RebeccaTaubMD

PubMed

• 24 citations
  Hepatic Fat Reduction Due to Resmetirom in Patients With Nonalcoholic Steatohepatitis Is Associated With Improvement of Quality of Life.
  Zobair M. Younossi, Maria Stepanova, Rebecca Taub, Jordan Mark Barbone, Stephen A. Harrison> ;Clinical Gastroenterology and Hepatology. 2021 Jul 27
• 65 citations
  Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH.
  Stephen A. Harrison, Mustafa R. Bashir, Sam E. Moussa, Kevin McCarty, Juan P. Frias, Rebecca Taub, Naim Alkhouri> ;Hepatology Communications. 2021 Jan 4
• 313 citations
  Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
  Stephen A. Harrison, Mustafa R. Bashir, Cynthia D. Guy, Rong Zhou, Cynthia A. Moylan, Juan P. Frias, Naim Alkhouri, Meena B. Bansal, Seth J. Baum, Brent A. Neuschwande...> ;Lancet. 2019 Nov 30
• 14 citations
  Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration
  Yang Jiao, Diana Z. Ye, Zhaoyu Li, Monica Teta-Bissett, Yong Peng, Rebecca Taub, Linda E. Greenbaum, Klaus H. Kaestner> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2015 Jan 15
• Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
  Paul Gillespie, Sherrie Lynn Pietranico-Cole, Michael Paul Myers, Joseph Anthony Bilotta, Karin Conde-Knape, Nader Fotouhi, Robert Alan Goodnow, Kevin Richard Guertin,...> ;Bioorganic & Medicinal Chemistry Letters. 2014 Jun 15
• 79 citations
  Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly ...
  Kelly Martha, Sherrie Lynn Pietranico-Cole, J Douglas Larigan, Nancy-Ellen Haynes, Charles H. Reynolds, Nathan Robert Scott, John Vermeulen, Mark T. Dvorozniak, Karin ...> ;Journal of Medicinal Chemistry. 2014 Apr 8
• 66 citations
  Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist
  Rebecca Taub, Edward Chiang, Malorie Chabot-Blanchet, Kelly Martha, Richard A. Reeves, Marie-Claude Guertin, Jean-Claude Tardif> ;Atherosclerosis. 2013 Oct 1
• 31 citations
  Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the...
  Yimin Qian, Stanley Wertheimer, Mushtaq Ahmad, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Stuart Hayden, Shiming Li, Nicholas Marcopulos, Le...> ;Journal of Medicinal Chemistry. 2011 Mar 17
• 76 citations
  Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations
  Samir Sayed, David R. Langdon, Stella Odili, Pan Chen, Carol Buettger, Alisa B. Schiffman, Mariko Suchi, Rebecca Taub, Joseph Grimsby, Franz M. Matschinsky, Charles A....> ;Diabetes. 2009 Jun 1
• 27 citations
  Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.
  Bogumil Zelent, Stella Odili, Carol Buettger, Chiyo Shiota, Joseph Grimsby, Rebecca Taub, Mark A. Magnuson, Jane M. Vanderkooi, Franz M. Matschinsky> ;The Biochemical Journal. 2008 Jul 15
• 7 citations
  Potent, selective MCH-1 receptor antagonists.
  Shawn David Erickson, Bruce L. Banner, Steven Joseph Berthel, Karin Conde-Knape, Fiorenza Falcioni, Irina Hakimi, Bernard Michael Hennessy, Robert Francis Kester, Kyun...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Feb 15
• 26 citations
  6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
  Harvey Wong, Randy C. Dockens, Lori Pajor, Suresh Yeola, James E. Grace, Arlene Stark, Rebecca Taub, Frank D. Yocca, Robert Zaczek, Yu-Wen Li> ;Drug Metabolism and Disposition. 2007 Aug 1
• 34 citations
  A glucose sensor role for glucokinase in anterior pituitary cells
  Dorothy Zelent, Maria L. Golson, Brigitte Koeberlein, Roel Quintens, Leentje Van Lommel, Carol Buettger, Heather Weik-Collins, Rebecca Taub, Joseph Grimsby, Frans Schu...> ;Diabetes. 2006 Jul 1
• 62 citations
  From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation
  Jørn V. Sagen, Stella Odili, Lise Bjørkhaug, Dorothy Zelent, Carol Buettger, Jae Kwagh, Charles A. Stanley, Knut Dahl-Jørgensen, Carine de Beaufort, Graeme I. Bell, Yi...> ;Diabetes. 2006 Jun 1
• 210 citations
  The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy
  Franz M. Matschinsky, Mark A. Magnuson, Dorothy Zelent, T. L. Jetton, Nicolai M. Doliba, Yi Han, Rebecca Taub, Joseph Grimsby> ;Diabetes. 2006 Jan 1
• 102 citations
  A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-κB inhibitor, IκBα
  Robert A. DeAngelis, Maciej M. Markiewski, Rebecca Taub, John D. Lambris> ;Hepatology. 2005 Nov 1
• Adenovirus-mediated overexpression of activin βC subunit accelerates liver regeneration in partially hepatectomized rats
  Rebecca Taub> ;Journal of Hepatology. 2005 Nov 1
• 71 citations
  Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity
  Charles F. Albright, Graciani Nilsa R, Wei Han, Eddy W. Yue, Ross L. Stein, Zhihong Lai, Melody Diamond, Randine Dowling, Lisa C. Grimminger, Shu-Yun Zhang, Davette L....> ;Molecular Cancer Therapeutics. 2005 May 1
• 77 citations
  Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young
  Anna L. Gloyn, Stella Odili, Dorothy Zelent, Carol Buettger, Harriet A.J. Castleden, Anna M. Steele, Amanda Stride, Chyio Shiota, Mark A. Magnuson, Renata Lorini, Gius...> ;The Journal of Biological Chemistry. 2005 Apr 8
• 88 citations
  Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
  Meena B. Bansal, Kellen Kovalovich, Ritu Gupta, Wei Li, Akansha Agarwal, Brian Radbill, Carlos E. Alvarez, Rifaat Safadi, M. Isabel Fiel, Scott L. Friedman, Rebecca Taub> ;Journal of Hepatology. 2005 Apr 1
• 15 citations
  Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents.
  Kenneth W. Rohrbach, Songping Han, Jinping Gan, Eva O’Tanyi, Hongwei Zhang, Cecilia L. Chi, Rebecca Taub, Brian L. Largent, Dong Cheng> ;European Journal of Pharmacology. 2005 Mar 21
• 1155 citations
  Liver regeneration: from myth to mechanism
  Rebecca Taub> ;Nature Reviews. Molecular Cell Biology. 2004 Oct 1
• 10 citations
  Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagoni...
  Carolyn Diane Dzierba, Amy G. Takvorian, Maria Rafalski, Padmaja Kasireddy-Polam, Harvey Wong, Thaddeus F. Molski, Ge Zhang, Yu-Wen Li, Snjezana Lelas, Yong Peng, John...> ;Journal of Medicinal Chemistry. 2004 Nov 4
• 67 citations
  Inhibition of Tumor Necrosis Factor-α-Converting Enzyme by a Selective Antagonist Protects Brain from Focal Ischemic Injury in Rats
  Xinkang Wang, Giora Z. Feuerstein, Lin Xu, Hugh Wang, William A. Schumacher, Martin L. Ogletree, Rebecca Taub, Jingwu Duan, Carl P. Decicco, Rui-Qin Liu> ;Molecular Pharmacology. 2004 Apr 1
• 43 citations
  Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-p...
  Snjezana Lelas, Harvey Wong, Yu-Wen Li, Karen Heman, Kathryn A. Ward, Kim L. Zeller, Kristine K. Sieracki, Joseph Polino, Helen E. Godonis, Shelly X. Ren, Xiao-Xin Yan...> ;The Journal of Pharmacology and Experimental Therapeutics. 2004 Apr 1
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