RizwanRomeeMD

Hematology • Boston, MA

Hematologic Oncology

Associate Professor, Harvard Medical School, Dana Farber Cancer Institute

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Office
450 Brookline Ave
Boston, MA 02215
Phone+1 617-632-5138
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Summary

I am a cancer immunologist and the research focus of my lab is to engineer NK cells for enhanced targeting of advanced malignancies.

Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Blood & Bone Marrow Transplant, 2011 - 2012
University of MinnesotaFellowship, Hematology and Medical Oncology, 2008 - 2011
University of MinnesotaResidency, Internal Medicine, 2005 - 2008
Government Medical College SrinagarClass of 2003

Certifications & Licensure

MA State Medical License 2018 - 2025
MO State Medical License 2011 - 2019
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

ASCO Career Development Award (faculty) 2015
ASH Scholar Award (faculty-clinical) American Society of Hematology, 2015
ICTS Translational Research Award Washington University, 2014
Barnes Jewish Hospital Foundation Team Science Award Barnes Jewish Hospital, 2014
Siteman Cancer Center Research & Development Award Siteman Cancer Center, 2013
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
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Clinical Trials

IL-15 Super Agonist ALT-803 to Treat Relapse Of Hematologic Malignancy After Allogeneic SCT Start of enrollment: 2013 Nov 11
Completed
Phase 1, Phase 2
Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Start of enrollment: 2014 Aug 11
Terminated
Phase 1, Phase 2
Study of Melphalan HCl for Injection (Propylene Glycol-free), Carmustine, Etoposide, Cytarabine (BEAM Regimen) and Autologous Stem Cell Transplantation for Lymphoma Start of enrollment: 2014 Mar 19
Completed
Phase 2
Allogeneic or Haploidentical Stem Cell Transplant Followed By High-Dose Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Start of enrollment: 2014 Feb 28
Terminated
Phase 1
Non-inferiority Study of XM02 Filgrastim (Granix) and Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Start of enrollment: 2014 Aug 20
Completed
Phase 2
A Study of Granix to Disrupt the Bone Marrow Microenvironment in Patients With Multiple Myeloma Undergoing Autologous Transplantation Start of enrollment: 2015 Jan 20
Terminated
Phase 2
Phase I Study of Bortezomib With G-CSF for Stem Cell Mobilization in Patients With Multiple Myeloma Start of enrollment: 2015 Feb 20
Completed
Phase 1
Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation Start of enrollment: 2016 Jun 27
Terminated
Phase 1
Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation Start of enrollment: 2017 Jan 30
Recruiting
Phase 2
Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant Start of enrollment: 2017 Oct 23
Recruiting
Phase 1, Phase 2
A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation Start of enrollment: 2019 Aug 31
Enrolling by invitation
Phase 1
CIML NK Cells With Venetoclax for AML Start of enrollment: 2024 Feb 20
Active, not recruiting
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

Nonpathogenicengineered to surface display cytokines as a new platform for immunotherapy.
Shaobo Yang, Michal Sheffer, Isabel E Kaplan, Zongqi Wang, Mubin Tarannum, Khanhlinh Dinh, Yasmin Abdulhamid, Roman Shapiro, Rebecca Porter, Robert Soiffer, Jerome Rit...> ;Research Square. 2024 Mar 22
2 citations
Genetic Manipulation Approaches to Enhance the Clinical Application of NK Cell-Based Immunotherapy.
Andreia Maia, Mubin Tarannum, Rizwan Romee> ;Stem Cells Translational Medicine. 2024 Mar 15
Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy.
Andreia Maia, Mubin Tarannum, Joana R Lérias, Sara Piccinelli, Luis Miguel Borrego, Markus Maeurer, Rizwan Romee, Mireia Castillo-Martin> ;Cells. 2024 Mar 5
1 citations
Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML.
Garcia, J., Kim, H., Murdock, H., Ansuinelli, M., Brock, J., Cutler, C., Gooptu, M., Ho, V., Koreth, J., Nikiforow, S., Romee, R., Shapiro, R., DeAngelo, D., Stone, R....> ;Blood Advances. 2024 Feb 27
1 citations
Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML.
Joshua A Fein, Roni Shouval, Elizabeth Krieger, Stephen R Spellman, Tao Wang, Henning Baldauf, Katharina Fleischhauer, Nicolaus Kröger, Mary Horowitz, Martin Maiers, J...> ;Blood Advances. 2024 Feb 13
1 citations
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.
Dufva, O., Gandolfi, S., Huuhtanen, J., Dashevsky, O., Duàn, H., Saeed, K., Klievink, J., Nygren, P., Bouhlal, J., Lahtela, J., Näätänen, A., Ghimire, B., Hannunen, T....> ;Immunity. 2023 Dec 12
1 citations
Opportunistic Infections in Patients Receiving Post-Transplantation Cyclophosphamide: Impact of Haploidentical versus Unrelated Donor Allograft.
Jessica S Little, Rémy Duléry, Roman M Shapiro, Muneerah M Aleissa, Susan E Prockop, John Koreth, Jerome Ritz, Joseph H Antin, Corey Cutler, Sarah Nikiforow, Rizwan Ro...> ;Transplantation and Cellular Therapy. 2024 Feb 1
1 citations
Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8αβ+ T cells targeting multiple myeloma.
Jooeun Bae, Shuichi Kitayama, Zach Herbert, Laurence Daheron, Keiji Kurata, Kenneth Livak, Shuqiang Li, Mubin Tarannum, Rizwan Romee, Nikhil C Munshi, Shin Kaneko, Jer...> ;Blood. 2024 Mar 7
Phase I-II Trial of Early Azacitidine after Matched Unrelated Donor Hematopoietic Cell Transplantation.
Ziheng Xu, Jaebok Choi, Matthew Cooper, Jeffrey King, Mark A Fiala, Jingxia Liu, Iskra Pusic, Rizwan Romee, Amanda Cashen, Meagan A Jacoby, Keith Stockerl-Goldstein, C...> ;Transplantation and Cellular Therapy. 2023 Nov 1
Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse.
Roman M Shapiro, Haesook T Kim, Michela Ansuinelli, Indira Guleria, Corey S Cutler, John Koreth, Mahasweta Gooptu, Joseph H Antin, Amar Kelkar, Jerome Ritz, Catherine ...> ;Blood Advances. 2023 Aug 8
1 citations
Profiling of Natural Killer Interactions With Cancer Cells Using Mass Cytometry.
Margaret Hallisey, Jenna Dennis, Elizabeth P Gabriel, Alyssa Masciarelli, Jiajia Chen, Charlotte Abrecht, Martha Brainard, William M Marcotte, Han Dong, Emma Hathaway,...> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2023 Aug 1
5 citations
Posttransplant cyclophosphamide vs tacrolimus-based GVHD prophylaxis: lower incidence of relapse and chronic GVHD.
Katie Maurer, Vincent T Ho, Eno Inyang, Corey Cutler, John Koreth, Roman M Shapiro, Mahasweta Gooptu, Rizwan Romee, Sarah Nikiforow, Joseph H Antin, Catherine J Wu, Je...> ;Blood Advances. 2023 Aug 8
Clinical Features of Acute Kidney Injury in the Early Post-Transplantation Period Following Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplan...
Juliana Vergara-Cadavid, P Connor Johnson, Haesook T Kim, Alisha Yi, Meghan E Sise, David E Leaf, Paul E Hanna, Vincent T Ho, Corey S Cutler, Joseph H Antin, Mahasweta...> ;Transplantation and Cellular Therapy. 2023 Jul 1
3 citations
Lower incidence of chronic GVHD observed after transplantation with cryopreserved unrelated allogeneic stem cells.
Katie Maurer, Haesook T Kim, Heather M Garrity, Deborah Liney, Corey Cutler, Joseph H Antin, John Koreth, Jerome Ritz, Roman M Shapiro, Rizwan Romee, Vincent T Ho, Mah...> ;Blood Advances. 2023 Jun 13
2 citations
The natural killer cell immunotherapy platform: An overview of the landscape of clinical trials in liquid and solid tumors.
Sara Piccinelli, Rizwan Romee, Roman M Shapiro> ;Seminars in Hematology. 2023 Jan 1
18 citations
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes.
Satyaki Sengupta, Sanjukta Das, Angela C Crespo, Annelisa M Cornel, Anand G Patel, Navin R Mahadevan, Marco Campisi, Alaa K Ali, Bandana Sharma, Jared H Rowe, Hao Huan...> ;Nature Cancer. 2022 Oct 1
42 citations
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia.
Han Dong, James Dongjoo Ham, Guangan Hu, Guozhu Xie, Juliana Vergara, Yong Liang, Alaa Ali, Mubin Tarannum, Hannah Donner, Joanna Baginska, Yasmin Abdulhamid, Khanhlin...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Jun 21
19 citations
Activation of Tumor-Cell STING Primes NK-Cell Therapy.
Erik H Knelson, Elena V Ivanova, Mubin Tarannum, Marco Campisi, Patrick H Lizotte, Matthew A Booker, Ismail Ozgenc, Moataz Noureddine, Brittany Meisenheimer, Minyue Ch...> ;Cancer Immunology Research. 2022 Aug 3
45 citations
Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse.
Roman M Shapiro, Grace C Birch, Guangan Hu, Juliana Vergara Cadavid, Sarah Nikiforow, Joanna Baginska, Alaa K Ali, Mubin Tarannum, Michal Sheffer, Yasmin Z Abdulhamid,...> ;The Journal of Clinical Investigation. 2022 Jun 1
8 citations
Invasive Yeast Infection after Haploidentical Donor Hematopoietic Cell Transplantation Associated with Cytokine Release Syndrome.
Jessica S Little, Roman M Shapiro, Muneerah M Aleissa, Austin Kim, Jun Bai Park Chang, David W Kubiak, Guohai Zhou, Joseph H Antin, John Koreth, Sarah Nikiforow, Corey...> ;Transplantation and Cellular Therapy. 2022 Aug 1
2 citations
Phenotypic and functional characterization of the CD6-ALCAM T-cell co-stimulatory pathway after allogeneic cell transplantation.
Benedetta Rambaldi, Haesook T Kim, Yohei Arihara, Takeru Asano, Carol Reynolds, Mariah Manter, Max Halpern, Augustine Weber, John Koreth, Corey Cutler, Mahasweta Goopt...> ;Haematologica. 2022 Nov 1
42 citations
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia.
Melissa M Berrien-Elliott, Jennifer A Foltz, David A Russler-Germain, Carly C Neal, Jennifer Tran, Margery Gang, Pamela Wong, Bryan Fisk, Celia C Cubitt, Nancy D Marin...> ;Science Translational Medicine. 2022 Feb 23
2 citations
Autologous cellular therapy for myeloma: Givingexpanded NK cells their due.
Roman M Shapiro, Rizwan Romee> ;Cell Reports. Medicine. 2022 Feb 15
2 citations
Editorial: Innate immune cell therapy of cancer.
Natasha Khatwani, Rizwan Romee, Asha B Pillai> ;Frontiers in Immunology. 2022 Jan 1
17 citations
Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy.
Mubin Tarannum, Rizwan Romee, Roman M Shapiro> ;Frontiers in Immunology. 2022 Jan 1
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Journal Articles

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Recommendations for Donor Selection in Haploidentical Hematopoietic Cell Transplantation
Leo Luznik, Karen Ballen, Asad Bashey, Hillard M Lazarus, Bipin N Savani, Rizwan Romee, Ephraim J Fuchs, Nature
Virescent Tongue
Rizwan Romee, Meagan Jacoby, Annals of Hematology
Single Institution Experience with G-CSF Mobilized T-cell Replete Haploidentical Hematopoietic Cell Transplantation
M A Schroeder, R Romee, J F DiPersio, T A Fehniger, F Gao, G L Uy, C N Abboud, P Westervelt, R Vij, Nature

Abstracts/Posters

Improved Outcomes with Cyclophosphamide/Total Body Irradiation 14 Gy Compared to Cyclophosphamide/Total Body Irradiation 12 Gy in Patients with Acute Lymphoblastic Leu...
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Hematopoietic Cell Transplantation Donor Selection Reimagined: KIR-KIR Ligand Interactions and a Formalized Donor Risk Index Effective at Predicting Survival
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
A Phase 1 Dose-Escalation Study of Adding Venetoclax to a Reduced Intensity Conditioning (RIC) Regimen Prior to Allogeneic Hematopoietic Cell Transplantation for Patie...
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Anti-CD6 Monoclonal Antibody Itolizumab Efficiently Inhibits T Cell Proliferation after in Vitro TCR Stimulation in the Setting of Acute Graft Versus Host Disease
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Heterogeneity of Molecular Mechanisms Determining Blood Cancer Cell Lines Resistance to Natural Killer Cells in the Context of Tumor-Stromal Interactions: Insights fro...
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Updated Study Results of CX-01, an Inhibitor of CXCL12/CXCR4, and Azacitidine for the Treatment of Hypomethylating Agent Refractory AML and MDSClinically Relevant Abst...
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Graft Failure after Haploidentical Hematopoietic Stem Cell Transplantation
Rizwan Romee, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Press Mentions

XNK Therapeutics Strengthens Its Scientific Network with Two More AdvisorsDecember 19th, 2021
CCF Researcher Spotlight: Rizwan Romee, MDOctober 10th, 2017
New Immunotherapy for Leukemia Shows Promise in Small Clinical TrialSeptember 26th, 2016