid biopsy for risk stratification of oligometastatic non-small cell lung cancer.
Nicholas P Semenkovich, Pamela P Samson, Shahed N Badiyan, Gregory Vlacich, Hayley B Stowe, Yun E Wang, Rachel Star, Siddhartha Devarakonda, Ramaswamy Govindan, Saiama...> ;Research Square. 2023 Mar 22
7 citations
Clonal Hematopoiesis and Risk of Incident Lung Cancer.
Tian, R., Wiley, B., Liu, J., Zong, X., Truong, B., Zhao, S., Uddin, M., Niroula, A., Miller, C., Mukherjee, S., Heiden, B., Luo, J., Puri, V., Kozower, B., Walter, M....> ;Journal of Clinical Oncology. 2023 Mar 1
5 citations
Management of infusion-related reactions (IRRs) in patients receiving amivantamab in the CHRYSALIS study.
Keunchil Park, Joshua K Sabari, Eric B Haura, Catherine A Shu, Alexander Spira, Ravi Salgia, Karen L Reckamp, Rachel E Sanborn, Ramaswamy Govindan, Joshua M Bauml, Jos...> ;Lung Cancer. 2023 Apr 1
36 citations
Tarlatamab, a First-in-Class DLL3-Targeted Bispecific T-Cell Engager, in Recurrent Small-Cell Lung Cancer: An Open-Label, Phase I Study.
Luis Paz-Ares, Stephane Champiat, W Victoria Lai, Hiroki Izumi, Ramaswamy Govindan, Michael Boyer, Horst-Dieter Hummel, Hossein Borghaei, Melissa L Johnson, Neeltje St...> ;Journal of Clinical Oncology. 2023 Jun 1
1 citations
Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition.
Ravshan Burikhanov, Saptadwipa Ganguly, Sally Ellingson, Vitaliy M Sviripa, Nathalia Araujo, Shunqiang Li, Prasanna Venkatraman, Mahadev Rao, Anuradha Choughule, Chris...> ;American Journal of Cancer Research. 2023 Jan 1
1 citations
Clinician Perspectives on Barriers and Enablers to Implementing an Inpatient Oncology Early Warning System: A Mixed-Methods Study.
Patrick G Lyons, Vanessa Chen, Tejas C Sekhar, Colleen A McEvoy, Marin H Kollef, Ramaswamy Govindan, Peter Westervelt, Kelly C Vranas, Thomas M Maddox, Elvin H Geng, P...> ;JCO Clinical Cancer Informatics. 2023 Jan 1
6 citations
Trends in Stage I Lung Cancer.
Aashray Singareddy, Mary Ellen Flanagan, Pamela P Samson, Saiama N Waqar, Siddhartha Devarakonda, Jeffrey P Ward, Brett H Herzog, Anjali Rohatgi, Clifford G Robinson, ...> ;Clinical Lung Cancer. 2023 Mar 1
5 citations
Ramucirumab plus atezolizumab in patients with stage IV non-small cell lung cancer previously treated with immune checkpoint inhibitors.
Brett H Herzog, Saiama N Waqar, Siddhartha Devarakonda, Jeffrey P Ward, Feng Gao, Ramaswamy Govindan, Daniel Morgensztern> ;Lung Cancer. 2022 Nov 1
40 citations
Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer.
Mark M Awad, Ramaswamy Govindan, Kristen N Balogh, David R Spigel, Edward B Garon, Meghan E Bushway, Asaf Poran, Joong Hyuk Sheen, Victoria Kohler, Ekaterina Esaulova,...> ;Cancer Cell. 2022 Sep 12
6 citations
Developmental Pathways Are Epigenetically Reprogrammed during Lung Cancer Brain Metastasis.
Jennifer A Karlow, Siddhartha Devarakonda, Xiaoyun Xing, Hyo Sik Jang, Ramaswamy Govindan, Mark Watson, Ting Wang> ;Cancer Research. 2022 Aug 3
5 citations
Phase I Study of Accelerated Hypofractionated Proton Therapy and Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer.
Jessika Contreras, Amar Srivastava, Pamela Samson, Todd DeWees, Ramaswamy Govindan, Maria Q Baggstrom, Daniel Morgensztern, Michael Roach, Shahed N Badiyan, Jeffrey Br...> ;International Journal of Radiation Oncology, Biology, Physics. 2022 Jul 15
5 citations
PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery.
Soner Koc, Michael W Lloyd, Jeffrey W Grover, Nan Xiao, Sara Seepo, Sai Lakshmi Subramanian, Manisha Ray, Christian Frech, John DiGiovanna, Phillip Webster, Steven Neu...> ;NAR Cancer. 2022 Jun 1
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Journal Articles

A Deep Learning Approach to Automate Refinement of Somatic Variant Calling from Cancer Sequencing Data
Ravindra Uppaluri, Gavin P Dunn, Ramaswamy Govindan, S Joshua Swamidass, Todd A Fehniger, Nature
Targeting Resistance to Targeted Therapies: Combating a Resilient Foe
Siddhartha Devarakonda, Ramaswamy Govindan, Clinical Cancer Research
Recurrent WNT Pathway Alterations Are Frequent in Relapsed Small Cell Lung Cancer
Saiama N. Waqar, Daniel Morgensztern, Robert S. Fulton, Ramaswamy Govindan, Nature

Lectures

An open-label, phase 1b study of NEO-PV-01 with pembrolizumab plus chemotherapy in patients with advanced or metastatic nonsquamous non-small cell lung cancer.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
Great Debates and Updates In Thoracic Malignancies
Imedex, San Francisco, California - 5/5/2012

Press Mentions

Washington University School of Medicine Investigators Probe Gene & Protein-Level Patterns Behind Lung Cancer RecurrenceJune 30th, 2022
$5.3M Grant Funds Washington University School of Medicine Lung Cancer Recurrence ResearchJune 29th, 2022
$5.3 Million Grant Supports Research into Lung Cancer RecurrenceJune 28th, 2022
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Committees

Member, International Association for the Study of Lung Cancer Core Program 2014 - Present
Member, ALCHEMIST Champions Team 2014 - Present
Member, SITC/Medscape CME Project Steering Committee 2014 - Present
Member, National Comprehensive Cancer Network (NCCN) National Cancer Institute (NCI) Non-Small Cell Lung Cancer Panel 2013 - Present
Chair, IASLC Pathology Committee 2012 - Present