RobertAbrahamMD

PubMed

• 26 citations
  Direct control of CAR T cells through small molecule-regulated antibodies.
  Spencer Park, Pascua Edward Derrick, Kevin Lindquist, Christopher R. Kimberlin, Xiaodi Deng, Yvonne S. L. Mak, Zea Melton, Theodore O. Johnson, Regina Lin, Bijan Bolda...> ;Nature Communications. 2021 Jan 29
• 19 citations
  Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells.
  Reeja S Maskey, Fang Wang, Elyssa Lehman, Yiqun Wang, Natasha Emmanuel, Wenyan Zhong, Guixian Jin, Robert T. Abraham, Kim Arndt, Jeremy S. Myers, Anthony Mazurek> ;Cell Cycle. 2021 Jan 2
• 16 citations
  Anti-tumor immunity influences cancer cell reliance upon ATG7.
  Michael D. Arensman, Xiaoran S. Yang, Wenyan Zhong, Stephanie Bisulco, Erik Upeslacis, Edward Rosfjord, Shibing Deng, Robert T. Abraham, Christina H. Eng> ;Oncoimmunology. 2020 Aug 23
• 4 citations
  A sugary input to leucine sensing
  Elyssa Lehman, Robert T. Abraham> ;Science. 2020 Jan 10
• 101 citations
  Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity.
  Michael D. Arensman, Xiaoran S. Yang, Danielle Leahy, Lourdes Toral-Barza, Mary Mileski, Edward Rosfjord, Fang Wang, Shibing Deng, Jeremy S. Myers, Robert T. Abraham, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 May 7
• 1445 citations
  The PI3K pathway in human disease
  David A. Fruman, Honyin Chiu, Benjamin D. Hopkins, Shubha Bagrodia, Lewis C. Cantley, Robert T. Abraham> ;Cell. 2017 Aug 10
• 78 citations
  Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
  Natasha Emmanuel, Shoba Ragunathan, Qin Shan, Fang Wang, Andreas Giannakou, Nanni Huser, Guixian Jin, Jeremy S. Myers, Robert T. Abraham, Keziban Unsal-Kacmaz> ;Cell Reports. 2017 Jun 27
• 99 citations
  Lysosomal adaptation: How cells respond to lysosomotropic compounds.
  Shuyan Lu, Tae Sung, Nianwei Lin, Robert T. Abraham, Bart Jessen> ;Plos One. 2017 Mar 16
• 8 citations
  The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration
  Nathan T. Ihle, Robert T. Abraham> ;Molecular Cell. 2017 Mar 16
• 2 citations
  4E-BP2 hardwires lymphocytes for rapamycin sensitivity.
  Robert T. Abraham> ;Science Signaling. 2016 May 31
• 1 citations
  Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation
  Robert T. Abraham> ;Cell Metabolism. 2016 Mar 8
• 169 citations
  Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy
  Christina H. Eng, Zuncai Wang, Diane Tkach, Lourdes Toral-Barza, Savuth Ugwonali, Shanming Liu, Stephanie Fitzgerald, Elizabeth George, Elizabeth Frias, Nadire Cochran...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Jan 5
• 40 citations
  Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.
  Anne M. Strohecker, Shilpy Joshi, Richard Possemato, Robert T. Abraham, David M. Sabatini, Eileen White> ;Oncogene. 2015 Nov 5
• 252 citations
  Molecular Pathways: Targeting the Cyclin D–CDK4/6 Axis for Cancer Treatment
  Todd VanArsdale, Chris Boshoff, Kim Arndt, Robert T. Abraham> ;Clinical Cancer Research. 2015 May 4
• 31 citations
  Making sense of amino acid sensing
  Robert T. Abraham> ;Science. 2015 Jan 9
• 60 citations
  Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion
  Naval P. Shanware, Kevin Bray, Christina H. Eng, Fang Wang, Maximillian T. Follettie, Jeremy S. Myers, Valeria Fantin, Robert T. Abraham> ;Nature Communications. 2014 Sep 25
• 3 citations
  Too Little mTORC1 Activity Injures the Liver
  Robert T. Abraham> ;Cell Metabolism. 2014 Jul 1
• 2 citations
  MTOR mutations in the crosshairs of targeted therapy.
  Paul A. Rejto, Robert T. Abraham> ;Cancer Discovery. 2014 May 1
• 9 citations
  Self-Eating Limits EGFR-Dependent Tumor Growth
  Valeria Fantin, Robert T. Abraham> ;Cell. 2013 Sep 12
• 69 citations
  The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics.
  Hans-Peter Gerber, Frank E. Koehn, Robert T. Abraham> ;Natural Product Reports. 2013 Apr 17
• 96 citations
  The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease
  Naval P. Shanware, Kevin Bray, Robert T. Abraham> ;Annual Review of Pharmacology and Toxicology. 2013 Jan 7
• 58 citations
  Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells
  Puja Sapra, Marc Damelin, John F. DiJoseph, Kimberly Ann Marquette, Kenneth G. Geles, Jonathan Golas, Maureen Dougher, Bitha Narayanan, Andreas Giannakou, Kiran Khandk...> ;Molecular Cancer Therapeutics. 2013 Jan 1
• 17 citations
  Chemokine to the Rescue: Interleukin-8 Mediates Resistance to PI3K-Pathway-Targeted Therapy in Breast Cancer
  Robert T. Abraham> ;Cancer Cell. 2012 Dec 11
• 35 citations
  Mechanisms of intrinsic and acquired resistance to kinase‐targeted therapies
  Shubha Bagrodia, Tod Smeal, Robert T. Abraham> ;Pigment Cell & Melanoma Research. 2012 Nov 1
• 69 citations
  The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming
  Christina H. Eng, Robert T. Abraham> ;Oncogene. 2011 Nov 24
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