RichardEugeneFryeMD

Child Neurology • Phoenix, AZ

Neurodevelopmental Disabilities

Professor, Child Health, University of Arizona COM

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Office
Phoenix Children's Hospital
1919 E Thomas St
Phoenix, AZ 85016
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Education & Training

Children's Hospital/Beth Israel Deaconess Medical Center/Harvard Medical SchoolFellowship, Child Neurology, 2000 - 2003
University of Miami/Jackson Health SystemResidency, Pediatrics, 1998 - 2000
Georgetown University School of MedicineClass of 1998

Certifications & Licensure

AZ State Medical License 2017 - 2025
CA State Medical License 2023 - 2025
FL State Medical License 2005 - 2025
KY State Medical License 2018 - 2019
AR State Medical License 2011 - 2018
TX State Medical License 2007 - 2017
MA State Medical License 2003 - 2005
American Board of Pediatrics Pediatrics
American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology

Clinical Trials

Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders Start of enrollment: 2010 Jul 01
Completed
Not Applicable
A Folinic Acid Intervention for Autism Spectrum Disorders Start of enrollment: 2012 May 01
Terminated
Phase 2
Mitochondrial Dysfunction in Phelan-McDermid Syndrome Start of enrollment: 2012 May 01
Completed
Mitochondrial Dysfunction in Autism Spectrum Disorder Start of enrollment: 2012 Oct 16
Active, not recruiting
Etiology and Early Diagnosis of Neurodevelopmental Disorders Start of enrollment: 2012 May 01
Active, not recruiting
Efficacy and Safety of Trichuris Suis Ova (TSO) as Compared to Placebo in Autism Spectrum Disorder Start of enrollment: 2014 May 01
Terminated
Phase 2
An Exploratory Open Label Study of EPI-743 (Vincerinone TM) in Children With Autism Spectrum Disorder Start of enrollment: 2014 Oct 31
Withdrawn
Phase 2
Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder Start of enrollment: 2020 Feb 01
Active, not recruiting
Phase 2
High-Frequency Transdermal Neuromodulation to Decrease Anxiety and Improve Sleep in ASD Start of enrollment: 2019 May 21
Completed
Not Applicable
Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium Start of enrollment: 2020 Sep 22
Recruiting
Phase 2
Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism Start of enrollment: 2020 Oct 08
Recruiting
Phase 2
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders Start of enrollment: 2024 Jul 01
Not yet recruiting
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

1 citations
Deciduous tooth biomarkers reveal atypical fetal inflammatory regulation in autism spectrum disorder.
Dani Dumitriu, Elena Baldwin, Roozie J J Coenen, Luke A Hammond, Darcy S Peterka, Lynne Heilbrun, Richard E Frye, Raymond Palmer, Hjalmar Nobel Norrman, Anna Fridell, ...> ;Iscience. 2023 Mar 17
13 citations
Modern Biomarkers for Autism Spectrum Disorder: Future Directions.
Amanda R Jensen, Alison L Lane, Brianna A Werner, Sallie E McLees, Tessa S Fletcher, Richard E Frye> ;Molecular Diagnosis & Therapy. 2022 Sep 1
4 citations
Blood RNA Sequencing Indicates Upregulatedandand DownregulatedandExpression in Children with Autism Spectrum Disorder.
Irena Voinsky, Yazeed Zoabi, Noam Shomron, Moria Harel, Hanoch Cassuto, Joseph Tam, Shannon Rose, Adrienne C Scheck, Mohammad A Karim, Richard E Frye, Adi Aran, David ...> ;International Journal of Molecular Sciences. 2022 Aug 30
5 citations
Integrated microRNA-mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism.
Pritmohinder S Gill, Harsh Dweep, Shannon Rose, Priyankara J Wickramasinghe, Kanan K Vyas, Sandra McCullough, Patricia A Porter-Gill, Richard E Frye> ;Journal of Personalized Medicine. 2022 Jun 1
Correction: Rossignol, D.A.; Frye, R.E. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Dis...
Daniel A Rossignol, Richard E Frye> ;Journal of Personalized Medicine. 2022 Apr 29
6 citations
Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis.
Danielle Brister, Brianna A Werner, Geoffrey Gideon, Patrick J McCarty, Alison Lane, Brian T Burrows, Sallie McLees, P David Adelson, Jorge I Arango, William Marsh, An...> ;Metabolites. 2022 Apr 20
4 citations
A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder.
Richard E Frye> ;Journal of Personalized Medicine. 2022 Mar 14
4 citations
Height and BMI in fragile X syndrome: A longitudinal assessment.
Tse-Hwei Choo, Qing Xu, Dejan Budimirovic, Reymundo Lozano, Amy N Esler, Richard E Frye, Howard Andrews, Milen Velinov> ;Obesity. 2022 Mar 1
14 citations
The association between mosaicism type and cognitive and behavioral functioning among males with fragile X syndrome.
Lu Meng, Walter E Kaufmann, Richard E Frye, Katherine Ong, Jennifer W Kaminski, Milen Velinov, Elizabeth Berry-Kravis> ;American Journal of Medical Genetics. Part A. 2022 Mar 1
A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder.
Richard E Frye, Shannon Rose, Richard G Boles, Daniel A Rossignol> ;Journal of Personalized Medicine. 2022 Jan 24
1 citations
Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects.
Brianna A Werner, Patrick J McCarty, Alison L Lane, Indrapal Singh, Mohammad A Karim, Shannon Rose, Richard E Frye> ;American Journal of Translational Research. 2022 Jan 1
4 citations
Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings.
Stephen T Foldes, Amanda R Jensen, Austin Jacobson, Sarah Vassall, Emily Foldes, Ann Guthery, Danni Brown, Todd Levine, William James Tyler, Richard E Frye> ;Journal of Personalized Medicine. 2021 Dec 6
26 citations
Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Ana...
Daniel A. Rossignol, Richard E. Frye> ;Journal of Personalized Medicine. 2021 Nov 3
15 citations
Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder.
Richard E. Frye, Loïc Lionnard, Indrapal N. Singh, Mohammad A. Karim, Hanane Chajra, Mathilde Fréchet, Karima Kissa, Victor Racine, Amrit Ammanamanchi, Patrick John Mc...> ;Translational Psychiatry. 2021 Oct 13
Challenges of Diagnosing Viral Myocarditis in Adolescents in the Era of COVID-19 and MIS-C.
Hemali P. Shah, Richard Frye, Sunny Chang, Erin Faherty, Jeremy Steele, Ruchika Karnik> ;Case Reports in Pediatrics. 2021 Oct 4
6 citations
Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder.
Patrick J. McCarty, Andrew R. Pines, Bethany L Sussman, Sarah N. Wyckoff, Amanda Jensen, Raymond Bunch, Richard E. Frye> ;Journal of Personalized Medicine. 2021 Sep 28
3 citations
Pregnant Mothers' Medical Claims and Associated Risk of Their Children being Diagnosed with Autism Spectrum Disorder.
Genevieve Grivas, Richard E. Frye, Juergen Hahn> ;Journal of Personalized Medicine. 2021 Sep 24
11 citations
MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation.
Richard E. Frye, Shannon Rose, Sandra S. McCullough, Sirish C. Bennuri, Patricia Porter-Gill, Harsh Dweep, Pritmohinder S. Gill> ;Journal of Personalized Medicine. 2021 Sep 17
6 citations
Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey.
James B. Adams, Anisha Bhargava, Devon M. Coleman, Richard E. Frye, Daniel A. Rossignol> ;Journal of Personalized Medicine. 2021 Aug 31
2 citations
Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study
Andrew R. Pines, Bethany L Sussman, Sarah N. Wyckoff, Patrick J. McCarty, Raymond Bunch, Richard E. Frye> ;Journal of Personalized Medicine. 2021 Aug 28
18 citations
The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
Daniel A. Rossignol, Richard E. Frye> ;Journal of Personalized Medicine. 2021 Aug 11
10 citations
Physiological mediators of prenatal environmental influences in autism spectrum disorder
Richard E. Frye, Janet Cakir, Shannon Rose, Raymond F. Palmer, Christine Austin, Paul Curtin> ;Bioessays. 2021 Jul 14
Correction to: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder.
Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li‑Ching ‑C Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Ji...> ;Molecular Autism. 2021 Jun 16
7 citations
Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder
Rita Barone, Jean Bastin, Fatima Djouadi, Indrapal Singh, Mohammad A. Karim, Amrit Ammanamanchi, Patrick John McCarty, Leanna Delhey, Rose Shannon, Antonino Casabona, ...> ;Journal of Personalized Medicine. 2021 Jun 4
15 citations
A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the Therapeutic Use of Intravenous Immunoglobulins (IVIG) in Autism Spectrum Disorder.
Daniel A. Rossignol, Richard E. Frye> ;Journal of Personalized Medicine. 2021 May 30
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Press Mentions

Stealth’s Phase III Elamipretide in Mitochondrial Myopathy Has Experts Wary While FDA Approval DebatedJune 17th, 2019
Phoenix Children’s Earns $1 Million in Grants for Autism ResearchJanuary 12th, 2019
Neurologist Andrew Zimmerman Fired by DOJ for Change of OpinionJanuary 9th, 2019
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Grant Support

Developmental Phonological Dyslexia: Neural MechanismsNational Institute Of Neurological Disorders And Stroke2006–2009
Developmental Phonological Dyslexia: Neural MechanismsNational Institute Of Neurological Disorders And Stroke2005