RichardLApplegateMD

Anesthesiology • Loma Linda, CA

Cardiothoracic Anesthesiology

Chair, Anesthesiology and Professor of the Floyd S. Brauer Endowed Chair in Anesthesia, Loma Linda University

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Office
11234 Anderson Street Room 2532
Loma Linda, CA 92354
Phone+1 909-558-4475
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Residency, Anesthesiology, 1985 - 1986
Loma Linda University Health Education ConsortiumResidency, Anesthesiology, 1982 - 1985
Loma Linda University School of MedicineClass of 1982

Certifications & Licensure

CA State Medical License 1983 - 2025
MN State Medical License 1985 - 1986
American Board of Anesthesiology Anesthesiology
National Board of EchocardiographyAdvanced Perioperative TEE

Awards, Honors, & Recognition

Top MD Consumers Checkbook

Clinical Trials

Continuous Hemoglobin Evaluation Start of enrollment: 2012 Nov 01
Completed
Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb Start of enrollment: 2013 Nov 26
Recruiting
Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Start of enrollment: 2016 Feb 01
Active, not recruiting
Not Applicable
Modified Pre-operative Oral Doses Acetaminophen Versus Intravenous Acetaminophen Start of enrollment: 2017 Aug 28
Completed
Phase 4
[Trial of device that is not approved or cleared by the U.S. FDA]
Withheld
Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients Start of enrollment: 2016 Sep 15
Completed
PVI as a Parameter to Predict Fluid Responsiveness
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Publications & Presentations

PubMed

1 citations
Effect of lipid-lowering medications in patients with coronary artery bypass grafting surgery outcomes.
Chunxia Shi, Zugui Zhang, Jordan Goldhammer, David Li, Bob Kiaii, Victor Rudriguez, Douglas Boyd, David Lubarsky, Richard Applegate, Hong Liu> ;BMC Anesthesiology. 2022 Apr 26
7 citations
Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospective analysis.
Liehua Deng, Shaoqing Lei, Xiaoyan Wang, Fang Jiang, David A. Lubarsky, Liangqing Zhang, Danyong Liu, Conghua Han, Dunrong Zhou, Zheng Wang, Xiaocong Sun, Yuanli Zhang...> ;Aging. 2021 Jun 30
18 citations
Frailty, Race/Ethnicity, Functional Status, and Adverse Outcomes After Total Hip/Knee Arthroplasty: A Moderation Analysis.
Charlie Dharmasukrit, Sut Yee Shirley Chan, Richard Lee Applegate, Daniel J. Tancredi, Theresa A Harvath, Jill G. Joseph> ;The Journal of Arthroplasty. 2021 Jan 21
11 citations
Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage: A Prospective Pilot Trial.
Ronak Raval, Oliver Small, Kristel Magsino, Vikram Chakravarthy, Briahnna Austin, Richard Lee Applegate, Ihab Dorotta> ;Neurocritical Care. 2021 Jun 1
12 citations
Oxygen Reserve Index: Utility as an Early Warning for Desaturation in High-Risk Surgical Patients.
Neal Fleming, Amrik Singh, Leonard Y. Lee, Richard Lee Applegate> ;Anesthesia and Analgesia. 2021 Mar 1
1 citations
Correction to: Multicenter comparison of three intraoperative hemoglobin trend monitoring methods.
Richard Lee Applegate, Patricia M Applegate, Maxime Cannesson, Prith Peiris, Beth L. Ladlie, Klaus D. Torp> ;Journal of Clinical Monitoring and Computing. 2021 May 1
9 citations
Perioperative Dexmedetomidine Improves Outcomes of Kidney Transplant
Jun Chen, Richard V Perez, Angelo M. de Mattos, Cecilia Wang, Zhongmin Li, Richard Lee Applegate, Hongfang Liu> ;Clinical and Translational Science. 2020 Nov 1
11 citations
Study of early warning for desaturation provided by Oxygen Reserve Index in obese patients
Ekaterina Tsymbal, Sebastian Ayala, Amrik Singh, Richard Lee Applegate, Neal Fleming> ;Journal of Clinical Monitoring and Computing. 2021 Aug 1
3 citations
Impact of preoperative pectoralis plane nerve blocks for mastectomy on perioperative opioid consumption: a retrospective study.
Susan Y Kim, Jorge Avila, Joshua Lee, Timothy J. Lee, Stephen M. Macres, Richard Lee Applegate, Machelle D. Wilson, Jon Y. Zhou> ;Pain Management. 2020 Apr 28
36 citations
Effect of Dexmedetomidine on Cardiac Surgery-Associated Acute Kidney Injury: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials.
Ke Peng, David Li, Richard Lee Applegate, David A. Lubarsky, Fu-hai Ji, Hong Liu> ;Journal of Cardiothoracic and Vascular Anesthesia. 2020 Mar 1
6 citations
Multicenter comparison of three intraoperative hemoglobin trend monitoring methods.
Richard Lee Applegate, Patricia M Applegate, Maxime Cannesson, Prith Peiris, Beth L. Ladlie, Klaus D. Torp> ;Journal of Clinical Monitoring and Computing. 2020 Oct 1
4 citations
Retrospective Cohort Study on the Optimal Timing of Orogastric Tube/Nasogastric Tube Insertion in Infants With Pyloric Stenosis.
Lisa K. Lee, Rebekah Burns, Rajvinder Singh Dhamrait, Harmony F. Carter, Marissa G. Vadi, Tristan Grogan, David Elashoff, Richard Lee Applegate, Marc Iravani> ;Anesthesia and Analgesia. 2019 Oct 1
10 citations
Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest
Lei Huang, Richard Lee Applegate, Patricia M Applegate, Lei Gong, Umut Ocak, Warren Boling, John H. Zhang> ;Medical Gas Research. 2019 Jul 1
4 citations
A comparison of postoperative outcomes with PDA ligation in the OR versus the NICU: a retrospective cohort study on the risks of transport.
Lisa K. Lee, Michelle Y. Woodfin, Marissa G. Vadi, Tristan Grogan, Phillip J. Ross, Richard Lee Applegate, Marc Iravani> ;BMC Anesthesiology. 2018 Dec 22
A comparison of midazolam and zolpidem as oral premedication in children, a prospective randomized double-blinded clinical trial.
Amgad H. Hanna, Davinder Ramsingh, Whitney Sullivan-Lewis, Sarah Cano, Patrick Leiter, Desiree Wallace, Gerald Andrews, Briahnna Austin, Richard Lee Applegate> ;Paediatric Anaesthesia. 2018 Dec 1
10 citations
Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest.
Lei Huang, Richard Lee Applegate, Patricia M Applegate, Warren Boling, John H. Zhang> ;Medical Gas Research. 2018 Jul 1
2 citations
Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α1-Adrenoceptor-Protein Kinase Cε-Endo...
Devin W. McBride, Cesar Reis, John H. Zhang, Richard Lee Applegate, Jiping Tang> ;Journal of the American Heart Association. 2018 Mar 24
1 citations
In Response: Sedation After Cardiac Surgery With Propofol or Dexmedetomidine: Between Scylla and Charybdis?
Hong Liu, Fuhai Ji, Ke Peng, Richard Lee Applegate, Neal Fleming> ;Anesthesia and Analgesia. 2017 Nov 1
12 citations
Is it the time to reconsider the choice of valves for cardiac surgery: mechanical or bioprosthetic?
Patricia M Applegate, W. Douglas Boyd, Richard Lee Applegate, Hong Liu> ;Journal of Biomedical Research. 2017 Sep 26
5 citations
Pharmacological Management Options to Prevent and Reduce Ischemic Hemorrhagic Transformation.
Wing Mann Ho, Cesar Reis, Onat Akyol, Gokce Yilmaz Akyol, Richard Lee Applegate, Gary Stier, Robert D. Martin, John H. Zhang> ;Current Drug Targets. 2017 Aug 31
16 citations
Comparison of the GlideScope Cobalt and Storz DCI Video Laryngoscopes in Children Younger Than 2 Years of Age During Manual In-Line Stabilization: A Randomized Trainee...
Marissa G. Vadi, Katie J. Roddy, Elizabeth A. Ghazal, Michael Um, Andrew J. Neiheisel, Richard Lee Applegate> ;Pediatric Emergency Care. 2017 Jul 1
Extreme Plasma Dilution Decreases Heparin and Protamine Cardiopulmonary Bypass Requirements: A Case Report on a Jehovah's Witness Patient.
Emilie Chang, Jason W. Gatling, Scott Bode, Paul C. Herrmann, Brian S. Bull, Richard Lee Applegate> ;A & A Case Reports. 2017 Jun 1
25 citations
Sedation After Cardiac Surgery: Is One Drug Better Than Another?
Hong Liu, Fuhai Ji, Ke Peng, Richard Lee Applegate, Neal Fleming> ;Anesthesia and Analgesia. 2017 Apr 1
27 citations
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research
Cesar Reis, Onat Akyol, Wing Mann Ho, Camila Araujo, Lei Huang, Richard Lee Applegate, John H. Zhang> ;Biomed Research International. 2017 Feb 14
4 citations
Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury.
Cherine H. Kim, Devin W. McBride, Ronak Raval, Prativa Sherchan, Karen L. Hay, Eric C.K. Gren, Wayne Kelln, Tim Lekic, William K. Hayes, Brian S. Bull, Richard Lee App...> ;Scientific Reports. 2017 Jan 19
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Journal Articles

Crotalus Atrox Venom Preconditioning Increases Plasma Fibrinogen and Reduces Perioperative Hemorrhage in a Rat Model of Surgical Brain Injury
Tim Lekic, Richard Applegate, Brian S Bull, Ronak Raval, Nature

Lectures

2013 CSA Winter Hawaii Anesthesia Seminar
California Society of Anesthesiologists, Maui, Hawaii - 1/21/2013

Press Mentions

Masimo ORi(TM) Granted De Novo as the First and Only FDA-Cleared Noninvasive and Continuous Parameter to Provide Insight into Hyperoxia Under Supplemental OxygenOctober 14th, 2023

Professional Memberships

American Society of Anesthesiologists - ASA
Member
California Society of Anesthesiologists
Member
Association of University Anesthesiologists
Member
Society of Cardiovascular Anesthesiologists
Member

Hospital Affiliations

UC Davis Medical CenterSacramento, California
UC Davis Medical CenterSacramento, California