Richard Eugene Frye MD

Child Neurology•Phoenix, AZ

Neurodevelopmental Disabilities

Professor, Child Health, University of Arizona COM

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1919 E Thomas RdPhoenix, AZ 85016
Phone+1 602-933-0970
Fax+1 602-933-4253

Education & Training

Boston Children’s Hospital/Beth Israel Deaconess Medical Center/Harvard Medical SchoolFellowship, Child Neurology, 2000 - 2003
University of Miami/Jackson Health SystemResidency, Pediatrics, 1998 - 2000
Georgetown University School of MedicineClass of 1998

Certifications & Licensure

AZ State Medical License 2017 - 2027
FL State Medical License 2022 - 2027
CA State Medical License 2023 - 2025
KY State Medical License 2018 - 2019
AR State Medical License 2011 - 2018
TX State Medical License 2007 - 2017
MA State Medical License 2003 - 2005
American Board of Pediatrics Pediatrics
American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology

Clinical Trials

Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders Start of enrollment: 2010 Jul 01
Completed
Not Applicable
A Folinic Acid Intervention for Autism Spectrum Disorders Start of enrollment: 2012 May 01
Terminated
Phase 2
Mitochondrial Dysfunction in Phelan-McDermid Syndrome Start of enrollment: 2012 May 01
Completed
Mitochondrial Dysfunction in Autism Spectrum Disorder Start of enrollment: 2012 Oct 16
ACTIVE_NOT_RECRUITING
Etiology and Early Diagnosis of Neurodevelopmental Disorders
COMPLETED
Efficacy and Safety of Trichuris Suis Ova (TSO) as Compared to Placebo in Autism Spectrum Disorder Start of enrollment: 2014 May 01
Terminated
Phase 2
An Exploratory Open Label Study of EPI-743 (Vincerinone TM) in Children With Autism Spectrum Disorder Start of enrollment: 2014 Oct 31
Withdrawn
Phase 2
Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder Start of enrollment: 2020 Feb 01
COMPLETED
PHASE2
High-Frequency Transdermal Neuromodulation to Decrease Anxiety and Improve Sleep in ASD Start of enrollment: 2019 May 21
Completed
Not Applicable
Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium Start of enrollment: 2020 Sep 22
RECRUITING
PHASE2
Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism Start of enrollment: 2020 Oct 08
RECRUITING
PHASE2
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders Start of enrollment: 2023 Dec 13
RECRUITING
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Early biomarker for autism spectrum disorder unveiled - what are we learning?
Daniel A Rossignol, Richard E Frye
Expert Review of Molecular Diagnostics. 2025-08-01
2 citations
A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial.
Zoë Hill, Patrick J McCarty, Richard G Boles, Richard E Frye
International Journal of Molecular Sciences. 2025-03-10
1 citations
Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative Review.
Kamila Castro, Richard E Frye, Eduarda Silva, Cristiane Vasconcelos, Laura Hoffmann
Journal of Personalized Medicine. 2024-08-02

Press Mentions

Generic Cancer Drug Shows Promise in Treating Autism, Sparks Hope for Future PreventionMarch 19th, 2025
Taking This Supplement While Pregnant Can Make Your Baby Smarter: StudyMarch 7th, 2025
Children with Autism May See Speech Improvements with off-Label Prescription DrugFebruary 22nd, 2025
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Grant Support

Developmental Phonological Dyslexia: Neural MechanismsNational Institute Of Neurological Disorders And Stroke2006–2009
Developmental Phonological Dyslexia: Neural MechanismsNational Institute Of Neurological Disorders And Stroke2005