RamonRDiaz-ArrastiaMD

Neurology • Philadelphia, PA

Epilepsy, Neuroimaging, Neurodegenerative, Neurocritical Care

University of Pennsylvania Perelman School of Medicine

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Office
Penn Presbyterian Medical Center
51 North 39th Street, Andrew Mutch Building, Room 409
Philadelphia, PA 19104
Phone+1 215-662-9732
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Education & Training

New York Presbyterian Hospital (Columbia Campus)Residency, Neurology, 1989 - 1992
Beth Israel Deaconess Medical CenterInternship, Internal Medicine, 1988 - 1989
Baylor College of MedicineClass of 1988

Certifications & Licensure

PA State Medical License 2016 - 2024
TX State Medical License 1989 - 2024
NY State Medical License 1990 - 1994
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT) Start of enrollment: 2007 Jul 01
Terminated
Phase 3
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury. Start of enrollment: 2008 Sep 01
Completed
Phase 2
Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI) Start of enrollment: 2009 Oct 01
Completed
Phase 2
Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury. Start of enrollment: 2013 Jan 01
Completed
Phase 2
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI Start of enrollment: 2014 Sep 01
Terminated
Phase 2
Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury Start of enrollment: 2016 Dec 01
Terminated
Derivatives of Omega-3 HUFA as Biomarkers of Traumatic Brain Injury Start of enrollment: 2017 Jan 01
Withdrawn
Phase 2
HITT Device Pilot Testing for Traumatic Brain Injury Start of enrollment: 2017 Aug 22
Completed
Not Applicable
Cerebrovascular Reactivity in American Football Players Start of enrollment: 2018 Mar 01
Terminated
Phase 1
Brain Oxygen Optimization in Severe TBI, Phase 3 Start of enrollment: 2019 Aug 28
Recruiting
Not Applicable
Safety and Tolerability of PNT001 in Patients With Acute Traumatic Brain Injury (TBI) Start of enrollment: 2021 Mar 29
Terminated
Phase 1
HITT for the Identification of Mild Traumatic Brain Injury Start of enrollment: 2021 Aug 01
Active, not recruiting
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study.
J Kent Werner, Jennifer Albrecht, Sonia Jain, Xiaoying Sun, Emerson Wickwire, , Vincent F Capaldi, Pratik Mukherjee, Scott G Williams, Jacob Collen, Ramon Diaz-Arrasti...> ;Neurology. 2024 Apr 23
Insights into epileptogenesis from post-traumatic epilepsy.
Kunal Gupta, Solomon L Moshé, Matthew Pease, Daniel J Correa, Aristea S Galanopoulou, David O Okonkwo, Jorge Gonzalez-Martinez, Lori Shutter, Ramon Diaz-Arrastia, Jame...> ;Nature Reviews. Neurology. 2024 Apr 3
Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study.
John K Yue, Esther Lim Yuh, Mahmoud M Elguindy, Xiaoying Sun, Thomas Arjan Van Essen, Hansen Deng, Patrick J Belton, Gabriela G Satris, Justin C Wong, Alex Valadka, Fr...> ;Journal of Neurotrauma. 2024 Mar 7
Monitoring patients with severe traumatic brain injury.
Bernard, F., Diaz-Arrastia, R., Shutter, L., Barsan, W., Silbergleit, R.> ;The Lancet. Neurology. 2024 Mar 1
Posttraumatic Epilepsy and Dementia Risk.
Andrea L C Schneider, Connor A Law, Rebecca F Gottesman, Gregory Krauss, Juebin Huang, Anna Kucharska-Newton, Frances E Jensen, James J Gugger, Ramon Diaz-Arrastia, Em...> ;JAMA Neurology. 2024 Feb 26
Data-driven characterization of traumatic brain injury severity from clinical, neuroimaging, and blood-based indicators.
Nelson, L., Magnus, B., Yue, J., Balsis, S., Patrick, C., Temkin, N., Manley, G., Diaz-Arrastia, R.> ;Research Square. 2024 Feb 16
Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest.
Ouyang, M., Patel, B., Burnett, R., Berg, R., Huang, H., Kirschen, M., Diaz-Arrastia, R., Topjian, A., Vossough, A., Berman, J.> ;Resuscitation. 2024 Mar 1
Diagnostic Utility of Glial Fibrillary Acidic Protein Beyond 12 Hours After Traumatic Brain Injury: A TRACK-TBI Study.
Puccio, A., Ferguson, A., Wang, K., Markowitz, A., Sun, X., Jain, S., Yue, J., Okonkwo, D., Diaz-Arrastia, R., Mukherjee, P., Deng, H., Manley, G., Korley, F., Yuh, E....> ;Journal of Neurotrauma. 2024 Mar 14
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study.
Prasad, A., Begunova, L., Olexa, M., Ortega-Gutierrez, S., Temkin, N., Barber, J., de Havenon, A., Gilmore, E., Kim, J., Beekman, R., Falcone, G., Matouk, C., Diaz-Arr...> ;Neurocritical Care. 2023 Dec 29
Association between structural brain MRI abnormalities and epilepsy in older adults.
Walter, A., Reid, R., Kucharska-Newton, A., Gugger, J., Diaz-Arrastia, R., Huang, J., Jack, C., Gottesman, R., Schneider, A., Johnson, E.> ;Annals of Clinical and Translational Neurology. 2024 Feb 1
Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study.
Roberts, C., Barber, J., Temkin, N., Dong, A., Robertson, C., Valadka, A., Yue, J., Markowitz, A., Manley, G., Nelson, L., , Badjatia, N., Diaz-Arrastia, R., Duhaime, ...> ;JAMA Surgery. 2024 Mar 1
1 citations
Age specific reference intervals for plasma biomarkers of neurodegeneration and neurotrauma in a Canadian population.
Jennifer G Cooper, Sophie Stukas, Mohammad Ghodsi, Nyra Ahmed, Ramon Diaz-Arrastia, Daniel T Holmes, Cheryl L Wellington> ;Clinical Biochemistry. 2023 Nov 1
Differences in time-frequency characteristics between healthy controls and TBI patients during hypercapnia assessed via fNIRS.
Pratusha Reddy, Kurtulus Izzetoglu, Patricia A Shewokis, Michael Sangobowale, Ramon Diaz-Arrastia> ;Neuroimage. Clinical. 2023 Jan 1
Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials.
Ramon Diaz-Arrastia, Patrick M Kochanek> ;Neurotherapeutics. 2023 Oct 1
1 citations
Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.
Priyanka Kalyani, Sara M Lippa, J Kent Werner, Franck Amyot, Carol B Moore, Kimbra Kenney, Ramon Diaz-Arrastia> ;Neurotherapeutics. 2023 Oct 1
Longitudinal Recovery Following Repetitive Traumatic Brain Injury.
Leila L Etemad, John K Yue, Jason Barber, Lindsay D Nelson, Yelena G Bodien, Gabriela G Satris, Patrick J Belton, Debbie Y Madhok, J Russell Huie, Sabah Hamidi, Joye X...> ;JAMA Network Open. 2023 Sep 5
6 citations
Biomarker-guided neuromodulation aids memory in traumatic brain injury.
Michael J Kahana, Youssef Ezzyat, Paul A Wanda, Ethan A Solomon, Richard Adamovich-Zeitlin, Bradley C Lega, Barbara C Jobst, Robert E Gross, Kan Ding, Ramon R Diaz-Arr...> ;Brain Stimulation. 2023 Jul 5
Spatiotemporal profile of atrophy in the first year following moderate-severe traumatic brain injury.
Daniel J Brennan, Jeffrey Duda, Jeffrey B Ware, John Whyte, Joon Yul Choi, James Gugger, Kristen Focht, Alexa E Walter, Tamara Bushnik, James C Gee, Ramon Diaz-Arrasti...> ;Human Brain Mapping. 2023 Sep 1
Association of obesity with mild traumatic brain injury symptoms, inflammatory profile, quality of life and functional outcomes: a TRACK-TBI Study.
Shawn R Eagle, Ava M Puccio, Lindsay D Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David...> ;Journal of Neurology, Neurosurgery, and Psychiatry. 2023 Dec 1
1 citations
Long-term Multidomain Patterns of Change After Traumatic Brain Injury: A TRACK-TBI LONG Study.
Benjamin L Brett, Nancy Temkin, Jason K Barber, David O Okonkwo, Murray Stein, Yelena G Bodien, John Corrigan, Ramon Diaz-Arrastia, Joseph T Giacino, Michael A McCrea,...> ;Neurology. 2023 Aug 15
1 citations
Integrating, Harmonizing, and Curating Studies With High-Frequency and Hourly Physiological Data: Proof of Concept from Seven Traumatic Brain Injury Data Sets.
Ashraf Yaseen, Claudia Robertson, Jovany Cruz Navarro, Jingxiao Chen, Brian Heckler, Stacia M DeSantis, Nancy Temkin, Jason Barber, Brandon Foreman, Ramon Diaz-Arrasti...> ;Journal of Neurotrauma. 2023 Nov 1
2 citations
Association Between Soluble Intercellular Adhesion Molecule-1 and Intracerebral Hemorrhage Outcomes in the FAST Trial.
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E Kasner, Stephan A Mayer, Santosh B Murthy> ;Stroke. 2023 Jul 1
1 citations
Associations of Microvascular Injury-Related Biomarkers With Traumatic Brain Injury Severity and Outcomes: A Transforming Research and Clinical Knowledge in Traumatic ...
Andrea L C Schneider, J Russell Huie, Sonia Jain, Xiaoying Sun, Adam R Ferguson, Cillian Lynch, John K Yue, Geoffrey T Manley, Kevin K W Wang, Danielle K Sandsmark, Ch...> ;Journal of Neurotrauma. 2023 Aug 1
2 citations
Structural brain network deviations predict recovery after traumatic brain injury.
James J Gugger, Nishant Sinha, Yiming Huang, Alexa E Walter, Cillian Lynch, Priyanka Kalyani, Nathan Smyk, Danielle Sandsmark, Ramon Diaz-Arrastia, Kathryn A Davis> ;Neuroimage. Clinical. 2023 Jan 1
Detection of visuomotor dysfunction in mild traumatic brain injury using binocular retinal polarization scanning.
Talia N Shoshany, Carlos Torres-Quinones, Erika Silverman, Justin Shaka, Ramon Diaz-Arrastia, David G Hunter, Goldstein, L.> ;Brain Injury. 2023 May 12
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Journal Articles

Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients with Moderate Traumatic Brain Injury
Ramon Diaz-Arrastia, MD, JAMA Network Open

Authored Content

Epilepsy as a Network Disorder (2): What Can We Learn from Other Network Disorders Such as Dementia and Schizophrenia, and What Are the Implications for Translational Research?☆October 2017

Press Mentions

Bright Prognosis for Brain Injury BiomarkersNovember 20th, 2022
Early Blood Tests for Traumatic Brain Injury Can Accurately Predict Which Patients Are Likely to DieAugust 20th, 2022
BRAINBox Solutions Awarded $3.5 Million NIH SBIR Grant to Develop Geriatric Specific Multi-Modality Diagnostic and Prognostic Testing System for mTBI (Concussion)March 21st, 2022
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Grant Support

Traumatic Brain Injury Clinical Trials NetworkEunice Kennedy Shriver National Institute Of Child Health &Human Development2003–2012
Phase II, Randomized Controlled Trial Of Brain Tissue Oxygen MonitoringNational Institute Of Neurological Disorders And Stroke2009–2010
Genetic Factors In Outcome From Traumatic Brain InjuryEunice Kennedy Shriver National Institute Of Child Health &Human Development2004–2008
Hyperhomocysteinemia In Alzheimer'S DiseaseNational Institute On Aging2001–2003
Candidate Genetic Polymorphisms/ Hiv-Associated DementiaNational Institute Of Mental Health2001–2002
Cpla2 And Neurodegenerative DiseaseNational Institute On Aging1999
Neuronal Phospholipase A2National Institute Of Neurological Disorders And Stroke1994–1998
Stress And The Neuropathology Of Alzheimers DiseaseNational Institute On Aging1997