RameshChandraGuptaIMDFACR

Rheumatology • Memphis, TN

Lupus & Related, Rheumatoid Arthritis & Related, Spondyloarthropathy

Private practice Rheumatology

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Office
6005 Park Ave
Suite 409
Memphis, TN 38119
Phone+1 901-681-9670

Fax+1 901-685-9023
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Education & Training

University of ColoradoFellowship, Rheumatology, 1972 - 1974
UMass Chan Medical SchoolResidency, Internal Medicine, 1971 - 1972
All India Institute of Medical SciencesClass of 1965

Certifications & Licensure

TN State Medical License 1982 - 2026
CO State Medical License 1977 - 2001

Awards, Honors, & Recognition

Fellow (FACR) American College of Rheumatology

Clinical Trials

Phase 1b/2a Study to Evaluate Safety and Efficacy of KPG-818 in SLE Start of enrollment: 2021 Jun 03
Active, not recruiting
Phase 1, Phase 2
Roles: Contact
The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW) Start of enrollment: 2022 Mar 31
Recruiting
Phase 2
Roles: Principal Investigator
The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE) Start of enrollment: 2022 Sep 16
Recruiting
Phase 2
Roles: Principal Investigator

Publications & Presentations

PubMed

28 citations
Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer
Raghuram Kandimalla, Farrukh Aqil, Neha Tyagi, Ramesh C. Gupta> ;American Journal of Reproductive Immunology. 2021 Feb 1
18 citations
Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells.
Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta> ;Oncotarget. 2020 Apr 21
19 citations
Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome
Ashley M. Mudd, Tao Gu, Radha Munagala, Jeyaprakash Jeyabalan, Nejat K. Egilmez, Ramesh C. Gupta> ;Cancer Prevention Research. 2020 Jan 1
114 citations
Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial.
Morand, E., Bruce, I., Vital, E., Lawrence Ford, T., Hiepe, F., Santiago, M., Brohawn, P., Berglind, A., Tummala, R., , Furie, R., Manzi, S., Kalunian, K., Gupta, R.> ;The Lancet. Rheumatology. 2019 Dec 1
164 citations
Milk exosomes - Natural nanoparticles for siRNA delivery.
Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Al-Hassan Kyakulaga, Sarah A. Wilcher, Ramesh C. Gupta> ;Cancer Letters. 2019 May 1
34 citations
Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells.
Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta> ;Scientific Reports. 2018 Oct 24
11 citations
Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate.
Varun Kushwah, Sameer S. Katiyar, Ashish Kumar Agrawal, Isha Saraf, Inder Pal Singh, Dimitrios A. Lamprou, Ramesh C. Gupta, Sanyog Jain> ;International Journal of Pharmaceutics. 2018 Jul 4
32 citations
Co-delivery of docetaxel and gemcitabine using PEGylated self-assembled stealth nanoparticles for improved breast cancer therapy.
Varun Kushwah, Sameer S. Katiyar, Ashish Kumar Agrawal, Ramesh C. Gupta, Sanyog Jain> ;Nanomedicine. 2018 Apr 21
6 citations
A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis
Daniel J. Lovell, Jason Dare, Megan Francis-Sedlak, Julie Ball, Brian LaMoreaux, Emily von Scheven, Adam L Reinhardt, Rita Jerath, Oral Alpan, Ramesh Gupta, Donald P. ...> ;Pediatric Rheumatology Online Journal. 2018 Jun 26
59 citations
Co-delivery of docetaxel and gemcitabine by anacardic acid modified self-assembled albumin nanoparticles for effective breast cancer management
Varun Kushwah, Sameer S. Katiyar, Chander Parkash Dora, Ashish Kumar Agrawal, Dimitrios A. Lamprou, Ramesh C. Gupta, Sanyog Jain> ;Acta Biomaterialia. 2018 Jun 1
6 citations
Development of a goat model for evaluation of withaferin A: Cervical implants for the treatment of cervical intraepithelial neoplasia
Leslie C. Sherwood, Farrukh Aqil, Manicka V. Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay K. Srivastava, Inder Pal Singh, Scott D. Cambron, M...> ;Experimental and Molecular Pathology. 2017 Dec 1
92 citations
Exosomal delivery of berry anthocyanidins for the management of ovarian cancer
Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Al-Hassan Kyakulaga, Radha Munagala, Lynn P. Parker, Ramesh C. Gupta> ;Food & Function. 2017 Nov 15
170 citations
Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin
Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ramesh C. Gupta> ;The AAPS Journal. 2017 Oct 18
11 citations
Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A.
Karine Z. Oben, Sara S. Alhakeem, Mary K. McKenna, Jason A. Brandon, Rajeswaran Mani, Sunil K. Noothi, Liu Jinpeng, Shailaja Akunuru, Sanjit K. Dhar, Inder Pal Singh, ...> ;Oncotarget. 2017 Aug 26
31 citations
Novel Gemcitabine Conjugated Albumin Nanoparticles: a Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment
Varun Kushwah, Ashish Kumar Agrawal, Chander Parkash Dora, David Mallinson, Dimitrios A. Lamprou, Ramesh C. Gupta, Sanyog Jain> ;Pharmaceutical Research. 2017 Aug 9
307 citations
Milk-derived exosomes for oral delivery of paclitaxel
Ashish Kumar Agrawal, Farrukh Aqil, Jeyaprakash Jeyabalan, Wendy A. Spencer, Joshua Beck, Beth W. Gachuki, Sara S. Alhakeem, Karine Z. Oben, Radha Munagala, Subbarao B...> ;Nanomedicine. 2017 Jul 1
128 citations
Exosomal formulation of anthocyanidins against multiple cancer types
Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ashley M. Mudd, Al Hassan Kyakulaga, Inder Pal Singh, Manicka V. Vadhanam, Ramesh C. Gupta> ;Cancer Letters. 2017 May 1
11 citations
Chemoprevention of Rat Mammary Carcinogenesis by Apiaceae Spices
Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Srivani Ravoori, Manicka V. Vadhanam, David J. Schultz, Ramesh C. Gupta> ;International Journal of Molecular Sciences. 2017 Feb 16
157 citations
Exosomal formulation enhances therapeutic response of celastrol against lung cancer
Farrukh Aqil, Hina Kausar, Ashish Kumar Agrawal, Jeyaprakash Jeyabalan, Al-Hassan Kyakulaga, Radha Munagala, Ramesh C. Gupta> ;Experimental and Molecular Pathology. 2016 Aug 1
22 citations
Prevention of hormonal breast cancer by dietary jamun.
Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Inder Pal Singh, Ramesh C. Gupta> ;Molecular Nutrition & Food Research. 2016 Jun 1
86 citations
Exosomal miRNAs as biomarkers of recurrent lung cancer.
Radha Munagala, Farrukh Aqil, Ramesh C. Gupta> ;Tumour Biology. 2016 Feb 11
533 citations
Bovine milk-derived exosomes for drug delivery.
Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ramesh C. Gupta> ;Cancer Letters. 2016 Feb 1
23 citations
Stability of anthocyanins- and anthocyanidins-enriched extracts, and formulations of fruit pulp of Eugenia jambolana (‘jamun’)
Ram Jee Sharma, Ramesh C. Gupta, Saranjit Singh, Arvind K. Bansal, Inder Pal Singh> ;Food Chemistry. 2016 Jan 1
1 citations
Controlled Delivery of Chemopreventive Agents by Polymeric Implants.
Farrukh Aqil, Ramesh C. Gupta> ;Methods in Molecular Biology. 2016 Jan 1
900 citations
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper
Thomas Lener, Mario Gimona, Ludwig Aigner, Verena Börger, Edit I. Buzás, Giovanni Camussi, Nathalie Chaput, Devasis Chatterjee, Felipe A. Court, Hernando A. del Portil...> ;Journal of Extracellular Vesicles. 2015 Dec 31
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Professional Memberships

American College of Rheumatology - ACR
Fellow

Hospital Affiliations

Saint Francis HospitalMemphis, Tennessee
Baptist Memorial Hospital - MemphisMemphis, Tennessee
Lt. Col. Luke Weathers, Jr. VA Medical CenterMemphis, Tennessee