RitaShaknovichMD

PubMed

• Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.
  Leandro C Cerchietti, Eloisi C Lopes, Shao Ning Yang, Katerina Hatzi, Karen L Bunting, Lucas A Tsikitas, Ana I Robles, Jennifer Walling, Gabriela Chiosis, Ari Melnick,...> ;Nature Medicine. 2024 Apr 3
• 38 citations
  The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice
  Lincoln Nadauld, Charles H. McDonnell, Tomasz M. Beer, Minetta C. Liu, Eric A. Klein, Andrew G. Hudnut, Richard Whittington, Bruce Taylor, Geoffrey R. Oxnard, Jafi A. ...> ;Cancers. 2021 Jul 13
• 41 citations
  Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA.
  Xiaoji Chen, Zhao Dong, Earl Hubbell, Kathryn N. Kurtzman, Geoffrey R. Oxnard, Venn Oliver Claude, Collin Melton, Christina A. Clarke, Rita Shaknovich, Ting Ma, Gerry ...> ;Clinical Cancer Research. 2021 Jun 4
• 60 citations
  Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
  Katerina Hatzi, Huimin Geng, Ashley S. Doane, Cem Meydan, Reed LaRiviere, Mariano G. Cardenas, Cihangir Duy, Hao Shen, Maria Nieves Calvo Vidal, Timour Baslan, Helai P...> ;Nature Immunology. 2019 Jan 1
• 22 citations
  Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations
  Sarah C. Rutherford, Angela A. Fachel, Sheng Li, Seema Sawh, Ashlesha Muley, Jennifer Ishii, Ashish Saxena, Pilar M. Dominguez, Eloisi Caldas Lopes, Xabier Agirre, Nya...> ;Blood. 2018 Aug 16
• 17 citations
  Precision Medicine for Relapsed Multiple Myeloma on the Basis of an Integrative Multiomics Approach
  Alessandro Laganà, Itai Beno, David Melnekoff, Violetta V. Leshchenko, Deepu Madduri, Dennis Ramdas, Larysa Sanchez, Scot Niglio, Deepak Perumal, Brian A. Kidd, Riccar...> ;JCO Precision Oncology. 2018 Aug 8
• 32 citations
  SOX11 augments BCR signaling to drive MCL-like tumor development
  Pei-Yu Kuo, Shashidhar S. Jatiani, Adeeb Rahman, Donna Edwards, Zewei Jiang, Katya Ahr, Deepak Perumal, Violetta V. Leshchenko, Joshua Brody, Rita Shaknovich, B. Hilda...> ;Blood. 2018 May 17
• 47 citations
  AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
  Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Ian...> ;Nature Communications. 2018 Jan 15
• 7 citations
  The new frontier of epigenetic heterogeneity in B-cell neoplasms.
  Pilar M. Dominguez, Matt Teater, Rita Shaknovich> ;Current Opinion in Hematology. 2017 Jul 1
• 175 citations
  CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
  Yanwen Jiang, Ana Ortega-Molina, Huimin Geng, Hsia-Yuan Ying, Katerina Hatzi, Sara Parsa, Dylan R. McNally, Ling Wang, Ashley S. Doane, Xabier Agirre, Matt Teater, Cem...> ;Cancer Discovery. 2017 Jan 1
• 109 citations
  Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma
  Mariano G. Cardenas, Wenbo Yu, Wendy Béguelin, Matthew R. Teater, Huimin Geng, Rebecca Goldstein, Erin Oswald, Katerina Hatzi, Shao Ning Yang, Joanna Cohen, Rita Shakn...> ;The Journal of Clinical Investigation. 2016 Sep 1
• 169 citations
  EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
  Wendy Béguelin, Matt Teater, Micah D. Gearhart, María Fernández, Rebecca Goldstein, Mariano G. Cardenas, Katerina Hatzi, Monica Rosen, Hao Shen, Connie M. Corcoran, Mi...> ;Cancer Cell. 2016 Aug 8
• 37 citations
  miR-181a negatively regulates NF-κB signaling and affects activated B-cell-like diffuse large B-cell lymphoma pathogenesis.
  Goldi A. Kozloski, Xiaoyu Jiang, Shruti Bhatt, Jose F. Ruiz, Francisco Vega, Rita Shaknovich, Ari Melnick, Izidore S. Lossos> ;Blood. 2016 Jun 9
• 34 citations
  Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma
  Rebecca Goldstein, Shao Ning Yang, Tony Taldone, Betty Y. Chang, John F. Gerecitano, Kojo S.J. Elenitoba-Johnson, Rita Shaknovich, Wayne Tam, John P. Leonard, Gabriela...> ;The Journal of Clinical Investigation. 2015 Dec 1
• 294 citations
  The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
  Ana Ortega-Molina, Isaac W. Boss, Andres Canela, Heng Pan, Yanwen Jiang, Chunying Zhao, Man Jiang, Deqing Hu, Xabier Agirre, Itamar Niesvizky, Ji-Eun Lee, Hua Tang Che...> ;Nature Medicine. 2015 Oct 1
• 78 citations
  DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID
  Pilar M. Dominguez, Matt Teater, Nyasha Chambwe, Matthias Kormaksson, David Redmond, Jennifer Ishii, Bao Q. Vuong, Jayanta Chaudhuri, Ari Melnick, Aparna Vasanthakumar...> ;Cell Reports. 2015 Sep 29
• 9 citations
  Erratum: TET1 is a tumor suppressor of hematopoietic malignancy.
  Luisa Cimmino, Meelad M. Dawlaty, Delphine Ndiaye-Lobry, Yoon Sing Yap, Sofia Bakogianni, Yiting Yu, Sanchari Bhattacharyya, Rita Shaknovich, Huimin Geng, Camille Lobr...> ;Nature Immunology. 2015 Jul 21
• 21 citations
  Signatures of accelerated somatic evolution in gene promoters in multiple cancer types
  Kyle S. Smith, Vinod Kumar Yadav, Brent S. Pedersen, Rita Shaknovich, Mark W. Geraci, Katherine S. Pollard, Subhajyoti De> ;Nucleic Acids Research. 2015 Jun 23
• 91 citations
  Epigenomic evolution in diffuse large B-cell lymphomas
  Heng Pan, Yanwen Jiang, Michela Boi, Fabrizio Tabbò, David Redmond, Kui Nie, Marco Ladetto, Annalisa Chiappella, Leandro Cerchietti, Rita Shaknovich, Ari Melnick, Gior...> ;Nature Communications. 2015 Apr 20
• 161 citations
  TET1 is a tumor suppressor of hematopoietic malignancy
  Luisa Cimmino, Meelad M. Dawlaty, Delphine Ndiaye-Lobry, Yoon Sing Yap, Sofia Bakogianni, Yiting Yu, Sanchari Bhattacharyya, Rita Shaknovich, Huimin Geng, Camille Lobr...> ;Nature Immunology. 2015 Jun 1
• 52 citations
  IL10 receptor is a novel therapeutic target in DLBCLs.
  Wendy Béguelin, Seema Sawh, Nyasha Chambwe, Fong Chun Chan, Yanwen Jiang, Choo Jw, David W. Scott, Chalmers A, Huimin Geng, Lucas Tsikitas, Wayne Tam, Govind Bhagat, R...> ;Leukemia. 2015 Mar 3
• 22 citations
  Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis.
  Pilar M. Dominguez, Rita Shaknovich> ;Frontiers in Immunology. 2014 Dec 18
• 12 citations
  Epigenetic diversity in hematopoietic neoplasms.
  Rita Shaknovich, Subhajyoti De, Franziska Michor> ;Biochimica Et Biophysica Acta. 2014 Dec 1
• 134 citations
  CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.
  Christopher J. Kemp, James M. Moore, Russell Moser, Brady Bernard, Matt Teater, Leslie E. Smith, Natalia A. Rabaia, Kay E. Gurley, Justin Guinney, Stephanie E. Busch, ...> ;Cell Reports. 2014 May 22
• 73 citations
  Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes
  Nyasha Chambwe, Matthias Kormaksson, Huimin Geng, Subhajyoti De, Franziska Michor, Nathalie A. Johnson, Ryan D. Morin, David W. Scott, Lucy A. Godley, Randy D. Gascoyn...> ;Blood. 2014 Mar 13
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Journal Articles

• Extracellular Vesicles in DLBCL Provide Abundant Clues to Aberrant Transcriptional Programming and Genomic Alterations  
  Sarah C Rutherford, Ashish Saxena, Rita Shaknovich, Blood

Lectures

• Development of a Neoantigen Prediction Tool for Patient Stratification in Immuno-Oncology Trials 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018