RaymondDCoakleyMD

Pulmonology • Chapel Hill, NC

Critical Care Medicine

Assistant Professor, Medicine, University of North Carolina at Chapel Hill School of Medicine

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Office
130 Mason Farm Rd
# 7020
Chapel Hill, NC 27599
Phone+1 919-966-2531

Fax+1 919-966-7013
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Education & Training

University of North Carolina HospitalsFellowship, Pulmonary Disease and Critical Care Medicine, 2001 - 2004
University College of Dublin National Univ SOMClass of 1990

Certifications & Licensure

NC State Medical License 2001 - 2024

Clinical Trials

Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects Start of enrollment: 2009 Feb 01
Completed

Publications & Presentations

PubMed

8 citations
Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding.
Arunava Ghosh, Vishruth Girish, Monet Lou Yuan, Raymond D. Coakley, Joe A Wrennall, Neil E. Alexis, Erin L. Sausville, Anand Vasudevan, Alexander R. Chait, Jason M. Sh...> ;American Journal of Respiratory and Critical Care Medicine. 2021 Nov 8
5 citations
Chronic E-Cigarette Exposure Alters Human Alveolar Macrophage Morphology and Gene Expression.
Davis Eric, Arunava Ghosh, Raymond D. Coakley, Joe A Wrennall, Bob A. Lubamba, Temperance R. Rowell, Hong Dang, Erica A. Pawlak, Quefeng Li, Neil E. Alexis, Carla Ribe...> ;Nicotine & Tobacco Research. 2021 Sep 14
13 citations
Use of elexacaftor/tezacaftor/ivacaftor in liver transplant patients with cystic fibrosis.
Cameron J. McKinzie, Christina T. Doligalski, Steven J. Lobritto, Raymond D. Coakley, W Adam Gower> ;Journal of Cystic Fibrosis. 2021 Aug 9
9 citations
Lipid-laden Macrophages Are Not Unique to Patients with E-Cigarette or Vaping Product Use-associated Lung Injury.
Arunava Ghosh, Saira Ahmad, Raymond D. Coakley, M. Flori Sassano, Neil E. Alexis, Robert Tarran> ;American Journal of Respiratory and Critical Care Medicine. 2021 Apr 15
107 citations
Chronic E-Cigarette Use Increases Neutrophil Elastase and Matrix Metalloprotease Levels in the Lung
Arunava Ghosh, Raymond D. Coakley, Andrew J. Ghio, Marianne S. Muhlebach, Charles R. Esther, Neil E. Alexis, Robert Tarran> ;American Journal of Respiratory and Critical Care Medicine. 2019 Dec 1
7 citations
Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.
Ashley G. Henderson, Wayne Anderson, Agathe Ceppe, Raymond D. Coakley, Brian Button, Neil E. Alexis, David B. Peden, Eduardo R. Lazarowski, C. W. Davis, Fred Fuller, M...> ;COPD. 2018 Dec 1
31 citations
Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia.
Lubna H. Abdullah, Raymond D. Coakley, Megan J. Webster, Yunxiang Zhu, Robert Tarran, Giorgia Radicioni, Mehmet Kesimer, Richard C. Boucher, C. William Davis, Carla Ri...> ;American Journal of Respiratory and Critical Care Medicine. 2017 Nov 3
29 citations
Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.
Lubna H. Abdullah, Jessica R. Evans, T. Tiffany Wang, Amina A. Ford, Alexander M. Makhov, Kristine Nguyen, Raymond D. Coakley, Jack D. Griffith, C. William Davis, Step...> ;JCI Insight. 2017 Mar 23
43 citations
Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis
Charles R. Esther, Raymond D. Coakley, Ashley G. Henderson, Yi-Hui Zhou, Fred A. Wright, Richard C. Boucher> ;Chest. 2015 Aug 1
109 citations
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis
Wayne Anderson, Raymond D. Coakley, Brian Button, Ashley G. Henderson, Kirby L. Zeman, Neil E. Alexis, David B. Peden, Eduardo R. Lazarowski, C. William Davis, Summer ...> ;American Journal of Respiratory and Critical Care Medicine. 2015 Jul 15
144 citations
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways
Alaina L. Garland, William G. Walton, Raymond D. Coakley, Chong D. Tan, Rodney C. Gilmore, Carey A. Hobbs, Ashutosh Tripathy, Lucy A. Clunes, Sompop Bencharit, M. Jack...> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Oct 1
191 citations
Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
Lucy A. Clunes, Catrin M. Davies, Raymond D. Coakley, Andrei A. Aleksandrov, Ashley G. Henderson, Kirby L. Zeman, Erin N. Worthington, Martina Gentzsch, Silvia M. Kred...> ;FASEB Journal. 2012 Feb 1
93 citations
A Prospective Multicenter Study of Competency Metrics and Educational Interventions in the Learning of Bronchoscopy Among New Pulmonary Fellows
Momen M. Wahidi, Gerard A. Silvestri, Raymond D. Coakley, J. Scott Ferguson, R. Wesley Shepherd, Leonard Moses, John Conforti, Loretta G. Que, Kevin J. Anstrom, Frankl...> ;Chest. 2010 May 1
83 citations
17β-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
Ray D. Coakley, Hengrui Sun, Lucy A. Clunes, Julia E. Rasmussen, James R. Stackhouse, Seiko F. Okada, Ingrid P. Fricks, Steven L. Young, Robert Tarran> ;The Journal of Clinical Investigation. 2008 Dec 1
44 citations
A2B Adenosine Receptors Regulate the Mucus Clearance Component of the Lung's Innate Defense System
Brett M. Rollins, Mellisa Burn, Ray D. Coakley, Lucy A. Chambers, Andrew J. Hirsh, Mark T. Clunes, Michael I. Lethem, Scott H. Donaldson, Robert Tarran> ;American Journal of Respiratory Cell and Molecular Biology. 2008 Mar 26
47 citations
Burkholderia gladioli: Five year experience in a cystic fibrosis and lung transplantation center
Marcus P. Kennedy, Raymond D. Coakley, Scott H. Donaldson, Robert M. Aris, Kathy Hohneker, Joel P. Wedd, Michael R. Knowles, Peter H. Gilligan, James R. Yankaskas> ;Journal of Cystic Fibrosis. 2007 Jul 1
166 citations
Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions
Sang Sun Yoon, Ray D. Coakley, Gee W. Lau, Sergei V. Lymar, Benjamin Gaston, Ahmet C. Karabulut, Robert F. Hennigan, Sung-Hei Hwang, Garry R. Buettner, Michael J. Schu...> ;The Journal of Clinical Investigation. 2006 Feb 1
88 citations
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1β in human bronchial epithelia
Thomas Gray, Ray D. Coakley, Andrew J. Hirsh, David J. Thornton, Sara Kirkham, Ja-Seok Koo, Lauranell H. Burch, Richard C. Boucher, Paul Nettesheim> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2004 Feb 1
207 citations
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
Raymond D. Coakley, Barbara R. Grubb, Anthony M. Paradiso, John T. Gatzy, Larry G. Johnson, Sylvia M. Kreda, Wanda K. O'Neal, Richard C. Boucher> ;Proceedings of the National Academy of Sciences of the United States of America. 2003 Dec 23
31 citations
Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia.
Anthony M. Paradiso, Raymond D. Coakley, Richard C. Boucher> ;The Journal of Physiology. 2003 Apr 1
22 citations
Regulation and Functional Significance of Airway Surface Liquid pH
Raymond D. Coakley, Richard C. Boucher> ;JOP. 2001 Jul 1
Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.
Rooney, C. P., Taggart, C., Coakley, R., McElvaney, N. G., O'Neill, S. J.> ;Am J Respir Cell Mol Biol. 2001 Jun
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Press Mentions

A New Test to Measure the Effectiveness of CF DrugsNovember 16th, 2017

Hospital Affiliations

University of North Carolina HospitalsChapel Hill, North Carolina