RobertJayBoorsteinMD

Pathology • New York, NY

Chemical Pathology, Molecular Genetics, Anatomic Pathology, Clinical Pathology

Physician

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Office
415 east 37th st
New York, NY 10016
Phone+1 917-312-3786

Fax+1 917-312-3786
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Education & Training

NYU Grossman School of MedicineResidency, Pathology-Anatomic and Clinical, 1983 - 1989
Harvard Medical SchoolClass of 1983

Certifications & Licensure

FL State Medical License 2015 - 2026
NJ State Medical License 2016 - 2025
NY State Medical License 1984 - 2025
PA State Medical License 2016 - 2024
American Board of Pathology Anatomic Pathology & Clinical Pathology

Publications & Presentations

PubMed

31 citations
Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization.
Maria T. Ocampo-Hafalla, Alvin Altamirano, Ashis K. Basu, Michael K. Chan, Jose Eliseo A. Ocampo, Archie Cummings, Robert J. Boorstein, Richard P. Cunningham, George W...> ;DNA Repair. 2006 Apr 8
90 citations
Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity.
Dina R. Marenstein, Michael K. Chan, Alvin Altamirano, Ashis K. Basu, Robert J. Boorstein, Richard P. Cunningham, George W. Teebor> ;The Journal of Biological Chemistry. 2003 Mar 14
18 citations
Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis
Sebastian Ulbert, Mike Cross, Robert J. Boorstein, George W. Teebor, Piet Borst> ;Nucleic Acids Research. 2002 Sep 15
81 citations
Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.
Maria T. A. Ocampo, Wenren Chaung, Dina R. Marenstein, Michael K. Chan, Alvin Altamirano, Ashis K. Basu, Robert J. Boorstein, Richard P. Cunningham, George W. Teebor> ;Molecular and Cellular Biology. 2002 Sep 1
115 citations
Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1.
Robert J. Boorstein, Archie Cummings, Dina R. Marenstein, Michael K. Chan, Yuliang Ma, Thomas A. Neubert, Stuart M. Brown, George W. Teebor> ;The Journal of Biological Chemistry. 2001 Nov 9
109 citations
Stimulation of Human Endonuclease III by Y Box-binding Protein 1 (DNA-binding Protein B) INTERACTION BETWEEN A BASE EXCISION REPAIR ENZYME AND A TRANSCRIPTION FACTOR
Dina R. Marenstein, Maria T. A. Ocampo, Michael K. Chan, Alvin Altamirano, Ashis K. Basu, Robert J. Boorstein, Richard P. Cunningham, George W. Teebor> ;The Journal of Biological Chemistry. 2001 Jun 15
7 citations
Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53
Li-Jun Mi, Wenren Chaung, Robert Horowitz, George W. Teebor, Robert J. Boorstein> ;Carcinogenesis. 2001 Jan 1
21 citations
5-chloro-2'-deoxyuridine cytotoxicity results from base excision repair of uracil subsequent to thymidylate synthase inhibition.
Mark L Brandon, Li-Jun Mi, Wenren Chaung, George W. Teebor, Robert J. Boorstein> ;Mutation Research. 2000 Mar 20
11 citations
Lack of phenotypic alteration of hmUra-DNA glycosylase-deficient hamster cells exposed to DNA-damaging agents
Li-Jun Mi, Evan Mahl, Wenren Chaung, Robert J. Boorstein> ;Mutation Research. 1997 Mar 21
125 citations
Cloning and Expression of the cDNA Encoding the Human Homologue of the DNA Repair Enzyme, Escherichia coli Endonuclease III
Timothy P. Hilbert, Wenren Chaung, Robert J. Boorstein, Richard P. Cunningham, George W. Teebor> ;The Journal of Biological Chemistry. 1997 Mar 7
97 citations
The p53 Status of Chinese Hamster V79 Cells Frequently Used for Studies on DNA Damage and DNA Repair
Wenren Chaung, Li-Jun Mi, Robert J. Boorstein> ;Nucleic Acids Research. 1997 Mar 1
14 citations
Molecular spectrum of mutations induced by 5-hydroxymethyl-2'-deoxyuridine in (CHO)-PL61 cells.
Wenren Chaung, Robert J. Boorstein> ;Mutation Research. 1997 Jan 3
577 citations
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).
Xiaozhong Wang, Beth Lawson, Joseph W. Brewer, Helene Zinszner, Archana Sanjay, Li-Jun Mi, Robert J. Boorstein, Gert Kreibich, Linda M. Hendershot, David Ron> ;Molecular and Cellular Biology. 1996 Aug 1
64 citations
Purification of a Mammalian Homologue of Escherichia coli Endonuclease III: Identification of a Bovine Pyrimidine Hydrate-Thymine Glycol DNA-Glycosylase/AP Lyase by Ir...
Timothy P. Hilbert, Robert J. Boorstein, Hsiang Chuan Kung, Philip H. Bolton, Dongxia Xing, Richard P. Cunningham, George W. Teebor> ;Biochemistry. 1996 Feb 27
4 citations
Comparison of the effects of UV irradiation on 5-methyl-substituted and unsubstituted pyrimidines in alternating pyrimidine-purine sequences in DNA.
S. Zuo, Robert J. Boorstein, Richard P. Cunningham, George W. Teebor> ;Biochemistry. 1995 Sep 12
7 citations
DNA base excision repair of 5-hydroxymethyl-2'-deoxyuridine stimulates poly(ADP-ribose) synthesis in Chinese hamster cells.
Robert J. Boorstein, Joydeep Haldar, Guy G. Poirier, Donna Putnam> ;Carcinogenesis. 1995 May 1
1 citations
Toxicity of camptothecin to Chinese hamster cells containing 5-hydroxymethyl-2'-deoxyuridine in their DNA.
Li-Jun Mi, Lai-No Chiu, Evan Mahl, Robert J. Boorstein> ;Mutation Research. 1995 May 1
14 citations
Effect of pH and temperature on the stability of UV-induced repairable pyrimidine hydrates in DNA
Robert E. O’Donnell, Robert J. Boorstein, Richard P. Cunningham, George W. Teebor> ;Biochemistry. 1994 Aug 23
45 citations
A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-...
Robert J. Boorstein, Lai-No Chiu, George W. Teebor> ;Molecular and Cellular Biology. 1992 Dec 1
60 citations
Synthesis of the diastereomers of thymidine glycol, determination of concentrations and rates of interconversion of their cis-trans epimers at equilibrium and demonstr...
M J Lustig, Jean Cadet, Robert J. Boorstein, George W. Teebor> ;Nucleic Acids Research. 1992 Sep 25
53 citations
Formation and stability of repairable pyrimidine photohydrates in DNA
Robert J. Boorstein, Timothy P. Hilbert, Richard P. Cunningham, George W. Teebor> ;Biochemistry. 1990 Nov 1
34 citations
Phylogenetic evidence of a role for 5-hydroxymethyluracil-DNA glycosylase in the maintenance of 5-methylcytosine in DNA.
Robert J. Boorstein, Lai-No Chiu, George W. Teebor> ;Nucleic Acids Research. 1989 Oct 11
84 citations
UV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian DNA glycosylase activities.
Robert J. Boorstein, Timothy P. Hilbert, Jean Cadet, Richard P. Cunningham, George W. Teebor> ;Biochemistry. 1989 Jul 25
22 citations
Effects of 5-Hydroxymethyluracil and 3-Aminobenzamide on the Repair and Toxicity of 5-Hydroxymethyl-2′-deoxyuridine in Mammalian Cells
Robert J. Boorstein, George W. Teebor> ;Cancer Research. 1989 Mar 15
28 citations
Mutagenicity of 5-Hydroxymethyl-2′-deoxyuridine to Chinese Hamster Cells
Robert J. Boorstein, George W. Teebor> ;Cancer Research. 1988 Oct 1
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Press Mentions

CompuGroup Medical (CGM) Helps Lenco Diagnostic Laboratory Launch Successful COVID-19 Testing ProgramSeptember 23rd, 2020
A Quick Virus Test? Sure, if You Can Afford ItAugust 31st, 2020
Elizabeth Holmes to Shut Theranos' Core Operations, Fire 40% of WorkersJanuary 6th, 2017

Grant Support

Hmura Mutagenicity And Base Excision RepairNational Cancer Institute1990–1994