Richard Frank Loeser Jr. MD

PubMed

• Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts.
  Philip R Coryell, Jorge G Fernandez Davila, Adam B Yanke, Kenneth H Pearce, Richard F Loeser
  Osteoarthritis and Cartilage. 2026-06-01
• Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types.
  Safia Mahabub Sauty, Jacqueline Shine, Hamed Bostan, Jian-Liang Li, Piotr A Mieczkowski
  Plos Genetics. 2026-05-01
• Osteoarthritic synovial fibroblasts drive inflammatory responses and impair chondrocyte function in response to a fibronectin matrikine.
  Jorge G Fernandez Davila, Ralph A Alberto, Seyoun Byun, Susan D'Costa, Jacqueline Shine
  Osteoarthritis and Cartilage. 2026-04-20

Journal Articles

• Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults with Knee Osteoarthritis  
  Richard Loeser Jr., MD, JAMA
• Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better?  
  Richard F Loeser, Ali Guermazi, Mary F Lyles, Arthritis Care & Research
• Sufficient Vitamin K Status Combined with Sufficient Vitamin D Status Is Associated with Better Lower Extremity Function: A Prospective Analysis of Two Knee Osteoarthr...  
  Richard Loeser Jr., MD, Arthritis Care & Research

Books/Book Chapters

• Advances in Geroscience 
  Chapter: Osteoarthritis in the Elderly 
  Page 309 - 353Loeser RF, Lotz MKEditors: Sierra, F and Kohanski R.Springer Science+Business Media, New York2015
• Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management 
  Chapter: Aging and Posttraumatic Arthritis 
  Page 165 - 183Ferguson CM, Lotz MKEditors: Olson SA and Guilak F.Springer Science+Business Media, New York2015
• Cecil Textbook of Medicine 
  Chapter: Connective Tissue Structure and Function 
  Page 1659 - 1662Loeser RFEditors: Goldman L, Schafer, AI.Saunders Elsevier, PhiladelphiaEdition 24th,2011

Abstracts/Posters

• Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments
  Wood ST, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, Poole L, Furdui C, Osteoarthritis and Cartilage, 1/1/2015
• Mitochondrial reactive oxygen species promote hyperoxidation of peroxiredoxins and inhibit pro-survival IGF-1 signaling in human articular chondrocytes
  Collins JA, Poole L, Furdui C, Nelson K, Osteoarthritis and Cartilage, 1/1/2015
• Ulici V, Long D, Osteoarthritis and Cartilage, 1/1/2015

Lectures

• Vitamin K Insufficiency and Osteoarthritis 
  Chicago, IL - 1/1/2015
• Aging, Oxidative Stress and the Development of Osteoarthritis 
  Multiple Locations, 2010, 2012, 2014 - 1/1/2015
• Aging and Osteoarthritis: What’s the Mechanistic Link? 
  Multiple Locations, 2011, 2014 - 1/1/2015