RobertLouisFerrisMDPhD

Otolaryngology (ENT) • Pittsburgh, PA

Associate Professor of Otolaryngology, University Pittsburgh

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Office
200 Lothrop Street
Suite 211, Shadyside Medical Building
Pittsburgh, PA 15213
Phone+1 412-621-0123

Fax+1 412-621-1449
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Education & Training

Johns Hopkins UniversityResidency, Otolaryngology - Head and Neck Surgery, 1996 - 2001
Johns Hopkins University/Bayview Medical CenterInternship, Transitional Year, 1995 - 1996
Johns Hopkins University School of MedicineClass of 1995

Certifications & Licensure

PA State Medical License 2001 - 2024
MD State Medical License 1996 - 2002
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2011-2014
America's Top Doctors for Cancer Castle Connolly, 2010-2013
Fellow (FACS) American College of Surgeons
Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery
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Clinical Trials

Vaccine Therapy in Treating Patients With Head and Neck Cancer Start of enrollment: 2005 Sep 01
Completed
Phase 1
Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer Start of enrollment: 2007 Nov 01
Completed
Phase 2
Study of HF10 in Patients With Refractory Head and Neck Cancer or Solid Tumors With Cutaneous and/or Superficial Lesions Start of enrollment: 2009 Aug 01
Completed
Phase 1
ERBITUX® Followed by Adjuvant Treatment With Chemoradiation and ERBITUX® for Locally Advanced Head and Neck Squamous Cell Carcinoma Start of enrollment: 2011 Feb 01
Completed
Phase 2
A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®) and Intensity Modulated Radiotherapy (IMRT) With Ipilimumab (YERVOY®) in Locally Advanced Head and Neck Cancer Start of enrollment: 2013 Apr 01
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer Start of enrollment: 2014 Jan 22
Active, not recruiting
Phase 2
Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer Start of enrollment: 2013 Apr 09
Completed
Phase 1
SBRT With Cetuximab +/- Docetaxel Followed by Adjuvant Cetuximab +/- Docetaxel in Recurrent, Previously-Irradiated SCCHN Start of enrollment: 2013 Jul 03
Completed
Phase 2
Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA Start of enrollment: 2016 Sep 01
Withdrawn
Phase 1
Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer Start of enrollment: 2018 Nov 16
Active, not recruiting
Phase 2
HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma Start of enrollment: 2020 Jul 06
Recruiting
Phase 2
Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) Start of enrollment: 2022 Oct 06
Recruiting
Phase 3
Roles: Principal Investigator
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Publications & Presentations

PubMed

Over 132 Years Ago, the Inaugural Immunotherapy Treated Its First Head and Neck Cancer Patient.
Joey Martin, Stéphane Hans, Robin Baudouin, Robert L Ferris> ;Otolaryngology--Head and Neck Surgery. 2024 Apr 8
1 citations
Treatment package time < 14 weeks improves recurrence free and disease specific survival in HPV positive OPC with high-risk features.
Manasa Melachuri, Chareeni Kurukulasuriya, Purva Rumde, Terral Patel, Daniel Awad, Seungwon Kim, Robert Ferris, Shaum Sridharan, Umamaheswar Duvvuri> ;Oral Oncology. 2024 Apr 1
2 citations
Longitudinal Analysis of Caregiver Burden in Head and Neck Cancer.
Lauren D Kudrick, Khalil Baddour, Richard Wu, Mark Fadel, Vusala Snyder, Aakriti Neopaney, Teresa H Thomas, Lindsay M Sabik, Marci L Nilsen, Jonas T Johnson, Robert L ...> ;JAMA Otolaryngology-- Head & Neck Surgery. 2023 Aug 1
10 citations
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, rand...
Benjamin H Kann, Jirapat Likitlersuang, Dennis Bontempi, Zezhong Ye, Sanjay Aneja, Richard Bakst, Hillary R Kelly, Amy F Juliano, Sam Payabvash, Jeffrey P Guenette, Ra...> ;The Lancet. Digital Health. 2023 Jun 1
1 citations
The effect of opioids on the efficacy of immunotherapy in recurrent/metastatic squamous cell carcinoma of the head and neck.
Nicole N Scheff, Marci L Nilsen, Jinhong Li, Alexandria L Harris, Rajesh Acharya, Andrew Swartz, Ronan W Hsieh, Jennifer L Anderson, Robert L Ferris, Ashley V Menk, Gr...> ;Oral Oncology. 2023 May 1
Discharge Disposition After Head and Neck Reconstruction: Effect on Adjuvant Therapy and Outcomes.
Sophia Dang, Terral Patel, Isabella Lao, Shaum S Sridharan, Mario G Solari, Seungwon Kim, Umamaheswar Duvvuri, Robert Ferris, Mark Kubik> ;The Laryngoscope. 2023 Nov 1
35 citations
Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment.
Ayana T Ruffin, Housaiyin Li, Lazar Vujanovic, Dan P Zandberg, Robert L Ferris, Tullia C Bruno> ;Nature Reviews. Cancer. 2023 Mar 1
1 citations
Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit.
Marco A Mascarella, Tolani F Olonisakin, Purva Rumde, Varun Vendra, Melonie A Nance, Seungwon Kim, Mark W Kubik, Shaum S Sridharan, Robert L Ferris, Moon J Fenton, Dan...> ;Clinical Cancer Research. 2023 Feb 16
1 citations
Cetuximab Responses in Patients with HNSCC Correlate to Clonal Expansion Feature of Peripheral and Tumor-Infiltrating T Cells with Top T-Cell Receptor Clonotypes.
Huaibin Ge, Robert L Ferris, Jing H Wang> ;Clinical Cancer Research. 2023 Feb 1
2 citations
An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors.
Xueer Chen, Lujia Chen, Cornelius H L Kürten, Fattaneh Jabbari, Lazar Vujanovic, Ying Ding, Binfeng Lu, Kevin Lu, Aditi Kulkarni, Tracy Tabib, Robert Lafyatis, Gregory...> ;Plos Computational Biology. 2022 Dec 1
1 citations
A phase Ⅱ prospective trial of photobiomodulation therapy in limiting oral mucositis in the treatment of locally advanced head and neck cancer patients.
Janielle K-A Taylor, Leila J Mady, Khalil Baddour, Uzoma K Iheagwara, Shuyan Zhai, James P Ohr, Daniel P Zandberg, Vikram C Gorantla, Robert L Ferris, Seungwon Kim, Um...> ;World Journal of Otorhinolaryngology - Head and Neck Surgery. 2022 Dec 1
Identifying metastatic renal cell carcinoma in thyroid fine-needle aspirates by molecular testing.
Tanner Freeman, Charit Taneja, N Paul Ohori, Abigail I Wald, John Skaugen, Linwah Yip, Seungwon Kim, Robert L Ferris, Marina N Nikiforova, Somak Roy, Yuri E Nikiforov> ;Endocrine-Related Cancer. 2022 Dec 1
1 citations
Clinical Trial Development in TP53-Mutated Locally Advanced and Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma.
Cristina P Rodriguez, Hyunseok Kang, Jessica L Geiger, Barbara Burtness, Christine H Chung, Curtis R Pickering, Carole Fakhry, Quynh Thu Le, Sue S Yom, Thomas J Gallow...> ;Journal of the National Cancer Institute. 2022 Dec 8
9 citations
Neoadjuvant immunotherapy of locoregionally advanced solid tumors.
Ahmad A Tarhini, Jennifer R Eads, Kathleen N Moore, Valerie Tatard-Leitman, John Wright, Patrick M Forde, Robert L Ferris> ;Journal for Immunotherapy of Cancer. 2022 Aug 1
7 citations
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
Shilpa Bhatia, Diemmy Nguyen, Laurel B Darragh, Benjamin Van Court, Jaspreet Sharma, Michael W Knitz, Miles Piper, Sanjana Bukkapatnam, Jacob Gadwa, Thomas E Bickett, ...> ;Nature Communications. 2022 Jun 20
4 citations
Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults.
James Riddell 4th, Andrew F Brouwer, Heather M Walline, Lora P Campredon, Rafael Meza, Marisa C Eisenberg, Emily C Andrus, Rachel L Delinger, Monica L Yost, Jodi K McC...> ;Tumour Virus Research. 2022 Jun 1
4 citations
Definitive local therapy to head and neck squamous cell carcinoma with distant metastasis.
Steven Borson, Yongli Shuai, Barton F Branstetter, Marci Lee Nilsen, Marion A Hughes, Moon Fenton, Mark Kubik, Shaum Sridharan, David A Clump, Heath D Skinner, Jonas T...> ;Laryngoscope Investigative Otolaryngology. 2022 Jun 1
3 citations
A Multicenter Randomized Phase II Study of Single Agent Efficacy and Optimal Combination Sequence of Everolimus and Pasireotide LAR in Advanced Thyroid Cancer.
Julie E Bauman, Zhengjia Chen, Chao Zhang, James P Ohr, Robert L Ferris, Gerald M McGorisk, Stephen Brandt, Sumathi Srivatsa, Amy Y Chen, Conor E Steuer, Dong M Shin, ...> ;Cancers. 2022 May 26
2 citations
The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss.
Chloe S Lalonde, Yong Teng, Barbara A Burtness, Robert L Ferris, Rafi Ahmed, Nabil F Saba> ;Journal of the National Cancer Institute. 2022 Oct 6
7 citations
Poor treatment tolerance in head and neck cancer patients with low muscle mass.
Marco A Mascarella, Terral Patel, Varun Vendra, Lauren Gardiner, Marie-Jeanne Kergoat, Mark W Kubik, Mario G Solari, Carl H Snyderman, Katie S Traylor, Robert L Ferris...> ;Head & Neck. 2022 Apr 1
13 citations
Phase I Trial of Cetuximab, Radiotherapy, and Ipilimumab in Locally Advanced Head and Neck Cancer.
Robert L Ferris, Jessica Moskovitz, Sheryl Kunning, Ayana T Ruffin, Carly Reeder, James Ohr, William E Gooding, Seungwon Kim, Brian J Karlovits, Dario A A Vignali, Uma...> ;Clinical Cancer Research. 2022 Apr 1
17 citations
Long-term Outcomes with Nivolumab as First-line Treatment in Recurrent or Metastatic Head and Neck Cancer: Subgroup Analysis of CheckMate 141.
Maura L Gillison, George Blumenschein, Jerome Fayette, Joel Guigay, A Dimitrios Colevas, Lisa Licitra, Kevin J Harrington, Stefan Kasper, Everett E Vokes, Caroline Eve...> ;The Oncologist. 2022 Mar 4
6 citations
The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site.
Juncheng Wang, Yuxi Tian, Huimei Huang, Donghai Huang, Yong Liu, Yongquan Tian, Gangcai Zhu, Xin Zhang, Robert L Ferris> ;Oral Oncology. 2022 Feb 1
78 citations
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
Cornelius H L Kürten, Aditi Kulkarni, Anthony R Cillo, Patricia M Santos, Anna K Roble, Sayali Onkar, Carly Reeder, Stephan Lang, Xueer Chen, Umamaheswar Duvvuri, Seun...> ;Nature Communications. 2021 Dec 17
4 citations
Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma
Guilherme Rabinowits, Michael R. Migden, Todd E. Schlesinger, Robert L. Ferris, Morganna Freeman, Valerie Guild, Shlomo A. Koyfman, Anna C. Pavlick, Neil A. Swanson, G...> ;JID Innovations. 2021 Dec 1
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Journal Articles

P16 as a Prognostic Biomarker for Nonoropharyngeal Squamous Cell Cancers: Avatar or Mirage?
Robert Ferris, MD, Journal of the National Cancer Institute
Staged Reconstruction (Delayed-Immediate) of the Maxillectomy Defect Using CAD/CAM Technology
Matthew M Hanasono, Mario G Solari, Robert L Ferris, Sebastian Brooke, Mark W Kubik, Matilda Dhima, Journal of Reconstructive Microsurgery

Lectures

Head and Neck Cancers. Integrating Immunotherapy Into Clinical Practice: Changes Over the Past Year (Part 2)
2018 ASCO Annual Meeting - Chicago, Illinois - 05/31/2018

Press Mentions

UPMC ‘S Cancer Center to Expand Clinical ResearchFebruary 7th, 2023
‘Outstanding’ Outcomes: Reduced Postop Radiation in HPV, Oropharynx CancerJanuary 5th, 2022
A New Post-Surgery Approach for Treating HPV-Related Throat Cancer Uses Less Radiation Safely and Spares the Majority of Patients from ChemotherapyDecember 21st, 2021
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Grant Support

Immune Activation By Cetuximab In Head And Neck Cancer PatientsNational Institute Of Dental &Craniofacial Research2010–2011
Chemokine Signals In Head And Neck Cancer ProgressionNational Cancer Institute2006–2010
Direct Measurement Rates Synthesis Turnover T-Lymphocytes Head/Neck CancerNational Center For Research Resources2005