RobertJohnGroplerMD

Radiology • Creve Coeur, MO

Cardiac CT & MRI, Nuclear Cardiology, Nuclear Medicine

Professor, Radiology, Washington University School of Medicine

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Office
12634 Olive Blvd
Creve Coeur, MO 63141
Phone+1 314-362-7092

Fax+1 314-362-4189
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Education & Training

Loyola University Medical CenterFellowship, Cardiovascular Disease, 1985 - 1988
McGaw Medical Center of Northwestern UniversityResidency, Internal Medicine, 1981 - 1984
University of Cincinnati College of MedicineClass of 1981

Certifications & Licensure

MO State Medical License 1987 - 2025
IL State Medical License 1981 - 1990
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology

Clinical Trials

Quantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy Start of enrollment: 2005 Aug 01
Completed
Not Applicable
Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults Start of enrollment: 2003 Jun 01
Completed
Not Applicable
Effects of Fatty Acid Delivery on Heart Metabolism and Function in Type 2 Diabetes (T2DM Start of enrollment: 2003 Oct 01
Completed
Not Applicable
Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling Start of enrollment: 2005 Sep 01
Completed
Not Applicable
Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function Start of enrollment: 2005 Oct 01
Unknown status
Not Applicable
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease Start of enrollment: 2010 Jul 01
Completed
Early Phase 1
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. Start of enrollment: 2009 Sep 01
Completed
Early Phase 1
A Phase 3 Multi-center Study to Assess PET Imaging of Flurpiridaz F 18 Injection in Patients With CAD. Start of enrollment: 2011 Jun 01
Completed
Phase 3
F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow Start of enrollment: 2018 Oct 16
Suspended
Early Phase 1
PET Detection of CCR2 in Human Atherosclerosis Start of enrollment: 2020 Oct 01
Recruiting
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.
Xiuli Zhang, Gyu Seong Heo, Alexandria Li, Divangana Lahad, Lisa Detering, Joan Tao, Xuefeng Gao, Xiaohui Zhang, Hannah Luehmann, Deborah Sultan, Lanlan Lou, Rajiu Ven...> ;Journal of Nuclear Medicine. 2024 Mar 28
In This Issue of the Journal.
Ruberg, F., Gropler, R.> ;Circulation. Cardiovascular Imaging. 2024 Feb 1
Toward Quantitative Multisite Preclinical Imaging Studies in Acute Myocardial Infarction: Evaluation of the Immune-Fibrosis Axis.
Strunk, M., Heo, G., Hess, A., Luehmann, H., Ross, T., Bengel, F., Liu, Y., Thackeray, J., Gropler, R.> ;Journal of Nuclear Medicine. 2024 Feb 1
1 citations
Rationale and design of the RAPID-WATER-FLOW trial: Radiolabeled perfusion to identify coronary artery disease using water to evaluate responses of myocardial FLOW.
Di Carli, M., Gormsen, L., Chareonthaitawee, P., Johnson, G., Beanlands, R., DeKemp, R., Schindler, T., Gropler, R., Kulkarni, H., McNeely, P., Soman, P., Oz, O., Zaha...> ;Journal of Nuclear Cardiology. 2024 Jan 1
Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System.
Hao Jiang, Charles Zhou, Lin Qiu, Robert J Gropler, Matthew R Brier, Gregory F Wu, Anne H Cross, Joel S Perlmutter, Tammie L S Benzinger, Zhude Tu> ;ACS Chemical Neuroscience. 2023 Nov 15
1 citations
Correction to: ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures.
Vasken Dilsizian, Stephen L Bacharach, Rob S Beanlands, Steven R Bergmann, Dominique Delbeke, Sharmila Dorbala, Robert J Gropler, Juhani Knuuti, Heinrich R Schelbert, ...> ;Journal of Nuclear Cardiology. 2023 Oct 1
Characterization of a S1PR2 specificC-labeled radiotracer in streptozotocin-induced diabetic murine model.
Hao Jiang, Tianyu Huang, Yanbo Yu, Charles Zhou, Lin Qiu, Hien Ngoc Mai, Robert J Gropler, Robyn S Klein, Zhude Tu> ;Nuclear Medicine and Biology. 2023 Jul 26
2 citations
Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models.
Alexander Maier, Yohana C Toner, Jazz Munitz, Nathaniel A T Sullivan, Ken Sakurai, Anu E Meerwaldt, Eliane E S Brechbühl, Geoffrey Prévot, Yuri van Elsas, Rianne J F M...> ;JACC. Basic to Translational Science. 2023 Jul 1
4 citations
Need for objective task-based evaluation of deep learning-based denoising methods: A study in the context of myocardial perfusion SPECT.
Zitong Yu, Md Ashequr Rahman, Richard Laforest, Thomas H Schindler, Robert J Gropler, Richard L Wahl, Barry A Siegel, Abhinav K Jha> ;Medical Physics. 2023 Jul 1
2 citations
Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain.
Lin Qiu, Hao Jiang, Charles Zhou, Jinzhi Wang, Yanbo Yu, Haiyang Zhao, Tianyu Huang, Robert Gropler, Joel S Perlmutter, Tammie L S Benzinger, Zhude Tu> ;Journal of Medicinal Chemistry. 2023 Apr 13
The United States Department of Energy and National Institutes of Health Collaboration: Medical Care Advances via Discovery in Physical Sciences.
Cynthia Keppel, Andrew Weisenberger, Tatjana Atanasijevic, Shumin Wang, George Zubal, Jeffrey Buchsbaum, Martin Brechbiel, Jacek Capala, Freddy Escorcia, Ceferino Obce...> ;Medical Physics. 2023 Mar 1
22 citations
Myocardial Perfusion PET for the Detection and Reporting of Coronary Microvascular Dysfunction: A JACC: Cardiovascular Imaging Expert Panel Statement.
Thomas H Schindler, William F Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D Ruddy, Krishna K Patel, Deepak L Bhatt, Timothy M Batema...> ;JACC. Cardiovascular Imaging. 2023 Apr 1
SNMMI/ACR/ASNC/SCMR Joint Credentialing Statement for Cardiac PET/MRI: Endorsed by the American Heart Association.
Terrence D Ruddy, Mouaz Al-Mallah, James A Arrighi, John P Bois, David A Bluemke, Marcelo F Di Carli, Vasken Dilsizian, Robert J Gropler, Hossein Jadvar, Saurabh Malho...> ;Journal of Nuclear Medicine. 2023 Jan 1
4 citations
Phase 1 Evaluation ofC-CS1P1 to Assess Safety and Dosimetry in Human Participants.
Matthew R Brier, Mahdjoub Hamdi, Jayashree Rajamanikam, Haiyang Zhao, Syahir Mansor, Lynne A Jones, Farzaneh Rahmani, Saurabh Jindal, Deborah Koudelis, Joel S Perlmutt...> ;Journal of Nuclear Medicine. 2022 Nov 1
6 citations
Post COVID-19 syndrome with impairment of flow-mediated epicardial vasodilation and flow reserve.
Amanda Verma, Tarun Ramayya, Anand Upadhyaya, Ines Valenta, Maureen Lyons, Jonas Marschall, Farrokh Dehdashti, Robert J Gropler, Pamela K Woodard, Thomas Hellmut Schin...> ;European Journal of Clinical Investigation. 2022 Dec 1
SNMMI/ACR/ASNC/SCMR Joint Credentialing Statement for Cardiac PET/MRI: Endorsed by the American Heart Association.
Terrence D Ruddy, Mouaz Al-Mallah, James A Arrighi, John P Bois, David A Bluemke, Marcelo F Di Carli, Vasken Dilsizian, Robert J Gropler, Hossein Jadvar, Saurabh Malho...> ;Circulation. Cardiovascular Imaging. 2022 Aug 1
1 citations
SNMMI/ACR/ASNC/SCMR joint credentialing statement for cardiac PET/MRI.
Terrence D Ruddy, Mouaz Al-Mallah, James A Arrighi, John P Bois, David A Bluemke, Marcelo F Di Carli, Vasken Dilsizian, Robert J Gropler, Hossein Jadvar, Saurabh Malho...> ;Journal of Cardiovascular Magnetic Resonance. 2022 Jul 19
In This Issue of the Journal.
Robert J Gropler> ;Circulation. Cardiovascular Imaging. 2022 Jul 1
In This Issue of the Journal.
Robert J Gropler> ;Circulation. Cardiovascular imaging. 2022 Jul 1
6 citations
Increased plasma fatty acid clearance, not fatty acid concentration, is associated with muscle insulin resistance in people with obesity.
Chao Cao, Han-Chow E Koh, Stephan Van Vliet, Bruce W Patterson, Dominic N Reeds, Richard Laforest, Robert J Gropler, Bettina Mittendorfer> ;Metabolism. 2022 Jul 1
8 citations
Coronary circulatory function with increasing obesity: A complex U-turn.
Anand Upadhyaya, Anita Bhandiwad, Jordan Lang, Justin S Sadhu, Chadwick Barrs, Sudhir Jain, David L Brown, Linda R Peterson, Farrokh Dehdashti, Robert J Gropler, Thoma...> ;European Journal of Clinical Investigation. 2022 Jun 1
In This Issue of the Journal.
Robert J Gropler> ;Circulation. Cardiovascular imaging. 2022 May 1
In This Issue of the Journal.
Robert J Gropler> ;Circulation. Cardiovascular Imaging. 2022 Apr 1
In This Issue of the Journal.
Robert J Gropler> ;Circulation. Cardiovascular Imaging. 2022 Mar 1
2 citations
Effect of obstructive sleep apnea on glucose metabolism.
Han-Chow E Koh, Stephan van Vliet, Chao Cao, Bruce W Patterson, Dominic N Reeds, Richard Laforest, Robert J Gropler, Yo-El S Ju, Bettina Mittendorfer> ;European Journal of Endocrinology. 2022 Feb 23
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Lectures

Young Investigator Awards: Clinical Investigations
2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019

Press Mentions

Abstracts of Original Contributions ASNC2019 the 24th Annual Scientific Session of the American Society of Nuclear CardiologyJune 10th, 2020
$5.1 Million to Target Silent Cause of Heart Attacks, StrokesApril 30th, 2019
Missouri University Awarded $6.3M to Develop Novel PET TracersDecember 12th, 2018
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Grant Support

PET Imaging Of Myocardial Oxidative Stress In T2dmNational Institute Of Biomedical Imaging And Bioengineering2010–2012
Cyclotron Produced Isotopes In Biology And MedicineNational Heart, Lung, And Blood Institute2007–2008
Human StudiesNational Heart, Lung, And Blood Institute2004–2008
Effect Of A Ppar-A Agonist On The Age Related Changes In Myocardial MetabolismNational Center For Research Resources2007
Impact Of Aging On The Myocardial Metabolic RelationNational Center For Research Resources2006–2007
Cyclotron Produced Isotopes In Biology And Medicine-Project 3National Center For Research Resources2005–2007
PET ObesityNational Center For Research Resources2004–2007
PET Detection Of The Effects Of Aging On The Human HeartNational Institute On Aging1998–2007
PET Detection Of The Effects Of Aging On The Human Heart;Aim 2National Center For Research Resources2006
PET Detection Of The Effects Of Aging On The Human Heart;Aim 1National Center For Research Resources2006
Altered Myocardial Fatty Acid Metabolism In ObesityNational Heart, Lung, And Blood Institute2003–2006
PET Quantification Of Myocardial Substrate MetabolismNational Heart, Lung, And Blood Institute2002–2006
PET Detection Of The Effects Of Aging On The Human Heart.National Center For Research Resources2004
PET Detection Of The Diabetic HeartNational Center For Research Resources2000–2004
PET Detection Of The Diabetic Heart--Measurement Of Blood FlowNational Center For Research Resources2000–2002
PET Detection Of The Diabetic HeartNational Heart, Lung, And Blood Institute1998–2002
Prospective Investigation Of Pulmonary Embolism Dx-IiNational Heart, Lung, And Blood Institute2001
PET Derived Estimates Of Efficiency Of Human MyocardiumNational Heart, Lung, And Blood Institute1995–1998
Metabolic Predictors Of Viable MyocardiumNational Heart, Lung, And Blood Institute1996–1997