RobertJosephApplegateMD

Cardiology • Winston Salem, NC

Adult Congenital Heart Disease, Interventional Cardiology

Professor of Medicine, Wake Forest University

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Office
S Hawthorne Rd
Winston Salem, NC 27157
Phone+1 336-716-2255

Fax+1 336-716-2067
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Education & Training

University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of MedicineFellowship, Cardiovascular Disease, 1984 - 1986
Oregon Health & Science UniversityResidency, Internal Medicine, 1980 - 1983
University of Virginia School of MedicineClass of 1980

Certifications & Licensure

OR State Medical License 1981 - Present
NC State Medical License 1987 - 2025
TX State Medical License 1984 - 1987
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification EpicCare Inpatient - Core EMR, Epic Systems Corporation, 2012
Men's Health Castle Connolly, 2007
Top MD Consumers Checkbook
Fellow (FACC) American College of Cardiology
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Clinical Trials

Angio-Seal Evolution Device Registry Start of enrollment: 2008 Jul 01
Completed
Xience V at Wake Forest University Baptist Medical Center (WFUBMC) Start of enrollment: 2009 Jul 01
Completed
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement Start of enrollment: 2010 Dec 10
Completed
Not Applicable
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI). Start of enrollment: 2012 Apr 01
Active, not recruiting
Not Applicable
Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement Start of enrollment: 2012 Aug 01
Active, not recruiting
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Publications & Presentations

PubMed

Five-Year Follow-Up from the CoreValve Expanded Use Transcatheter Aortic Valve-in-Surgical Aortic Valve Study.
Bajwa, T., Laham, R., Khabbaz, K., Dauerman, H., Waksman, R., Weiss, E., Allaqaband, S., Badr, S., Caskey, M., Byrne, T., Applegate, R., Kon, N., Li, S., Kleiman, N., ...> ;The American Journal of Cardiology. 2024 Mar 1
1 citations
Influence of Household Income on Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock.
Sri Harsha Patlolla, Ardaas Kanwar, P Matthew Belford, Robert J Applegate, David X Zhao, Mandeep Singh, Saraschandra Vallabhajosyula> ;The American Journal of Cardiology. 2022 Aug 15
1 citations
Redo-aortic valve replacement in prior stentless prosthetic aortic valves: Transcatheter versus surgical approach.
Charles H. Choi, Kevin Cao, Diego Malaver, Edward H. Kincaid, Adrian L Lata, Neal D. Kon, P. Matthew Belford, Sanjay Gandhi, Robert J. Applegate, David Zhao> ;Catheterization and Cardiovascular Interventions. 2021 Aug 17
3 citations
Echocardiography and EuroSCORE II for the stratification of low-gradient severe aortic stenosis and preserved left ventricular ejection fraction
Yan Fan, Hong Shen, Brandon Stacey, David Zhao, Robert J. Applegate, Neal D. Kon, Edward H. Kincaid, Sanjay Gandhi, Min Pu> ;The International Journal of Cardiovascular Imaging. 2021 Aug 14
4 citations
A novel technique for postclosure of large-bore sheaths using two Perclose devices.
Charles H. Choi, James Kevin Hall, Diego Malaver, Robert J. Applegate, David Zhao> ;Catheterization and Cardiovascular Interventions. 2021 Apr 1
Charles Chambers MD MSCAI-A tribute.
James C. Blankenship, Robert J. Applegate, Ehtisham Mahmud> ;Catheterization and Cardiovascular Interventions. 2020 Jun 2
2 citations
Impact of anatomical variations of the left ventricular outflow tract on stroke volume calculation by Doppler echocardiography in aortic stenosis.
Min Pu, Zhifeng Dong, Li Zhou, Richard B Stacey, Karl Richardson, Robert J. Applegate, David Zhao> ;Echocardiography. 2020 May 19
8 citations
Assessment of the prognostic significance of low gradient severe aortic stenosis and preserved left ventricular function requires the integration of the consistency of...
Hong Shen, Brandon Stacey, Robert J. Applegate, David Zhao, Sanjay Gandhi, Neal D. Kon, Edward H. Kincaid, Min Pu> ;Echocardiography. 2020 Jan 1
17 citations
Impact of the COVID-19 pandemic on interventional cardiology training in the United States.
Samit Shah, Yulanka Castro-Dominguez, Tanush Gupta, Robert R. Attaran, Graham V. Byrum, Adam Taleb, Amanda Pettyjohn, Robert C. Bartel, Molly Szerlip, Timothy D. Henry...> ;Catheterization and Cardiovascular Interventions. 2020 Jan 1
12 citations
A comparison of valve-in-valve transcatheter aortic valve replacement in failed stentless versus stented surgical bioprosthetic aortic valves
Charles H. Choi, Vivian Cheng, Diego Malaver, Neal D. Kon, Edward H. Kincaid, Sanjay Gandhi, Robert J. Applegate, David Zhao> ;Catheterization and Cardiovascular Interventions. 2019 May 1
9 citations
Comparison of paravalvular aortic leak characteristics in the Medtronic CoreValve versus Edwards Sapien Valve: Paravalvular aortic leak characteristics.
Olivia N. Gilbert, Charles H. Choi, Jodie Franzil, Melissa C. Caughey, Waqas Qureshi, R. Brandon Stacey, Min Pu, Robert J. Applegate, Sanjay Gandhi, David Zhao> ;Catheterization and Cardiovascular Interventions. 2018 Nov 1
21 citations
Comparison of outcomes with surgical cut-down versus percutaneous transfemoral transcatheter aortic valve replacement: TAVR transfemoral access comparisons between sur...
Brandon C. Drafts, Charles H. Choi, Kunal Sangal, Michael W. Cammarata, Robert J. Applegate, Sanjay Gandhi, Edward H. Kincaid, Neal D. Kon, David Zhao> ;Catheterization and Cardiovascular Interventions. 2018 Jun 1
2 citations
Early and Late Bioresorbable Vascular Scaffold Thrombosis: Size Matters.
Manrique Alvarez, Robert J. Applegate> ;JACC. Cardiovascular Interventions. 2017 Dec 11
15 citations
Safety and efficacy of drug eluting stents in patients with spontaneous coronary artery dissection
Federico Conrotto, Fabrizio D'Ascenzo, Enrico Cerrato, Antonio Fernández-Ortiz, Nieves Gonzalo, Fernando Macaya, Corrado Tamburino, Marco Barbanti, Martijn A. van Lavi...> ;International Journal of Cardiology. 2017 Jul 1
Percutaneous Coronary Intervention for Multivessel Disease and ST-Segment Elevation Myocardial Infarction: When, Not Whether
Robert J. Applegate> ;JACC. Cardiovascular Interventions. 2016 Sep 12
Walking the Tightrope Between Suppressing Ischemia and Minimizing Bleeding.
Robert J. Applegate> ;JACC. Cardiovascular Interventions. 2016 Jul 25
10 citations
Clinical outcomes in real-world patients with bifurcation lesions receiving Xience V everolimus-eluting stents: Four-year results from the Xience V USA study
James B. Hermiller, Robert J. Applegate, Colleen Baird, Michael M. Butler, David R. Rutledge, Jin Wang, Kalyan Kakarala, Mitchell W. Krucoff, Krishnankutty Sudhir> ;Catheterization and Cardiovascular Interventions. 2016 Jul 1
Unraveling the Biological Effects of Drug-Eluting Stents.
Robert J. Applegate> ;JACC. Cardiovascular Interventions. 2016 Feb 8
Allen's Testing Prior to Transradial Cardiac Catheterization: State of the Arch.
Rahul Sharma, Robert J. Applegate> ;The Journal of Invasive Cardiology. 2015 Sep 1
3 citations
Retrograde Percutaneous Coronary Intervention for Chronic Total Occlusion: Going Backward to Go Forward.
Robert J. Applegate> ;Journal of the American College of Cardiology. 2015 Jun 9
44 citations
Correlates and outcomes of late and very late drug-eluting stent thrombosis: results from DESERT (International Drug-Eluting Stent Event Registry of Thrombosis).
Ron Waksman, Ajay J. Kirtane, Rebecca Torguson, David Cohen, Thomas J. Ryan, Lorenz Räber, Robert J. Applegate, Sergio Waxman, Paul C. Gordon, Kimberly Kaneshige, Dese...> ;JACC. Cardiovascular Interventions. 2014 Oct 1
1 citations
Conversations in cardiology: bridging antiplatelet therapy before surgery.
Morton J. Kern, Robert J. Applegate, Malcolm R. Bell, Emmanouil S. Brilakis, Samuel M. Butman, Richard G. Bach, Prashant Kaul, Lloyd W. Klein, Mitchell W. Krucoff, Jos...> ;Catheterization and Cardiovascular Interventions. 2014 Apr 1
8 citations
Radial Access for Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction : Time for a Paradigm Shift?∗
Robert J. Applegate> ;Journal of the American College of Cardiology. 2014 Mar 18
16 citations
Cost effectiveness of radial access for diagnostic cardiac catheterization and coronary intervention.
Robert J. Applegate, Matthew T. Sacrinty, Pascha Schafer, Justin W. Smith, Sanjay Gandhi, Michael A. Kutcher, Renato M. Santos, Adam C. Cecile, William C. Little> ;Catheterization and Cardiovascular Interventions. 2013 Oct 1
145 citations
Incidence and predictors of coronary stent thrombosis: Evidence from an international collaborative meta-analysis including 30 studies, 221,066 patients, and 4276 thro...
Fabrizio D'Ascenzo, Mario Bollati, Fabrizio Clementi, Davide Castagno, Bo Lagerqvist, José M. de la Torre Hernández, Juriën M. ten Berg, Bruce R. Brodie, Philip Urban,...> ;International Journal of Cardiology. 2013 Jul 31
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Lectures

Interventional Live Case Session I: Coronary Transmission from Beth Israel Deaconess Medical Center
2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019