RavindraMajetiMD

PubMed

• Genetically corrected RAG2-SCID human hematopoietic stem cells restore V(D)J-recombinase and rescue lymphoid deficiency.
  Mara Pavel-Dinu, Cameron L Gardner, Yusuke Nakauchi, Tomoki Kawai, Ottavia M Delmonte, Boaz Palterer, Marita Bosticardo, Francesca Pala, Sebastien Viel, Harry L Malech...> ;Blood Advances. 2024 Apr 9
• Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors.
  Fabian P Suchy, Daiki Karigane, Yusuke Nakauchi, Maimi Higuchi, Jinyu Zhang, Katja Pekrun, Ian Hsu, Amy C Fan, Toshinobu Nishimura, Carsten T Charlesworth, Joydeep Bha...> ;Nature Biotechnology. 2024 Apr 8
• Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
  Jonas L Fowler, Sherry Li Zheng, Alana Nguyen, Angela Chen, Xiaochen Xiong, Timothy Chai, Julie Y Chen, Daiki Karigane, Allison M Banuelos, Kouta Niizuma, Kensuke Kaya...> ;Developmental Cell. 2024 Apr 1
• Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity.
  Matthew Schwede, Katharina Jahn, Jack Kuipers, Linde A Miles, Robert L Bowman, Troy Robinson, Ken Furudate, Hidetaka Uryu, Tomoyuki Tanaka, Yuya Sasaki, Asiri Ediriwic...> ;Leukemia. 2024 Mar 11
• Human ASXL1-mutant hematopoiesis is driven by a truncated protein associated with aberrant de-ubiquitination of H2AK119.
  Kohnke, T., Nuno, K., Alder, C., Phan, P., Fan, A., Gars, E., Majeti, R.> ;Blood Cancer Discovery. 2024 Feb 15
• IDH1-mutant preleukemic hematopoietic stem cells can be eliminated by inhibition of oxidative phosphorylation.
  Landberg, N., Köhnke, T., Feng, Y., Nakauchi, Y., Fan, A., Linde, M., Karigane, D., Lim, K., Sinha, R., Malcovati, L., Thomas, D., Majeti, R.> ;Blood Cancer Discovery. 2023 Dec 13
• Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis.
  Yusuke Nakauchi, Asiri Ediriwickrema, Daniel Martinez-Krams, Feifei Zhao, Athreya Rangavajhula, Daiki Karigane, Ravindra Majeti> ;Journal of Visualized Experiments. 2023 Nov 10
• Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity.
  Matthew Schwede, Katharina Jahn, Jack Kuipers, Linde A Miles, Robert L Bowman, Troy Robinson, Ken Furudate, Hidetaka Uryu, Tomoyuki Tanaka, Yuya Sasaki, Asiri Ediriwic...> ;Research Square. 2023 Nov 6
• 1 citations
  Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells.
  Annika Nelde, Heiko Schuster, Jonas S Heitmann, Jens Bauer, Yacine Maringer, Melissa Zwick, Jens-Peter Volkmer, James Y Chen, Anna M Paczulla Stanger, Ariane Lehmann, ...> ;Blood Cancer Discovery. 2023 Nov 1
• Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia.
  Kevin A Nuno, Thomas Köhnke, Caleb A Lareau, Asiri Ediwirickrema, M Ryan Corces, Ansuman T Satpathy, Ravindra Majeti, Armon Azizi> ;Biorxiv. 2023 Oct 10
• RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition.
  Amy C Fan, Yusuke Nakauchi, Lawrence Bai, Kevin A Nuno, Feifei Zhao, Thomas Köhnke, Daiki Karigane, David Cruz-Hernandez, Andreas Reinisch, Purvesh Khatri, Ravindra Ma...> ;The Journal of Clinical Investigation. 2023 Oct 2
• 3 citations
  Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia.
  Andriana G Kotini, Saul Carcamo, Nataly Cruz-Rodriguez, Malgorzata Olszewska, Tiansu Wang, Deniz Demircioglu, Chan-Jung Chang, Elsa Bernard, Mark P Chao, Ravindra Maje...> ;Blood Cancer Discovery. 2023 Jul 5
• 10 citations
  MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.
  Benjamin A H Smith, Anja Deutzmann, Kristina M Correa, Corleone S Delaveris, Renumathy Dhanasekaran, Christopher G Dove, Delaney K Sullivan, Simon Wisnovsky, Jessica C...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Mar 14
• 6 citations
  Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1International Workshop on MDS (iwMDS) Of t...
  Jan Philipp Bewersdorf, Zhuoer Xie, Rafael Bejar, Uma Borate, Jacqueline Boultwood, Andrew M Brunner, Rena Buckstein, Hetty E Carraway, Jane E Churpek, Naval G Daver, ...> ;Blood Reviews. 2023 Jul 1
• 2 citations
  Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells.
  Tommaso Sconocchia, Johannes Foßelteder, Thomas Köhnke, Ravindra Majeti, Andreas Reinisch> ;Journal of Visualized Experiments. 2023 Mar 10
• 2 citations
  Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy.
  Miles H Linde, Amy C Fan, Thomas Köhnke, Aaron C Trotman-Grant, Sarah F Gurev, Paul Phan, Feifei Zhao, Naomi L Haddock, Kevin A Nuno, Eric J Gars, Melissa Stafford, Pa...> ;Cancer Discovery. 2023 May 4
• 12 citations
  Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability.
  Daniel Thomas, Manhong Wu, Yusuke Nakauchi, Ming Zheng, Chloe A L Thompson-Peach, Kelly Lim, Niklas Landberg, Thomas Köhnke, Nirmal Robinson, Satinder Kaur, Monika Kut...> ;Cancer Discovery. 2023 Feb 6
• 13 citations
  Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes.
  Amer M Zeidan, Jan Philipp Bewersdorf, Rena Buckstein, Mikkael A Sekeres, David P Steensma, Uwe Platzbecker, Sanam Loghavi, Jacqueline Boultwood, Rafael Bejar, John M ...> ;Leukemia. 2022 Dec 1
• 4 citations
  An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS.
  Maximilian Stahl, Omar Abdel-Wahab, Andrew H Wei, Michael R Savona, Mina L Xu, Zhuoer Xie, Justin Taylor, Daniel Starczynowski, Guillermo F Sanz, David A Sallman, Vale...> ;Blood Advances. 2023 Jun 27
• 35 citations
  TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions.
  Naval G Daver, Abhishek Maiti, Tapan M Kadia, Paresh Vyas, Ravindra Majeti, Andrew H Wei, Guillermo Garcia-Manero, Charles Craddock, David A Sallman, Hagop M Kantarjian> ;Cancer Discovery. 2022 Nov 2
• 14 citations
  Single-cell genomics in AML: extending the frontiers of AML research.
  Asiri Ediriwickrema, Andrew J Gentles, Ravindra Majeti> ;Blood. 2023 Jan 26
• 3 citations
  Reengineering Ponatinib to Minimize Cardiovascular Toxicity.
  Anna P Hnatiuk, Arne A N Bruyneel, Dhanir Tailor, Mallesh Pandrala, Arpit Dheeraj, Wenqi Li, Ricardo Serrano, Dries A M Feyen, Michelle M Vu, Prashila Amatya, Saloni G...> ;Cancer Research. 2022 Aug 3
• 19 citations
  Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1.
  Nathaniel W Mabe, Min Huang, Guillermo N Dalton, Gabriela Alexe, Daniel A Schaefer, Anna C Geraghty, Amanda L Robichaud, Amy S Conway, Delan Khalid, Marius M Mader, Ju...> ;Nature Cancer. 2022 Aug 1
• 1 citations
  Author Correction: Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia.
  Mahmoud A Bassal, Saumya E Samaraweera, Kelly Lim, Brooks A Benard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya ...> ;Nature Communications. 2022 Jul 15
• 7 citations
  The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia.
  Yusuke Nakauchi, Armon Azizi, Daniel Thomas, M Ryan Corces, Andreas Reinisch, Rajiv Sharma, David Cruz Hernandez, Thomas Köhnke, Daiki Karigane, Amy Fan, Daniel Martin...> ;Blood Cancer Discovery. 2022 Jul 6
• Join now to see all

Journal Articles

• Macrophage De Novo NAD+ Synthesis Specifies Immune Function in Aging and Inflammation  
  Ravindra Majeti, Paras S Minhas, Katrin I Andreasson, Christopher Dove, Nature
• CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma  
  Mark P Chao, Sonali M Smith, Ranjana Advani, Ian Flinn, Ravindra Majeti, Nancy L Bartlett, Leslie Popplewell, Justin Kline, Nilanjan Ghosh, Ann LaCasce, The New England Journal of Medicine

Abstracts/Posters

• Reprogramming Leukemia Cells into Antigen Presenting Cells As a Novel Cancer Vaccination Immunotherapy
  Ravindra Majeti, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/2019
• Enasidenib Drives Maturation of Human Erythroid Precursors Independently of IDH2
  Ravindra Majeti, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Metabolism and Hematologic Malignancies 
  60th American Society of Hematology Annual Meeting - 12/2/2018
• Single-Cell Mutational Profiling of Clonal Evolution in De Novo AML during Therapy and Relapse 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018