RobertJeffreyFreishtatMDMPH

PubMed

• Bacterial small RNAs may mediate immune response differences seen in respiratory syncytial virus versus rhinovirus bronchiolitis.
  Kylie I Krohmaly, Marcos Perez-Losada, Ignacio Ramos-Tapia, Zhaozhong Zhu, Kohei Hasegawa, Carlos A Camargo Jr, Brennan Harmon, Janice A Espinola, Laura Reck Cechinel,...> ;Frontiers in Immunology. 2024 Jan 1
• Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood, a discovery analysis.
  Kunte, P., Barberio, M., Tiwari, P., Sukla, K., Harmon, B., Epstein, S., Bhat, D., Goldberg, M., Rao, S., Damle, H., Yajnik, C., Authelet, K., Freishtat, R.> ;International Journal of Obesity. 2024 Mar 1
• Circulating Total Extracellular Vesicles Cargo Are Associated with Age-Related Oxidative Stress and Susceptibility to Cardiovascular Diseases: Exploratory Results from...
  Laura Reck Cechinel, Rachael Ann Batabyal, Giana Blume Corssac, Madeleine Goldberg, Brennan Harmon, Virgínia Mendes Russo Vallejos, Gisele E Bruch, André Ricardo Masse...> ;Biomedicines. 2023 Oct 28
• Immune profile of adipose tissue from youth with obesity and asthma.
  Anna Reichenbach, Wade O'Brien, Sarai Duran, Kayla J Authelet, Robert J Freishtat, Evan P Nadler, Rastogi, D., Deepa Rastogi> ;Pediatric Obesity. 2024 Jan 1
• Adipocyte-Derived Small Extracellular Vesicles from Patients with Alzheimer Disease Carry miRNAs Predicted to Target the CREB Signaling Pathway in Neurons.
  Rachael A Batabyal, Ankush Bansal, Laura Reck Cechinel, Kayla Authelet, Madeleine Goldberg, Evan Nadler, C Dirk Keene, Suman Jayadev, Kimiko Domoto-Reilly, Gail Li, El...> ;International Journal of Molecular Sciences. 2023 Sep 13
• 3 citations
  Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study.
  Zhaozhong Zhu, Yijun Li, Robert J Freishtat, Juan C Celedón, Janice A Espinola, Brennan Harmon, Andrea Hahn, Carlos A Camargo Jr, Liming Liang, Kohei Hasegawa> ;Nature Communications. 2023 Sep 7
• Nasopharyngeal fungal subtypes of infant bronchiolitis and disease severity risk.
  Ryohei Shibata, Zhaozhong Zhu, Michihito Kyo, Tadao Ooka, Robert J Freishtat, Jonathan M Mansbach, Marcos Pérez-Losada, Carlos A Camargo Jr, Kohei Hasegawa> ;Ebiomedicine. 2023 Sep 1
• Children with single ventricle heart disease have a greater increase in sRAGE after cardiopulmonary bypass.
  Bonnie A Brooks, Pranava Sinha, Steven J Staffa, Marni B Jacobs, Robert J Freishtat, Jason T Patregnani> ;Perfusion. 2023 Jul 19
• 5 citations
  Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: a multicentre prospective study.
  Zhaozhong Zhu, Robert J Freishtat, Brennan Harmon, Andrea Hahn, Stephen J Teach, Marcos Pérez-Losada, Kohei Hasegawa, Carlos A Camargo Jr> ;The European Respiratory Journal. 2023 Aug 1
• 4 citations
  Metabolic Contributions to Pathobiology of Asthma.
  Tamanna Roshan Lal, Laura Reck Cechinel, Robert Freishtat, Rastogi, D., Deepa Rastogi> ;Metabolites. 2023 Jan 31
• Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood.
  Pooja Kunte, Matthew Barbeno, Pradeep Tiwari, Krishna Sukla, Brennan Harmon, Samuel Epstein, Dattatray Bhat, Kayla Authelet, Madeleine Goldberg, Sudha Rao, Hemant Daml...> ;Research Square. 2023 Jan 31
• 1 citations
  Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with reductions in microbial richness and diversity in persons with cystic fibrosis.
  Andrea Hahn, Aszia Burrell, Hollis Chaney, Iman Sami, Anastassios C Koumbourlis, Robert J Freishtat, Keith A Crandall, Edith T Zemanick> ;Scientific Reports. 2023 Jan 21
• 1 citations
  Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma.
  Ryohei Shibata, Zhaozhong Zhu, Tadao Ooka, Robert J Freishtat, Jonathan M Mansbach, Marcos Pérez-Losada, Ignacio Ramos-Tapia, Stephen Teach, Carlos A Camargo Jr, Kohei...> ;Frontiers in Immunology. 2023 Jan 1
• 1 citations
  Potential involvement of circulating extracellular vesicles and particles on exercise effects in malignancies.
  Ionara Rodrigues Siqueira, Rachael A Batabyal, Robert Freishtat, Laura Reck Cechinel> ;Frontiers in Endocrinology. 2023 Jan 1
• Bioinformatic and experimental methods to identify and validate bacterial RNA-human RNA interactions.
  Kylie I Krohmaly, Robert J Freishtat, Andrea L Hahn> ;Journal of Investigative Medicine. 2023 Jan 1
• 10 citations
  Nasopharyngeal lipidomic endotypes of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study.
  Michimasa Fujiogi, Zhaozhong Zhu, Yoshihiko Raita, Tadao Ooka, Juan C Celedon, Robert Freishtat, Carlos A Camargo, Kohei Hasegawa> ;Thorax. 2022 Nov 1
• 1 citations
  Dichotomous role of integrin-β5 in lung endothelial cells.
  Neil Blanchard, Patrick A Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D Cool, Rebecca L Heise, Robert ...> ;Pulmonary Circulation. 2022 Oct 1
• 2 citations
  Impact of Antibiotics on the Lung Microbiome and Lung Function in Children With Cystic Fibrosis 1 Year After Hospitalization for an Initial Pulmonary Exacerbation.
  Zaina Inam, Erin Felton, Aszia Burrell, Hollis Chaney, Iman Sami, Anastassios C Koumbourlis, Robert J Freishtat, Edith T Zemanick, Keith A Crandall, Andrea Hahn> ;Open Forum Infectious Diseases. 2022 Sep 1
• 9 citations
  Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity.
  Michimasa Fujiogi, Yoshihiko Raita, Marcos Pérez-Losada, Robert J Freishtat, Juan C Celedón, Jonathan M Mansbach, Pedro A Piedra, Zhaozhong Zhu, Carlos A Camargo Jr, K...> ;Nature Communications. 2022 Aug 30
• 4 citations
  Association of Nasopharyngeal and Serum Glutathione Metabolism with Bronchiolitis Severity and Asthma Risk: A Prospective Multicenter Cohort Study.
  Michihito Kyo, Zhaozhong Zhu, Makiko Nanishi, Ryohei Shibata, Tadao Ooka, Robert J Freishtat, Jonathan M Mansbach, Carlos A Camargo Jr, Kohei Hasegawa> ;Metabolites. 2022 Jul 22
• 2 citations
  Serum periostin among infants with severe bronchiolitis and risk of developing asthma: A prospective multicenter cohort study.
  Makiko Nanishi, Michimasa Fujiogi, Robert J Freishtat, Claire E Hoptay, Cindy S Bauer, Michelle D Stevenson, Carlos A Camargo Jr, Kohei Hasegawa> ;Allergy. 2022 Jul 1
• 15 citations
  Nasopharyngeal metatranscriptome profiles of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study.
  Yoshihiko Raita, Marcos Pérez-Losada, Robert J Freishtat, Andrea Hahn, Eduardo Castro-Nallar, Ignacio Ramos-Tapia, Nathaniel Stearrett, Yury A Bochkov, James E Gern, J...> ;The European Respiratory Journal. 2022 Jul 1
• 12 citations
  Proteomics endotyping of infants with severe bronchiolitis and risk of childhood asthma.
  Tadao Ooka, Yoshihiko Raita, Michimasa Fujiogi, Robert J Freishtat, Robert E Gerszten, Jonathan M Mansbach, Zhaozhong Zhu, Carlos A Camargo Jr, Kohei Hasegawa> ;Allergy. 2022 Nov 1
• 8 citations
  Air pollution, bronchiolitis, and asthma: the role of nasal microRNAs.
  Heidi Makrinioti, Carlos A Camargo, Zhaozhong Zhu, Robert J Freishtat, Kohei Hasegawa> ;The Lancet. Respiratory Medicine. 2022 Aug 1
• 15 citations
  Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study.
  Zhaozhong Zhu, Carlos A Camargo Jr, Yoshihiko Raita, Robert J Freishtat, Michimasa Fujiogi, Andrea Hahn, Jonathan M Mansbach, Jonathan M Spergel, Marcos Pérez-Losada, ...> ;The Journal of Allergy and Clinical Immunology. 2022 Oct 1
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Journal Articles

• Changes in Microbiome Diversity Following Beta-Lactam Antibiotic Treatment Are Associated with Therapeutic Versus Subtherapeutic Antibiotic Exposure in Cystic Fibrosis  
  Geovanny F Perez, Anastassios C Koumbourlis, Andrea Hahn, Robert J Freishtat, Edith T Zemanick, Hollis Chaney, Nature
• Episodic stridor with latex nipple use in a two-month-old  
  Freishtat RJ, Goepp JGK, Pediatrics: Food Allergy, Gastroenterology and Nutrition, 1/1/2003
• Issues in Children's Hospital Disaster Preparedness  
  Freishtat RJ, Wright JL, Holbrook PR, Clinical Pediatric Emergency Medicine, 1/1/2002

Books/Book Chapters

• The Pediatric Clinical Advisor 
  Chapter: Insect Stings. 
  Freishtat RJEditors: Garfunkel LC, et al..Mosby, St. Louis2002
• The Pediatric Clinical Advisor 
  Chapter: Spider Bites. 
  Freishtat RJEditors: Garfunkel LC, et al..Mosby, St. Louis2002
• The Pediatric Clinical Advisor 
  Chapter: Marine Stings. 
  Freishtat RJEditors: Garfunkel LC, et al..Mosby, St. Louis2002
• The Pediatric Clinical Advisor 
  Chapter: Animal Bites. 
  Freishtat RJEditors: Garfunkel LC, et al..Mosby, St. Louis2002
• The Pediatric Clinical Advisor 
  Chapter: Snake Bites. 
  Freishtat RJEditors: Garfunkel LC, et al..Mosby, St. Louis2002
• The Pediatric Clinical Advisor 
  Chapter: Scorpion Stings. 
  Freishtat RJEditors: Garfunkel LC, et al..Mosby, St. Louis2002
• Procedures for Primary Care Pediatricians 
  Chapter: Emergency Procedures. 
  Freishtat RJ, Volk G, Maffei FAEditors: Goepp JG, Hostetler M.Mosby, St. Louis2000
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Abstracts/Posters

• Regenerative Asynchrony Is A Driver In Chronic Inflammation In Aging.
  Hoptay CE, Alcala SE, Mubeen H, Reynolds SD, Hoffman E, Freishtat RJ, American Thoracic Society International Conference, San Diego, CA, 5/20/2014
• Adipocyte Exosomal miRNA Regulate A549 Lung Epithelial Cell Gene Expression in a Dose-Dependent Manner.
  Pillai DK, Wang J, Ferrante SC, Mubeen H, El-Magbri E, Koeck E, Wiles A, Wang Z, Sevilla S, Nadler E, Hubal M, Freishtat RJ, American Thoracic Society International Conference, San Diego, CA, 5/20/2014
• Vitamin D And Glucocorticoids Interact To Reduce Ubiquitin C In Asthmatic Epithelium.
  Mansell DM, Iqbal S, Teach SJ, Camargo CA, Wang Z, Pillai DK, Gordish-Dressman H, Maltz L, Wiles A, Payne AS, Prosper D, Nwachukwu F, Tsegaye Y, Certner N, Lazaroff R,..., American Thoracic Society International Conference, San Diego, CA, 5/20/2014
• Regenerative Asynchrony As A Driver In Chronic Inflammation: Mitotic Asynchrony Induces A Pro-Inflammatory State In Airway Epithelium.
  Alcala SE, Benton A, Watson AM, Kureshi S, Reeves E, Damsker J, Wang Z, Kanneboyina N, Anderson J, Williams A, Lee A, Hayes K, Rose M, Hoffman E, Freishtat RJ, American Thoracic Society International Conference, San Diego, CA, 5/20/2014
• Rhinovirus Infection In Early Childhood Is Associated With Elevated Airway Thymic Stromal Lymphopoetin Levels And A Th2 Bias An Airway Immune Response.
  Perez GF, Pancham K, Huseni S, Preciado D, Hoffman EP, Freishtat RJ, Rose MC, Colberg-Poley A, Nino G, American Thoracic Society International Conference, San Diego, CA, 5/19/2014
• Evidence For Epithelial-Mesenchymal Cross Talk: Asthmatic Airway Epithelium Promotes Fibroproliferation And Airway Remodeling In Vivo.
  Ferrante SC, Hackett T-L, Shaheen F, Alcala SE, Engelhardt J, Hoptay CE, Pillai DK, Rose M, Freishtat RJ, American Thoracic Society International Conference, San Diego, CA, 5/18/2014
• Regenerative Asynchrony Is A Driver In Chronic Inflammation In Aging.
  Hoptay CE, Alcala SE, Mubeen H, Reynolds SD, Hoffman E, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2014
• Adipocyte Exosomal miRNA Regulate A549 Lung Epithelial Cell Gene Expression in a Dose-Dependent Manner.
  Pillai DK, Wang J, Ferrante SC, Mubeen H, El-Magbri E, Koeck E, Wiles A, Wang Z, Sevilla S, Nadler E, Hubal M, Freishtat R, Am J Respir Crit Care Med, 1/1/2014
• Vitamin D And Glucocorticoids Interact To Reduce Ubiquitin C In Asthmatic Epithelium.
  Mansell DM, Iqbal S, Teach SJ, Camargo CA, Wang Z, Pillai DK, Gordish-Dressman H, Maltz L, Wiles A, Payne AS, Prosper D, Nwachukwu F, Tsegaye Y, Certner N, Lazaroff R,..., Am J Respir Crit Care Med, 1/1/2014
• Rhinovirus Infection In Early Childhood Is Associated With Elevated Airway Thymic Stromal Lymphopoetin Levels And A Th2 Bias An Airway Immune Response.
  Perez GF, Pancham K, Huseni S, Preciado D, Hoffman EP, Freishtat RJ, Rose MC, Colberg-Poley A, Nino G, Am J Respir Crit Care Med, 1/1/2014
• Larger Neck Circumference Is Associated With Poor Asthma Control In Obese Youth.
  Maltz LA, Behniwal SK, Gordish-Dressman H, Marwah R, Certner N, Mansell DM, Pillai DK, Lazaroff R, Tsegaye Y, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2014
• Evidence For Epithelial-Mesenchymal Cross Talk: Asthmatic Airway Epithelium Promotes Fibroproliferation And Airway Remodeling In Vivo.
  Ferrante SC, Hackett T-L, Shaheen F, Alcala SE, Engelhardt J, Hoptay CE, Pillai DK, Rose M, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2014
• Regenerative Asynchrony As A Driver In Chronic Inflammation: Mitotic Asynchrony Induces A Pro-Inflammatory State In Airway Epithelium.
  Alcala SE, Benton A, Watson AM, Kureshi S, Reeves E, Damsker J, Wang Z, Kanneboyina N, Anderson J, Williams A, Lee A, Hayes K, Rose M, Hoffman E, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2014
• Adipocyte Exosomal miRNAs May Mediate the Effects of Obesity on Lung Disease.
  Ferrante SC, Nadler E, Wang Z, Hubal M, Pillai DK, Sevilla S, Wiles A, Koeck E, Williams AM, Anderson J, Freishtat RJ, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Aging Is Sufficient To Induce Progenitor Cell Mitotic Dyssynchrony.
  Hoptay CE, Alcala SE, Mubeen H, Wiles AA, Williams AM, Anderson J, Margolis J, Hoffman EP, Freishtat RJ, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Estrogen and Transforming Growth Factor Beta-1 Increase Fibronectin mRNA and Protein Expression in Asthmatic Epithelium.
  Payne AS, Mubeen H, Nagaraju K, Freishtat RJ, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Hypoxia and Re-Oxygenation Do Not Modulate Bronchial Epithelial Cell Cycle Gene Expression.
  Ibla JC, Su Y, Freishtat RJ, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Identifying Risk Factors and Their Interactions for Reduced Lung Function in Pediatric Asthma, A Bayesian Network Analysis.
  Fu L, Freishtat RJ, Teach SJ, Resca L, Hoffman EP, Wang Z, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Mitotic Dyssynchrony Induces TGFB1 Secretion In Airway Epithelial Progenitor Cells.
  Alcala SE, Benton AS, Watson AM, Kureshi S, Reeves E, Damsker J, Wang Z, Anderson J, Williams A, Lee A, Hayes K, Nagaraju K, Rose MC, Hoffman EP, Freishtat, RJ, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Modeling Asthmatic Airway Epithelial Mitotic Dyssynchrony In Vivo and Its Role in Airway Remodeling.
  Ferrante SC, Hackett TL, Alcala SE, Engelhardt J, Pillai DK, Shaheen F, Wiles AA, Gross R, Rose MC, Freishtat RJ, American Thoracic Society International Conference, Philadelphia, PA, 5/19/2013
• Adipocyte Exosomal miRNAs May Mediate the Effects of Obesity on Lung Disease.
  Ferrante SC, Nadler E, Wang Z, Hubal M, Pillai DK, Sevilla S, Wiles A, Koeck E, Williams AM, Anderson J, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2013
• Aging Is Sufficient To Induce Progenitor Cell Mitotic Dyssynchrony.
  Hoptay CE, Alcala SE, Mubeen H, Wiles AA, Williams AM, Anderson J, Margolis J, Hoffman EP, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2013
• Estrogen and Transforming Growth Factor Beta-1 Increase Fibronectin mRNA and Protein Expression in Asthmatic Epithelium.
  Payne AS, Mubeen H, Nagaraju K, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2013
• Hypoxia and Re-Oxygenation Do Not Modulate Bronchial Epithelial Cell Cycle Gene Expression.
  Ibla JC, Su Y, Freishtat RJ, Am J Respir Crit Care Med, 1/1/2013
• Identifying Risk Factors and Their Interactions for Reduced Lung Function in Pediatric Asthma, A Bayesian Network Analysis.
  Fu L, Freishtat RJ, Teach SJ, Resca L, Hoffman EP, Wang Z, Am J Respir Crit Care Med, 1/1/2013
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Lectures

• Larger Neck Circumference Is Associated With Poor Asthma Control In Obese Youth. 
  San Diego, CA - 5/21/2014
• "Serendipity in Science: Lung." 
  Washington, DC - 4/17/2014
• "Grantsmanship for NIH Early Stage Investigators Short Course." 
  Washington, DC - 4/17/2013
• Grand Rounds: "Lessons from Bridges: Toward Reengineering the Approach to Asthma." 
  Comprehensive Pneumology Center, Ludwig-Maximillian University, Munich, Germany - 1/16/2013
• "Lessons from Bridges: Toward Reengineering the Approach to Asthma." Keynote Address 
  12/5/2012
• Lessons from Bridges: Toward Reengineering the Approach to Asthma. 
  National Jewish Health, Denver, CO - 10/5/2012
• "Asthma Platform Session" Moderator 
  Boston, MA - 4/28/2012
• Lessons from Bridges: Toward Re-engineering Asthmatic Airways. 
  Center for Childhood Asthma in the Urban Environment, Johns Hopkins University Schools of Medicine a - 4/19/2012
• "Emergency Medicine Platform Session" Moderator 
  Denver, CO - 4/30/2011
• Systems biology of steroid hormones in asthma. 
  Washington, DC - 4/12/2011
• Asthmatic bronchial epithelium is intrinsically inflammogenic, mitotically dyssynchronous, and is rescued by glucocorticoids. 
  Graz, Austria - 4/2/2011
• Steroid hormones in asthma: Towards an integrative multi-scale systems biology approach. 
  Aspen, CO - 6/10/2010
• Asthmatic airway epithelium is intrinsically inflammatory and mitotically dyssynchronous. 
  New Orleans, LA - 5/17/2010
• A systems biology approach to the asthma epidemic. 
  Washington, DC - 3/17/2010
• Systems biology investigations of glucocorticoid efficacy in tissue remodeling. 
  New Orleans, LA - 4/22/2009
• Professorial Rounds: "Translational Research" 
  Children's National Medical Center - 2/12/2009
• "NIH Grant Training Seminar" 
  MD Anderson Cancer Center - 11/22/2008
• A TIMP-1-nucleated network is critical for the bronchial epithelial response to tobacco smoke in asthma. 
  Aspen, CO - 6/5/2008
• Data integration of mRNA expression profiles as an approach for dissecting asthma pathogenesis. 
  Toronto, ON, Canada - 5/17/2008
• Platelets as cytotoxic mediators in sepsis: Platelet granzyme B induces lymphocyte apoptosis. 
  Honolulu, HI - 5/3/2008
• Professorial Rounds: "Sepsis" 
  Children's National Medical Center - 4/14/2008
• "New Frontiers in Asthma Management." 
  Washington, DC - 5/18/2007
• "Intensive Grantsmanship Workshop" 
  5/15/2007
• Platelets and megakaryocytes show correlated up-regulation of granzymes in early sepsis. 
  San Francisco, CA - 5/2/2006
• "Developing, Sustaining, and Surviving Mentoring Relationships: An Interactive Workshop for Mentees and Mentors." 
  4/29/2006
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Other

• "Adjunctive Therapies for Emergency Management of Acute Asthma." Invited Lecturer 
  Freishtat RJ, Invited Lecturer
  http://www.aap.org