RobbieMajznerMD

PubMed

• INSPIRED Symposium Part 5: Expanding the Use of CAR T Cells in Children and Young Adults.
  Crystal Mackall, Rosa Nguyen, Aimee C Talleur, Vanessa A Fabrizio, Richard Aplenc, Stephan A Grupp, Robbie Majzner, Rayne Rouce, Amy Moskop, Kevin O McNerney> ;Transplantation and Cellular Therapy. 2024 Apr 7
• 6 citations
  Latent human herpesvirus 6 is reactivated in CAR T cells.
  Caleb A Lareau, Yajie Yin, Katie Maurer, Katalin D Sandor, Bence Daniel, Garima Yagnik, José Peña, Jeremy Chase Crawford, Anne M Spanjaart, Jacob C Gutierrez, Nicholas...> ;Nature. 2023 Nov 1
• 17 citations
  Tumor inflammation-associated neurotoxicity.
  Jasia Mahdi, Jorg Dietrich, Karin Straathof, Claire Roddie, Brian J Scott, Tom Belle Davidson, Laura M Prolo, Tracy T Batchelor, Cynthia J Campen, Kara L Davis, Julian...> ;Nature Medicine. 2023 Apr 1
• 49 citations
  Co-opting signalling molecules enables logic-gated control of CAR T cells.
  Aidan M Tousley, Maria Caterina Rotiroti, Louai Labanieh, Lea Wenting Rysavy, Won-Ju Kim, Caleb Lareau, Elena Sotillo, Evan W Weber, Skyler P Rietberg, Guillermo Nicol...> ;Nature. 2023 Mar 1
• 2 citations
  Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy.
  Miles H Linde, Amy C Fan, Thomas Köhnke, Aaron C Trotman-Grant, Sarah F Gurev, Paul Phan, Feifei Zhao, Naomi L Haddock, Kevin A Nuno, Eric J Gars, Melissa Stafford, Pa...> ;Cancer Discovery. 2023 May 4
• Time to resolution of iodine-123 metaiodobenzylguanidine (I-MIBG) avidity and local control outcomes for high-risk neuroblastoma following radiation therapy.
  Justin Oh, Yi Peng Wang, Navjot Sandhu, Robbie G Majzner, Helen Nadel, Hiroyuki Shimada, Olivia Lansinger, Rie von Eyben, Sarah Donaldson, Matias Bruzoni, Quaovi H Sod...> ;Journal of Medical Imaging and Radiation Oncology. 2023 Feb 1
• 32 citations
  Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas.
  Jin, M., Brian J Sworder, David M Kurtz, Stefan K Alig, Matthew J Frank, Navika Shukla, Andrea Garofalo, Charles W Macaulay, Mohammad Shahrokh Esfahani, Mari N Olsen, ...> ;Cancer Cell. 2023 Jan 9
• 70 citations
  Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours.
  Christian L Flugel, Robbie G Majzner, Giedre Krenciute, Gianpietro Dotti, Stanley R Riddell, Dimitrios L Wagner, Mohamed Abou-El-Enein> ;Nature Reviews. Clinical Oncology. 2023 Jan 1
• 32 citations
  Enhanced T cell effector activity by targeting the Mediator kinase module.
  Katherine A Freitas, Julia A Belk, Elena Sotillo, Patrick J Quinn, Maria C Ramello, Meena Malipatlolla, Bence Daniel, Katalin Sandor, Dorota Klysz, Jeremy Bjelajac, Pe...> ;Science. 2022 Nov 11
• 23 citations
  Immunotherapy of Neuroblastoma: Facts and Hopes.
  John Anderson, Robbie G Majzner, Paul M Sondel> ;Clinical Cancer Research. 2022 Aug 2
• 20 citations
  Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1.
  Nathaniel W Mabe, Min Huang, Guillermo N Dalton, Gabriela Alexe, Daniel A Schaefer, Anna C Geraghty, Amanda L Robichaud, Amy S Conway, Delan Khalid, Marius M Mader, Ju...> ;Nature Cancer. 2022 Aug 1
• 78 citations
  Enhanced safety and efficacy of protease-regulated CAR-T cell receptors.
  Louai Labanieh, Robbie G Majzner, Dorota Klysz, Elena Sotillo, Chris J Fisher, José G Vilches-Moure, Kaithlen Zen B Pacheco, Meena Malipatlolla, Peng Xu, Jessica H Hui...> ;Cell. 2022 May 12
• 306 citations
  GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.
  Robbie G Majzner, Sneha Ramakrishna, Kristen W Yeom, Shabnum Patel, Harshini Chinnasamy, Liora M Schultz, Rebecca M Richards, Li Jiang, Valentin Barsan, Rebecca Mancus...> ;Nature. 2022 Mar 1
• 31 citations
  In vivo imaging of nanoparticle-labeled CAR T cells.
  Louise Kiru, Aimen Zlitni, Aidan Michael Tousley, Guillermo Nicolás Dalton, Wei Wu, Famyrah Lafortune, Anna Liu, Kristen May Cunanan, Hossein Nejadnik, Todd Sulchek, M...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Feb 8
• 85 citations
  Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.
  Johanna Theruvath, Marie Menard, Benjamin A H Smith, Miles H Linde, Garry L Coles, Guillermo Nicolas Dalton, Wei Wu, Louise Kiru, Alberto Delaidelli, Elena Sotillo, Jo...> ;Nature Medicine. 2022 Feb 1
• 57 citations
  GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
  Sabine Heitzeneder, Kristopher R Bosse, Zhongyu Zhu, Doncho Zhelev, Robbie G Majzner, Molly T Radosevich, Shaurya Dhingra, Elena Sotillo, Samantha Buongervino, Guillem...> ;Cancer Cell. 2022 Jan 10
• 31 citations
  NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity.
  Rebecca Richards, Feifei Zhao, Katherine A. Freitas, Kevin R. Parker, Peng Xu, Amy Fan, Elena Sotillo, Mads Daugaard, Htoo Zarni Oo, Jie Liu, Wan-Jen Hong, Poul H. Sor...> ;Blood Cancer Discovery. 2021 Sep 16
• 230 citations
  CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
  Jay Y. Spiegel, Shabnum Patel, Lori Muffly, Nasheed Hossain, Jean Oak, John H. Baird, Matthew J. Frank, Parveen Shiraz, Bita Sahaf, Juliana Craig, Maria Iglesias, Sher...> ;Nature Medicine. 2021 Jul 26
• 6 citations
  Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Fo...
  Sarah B. Whittle, Katharine Offer, Ryan D. Roberts, Amy K. LeBlanc, Cheryl A. London, Robbie G. Majzner, Alex Yee-Chen Huang, Peter J. Houghton, E. Alejandro Sweet Cor...> ;Pediatric Blood & Cancer. 2021 Jun 16
• 16 citations
  Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins.
  Franziska Blaeschke, Dana Stenger, Antonia Apfelbeck, Bruno L Cadilha, Mohamed-Reda Benmebarek, Jasmin Mahdawi, Eva Ortner, Mareike Lepenies, Nicola Habjan, Felicitas ...> ;Blood Cancer Journal. 2021 Jun 4
• 9 citations
  How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol
  Heike E. Daldrup-Link, Michael, Robbie G. Majzner, Sheri L. Spunt, Stuart B. Goodman, Michael E. Moseley, Ashok J Theruvath, Ali Rashidi> ;Pediatric Radiology. 2021 May 27
• 214 citations
  Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
  Evan W. Weber, Kevin R. Parker, Elena Sotillo, Rachel C. Lynn, Hima Anbunathan, John Lattin, Zinaida Good, Julia A. Belk, Bence Daniel, Dorota Klysz, Meena Malipatloll...> ;Science. 2021 Apr 2
• 45 citations
  Immune receptor inhibition through enforced phosphatase recruitment
  Ricardo A. Fernandes, Leon Su, Yoko Nishiga, Junming Ren, Aladdin M. Bhuiyan, Ning Cheng, Calvin J. Kuo, Lora Picton, Shozo Ohtsuki, Robbie G. Majzner, Skyler P. Rietb...> ;Nature. 2020 Oct 21
• 19 citations
  PET Reporter Gene Imaging and Ganciclovir-Mediated Ablation of Chimeric Antigen Receptor T Cells in Solid Tumors.
  Surya Murty, Louai Labanieh, Tara Murty, Gayatri Gowrishankar, Tom Haywood, Israt S. Alam, Corinne Beinat, Elise Robinson, Amin Aalipour, Dorota Klysz, Jennifer R. Coc...> ;Cancer Research. 2020 Nov 1
• 2 citations
  Identification of dual positive CD19+/CD3+ T cells in a leukapheresis product undergoing CAR transduction: a case report
  Liora M. Schultz, Shabnum Patel, Kara L. Davis, Sneha Ramakrishna, Bita Sahaf, Neehar Bhatia, Christina Baggott, Courtney Erickson, Robbie G. Majzner, Jean Oak, Alice ...> ;Journal for Immunotherapy of Cancer. 2020 Sep 1
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Journal Articles

• Tumor Antigen Escape from CAR T-cell Therapy  
  Crystal L Mackall, Robbie G Majzner, Clinical Cancer Research

Abstracts/Posters

• Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)
  Robbie G. Majzner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Identification of Dual Positive CD19+/CD3+ T Cells in an Apheresis Product Undergoing Chimeric Antigen Receptor (CAR) Transduction
  Robbie G. Majzner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• CAR T Cell Therapy for Neuroblastoma
  Robbie Majzner, MD, Frontiers in Neurology, Orlando, FL, 12/9/2019