RandalCPanielloMDPhD MBA

Otolaryngology (ENT) • Saint Louis, MO

Christy and Richard Hawes III Professor of Otolaryngology, Washington University School of Medicine

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Office
4921 Parkview Pl
Saint Louis, MO 63110
Phone+1 314-362-7509

Fax+1 314-747-8687
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Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Otolaryngology - Head and Neck Surgery, 1985 - 1990
Washington University/B-JH/SLCH ConsortiumInternship, Transitional Year, 1984 - 1985
University of Illinois College of MedicineClass of 1984

Certifications & Licensure

IL State Medical License 1991 - 2026
MO State Medical License 1985 - 2025
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery

Clinical Trials

Surgery for Vocal Cord Paralysis Start of enrollment: 2002 Oct 01
Terminated
Phase 3
GSK1120212 in Surgically Resectable Oral Cavity Squamous Cell Cancer Start of enrollment: 2013 Feb 01
Completed
Phase 2
Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx Cancer Start of enrollment: 2013 Jan 10
Terminated
Phase 3
Examining the Spasmodic Dysphonia Diagnosis and Assessment Procedure (SD-DAP) for Measuring Symptom Change Start of enrollment: 2015 Oct 01
Withdrawn
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Publications & Presentations

PubMed

1 citations
Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies.
Katherine W Chang, Angela L Mazul, Daniel P Lander, Benjamin M Wahle, Emily Z Yan, Wade L Thorstad, Sidharth V Puram, Ryan S Jackson, Patrik Pipkorn, Randal C Paniello...> ;Otolaryngology--Head and Neck Surgery. 2024 Apr 1
3 citations
Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Nathan T Wamsley, Emily M Wilkerson, Li Guan, Kyle M LaPak, Travis P Schrank, Brittany J Holmes, Robert W Sprung, Petra Erdmann Gilmore, Sophie P Gerndt, Ryan S Jackso...> ;Molecular & Cellular Proteomics. 2023 Nov 1
1 citations
Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer.
Miriam T Jacobs, Pamela Wong, Alice Y Zhou, Michelle Becker-Hapak, Nancy D Marin, Lynne Marsala, Mark Foster, Jennifer A Foltz, Celia C Cubitt, Jennifer Tran, David A ...> ;Clinical Cancer Research. 2023 Oct 13
Immune Cell Deconvolution Reveals Possible Association of γδ T Cells with Poor Survival in Head and Neck Squamous Cell Carcinoma.
Anuraag S Parikh, Yize Li, Angela Mazul, Victoria X Yu, Wade Thorstad, Jason Rich, Randal C Paniello, Salvatore M Caruana, Scott H Troob, Ryan S Jackson, Paul Zolkind,...> ;Cancers. 2023 Oct 5
5 citations
Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer.
Oliveira, G., Egloff, A., Afeyan, A., Wolff, J., Zeng, Z., Chernock, R., Zhou, L., Messier, C., Lizotte, P., Pfaff, K., Stromhaug, K., Penter, L., Haddad, R., Hanna, G...> ;Science Immunology. 2023 Sep 8
Recurrent laryngeal motor nerve conduction studies in a rat model: Establishing an objective measure for investigating laryngeal innervation.
Hans Baertsch, David J Cvancara, Randal C Paniello, Allen D Hillel, Neel K Bhatt> ;Muscle & Nerve. 2023 Oct 1
Enhanced Abductor Function in Bilateral Vocal Fold Paralysis with Muscle Stem Cells.
Randal C Paniello, Sarah Brookes, Hongji Zhang, Halum, S.> ;The Laryngoscope. 2024 Jan 1
5 citations
Interim Results of a Phase 1/2 Open-Label Study of INO-3107 for HPV-6 and/or HPV-11-Associated Recurrent Respiratory Papillomatosis.
Ted Mau, Milan R Amin, Peter C Belafsky, Simon R Best, Aaron D Friedman, Adam M Klein, David G Lott, Randal C Paniello, Seth M Pransky, Nabil F Saba, Tamara Howard, Mi...> ;The Laryngoscope. 2023 Nov 1
10 citations
Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma.
Sidharth V Puram, Michael Mints, Ananya Pal, Zongtai Qi, Ashley Reeb, Kyla Gelev, Thomas F Barrett, Sophie Gerndt, Ping Liu, Anuraag S Parikh, Salma Ramadan, Travis La...> ;Nature Genetics. 2023 Apr 1
2 citations
Race and socioeconomic status interact with HPV to influence survival disparities in oropharyngeal squamous cell carcinoma.
Emily Z Yan, Benjamin M Wahle, Sean T Massa, Paul Zolkind, Randal C Paniello, Ryan S Jackson, Jason T Rich, Sidharth V Puram, Angela L Mazul, Pipkorn, P.> ;Cancer Medicine. 2023 Apr 1
1 citations
Extracellular matrix deformations of the porcine recurrent laryngeal nerve in response to hydrostatic pressure.
Hirut G Kollech, Melissa R Chao, Amanda C Stark, Rebecca Z German, Randal C Paniello, Michael B Christensen, Julie M Barkmeier-Kraemer, Jonathan P Vande Geest> ;Acta Biomaterialia. 2022 Nov 1
2 citations
The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database.
Thomas F. Barrett, Angela L. Mazul, Katelyn O. Stepan, C. Burton Wood, R.C. Paniello, Jose P. Zevallos, Sean T. Massa, Ryan S. Jackson, Nicole C. Schmitt, Joseph Zenga...> ;Oral Oncology. 2021 May 12
11 citations
nab-Paclitaxel and cisplatin followed by cisplatin and radiation (Arm 1) and nab-paclitaxel followed by cetuximab and radiation (Arm 2) for locally advanced head and n...
Peter Oppelt, Jessica Ley, Mackenzie Daly, Jason T. Rich, Randal C. Paniello, Ryan S. Jackson, Jingxia Liu, Kevin Palka, Prakash Neupane, Steven Francis Powell, Willia...> ;Medical Oncology. 2021 Mar 8
9 citations
The prognostic significance of race in nasopharyngeal carcinoma by histological subtype.
Katelyn O. Stepan, Angela L. Mazul, S. Andrew Skillington, Randal C. Paniello, Jason T. Rich, Jose P. Zevallos, Ryan S. Jackson, Sean T. Massa, Sidharth V. Puram> ;Head & Neck. 2021 Feb 23
Low-risk human papilloma virus positive oropharyngeal cancer with one positive lymph node: Equivalent outcomes in patients treated with surgery and radiation therapy v...
Reilly A. Sample, Carey Burton Wood, Angela L. Mazul, Thomas F. Barrett, Randal C. Paniello, Jason T. Rich, Stephen Y. Kang, Jose P. Zevallos, Mackenzie Daly, Wade L. ...> ;Head & Neck. 2021 Feb 15
11 citations
Regional lymph node irradiation in locally advanced Merkel cell carcinoma reduces regional and distant relapse and improves disease-specific survival.
Neal Andruska, Lily Mahapatra, Randall Brenneman, Yi Huang, Randal C. Paniello, Sidharth V. Puram, Mena Mansour, Jason T. Rich, Brian C. Baumann, Wade L. Thorstad, Mac...> ;Radiotherapy and Oncology. 2021 Feb 1
4 citations
Outcomes of Patients With Single-Node Metastasis of Human Papillomavirus–Related Oropharyngeal Cancer Treated With Transoral Surgery
, , , , , , , , , , , , , , , > ;JAMA Otolaryngology-- Head & Neck Surgery. 2021 Jan 1
11 citations
Oromandibular Dystonia: A Clinical Examination of 2,020 Cases.
, , , , , , , , , , , , , , , , , , , > ;Frontiers in Neurology. 2021 Jan 1
78 citations
Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial.
Uppaluri, R., Campbell, K., Egloff, A., Zolkind, P., Skidmore, Z., Nussenbaum, B., Paniello, R., Rich, J., Jackson, R., Pipkorn, P., Michel, L., Ley, J., Oppelt, P., D...> ;Clinical Cancer Research. 2020 Oct 1
18 citations
Regional, not global, functional connectivity contributes to isolated focal dystonia.
Scott A. Norris, Aimee E. Morris, Meghan C. Campbell, Morvarid Karimi, Babatunde Adeyemo, Randal C. Paniello, Abraham Z. Snyder, Steven E. Petersen, Jonathan W. Mink, ...> ;Neurology. 2020 Sep 10
13 citations
Duration of radiation therapy is associated with worse survival in head and neck cancer.
Angela L. Mazul, Katelyn O. Stepan, Thomas F. Barrett, Wade L. Thorstad, Sean T. Massa, Douglas Adkins, Mackenzie Daly, Jason T. Rich, Randal C. Paniello, Jose P. Zeva...> ;Oral Oncology. 2020 Sep 1
1 citations
Development of In-Office Laryngeal Nerve Conduction Studies: Computed Tomography and Cadaveric Study.
Neel K. Bhatt, Franklin Wu, Leila Darki, Karla O'Dell, Randal C. Paniello, Michael M. Johns> ;The Laryngoscope. 2021 Jul 1
1 citations
Factors associated with skin graft take in fibula and radial forearm free flap donor sites.
Michelle S. Hwang, Christopher J. Britt, Peter M. Vila, Rajan P. Dang, Shannon I. Fleming, Aman M. Patel, Randal C. Paniello, Jason T. Rich, Matthew M. Hanasono, Shaun...> ;American Journal of Otolaryngology. 2020 Jul 1
53 citations
Extranodal extension is a strong prognosticator in HPV-positive oropharyngeal squamous cell carcinoma
Eric Bauer, Angela L. Mazul, Rebecca D. Chernock, Jason T. Rich, Ryan S. Jackson, Randal C. Paniello, Peter Oppelt, Mackenzie Daly, Samir K. El-Mofty, Wade L. Thorstad...> ;The Laryngoscope. 2020 Apr 1
6 citations
Superior laryngeal nerve transection for neuropathic cough: A pilot study.
Joseph Bradley, Jennifer Gross, Randal C. Paniello> ;Auris, Nasus, Larynx. 2020 Mar 31
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Press Mentions

Finding Her Voice AgainOctober 26th, 2015

Grant Support

Selective Adductor Recovery After Laryngeal Nerve InjuryNational Institute On Deafness And Other Communication Disorders2010–2011
Medialization Vs. Reinnervation For Vocal Cord ParalysisNational Institute On Deafness And Other Communication Disorders2002–2003
Laryngeal Reinnervation--Characterization Of SynkinesisNational Institute On Deafness And Other Communication Disorders1998–2000