RichardAlanYoungMD

PubMed

• 125 citations
  Biomolecular Condensates and Cancer.
  Ann Boija, Isaac A. Klein, Richard A. Young> ;Cancer Cell. 2021 Feb 8
• 11 citations
  Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.
  Hadley E. Sheppard, Alessandra Dall’Agnese, Woojun D Park, M. Hamza Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Patricia Cogswell, Josh Sommer, Joan Levy...> ;Cell Reports. Medicine. 2021 Jan 19
• 248 citations
  RNA-Mediated Feedback Control of Transcriptional Condensates.
  Jonathan E. Henninger, Ozgur Oksuz, Krishna Shrinivas, Ido Sagi, Gary LeRoy, Ming M. Zheng, J Owen Andrews, Alicia V. Zamudio, Charalampos Lazaris, Nancy M. Hannett, T...> ;Cell. 2021 Jan 7
• 23 citations
  SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome
  Liguo Zhang, Alexsia Richards, Andrew S. Khalil, Emile Wogram, Haiting Ma, Richard A. Young, Rudolf Jaenisch> ;Biorxiv. 2020 Dec 13
• 18 citations
  Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature Genetics. 2020 Nov 23
• 196 citations
  Biomolecular Condensates in the Nucleus.
  Benjamin R. Sabari, Alessandra Dall’Agnese, Richard A. Young> ;Trends in Biochemical Sciences. 2020 Nov 1
• 83 citations
  lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation.
  Kaveh Daneshvar, M. Behfar Ardehali, Isaac A. Klein, Fu-Kai Hsieh, Arcadia J. Kratkiewicz, Amin Mahpour, Sabrina O L Cancelliere, Chan Zhou, Brett M. Cook, Wenyang Li,...> ;Nature Cell Biology. 2020 Sep 7
• 13 citations
  CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.
  Jingmei Hsu, Hsuan-Ting Huang, Chung-Tsai Lee, Avik Choudhuri, Nicola K. Wilson, Brian J. Abraham, Victoria Moignard, Iwo Kucinski, Shuqian Yu, R. Katherine Hyde, Joan...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 3
• 95 citations
  MeCP2 links heterochromatin condensates and neurodevelopmental disease
  Charles H. Li, Eliot L. Coffey, Alessandra Dall’Agnese, Nancy M. Hannett, Xin Tang, Jonathan E. Henninger, Jesse M. Platt, Ozgur Oksuz, Alicia V. Zamudio, Lena K. Afey...> ;Nature. 2020 Jul 22
• 30 citations
  LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
  Ting Tao, Hui Shi, Luca Mariani, Brian J. Abraham, Adam D. Durbin, Mark W. Zimmerman, John T. Powers, Pavlos Missios, Kenneth N. Ross, Antonio R. Perez-Atayde, Martha ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Jul 14
• 229 citations
  Partitioning of Cancer Therapeutics in Nuclear Condensates
  Isaac A. Klein, Ann Boija, Lena K. Afeyan, Susana Wilson Hawken, Mengyang Fan, Alessandra Dall’Agnese, Ozgur Oksuz, Jonathan E. Henninger, Krishna Shrinivas, Benjamin ...> ;Science. 2020 Jun 19
• 61 citations
  Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells.
  Wojciech Michowski, Joel M. Chick, Chen Chu, Aleksandra Kolodziejczyk, Yichen Wang, Jan M. Suski, Brian J. Abraham, Lars Anders, Daniel S. Day, Lukas M. Dunkl, Mitchel...> ;Molecular Cell. 2020 May 7
• 49 citations
  ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
  Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Ly...> ;Nature Communications. 2019 Dec 9
• 55 citations
  Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs
  Yuelin Song, Patrick R. van den Berg, Styliani Markoulaki, Frank Soldner, Alessandra Dall’Agnese, Jonathan E. Henninger, Jesse Drotar, Nicholas Rosenau, Malkiel A. Coh...> ;Molecular Cell. 2019 Sep 5
• 221 citations
  Enhancer features that drive formation of transcriptional condensates
  Krishna Shrinivas, Benjamin R. Sabari, Eliot L. Coffey, Isaac A. Klein, Ann Boija, Alicia V. Zamudio, Jurian Schuijers, Nancy M. Hannett, Phillip A. Sharp, Richard A. ...> ;Molecular Cell. 2019 Aug 8
• 72 citations
  BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells
  David Debruyne, Ruben Dries, Satyaki Sengupta, Davide Seruggia, Yang Gao, Bandana Sharma, Hao Huang, Lisa A. Moreau, Michael McLane, Daniel S. Day, Eugenio Marco, Ting...> ;Nature. 2019 Aug 1
• 368 citations
  Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
  Yang Eric Guo, John C. Manteiga, Jonathan E. Henninger, Benjamin R. Sabari, Alessandra Dall’Agnese, Nancy M. Hannett, Jan-Hendrik Spille, Lena K. Afeyan, Alicia V. Zam...> ;Nature. 2019 Aug 1
• 143 citations
  CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
  Małgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver ...> ;Nature Communications. 2019 Apr 15
• 914 citations
  Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
  Ann Boija, Isaac A. Klein, Benjamin R. Sabari, Alessandra Dall’Agnese, Eliot L. Coffey, Alicia V. Zamudio, Charles H. Li, Krishna Shrinivas, John C. Manteiga, Nancy M....> ;Cell. 2018 Dec 13
• 3 citations
  Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.
  Warren A. Whyte, Steve Bilodeau, David A. Orlando, Heather A. Hoke, Garrett M. Frampton, Charles T. Foster, Shaun M. Cowley, Richard A. Young> ;Nature. 2018 Oct 1
• 1299 citations
  Coactivator condensation at super-enhancers links phase separation and gene control
  Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A. Klein, Eliot L. Coffey, Krishna Shrinivas, Brian J. Abraham, Nancy M. Hannett, Alicia V. Zamudio, John ...> ;Science. 2018 Jul 27
• 18 citations
  JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
  Marc R. Mansour, Shuning He, Zhaodong Li, Riadh Lobbardi, Brian J. Abraham, Clemens B. Hug, Sunniyat Rahman, Theresa E. Leon, Youyi Kuang, Mark W. Zimmerman, Traci M. ...> ;The Journal of Experimental Medicine. 2018 Jul 2
• 1200 citations
  Correction: Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomas
  Akdes Serin Harmanci, Mark W. Youngblood, Victoria E. Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E. Zeynep Erson-Omay, Leon D. Kaulen, Tong Ihn Lee, Bri...> ;Nature Communications. 2018 Apr 20
• 111 citations
  Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism.
  Jurian Schuijers, John C. Manteiga, Abraham S. Weintraub, Daniel S. Day, Alicia V. Zamudio, Denes Hnisz, Tong Ihn Lee, Richard A. Young> ;Cell Reports. 2018 Apr 10
• 50 citations
  BET bromodomain proteins regulate enhancer function during adipogenesis.
  Jonathan D. Brown, Zachary B. Feldman, Sean P. Doherty, Jaime M. Reyes, Peter B. Rahl, Charles Y. Lin, Quanhu Sheng, Qiong Duan, Alexander J. Federation, Andrew L. Kun...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Feb 14
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