RebeccaLAftMD

General Surgery • Saint Louis, MO

Breast, Surgical Oncology (Other than Breast)

Professor, Surgery, Washington University School of Medicine

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Office
660 South Euclid avenue
Saint Louis, MO 63110
Phone+1 314-747-0063
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Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Surgery, 1992 - 1997
Washington University in St. Louis School of MedicineClass of 1992

Certifications & Licensure

IL State Medical License 1999 - 2026
MO State Medical License 1997 - 2025
American Board of Surgery Surgery

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
Fellow (FACS) American College of Surgeons

Clinical Trials

Evaluation of Chemotherapy Prior to Surgery With or Without Zometa for Women With Locally Advanced Breast Cancer Start of enrollment: 2002 Oct 01
Completed
Phase 2
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells Start of enrollment: 2005 Sep 14
Recruiting
Effect of Chemotherapy and Radiation Prior to Surgery for Triple Negative Breast Cancer Start of enrollment: 2007 Dec 01
Terminated
Phase 2
Neoadjuvant Platinum-based Chemoradiation Therapy for Locally Advanced Triple Negative Breast Cancer Start of enrollment: 2011 Feb 01
Terminated
Phase 2
LDE225 in Treating Patients With Stage II-III Estrogen Receptor- and HER2-Negative Breast Cancer Start of enrollment: 2014 Apr 01
Withdrawn
Phase 2
Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Disseminated Tumor Cells Start of enrollment: 2013 Dec 19
Terminated
Phase 2
Axillary Ultrasound With or Without Sentinel Lymph Node Biopsy in Detecting the Spread of Breast Cancer in Patients Receiving Breast Conservation Therapy Start of enrollment: 2013 Apr 04
Terminated
Not Applicable
Paclitaxel and BKM120 Before Surgery in Treating Patients With Stage II or III Estrogen Receptor-Positive and HER2-Negative Breast Cancer Start of enrollment: 2014 Aug 01
Withdrawn
Phase 2
Neoadjuvant Treatment of Triple Negative Breast Cancer Patients With Docetaxel and Carboplatin to Assess Anti-tumor Activity Start of enrollment: 2014 Jul 07
Terminated
Phase 2
Safety and Immune Response to a Mammaglobin-A DNA Vaccine In Breast Cancer Patients Undergoing Neoadjuvant Endocrine Therapy Start of enrollment: 2015 Jan 07
Active, not recruiting
Phase 1
Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score Start of enrollment: 2017 Jan 17
Recruiting
Phase 2
Robotic vs. Open NSM for Early Stage Breast Cancer Start of enrollment: 2023 May 08
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME.
Tri Giang Phan, Katherine N Weilbaecher, Peter I Croucher, Christine L Chaffer, Rebecca Aft> ;Cancer Discovery. 2024 Apr 4
9 citations
The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring.
Syeda Maheen Batool, Anudeep Yekula, Prerna Khanna, Tiffaney Hsia, Austin S Gamblin, Emil Ekanayake, Ana K Escobedo, Dong Gil You, Cesar M Castro, Hyungsoon Im, Tugba ...> ;Cell Reports. Medicine. 2023 Oct 17
2 citations
Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer.
C Alston James, John M Baer, Chong Zou, Usman Y Panni, Brett L Knolhoff, Graham D Hogg, Natalie L Kingston, Liang-I Kang, Varintra E Lander, Jingqin Luo, Yu Tao, Mark ...> ;Cancer Immunology Research. 2023 Aug 3
2 citations
A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN).
Foluso O Ademuyiwa, Donald W Northfelt, Tracey O'Connor, Ellis Levine, Jingqin Luo, Yu Tao, Jeremy Hoog, Marie L Laury, Tracy Summa, Trish Hammerschmidt, Zhanfang Guo,...> ;NPJ Breast Cancer. 2023 Jan 6
1 citations
Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment.
Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Denn...> ;Nature Communications. 2022 Jan 7
48 citations
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment
Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C. Wendl, Sherri R. Davies, Matthew H. Bailey, Tina Primeau, Jeremy Hoog, Jacqueline Mudd, Denn...> ;Nature Communications. 2021 Aug 24
23 citations
Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis
Andreas D. Hartkopf, Sara Y. Brucker, Florin Andrei Taran, Nadia Harbeck, Alexandra von Au, Bjørn Naume, Jean-Yves Pierga, Oliver Hoffmann, Matthias W. Beckmann, Lisa ...> ;European Journal of Cancer. 2021 Sep 1
2 citations
Impact of consensus guidelines for breast-conserving surgery in patients with ductal carcinoma in situ
Abigail Tremelling, Rebecca Aft, Amy E. Cyr, William E. Gillanders, Katherine Glover-Collins, Virginia Herrmann, Julie A. Margenthaler> ;Cancer Reports. 2021 Jul 10
2 citations
A microfluidic-based filtration system to enrich for bone marrow disseminated tumor cells from breast cancer patients
Sreeraj G. Pillai, Chidananda M. Siddappa, Cynthia X. Ma, Jackie Snider, Madhurima Kaushal, Mark A. Watson, Rebecca Aft> ;Plos One. 2021 May 14
152 citations
NCCN Guidelines® Insights: Breast Cancer, Version 4.2021.
William J Gradishar, Meena S Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H Allison, Sarah L Blair, Harold J Burstein, Chau Dang, Anthony D Elias, Sharon ...> ;Journal of the National Comprehensive Cancer Network. 2021 May 1
11 citations
Breast cancer, version 4.2021 featured updates to the NCCN guidelines
William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen M. Agnese, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau T. Dang, Anthony D. El...> ;Journal of The National Comprehensive Cancer Network. 2021 May 1
3 citations
Assessment of postoperative opioid stewardship using a novel electronic-based automated text and phone messaging platform.
Bradley S. Kushner, Wen Hui Tan, Margaret Sehnert, Katherine Jordan, Rebecca Aft, Matthew L. Silviera, L. Michael Brunt> ;Surgery. 2021 Mar 1
4 citations
Long-term outcome of (neo)adjuvant zoledronic acid therapy in locally advanced breast cancer.
Andrew P. Jallouk, Sriram Paravastu, Katherine N. Weilbaecher, Rebecca Aft> ;Breast Cancer Research and Treatment. 2021 Feb 16
35 citations
What matters most: Randomized controlled trial of breast cancer surgery conversation aids across socioeconomic strata.
Marie-Anne Durand, Renata W. Yen, A. James O'Malley, Danielle Schubbe, Mary C. Politi, Catherine H. Saunders, Shubhada Dhage, Kari M. Rosenkranz, Julie A. Margenthaler...> ;Cancer. 2021 Feb 1
8 citations
Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models
Zhanfang Guo, Tina Primeau, Jingqin Luo, Cynthia Zhang, Hua Sun, Jeremy Hoog, Feng Gao, Shixia Huang, Dean P. Edwards, Sherri R. Davies, Rebecca Aft, Li Ding, Matthew ...> ;Cancers. 2020 Dec 21
240 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
450 citations
Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
Elias, A., Savur Moran, M. S., William J Gradishar, Benjamin O Anderson, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H Allison, Sarah L Blair, Harold J Burstein...> ;Journal of the National Comprehensive Cancer Network. 2020 Apr 1
232 citations
Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
Thomas W Flaig, Philippe E Spiess, Neeraj Agarwal, Rick Bangs, Stephen A Boorjian, Mark K Buyyounouski, Sam Chang, Tracy M Downs, Jason A Efstathiou, Terence Friedland...> ;Journal of the National Comprehensive Cancer Network. 2020 Mar 1
6 citations
Gene expression analysis to detect disseminated tumor cells in the bone marrow of triple-negative breast cancer patients predicts metastatic relapse
Chidananda M. Siddappa, Sreeraj G. Pillai, Jackie Snider, Patricia A. Alldredge, Kathyrn Trinkaus, Mark A. Watson, Rebecca Aft> ;Breast Cancer Research and Treatment. 2019 Aug 20
34 citations
High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity
Pengfei Hai, Toru Imai, Song Xu, Ruiying Zhang, Rebecca Aft, Jun Zou, Lihong V. Wang> ;Nature Biomedical Engineering. 2019 Apr 1
172 citations
Breast cancer, version 3.2018 featured updates to the NCCN guidelines
Matthew P. Goetz, William J. Gradishar, Benjamin O. Anderson, Jame Abraham, Rebecca Aft, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau T. Dang, Anthony...> ;Journal of the National Comprehensive Cancer Network. 2019 Feb 1
145 citations
Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids
Venktesh S. Shirure, Ye Bi, Matthew B. Curtis, Andrew Lezia, Madeleine M. Goedegebuure, S. Peter Goedegebuure, Rebecca Aft, Ryan C. Fields, Steven C. George> ;Lab on a Chip. 2018 Nov 20
132 citations
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance.
Melissa A. Meyer, John M. Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, Cynthia X. Ma, Ryan...> ;Nature Communications. 2018 Mar 28
20 citations
Radial scar on image-guided breast biopsy: is surgical excision necessary?
Wendy Yen Yun Chou, Deborah J. Veis, Rebecca Aft> ;Breast Cancer Research and Treatment. 2018 Mar 12
16 citations
Identifying biomarkers of breast cancer micrometastatic disease in bone marrow using a patient-derived xenograft mouse model.
Sreeraj G. Pillai, Shunqiang Li, Chidananda M. Siddappa, Matthew J. Ellis, Mark A. Watson, Rebecca Aft> ;Breast Cancer Research. 2018 Jan 2
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Lectures

Highlights of the 2011 San Antonio Breast Cancer Symposium
Washington University School of Medicine, Saint Louis, Missouri - 2/11/2012

Press Mentions

Study: New Photoacoustic Imaging Hastens Tumor Imaging, Holds Potential for Breast Cancer ProceduresMay 19th, 2017
New Imaging Technique Aims to Ensure Surgeons Completely Remove CancerMay 17th, 2017

Grant Support

Prognostic Marker Analysis Of Disseminated Cancer CellsNational Cancer Institute2005–2006
Tissue-Specific Control Of Muscle Gene ExpressionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1988–1990
Trans-Acting Factors In Muscle Gene ExpressionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1986