RobertH.BrownJr.MD

PubMed

• Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report.
  Kaminski, N., Montesi, S., Gomez, C., Beers, M., Brown, R., Chattopadhyay, I., Flaherty, K., Garcia, C., Gomperts, B., Hariri, L., Hogaboam, C., Jenkins, R., Kaminski,...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Feb 15
• PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS.
  Issa O Yusuf, Sepideh Parsi, Lyle W Ostrow, Robert H Brown, Paul R Thompson, Zuoshang Xu> ;Neurobiology of Disease. 2024 Mar 1
• 1 citations
  Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice.
  Aydan Kahriman, James Bouley, Idil Tuncali, Elif O Dogan, Mariana Pereira, Thuyvan Luu, Daryl A Bosco, Samer Jaber, Owen M Peters, Robert H Brown Jr, Nils Henninger> ;Brain. 2023 Dec 1
• Rescue of GM3 synthase deficiency by spatially controlled, rAAV-mediated ST3GAL5 delivery.
  Huiya Yang, Robert H Brown Jr, Dan Wang, Kevin A Strauss, Guangping Gao> ;JCI Insight. 2023 May 8
• Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis.
  Minggang Fang, Sara K Deibler, Alissa L Nana, Sarat C Vatsavayai, You Zhou, Sandra Almeida, Alexandra Weiss, Robert H Brown, William W Seeley, Fen-Biao Gao, Michael R ...> ;Frontiers in Neuroscience. 2023 Jan 1
• 9 citations
  Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis.
  Danilo Bilches Medinas, Sajid Malik, Esra Yıldız-Bölükbaşı, Janina Borgonovo, Mirva J Saaranen, Hery Urra, Eduardo Pulgar, Muhammad Afzal, Darwin Contreras, Madison T ...> ;The EMBO Journal. 2022 Dec 17
• 12 citations
  Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review.
  Jeremy M Shefner, Richard Bedlack, Jinsy A Andrews, James D Berry, Robert Bowser, Robert Brown, Jonathan D Glass, Nicholas J Maragakis, Timothy M Miller, Jeffrey D Rot...> ;JAMA Neurology. 2022 Dec 1
• 9 citations
  The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.
  Sarah Opie-Martin, Alfredo Iacoangeli, Simon D Topp, Olubunmi Abel, Keith Mayl, Puja R Mehta, Aleksey Shatunov, Isabella Fogh, Harry Bowles, Naomi Limbachiya, Thomas P...> ;Nature Communications. 2022 Nov 12
• 14 citations
  CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
  Katharina E Meijboom, Abbas Abdallah, Nicholas P Fordham, Hiroko Nagase, Tomás Rodriguez, Carolyn Kraus, Tania F Gendron, Gopinath Krishnan, Rustam Esanov, Nadja S And...> ;Nature Communications. 2022 Oct 21
• 12 citations
  Approaches to Gene Modulation Therapy for ALS.
  Katharina E Meijboom, Robert H Brown> ;Neurotherapeutics. 2022 Jul 1
• 20 citations
  Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.
  Gopinath Krishnan, Denitza Raitcheva, Daniel Bartlett, Mercedes Prudencio, Diane M McKenna-Yasek, Catherine Douthwright, Björn E Oskarsson, Shafeeq Ladha, Oliver D Kin...> ;Nature Communications. 2022 May 19
• 27 citations
  Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
  Cristian Arredondo, Carolina Cefaliello, Agnieszka Dyrda, Nur Jury, Pablo Martinez, Iván Díaz, Armando Amaro, Helene Tran, Danna Morales, Maria Pertusa, Lorelei Stoica...> ;Neuron. 2022 May 18
• 14 citations
  Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice.
  Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H Brown, Huaibin Cai, Zuoshang Xu> ;Plos One. 2022 Jan 1
• 7 citations
  Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort.
  Vickram Tejwani, Ashraf Fawzy, Nirupama Putcha, Peter J. Castaldi, Michael H. Cho, Katherine A. Pratte, Surya P. Bhatt, David A. Lynch, Stephen M. Humphries, Gregory L...> ;Chest. 2021 Oct 1
• 4 citations
  HIV is Associated with Impaired Pulmonary Diffusing Capacity Independent of Emphysema.
  Sarath Raju, Jacquie Astemborski, M. Bradley Drummond, Hema C. Ramamurthi, Jing Sun, Robert H. Brown, Gregory D. Kirk, Meredith C. McCormack> ;Journal of Acquired Immune Deficiency Syndromes. 2021 Sep 24
• 4 citations
  Losartan Effects on Emphysema Progression Randomized Clinical Trial: Rationale, Design, Recruitment, and Retention.
  Robert A. Wise, Janet T. Holbrook, Robert H. Brown, Gerard J. Criner, Mark T. Dransfield, MeiLan K. Han, Jerry A. Krishnan, Ellen Looney, Enid Neptune, Vicky Palombizi...> ;Chronic Obstructive Pulmonary Diseases. 2021 Oct 28
• 76 citations
  Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis
  Payam Mohassel, Sandra Donkervoort, Museer A. Lone, Matthew Nalls, Kenneth Gable, Sita D. Gupta, A. Reghan Foley, Ying Hu, Jonas Alex Morales Saute, Ana Lucila Moreira...> ;Nature Medicine. 2021 May 31
• 5 citations
  The Association between Lung Hyperinflation and Coronary Artery Disease in Smokers.
  Divay Chandra, Aman Gupta, Gregory L. Kinney, Carl R. Fuhrman, Joseph K. Leader, Alejandro A. Diaz, Jessica Bon, R. Graham Barr, George R. Washko, Matthew J. Budoff, J...> ;Chest. 2021 Sep 1
• 14 citations
  Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease
  Owen M. Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A. Smith, Michael A. Schwarzschild, Christian Mueller, Robert H. Brown, Marc R. Freeman> ;Neurobiology of Disease. 2021 Jul 31
• 40 citations
  Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models.
  Yuanjing Liu, Jean-Cosme Dodart, Helene Tran, Shaunna Berkovitch, Maurine Braun, Michael Byrne, Ann Fiegen Durbin, Xiao Shelley Hu, Naoki Iwamoto, Hyun Gyung Jang, Pac...> ;Nature Communications. 2021 Feb 8
• 3 citations
  Single breath counting is an effective screening tool for forced vital capacity in ALS.
  Colin Quinn, Corey T. McMillan, Margaret A. Owegi, Kelly Almasy, Catherine Douthwright, Diane McKenna-Yasek, Namita Goyal, James D. Berry, Robert H. Brown> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2021 Aug 4
• 5 citations
  Association of Lung Function With HIV-Related Quality of Life and Health Care Utilization in a High-Risk Cohort.
  Sarath Raju, Meredith C. McCormack, M.B. Drummond, Hema C. Ramamurthi, Christian A. Merlo, Robert A. Wise, Shruti H. Mehta, Robert H. Brown, Gregory D. Kirk> ;Journal of Acquired Immune Deficiency Syndromes. 2020 Oct 1
• 59 citations
  Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides.
  Hirosha Geekiyanage, Shima Rayatpisheh, James A. Wohlschlegel, Robert H. Brown, Victor R. Ambros> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 14
• 14 citations
  Effects of Obstructive Sleep Apnea and Obesity on Morphine Pharmacokinetics in Children.
  Nicholas M. Dalesio, Carlton K. K. Lee, Craig W. Hendrix, Nikole Kerns, Aaron Hsu, William Clarke, Joseph M. Collaco, Sharon A. McGrath-Morrow, Myron Yaster, Robert H....> ;Anesthesia and Analgesia. 2020 Sep 1
• CT, MRI, COPD, and Worsening FEV1; "Once You Do Know What the Question Actually Is, You'll Know What the Answer Means".
  Robert H. Brown> ;Academic Radiology. 2021 Apr 1
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