RobertVFareseMD

PubMed

• Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
  Xuewu Sui, Kun Wang, Nina L. Gluchowski, Shane D. Elliott, Maofu Liao, Tobias C. Walther, Robert V. Farese> ;Nature. 2020 May 13
• Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant <i>wobbler</i> mice, a model of motor neuron degeneration.
  Petit, C. S., Lee, J. J., Boland, S., Swarup, S., Christiano, R., Lai, Z. W., Mejhert, N., Elliott, S. D., McFall, D., Haque, S., Huang, E. J., Bronson, R. T., Harper,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Apr 30
• Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.
  Mejhert, N., Kuruvilla, L., Gabriel, K. R., Elliott, S. D., Guie, M., Wang, H., Lai, Z. W., Lane, E. A., Christiano, R., Danial, N. N., Farese, R. V., Walther, T. C.> ;Molecular cell. 2020 Feb 6
• LDAF1 and Seipin Form a Lipid Droplet Assembly Complex
  Jeeyun Chung, Xudong Wu, Talley J. Lambert, Zon Weng Lai, Tobias C. Walther, Robert V. Farese> ;Developmental Cell. 2019 Dec 2
• Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics.
  Walther, T. C., Farese, R. V.> ;Developmental cell. 2019 Sep 11
• Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.
  Gluchowski, N. L., Gabriel, K. R., Chitraju, C., Bronson, R. T., Mejhert, N., Boland, S., Wang, K., Lai, Z. W., Farese, R. V., Walther, T. C.> ;Hepatology (Baltimore, Md.). 2019 May 14
• The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.
  Chitraju, C., Walther, T. C., Farese, R. V.> ;Journal of lipid research. 2019 Apr 3
• 17 citations
  Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
  Piccolis, M., Bond, L. M., Kampmann, M., Pulimeno, P., Chitraju, C., Jayson, C. B., Vaites, L. P., Boland, S., Lai, Z. W., Gabriel, K. R., Elliott, S. D., Paulo, J. A....> ;Molecular cell. 2019 Mar 9
• Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
  Saranna Fanning, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M. Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P.H. Ho, Tallie Noble, ...> ;Molecular Cell. 2019 Mar 7
• 22 citations
  Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.
  Prévost, C., Sharp, M. E., Kory, N., Lin, Q., Voth, G. A., Farese, R. V., Walther, T. C.> ;Developmental cell. 2018 Jan 10
• Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other...
  Mini P. Sajan, Barbara C. Hansen, Margaret Genevieve Higgs, C. Ron Kahn, Ursula Braun, Michael Leitges, Collin R. Park, David M. Diamond, Robert V. Farese> ;Neurobiology of Aging. 2018 Jan 1
• Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.
  Sajan, M. P., Lee, M. C., Foufelle, F., Sajan, J., Cleland, C., Farese, R. V.> ;Cellular signalling. 2017 Dec 23
• An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations
  Sharon J. Sha, Zachary A. Miller, Sang-Won Min, Yungui Zhou, Jesse A. Brown, Laura L. Mitic, Anna Karydas, Mary Koestler, Richard M. Tsai, Chiara Corbetta-Rastelli, S....> ;Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions. 2017 Nov 1
• 7 citations
  Lipid Droplet Biogenesis.
  Tobias C. Walther, Jeeyun Chung, Robert V. Farese> ;Annual Review of Cell and Developmental Biology. 2017 Oct 6
• 35 citations
  Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
  Chitraju, C., Mejhert, N., Haas, J. T., Diaz-Ramirez, L. G., Grueter, C. A., Imbriglio, J. E., Pinto, S., Koliwad, S. K., Walther, T. C., Farese, R. V.> ;Cell metabolism. 2017 Aug 3
• Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
  Nina L. Gluchowski, Chandramohan Chitraju, Joseph A. Picoraro, Niklas Mejhert, Shirly Pinto, Winnie Xin, Daniel Kamin, Harland S. Winter, Wendy K. Chung, Tobias C. Wal...> ;Journal of Lipid Research. 2017 Jun 1
• 4 citations
  Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
  Grietje Krabbe, S. Sakura Minami, Jon I. Etchegaray, Praveen Taneja, Biljana Djukic, Dimitrios Davalos, David Le, Iris Lo, Lihong Zhan, Meredith C. Reichert, Faten A. ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 May 9
• 72 citations
  Lipid droplets and liver disease: from basic biology to clinical implications
  Nina L. Gluchowski, Michel Becuwe, Tobias C. Walther, Robert V. Farese> ;Nature Reviews Gastroenterology &amp; Hepatology. 2017 Apr 21
• 4 citations
  Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
  Mauricio D. Dorfman, Jordan E Krull, Jarrad M. Scarlett, Stephan J. Guyenet, Mini P. Sajan, Vincent Damian, Hong T. Nguyen, Michael Leitges, Gregory J. Morton, Robert ...> ;Diabetes. 2017 Apr 1
• Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism
  Nora Kory, Susanne Grond, Siddhesh S. Kamat, Zhihuan Li, Natalie Krahmer, Chandramohan Chitraju, Ping Zhou, Florian Fröhlich, Ivana Semova, Christer S. Ejsing, Rudolf ...> ;Journal of Lipid Research. 2017 Jan 1
• 5 citations
  Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.
  Fröhlich, F., Olson, D. K., Christiano, R., Farese, R. V., Walther, T. C.> ;Proteomics. 2016 Nov 4
• 40 citations
  Seipin is required for converting nascent to mature lipid droplets.
  Huajin Wang, Michel Becuwe, Benjamin E. Housden, Chandramohan Chitraju, Ashley J. Porras, Morven Graham, Xinran Liu, Abdou Rachid Thiam, David B. Savage, Anil K. Agarw...> ;eLife. 2016 Aug 26
• 28 citations
  Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets
  Nora Kory, Robert V. Farese, Tobias C. Walther> ;Trends in Cell Biology. 2016 Jul 1
• Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice.
  Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hernández AI, Cottr...> ;Elife. 2016-05-17
• 7 citations
  Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.
  Hansen Lui, Jiasheng Zhang, Stefanie Ritter Makinson, Michelle K. Cahill, Kevin W. Kelley, Hsin Yi Huang, Yulei Shang, Michael C. Oldham, Lauren Herl Martens, Fuying G...> ;Cell. 2016 May 5
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Lectures

• Akt-dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/Propeller/FYVE Scaffold and Selectively Inhibited by Atypical PKC in High-Fat Fed and ob/... 
  Tampa, FL - 6/16/2014