RobertVFareseMD

PubMed

• Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues.
  C. Shan Xu, Song Pang, Gleb Shtengel, Andreas Müller, Alex T. Ritter, Huxley K. Hoffman, Shin-ya Takemura, Zhiyuan Lu, H. Amalia Pasolli, Nirmala Iyer, Jeeyun Chung, D...> ;Nature. 2021 Nov 1
• 18 citations
  An open-access volume electron microscopy atlas of whole cells and tissues.
  C. Shan Xu, Song Pang, Gleb Shtengel, Andreas Müller, Alex T. Ritter, Huxley K. Hoffman, Shin-ya Takemura, Zhiyuan Lu, H. Amalia Pasolli, Nirmala Iyer, Jeeyun Chung, D...> ;Nature. 2021 Oct 6
• 12 citations
  The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting.
  Maria-Jesus Olarte, Jessica M. J. Swanson, Tobias C. Walther, Robert V. Farese> ;Trends in Biochemical Sciences. 2021 Sep 25
• 4 citations
  Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus.
  Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo-Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese> ;Medcomm. 2021 Feb 25
• Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B.
  Mini P Sajan, Michael Leitges, Colin Park, David M Diamond, Jin Wu, Barbara C Hansen, Mildred A Duncan, Christopher A Apostolatos, Andre H Apostolatos, Mark Kindy, Rob...> ;Current Alzheimer Research. 2021 Jan 1
• 25 citations
  Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
  Xuewu Sui, Kun Wang, Nina L. Gluchowski, Shane D. Elliott, Maofu Liao, Tobias C. Walther, Robert V. Farese> ;Nature. 2020 May 13
• 17 citations
  Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
  Constance S. Petit, Jane J. Lee, Sebastian Boland, Sharan Swarup, Romain Christiano, Zon Weng Lai, Niklas Mejhert, Shane D. Elliott, David McFall, Sara Haque, Eric J. ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Apr 28
• 43 citations
  Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
  Niklas Mejhert, Leena Kuruvilla, Katlyn R. Gabriel, Shane D. Elliott, Marie-Aude Guié, Huajin Wang, Zon Weng Lai, Elizabeth A. Lane, Romain Christiano, Nika N. Danial,...> ;Molecular Cell. 2020 Mar 19
• 84 citations
  LDAF1 and Seipin Form a Lipid Droplet Assembly Complex
  Jeeyun Chung, Xudong Wu, Talley J. Lambert, Zon Weng Lai, Tobias C. Walther, Robert V. Farese> ;Developmental Cell. 2019 Dec 2
• 1 citations
  Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics
  Tobias C. Walther, Robert V. Farese> ;Developmental Cell. 2019 Sep 9
• 42 citations
  Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.
  Nina L. Gluchowski, Katlyn R. Gabriel, Chandramohan Chitraju, Roderick T. Bronson, Niklas Mejhert, Sebastian Boland, Kun Wang, Zon Weng Lai, Robert V. Farese, Tobias C...> ;Hepatology. 2019 Dec 1
• 59 citations
  The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes
  Chandramohan Chitraju, Tobias C. Walther, Robert V. Farese> ;Journal of Lipid Research. 2019 Jun 1
• 96 citations
  Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
  Manuele Piccolis, Laura M. Bond, Martin Kampmann, Pamela Pulimeno, Chandramohan Chitraju, Christina B. K. Jayson, Laura Pontano Vaites, Sebastian Boland, Zon Weng Lai,...> ;Molecular Cell. 2019 Apr 4
• 125 citations
  Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
  Saranna Fanning, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M. Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P.H. Ho, Tallie Noble, ...> ;Molecular Cell. 2019 Mar 7
• 28 citations
  Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay
  Andrew D. Nguyen, Thi A. Nguyen, Jiasheng Zhang, Swathi Devireddy, Ping Zhou, Anna Karydas, Xialian Xu, Bruce L. Miller, Frank Rigo, Shawn M. Ferguson, Eric J. Huang, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Mar 20
• 103 citations
  Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets
  Coline Prevost, Morris E. Sharp, Nora Kory, Qingqing Lin, Gregory A. Voth, Robert V. Farese, Tobias C. Walther> ;Developmental Cell. 2018 Jan 8
• 12 citations
  Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other...
  Mini P. Sajan, Barbara C. Hansen, Margaret Genevieve Higgs, C. Ron Kahn, Ursula Braun, Michael Leitges, Collin R. Park, David M. Diamond, Robert V. Farese> ;Neurobiology of Aging. 2018 Jan 1
• 27 citations
  Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets
  Jordon M. Inloes, William B. Kiosses, Huajin Wang, Tobias C. Walther, Robert V. Farese, Benjamin F. Cravatt> ;Biochemistry. 2018 Feb 6
• 15 citations
  Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.
  Mini P. Sajan, Mackenzie C. Lee, Fabienne Foufelle, Joshua Sajan, Courtney Cleland, Robert V. Farese> ;Cellular Signalling. 2018 Mar 1
• 26 citations
  An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations
  Sharon J. Sha, Zachary A. Miller, Sang-Won Min, Yungui Zhou, Jesse A. Brown, Laura L. Mitic, Anna Karydas, Mary Koestler, Richard M. Tsai, Chiara Corbetta-Rastelli, S....> ;Alzheimer's & Dementia. 2017 Nov 1
• 346 citations
  Lipid Droplet Biogenesis.
  Tobias C. Walther, Jeeyun Chung, Robert V. Farese> ;Annual Review of Cell and Developmental Biology. 2017 Oct 6
• 165 citations
  Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis
  Chandramohan Chitraju, Niklas Mejhert, Joel T. Haas, L. Grisell Diaz-Ramirez, Carrie A. Grueter, Jason E. Imbriglio, Shirly Pinto, Suneil K. Koliwad, Tobias C. Walther...> ;Cell Metabolism. 2017 Aug 1
• 27 citations
  Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
  Nina L. Gluchowski, Chandramohan Chitraju, Joseph A. Picoraro, Niklas Mejhert, Shirly Pinto, Winnie Xin, Daniel Kamin, Harland S. Winter, Wendy K. Chung, Tobias C. Wal...> ;Journal of Lipid Research. 2017 Jun 1
• 67 citations
  Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
  Grietje Krabbe, S. Sakura Minami, Jon Iker Etchegaray, Praveen Taneja, Biljana Djukic, Dimitrios Davalos, David Le, Iris Lo, Lihong Zhan, Meredith C. Reichert, Faten A...> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 May 9
• 270 citations
  Lipid droplets and liver disease: from basic biology to clinical implications
  Nina L. Gluchowski, Michel Becuwe, Tobias C. Walther, Robert V. Farese> ;Nature Reviews. Gastroenterology & Hepatology. 2017 Apr 21
• Join now to see all

Lectures

• Akt-dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/Propeller/FYVE Scaffold and Selectively Inhibited by Atypical PKC in High-Fat Fed and ob/... 
  Tampa, FL - 6/16/2014