RichardNKolesnickMD

PubMed

• 1 citations
  MicroRNA-10a enrichment in factor VIIa-released endothelial extracellular vesicles: potential mechanisms.
  Kaushik Das, Shiva Keshava, Richard Kolesnick, Usha R Pendurthi, L Vijaya Mohan Rao> ;Journal of Thrombosis and Haemostasis. 2024 Feb 1
• 2 citations
  Factor VIIa releases phosphatidylserine-enriched extracellular vesicles from endothelial cells by activating acid sphingomyelinase.
  Kaushik Das, Shiva Keshava, Tanmoy Mukherjee, Jue Wang, Jhansi Magisetty, Richard Kolesnick, Usha R Pendurthi, L Vijaya Mohan Rao> ;Journal of Thrombosis and Haemostasis. 2023 Dec 1
• Anti-ceramide Single-Chain Variable Fragment Mitigates Gastrointestinal-Acute Radiation Syndrome and Improves Marrow Reconstitution, Rendering Near-Normal 90-Day Autop...
  Prashanth K B Nagesh, Sebastien Monette, Tambudzai Shamu, Sergio Giralt, Samantha C St Jean, Zhigang Zhang, Zvi Fuks, Richard Kolesnick> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Sep 18
• 1 citations
  Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis.
  Jue Wang, Shiva Keshava, Kaushik Das, Richard Kolesnick, Xian-Cheng Jiang, Usha R Pendurthi, L Vijaya Mohan Rao> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Jan 1
• 6 citations
  Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles.
  Ayan Mohamud Yusuf, Nina Hagemann, Xiaoni Zhang, Maria Zafar, Tanja Hussner, Carolin Bromkamp, Carlotta Martiny, Tobias Tertel, Verena Börger, Fabian Schumacher, Fiore...> ;Basic Research in Cardiology. 2022 Dec 1
• 1 citations
  Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate.
  Christy Li, Stefan Klingler, Sahra Bodo, Jin Cheng, Yan Pan, Mohammed Adileh, Maria Laura Martin, John Fuller, Regina Feldman, Adam Michel, Zhigang Zhang, Zvi Fuks, Ri...> ;Cellular Physiology and Biochemistry. 2022 Aug 31
• Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability.
  Xinzhu Deng, Jason Tchieu, Daniel S. Higginson, Kuo-Shun Hsu, Regina Feldman, Lorenz Studer, Shai Shaham, Simon N. Powell, Zvi Fuks, Richard Kolesnick> ;Cancer Research. 2021 May 3
• 3 citations
  Acid-Sphingomyelinase Triggered Fluorescently Labeled Sphingomyelin Containing Liposomes in Tumor Diagnosis after Radiation-Induced Stress.
  Carola Heneweer, Tuula Peñate Medina, Robert J. Tower, Holger Kalthoff, Richard Kolesnick, Steven M. Larson, Oula Peñate Medina> ;International Journal of Molecular Sciences. 2021 Apr 8
• 11 citations
  Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair.
  Jimmy A. Rotolo, Chii Shyang Fong, Sahra Bodo, Prashanth K.B. Nagesh, John D. Fuller, Thivashnee Sharma, Alessandra Piersigilli, Zhigang Zhang, Zvi Fuks, Vijay K. Sing...> ;JCI Insight. 2021 Apr 22
• 49 citations
  Phase 3 Multi-Center, Prospective, Randomized Trial Comparing Single-Dose 24 Gy Radiation Therapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer.
  Michael J. Zelefsky, Yoshiya Yamada, Carlo Greco, Eric Lis, Heiko Schöder, Stephanie Lobaugh, Zhigang Zhang, Steve Braunstein, Mark H. Bilsky, Simon N. Powell, Richard...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jul 1
• 7 citations
  Conformal Avoidance of Normal Organs at Risk by Perfusion-Modulated Dose Sculpting in Tumor Single-Dose Radiation Therapy
  Carlo Greco, Richard Kolesnick, Zvi Fuks> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jan 1
• 13 citations
  Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency ...
  Nina Hagemann, Ayan Mohamud Yusuf, Carlotta Martiny, Xiaoni Zhang, Christoph Kleinschnitz, Matthias Gunzer, Richard Kolesnick, Erich Gulbins, Dirk M. Hermann> ;Basic Research in Cardiology. 2020 Oct 14
• 1 citations
  Enhancement of Soft Tissue Sarcoma Response to Gemcitabine through Timed Administration of a Short-Acting Anti-Angiogenic Agent.
  Jin Cheng, John D. Fuller, Regina Feldman, William D. Tap, Takashi Owa, Zvi Fuks, Richard Kolesnick> ;Cellular Physiology and Biochemistry. 2020 Jul 29
• 27 citations
  Fusion of lysosomes to plasma membrane initiates radiation-induced apoptosis
  Charles S Ferranti, Jin Cheng, Chris Thompson, Jianjun Zhang, Jimmy A. Rotolo, Salma Buddaseth, Zvi Fuks, Richard Kolesnick> ;The Journal of Cell Biology. 2020 Apr 6
• 78 citations
  T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage
  Shuichiro Takashima, Maria Laura Martin, Suze A. Jansen, Ya-Yuan Fu, Joris Bos, Daniel J. Chandra, Margaret O'Connor, Anna Mertelsmann, Paola Vinci, Jason Kuttiyara, S...> ;Science Immunology. 2019 Dec 6
• 22 citations
  Organoids reveal that inherent radiosensitivity of small and large intestinal stem cells determines organ sensitivity
  Maria Laura Martin, Mohammad Adileh, Kuo-Shun Hsu, Guoqiang Hua, Sang-gyu Lee, Christy Li, John D. Fuller, Jimmy A. Rotolo, Sahra Bodo, Stefan Klingler, Adriana Haimov...> ;Cancer Research. 2020 Mar 1
• 10 citations
  Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.
  Jana Meiners, Vittoria Palmieri, Robert Klopfleisch, Jana-Fabienne Ebel, Lukasz Japtok, Fabian Schumacher, Ayan Mohamud Yusuf, Katrin Anne Becker, Julia Zöller, Matthi...> ;Frontiers in Immunology. 2019 Jun 19
• 30 citations
  Phenotype-Oriented Ablation of Oligometastatic Cancer with Single Dose Radiation Therapy.
  Carlo Greco, Oriol Pares, N. Pimentel, V. Louro, J. Morales, Beatriz Nunes, Joana C. Castanheira, Carla Oliveira, Angelo Silva, Sofia C. Vaz, Durval C. Costa, Michael ...> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Jul 1
• 43 citations
  Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
  Sahra Bodo, Cecile G. Campagne, Tin Htwe Thin, Daniel S. Higginson, H. Alberto Vargas, Guoqiang Hua, John D. Fuller, Ellen Ackerstaff, James A. Russell, Zhigang Zhang,...> ;The Journal of Clinical Investigation. 2019 Feb 1
• 31 citations
  Logarithmic expansion of LGR5+ cells in human colorectal cancer.
  Maria Laura Martin, Zhaoshi Zeng, Mohammad Adileh, Adrian Jacobo, Christy Li, Efsevia Vakiani, Guoqiang Hua, Lixing Zhang, Adriana Haimovitz-Friedman, Zvi Fuks, Richar...> ;Cellular Signalling. 2018 Jan 1
• 29 citations
  Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?
  Wing-Kee Lee, Richard Kolesnick> ;Cellular Signalling. 2017 Oct 1
• 12 citations
  Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.
  Albert J. van Hell, Adriana Haimovitz-Friedman, Zvi Fuks, William D. Tap, Richard Kolesnick> ;Cellular Signalling. 2017 Jun 1
• 42 citations
  Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.
  Guoqiang Hua, Chu Wang, Yan Pan, Zhaoshi Zeng, Sang-gyu Lee, Maria Laura Martin, Adriana Haimovitz-Friedman, Zvi Fuks, Philip B. Paty, Richard Kolesnick> ;Cancer Research. 2017 Apr 15
• 30 citations
  Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells
  Lixing Zhang, Mohammad Adileh, Maria Laura Martin, Stefan Klingler, Julie R. White, Xiaojing Ma, Louise R. Howe, Anthony M. C. Brown, Richard Kolesnick> ;Cellular Signalling. 2017 Jan 1
• 15 citations
  Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.
  Jeanna Jacobi, Monica Garcia-Barros, Shyam Rao, Jimmy A. Rotolo, Chris Thompson, Aviram Mizrachi, Regina Feldman, Katia Manova, Alicja Bielawska, Jacek Bielawska, Zvi ...> ;Cellular Signalling. 2017 Jan 1
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Journal Articles

• Logarithmic Expansion of LGR5+ Cells in Human Colorectal Cancer  
  Efsevia Vakiani, Philip B Paty, Richard Kolesnick, Zvi Fuks, ScienceDirect

Abstracts/Posters

• Mitochondrial Complex II in Intestinal Epithelial Cells Is a Critical Metabolic Checkpoint That Regulates Severity of Gastrointestinal Graft-Versus-Host Disease
  Richard Kolesnick, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019