RobertMarkJacksonMD

PubMed

• 8 citations
  Activity of the growth hormone-releasing hormone antagonist MIA602 and its underlying mechanisms of action in sarcoidosis-like granuloma.
  Chongxu Zhang, Runxia Tian, Emilee M Dreifus, Abdolrazagh Hashemi Shahraki, Gregory E. Holt, Renzhi Cai, Anthony J. Griswold, Pablo A. Bejarano, Robert M. Jackson, And...> ;Clinical & Translational Immunology. 2021 Jan 1
• 15 citations
  Growth Hormone-Releasing Hormone in Lung Physiology and Pulmonary Disease.
  Chongxu Zhang, Tengjiao Cui, Renzhi Cai, Medhi Wangpaichitr, Mehdi Mirsaeidi, Andrew V. Schally, Robert M. Jackson> ;Cells. 2020 Oct 21
• 20 citations
  Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model.
  Chongxu Zhang, Stephanie Chery, Aaron Lazerson, Norman H. Altman, Robert M. Jackson, Greg Holt, Michael Campos, Andrew V. Schally, Mehdi Mirsaeidi> ;Scientific Reports. 2020 Apr 29
• 6 citations
  Effects of 100 % oxygen during exercise in patients with interstitial lung disease
  Jeffry Cournoyer, Carol F. Ramos, Brian Sturgill, Fei Tang, Nicole DeLuca, Mehdi Mirsaeidi, Robert M. Jackson> ;Respiratory Physiology & Neurobiology. 2020 Jan 3
• 28 citations
  Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin
  Chongxu Zhang, Renzhi Cai, Aaron Lazerson, Gaëtan J.-R. Delcroix, Medhi Wangpaichitr, Mehdi Mirsaeidi, Anthony J. Griswold, Andrew V. Schally, Robert M. Jackson> ;Lung. 2019 Aug 7
• 24 citations
  Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis
  Jayanta Kumar Das, Quentin Felty, Robert J. Poppiti, Robert M. Jackson, Deodutta Roy> ;Cells. 2018 Nov 27
• 34 citations
  Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells
  Victor Okoh, N A Garba, R B Penney, Jayanta Kumar Das, Alok Deoraj, Kamaleshwar P. Singh, Shubhashish Sarkar, Quentin Felty, Changwon Yoo, Robert M. Jackson, Deodutta Roy> ;British Journal of Cancer. 2015 May 12
• 61 citations
  Physical Activity and Quality of Life Improvements of Patients With Idiopathic Pulmonary Fibrosis Completing a Pulmonary Rehabilitation Program
  Ignacio Gaunaurd, Orlando Gomez-Marin, Carol F. Ramos, Constanza M Sol, Meryl Cohen, Lawrence P. Cahalin, Diana D. Cardenas, Robert M. Jackson> ;Respiratory Care. 2014 Dec 1
• 58 citations
  Exercise Limitation in IPF Patients: A Randomized Trial of Pulmonary Rehabilitation
  Robert M. Jackson, Orlando Gomez-Marin, Carol F. Ramos, Constanza M Sol, Meryl Cohen, Ignacio Gaunaurd, Lawrence P. Cahalin, Diana D. Cardenas> ;Lung. 2014 Apr 5
• 21 citations
  Exercise decreases plasma antioxidant capacity and increases urinary isoprostanes of IPF patients.
  Robert M. Jackson, Carol F. Ramos, C. Gupta, Orlando Gomez-Marin> ;Respiratory Medicine. 2010 Dec 1
• 58 citations
  Sildenafil therapy and exercise tolerance in idiopathic pulmonary fibrosis.
  Robert M. Jackson, Marilyn K. Glassberg, Carol F. Ramos, Pablo A. Bejarano, Ghazwan Butrous, Orlando Gomez-Marin> ;Lung. 2010 Apr 1
• 6 citations
  Hypoxia and kinase activity regulate lung epithelial cell glutathione.
  Robert M. Jackson, Chhavi Gupta> ;Experimental Lung Research. 2010 Feb 3
• 7 citations
  Etanercept for idiopathic pulmonary fibrosis: lessons on clinical trial design.
  Robert M. Jackson, Charlene D. Fell> ;American Journal of Respiratory and Critical Care Medicine. 2008 Nov 1
• 9 citations
  Kinase activity, heat shock protein 27 phosphorylation, and lung epithelial cell glutathione.
  Robert M. Jackson, Rolando Garcia-Rojas> ;Experimental Lung Research. 2008 Jun 1
• 23 citations
  A critical assessment of treatment options for idiopathic pulmonary fibrosis.
  Nirav R. Shah, Paul W. Noble, Robert M. Jackson, Talmadge E. King, Steven D. Nathan, Maria Padilla, Ganesh Raghu, Melissa Bruce Rhodes, Marvin I. Schwarz, Gregory Tino...> ;Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 2005 Oct 1
• 1 citations
  EFFECTS OF INTRATRACHEAL TUMOR NECROSIS FACTOR-ALPHA PLASMID VECTOR ON LIPOPOLYSACCHARIDE LETHALITY AND LUNG INJURY IN MICE
  Marcienne M. Wright, Charles Stephenson Powell, Robert M. Jackson> ;Experimental Lung Research. 2004 Dec 1
• 17 citations
  p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia.
  Charles S. Powell, Marcienne M. Wright, Robert M. Jackson> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2004 Apr 1
• 96 citations
  Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD.
  Charles S. Powell, Robert M. Jackson> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2003 Jul 1
• 142 citations
  Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases.
  Stephan Baldus, J. P. Eiserich, Marie Luise Brennan, Robert M. Jackson, C. Bruce Alexander, Bruce A. Freeman> ;Free Radical Biology & Medicine. 2002 Oct 1
• 61 citations
  REACTIVE SPECIES MEDIATED INJURY OF HUMAN LUNG EPITHELIAL CELLS AFTER HYPOXIA-REOXYGENATION
  Chuanyu Li, Marcienne M. Wright, Robert M. Jackson> ;Experimental Lung Research. 2002 Jul 1
• 775 citations
  Reactive species mechanisms of cellular hypoxia-reoxygenation injury.
  Chuanyu Li, Robert M. Jackson> ;American Journal of Physiology. Cell Physiology. 2002 Feb 1
• 3 citations
  Association of reactive nitrogen species metabolites, myeloperoxidase, and airway inflammation in lung transplants
  J.A. De Andrade, J. D. Christie, C. B. Alexander, K. R. Young, David C. McGiffin, George L. Zorn, Robert M. Jackson> ;Journal of Investigative Medicine. 2001 Mar 1
• 35 citations
  Protein Nitration, Metabolites of Reactive Nitrogen Species, and Inflammation in Lung Allografts
  Joao A. de Andrade, John P. Crow, Liliana Viera, C. Bruce Alexander, K. Randall Young, David C. McGiffin, George L. Zorn, Sha Zhu, Sadis Matalon, Robert M. Jackson> ;American Journal of Respiratory and Critical Care Medicine. 2000 Jan 1
• 14 citations
  Hypoxic modulation of manganese superoxide dismutase promoter activity and gene expression in lung epithelial cells.
  Tauni Ohman, Gregory Parish, Robert M. Jackson> ;American Journal of Respiratory Cell and Molecular Biology. 1999 Jul 1
• Peroxynitrite Modulates Manganese-Containing Superoxide Dismutase Gene Expression in Lung Epithelial Cells
  Robert M. Jackson, Gregory Parish, E. Helton> ;Chest. 1999 Jul 1
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Journal Articles

• Redox signaling to nuclear regulatory proteins by reactive oxygen species contributes to estrogen-induced growth of breast cancer cells  
  Okoh, V., Garba, N., Penney, R., Das, J., Deoraj, A., Singh, K., Sarkar, S. Felty, Q., Yoo, C., Jackson, R., and Roy, D, British Journal of Cancer, 1/1/2014
• Exercise limitation in IPF patients: A randomized trial of pulmonary rehabilitation  
  Jackson, R. Ramos, C., Sol, C., Cohen, M., Gaunaurd, I., Cahalin, L., Gomez-Marin, O., Cardenas, D, Lung, 1/1/2014
• Physical activity and quality of life improvements of patients with IPF completing a pulmonary rehabilitation program  
  Gaunaurd, I., Gomez-Marin, O., Ramos, C., Sol, C., Cohen, M., Cahalin, L., Jackson, R, Respiratory Care, 1/1/2014
• Development and utility of pirfenidone in the treatment of idiopathic pulmonary fibrosis: Review of preclinical science and recent clinical trials  
  Jackson, R. and Gomez-Marin, O, Transplant Research and Risk Management, 1/1/2011
• Hypoxia and kinase activity regulate lung epithelial cellular glutathione  
  Jackson, R. and Gupta, C, Exp Lung Res, 1/1/2010
• Sildenafil therapy and exercise tolerance in idiopathic pulmonary fibrosis: a randomized, controlled trial  
  Jackson, R., C. Ramos, M. Glassberg, P. Bejarano, O. Gomez-Marin, Lung, 1/1/2010
• Exercise decreases plasma antioxidant capacity and increases urinary isoprostanes in IPF  
  Jackson, R., C. Ramos, C. Gupta, O. Gomez-Marin, Respiratory Medicine, 1/1/2010
• Kinase activity, Hsp27 phosphorylation and lung epithelial cell glutathione  
  Jackson, R. and R. Garcia-Rojas, Exp Lung Res, 1/1/2008
• Etanercept for idiopathic pulmonary fibrosis: Lessons on clinical trial design  
  Jackson, R. and C. Fell, Am J Resp Crit Care Med, 1/1/2008
• The ECHM Collection, Volume 1: Consensus conferences and workshops, 1994-1999 (Book review)  
  Jackson, R, Respiratory Care, 1/1/2006
• A critical assessment of treatment options for idiopathic pulmonary fibrosis  
  Shah, N., P. Noble, R. Jackson, T. King, S. Nathan, M. Padilla, G. Raghu, M. Rhodes, M. Schwarz, G. Tino and R. Dubois, fibrosis. Sarcoidosis, Vasculitis and Diffuse Lung Diseases, 1/1/2005
• Intratracheal tumor necrosis factor alpha-expressing plasmid vector decreases LPS lethality in mice  
  Wright, M., C. Powell and R. Jackson, Exp Lung Res, 1/1/2004
• p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia  
  Powell, C., M. Wright and R. Jackson, Am J Physiol (Lung Cell Molec Physiol), 1/1/2004
• Mitochondrial Complex I and aconitase during hypoxia-reoxygenation: Modulation of enzyme activities by mitochondrial MnSOD augmentation  
  Powell, C. Wright, M. and R. Jackson, Am. J Physiol (Lung Cell. and Molec. Physiol.), 1/1/2003
• Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation  
  Li, C., M. Wright and R. Jackson, Exp Lung Res, 1/1/2002
• Cellular and molecular mechanisms of reoxygenation injury  
  Li, C. and R. Jackson, Am J Physiol (Cell Physiol), 1/1/2002
• Spatial mapping of nitrotyrosine in vascular and pulmonary inflammatory diseases reveals a pivotal role for myeloperoxidase as a catalyst for tyrosine nitration in vivo  
  Baldus S., Jason P. Eiserich, Robert M. Jackson, Bruce Alexander, Bruce A. Freeman, Free Radical Biology and Medicine, 1/1/2002
• Reactive nitrogen species and myeloperoxidase correlate with airway inflammation in lung transplant patients  
  de Andrade, J., C. B. Alexander , L. Viera, K. R. Young, D. C. McGiffin, G. Zorn, R. Jackson, J Invest Med, 1/1/2001
• Protein nitration, metabolites of reactive nitrogen species and inflammation in lung allografts  
  deAndrade, J., J. Crow, L. Viera, C. B. Alexander, K. R. Young, D. C. McGiffin, G. Zorn, S. Matalon, R. Jackson, Am J Resp Crit Care Med, 1/1/2000
• The basics of diving-related respiratory problems  
  Jackson, R, J Resp Dis, 1/1/2000
• Hypoxic modulation of MnSOD promoter activity and gene expression in lung epithelial cells  
  T. Ohman, G. Parish, Y-S. Ho, R. Jackson, Am J Resp Cell Molec Biol, 1/1/1999
• Survival, lung injury and lung protein nitration in heterozygous MnSOD knockout mice in hyperoxia  
  Jackson, R., E. Helton, L. Viera, T. Ohman, Exp Lung Res, 1/1/1999
• Modulation of lung and alveolar epithelial Na+, K+-ATPase gene expression by hyperoxia  
  Johnson, C., Guo, Y., Helton, S., Matalon, S., Jackson, R, Exp Lung Res, 1/1/1998
• Peroxynitrite modulates MnSOD gene expression in lung epithelial cells  
  R. Jackson, G. Parish, E. Helton, Free Radical Biology and Medicine, 1/1/1998
• Effects of hypoxia and hyperoxia on lung prostaglandin E1 metabolism  
  Pisarello, J., Flores, D., Jackson, R, Am J Med Sci, 1/1/1997
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Books/Book Chapters

• Oxford Textbook of Critical Care. 
  Chapter: Oxygen as a pharmaco-therapeutic agent in the critically ill. 
  Page 1265 - 1269Jackson, REditors: Webb. A., Shapiro M., Singer, M., Suter, P.Oxford University Press, Oxford, United Kingdom1998
• Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management. (NATO ASI Series A: Life Sciences) 
  Chapter: Divergent effects of hypoxia and oxidants on MnSOD expression. 
  Page 225 - 233Jackson, G. Parish, E. HeltonEditors: S. Matalon and I. Sznajder.Plenum Publishing Corp., New York, NY1998
• Oxygen, Gene Expression and Cellular Function. 
  Chapter: Regulation of sodium transport across the alveolar epithelium by hyperoxia. 
  Page 339 - 366Duvall M, Guo Y, Jackson R, Matalon SEditors: Clerch, L. and Massaro, D.Marcel Dekker, New York, NY1997
• Textbook of Critical Care. 
  Chapter: Oxygen therapy and toxicity. 
  Page 784 - 789Jackson, R.Editors: Ayres, S., Grenvik, A., Holbrook, P..W.B. Saunders CompanyEdition 3rd,1995
• Endothelial Cells. Volume III. 
  Chapter: Biochemical and functional aspects of oxygen-mediated injury to vascular endothelium. 
  Page 13 - 31Freeman, B.A., Jackson, R.M., Matalon, S., Harding, S.M.Editors: Ryan, U.S..CRC Press, Boca Raton, FL1988
• Current Topics in Pulmonary Pharmacology and Toxicology 
  Chapter: Pulmonary Oxygen Toxicity: A Contemporary Survey of Basic and Clinical Aspects. 
  Page 27 - 52Jackson, R.M.Editors: Hollinger M.A..Praeger Publishing Co., Philadelphia, PA1987
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Abstracts/Posters

• Exploratory Analysis of Ventilatory Inefficiency in Idiopathic Pulmonary Fibrosis.
  Lawrence P. Cahalin, Carol F. Ramos, Constanza M. Sol, Meryl I. Cohen, Ignacio A. Gaunaurd,, Diana D. Cardenas, Orlando W. Gomez-Marin, Robert M. Jackson, A4164, ATS, 1/1/2014
• Exercise limitations and rehabilitation of IPF patients.
  Robert M. Jackson, Carol F. Ramos, Constanza M. Sol, Meryl I. Cohen, Ignacio A. Gaunaurd, Lawrence P. Cahalin, Orlando W. Gomez-Marin, Diana D. Cardenas, A2639, ATS, 1/1/2014
• Health-related quality of life of IPF patients in a pulmonary rehabilitation program.
  Gaunaurd I, Cohen M, Cardenas D, Cahalin L, Ramos C, Jackson R, Gomez-Marin O, A1800, ATS, 1/1/2014
• The Dutch hypothesis revisited: interleukin 9 over-expression promotes lung emphysema after chronic tobacco smoke exposure.
  Li Qiongzhen, Jackson R, Capellan D, Van Snick J, Renauld J, Levitt R, ATS International Conference, 1/1/2012
• Gomez-Marin. Effects of aerobic and strength training on symptoms and exercise capacity of IPF patients.
  Jackson, R., C.F. Ramos, D. Cardenas, I. Gaunaurd, N. Eustis, M. Cohen, O, ATS International Conference, 1/1/2012
• Exercise training during pulmonary rehabilitation increases activity levels of IPF patients.
  Gomez O, C.F. Ramos, D. Cardenas, I. Gaunaurd, N. Eustis, M. Cohen, R.M. Jackson, ATS International Conference, 1/1/2012
• Effects of a Pulmonary Rehabilitation Program on Exercise Capacity and Functional Mobility for Patients with IPF.
  Gaunaurd IA, Gomez-Marin O, Ramos C, Cardenas D, Cahalin L, Cohen M, Jackson RM, ATS International Conference, 1/1/2012
• Derivation and characterization of young and aged stem cell populations in an interleukin-1 receptor antagonist mouse model system.
  Daniel Pelaez, Robert M. Jackson, Qiongzhen Li, Roy Levitt, Herman S Cheung, European Respiratory Society, 1/1/2012
• IL-1 deficiency or over expression of IL-1 receptor antagonist protect against chronic tobacco smoke-induced lung injury in aged mice.
  Li Qiongzhen, Capellan D, Casamayor N, Maestre-Mesa J, Jackson R, Levitt R, Am J Resp Crit Care Med, 1/1/2011
• IL1/IL1RA axis mediates bone marrow stem cell senescence and emphysema.
  Li Qiongzhen, Casamayor N, Maestre-Mesa J, Jackson R, Levitt R, ERS Lung Science Conference, 1/1/2011
• Effects of sildenafil on exercise and dyspnea in IPF patients.
  Jackson R M, C F Ramos, M Glassberg, P Bejarano and O Gomez-Marin, Am J Resp Crit Care Med, 1/1/2009
• Baseline variables predicting change over six months in 6-minute walk test distance of IPF patients.
  Novela I, R M Jackson, C F Ramos and O Gomez-Marin, Am J Resp Crit Care Med, 1/1/2009
• Serum and urine isoprostanes as markers of oxidant stress after standardized exercise in patients with IPF.
  Gomez-Marin, O., C. Ramos, M. Glassberg, R. Jackson, Am J Resp Crit Care Med, 1/1/2008
• Heat shock protein (Hsp27) expression regulates glutathione and the response to oxidant stress in lung epithelial cells.
  R. Jackson, R., Garcia-Rojas, Proc Am Thorac Soc, 1/1/2007
• Vasodilator therapy of idiopathic pulmonary fibrosis (IPF): Design and initiation of a randomized controlled trial.
  Gomez-Marin, O., C. Ramos, A. LaPerriere, R. Jackson, European Respiratory Society, 1/1/2007
• MAPK inhibition modulates Hsp27 phosphorylation and glutathione in lung epithelial cells.
  R. Jackson, R. Garcia-Rojas, ERS Lung Science Conference, 1/1/2006
• Oxidant stress markers in IPF patients.
  J.C. Rodriguez, R. M. Jackson, Proc Am Thorac Soc, 1/1/2006
• MAPK inhibition modulates Hsp27 phosphorylation and glutathione in lung epithelial cells.
  R. Jackson, R. Garcia-Rojas, Proc Am Thorac Soc, 1/1/2006
• p38mapk and MEK1/2 inhibition contribute to cellular reoxygenation injury.
  C. Powell, M. Wright, R. Jackson, ERS Lung Science Conference, 1/1/2004
• Mitochondrial complex I and aconitase inactivation by hypoxia-reoxygenation: Modulation by mitochondrial MnSOD augmentation.
  Powell, C. and R. Jackson, Am J Resp Crit Care Med, 1/1/2002
• Intratracheal "naked" DNA vaccination with pcDNA3-TNF-Alpha, LPS-induced lung injury and mortality.
  M. Wright, C. Myles and R. Jackson, Am J Resp Crit Care Med, 1/1/2002
• Increases in Plasminogen Activator Inhibitor-1 Predict Chronic Rejection in Lung Transplant Recipients.
  K J Leon, S L Hallit, P Prabhakaran, R Jackson, J de Andrade, P O'Reilly, S Matalon, J Hickman-Davis and M A Olman, Am J Resp Crit Care Med, 1/1/2002
• MAPK and MEK inhibition contribute to cellular reoxygenation injury.
  Powell, C. Wright, M. and R. Jackson, Experimental Biology, 1/1/2002
• Mechanisms of acute and chronic lung injury.
  Jackson RM, ERS meeting, Berlin, Germany, 9/24/2001
• Hypoxia and reoxygenation modulate lung epithelial cell glutathione content, oxygen consumption and reactive oxygen species (ROS) production.
  R. M. Jackson, Eur Resp J, 1/1/2001
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Lectures

• Scientific Basis of Pulmonary Rehabilitation. 
  1/24/2012
• Oxidant stress in IPF. 
  Miami, FL - 1/13/2011
• Hypoxic regulation of cellular glutathione. 
  Munich, Germany, 2009; Giessen, Germany, 2009 - 7/9/2009
• Oxidant stress as a mechanism of exercise limitation in IPF. 
  Key Biscayne, FL - 4/22/2006
• ERS Conference on Hypoxia. 
  3/3/2005
• H-R, redox signaling and antioxidant defense. 
  1/19/2005
• Mitochondrial reactive species and signaling in lung epithelial cells. 
  3/2/2004
• Redox signaling in lung cells. 
  Vienna, Austria - 9/29/2003
• Oxidants and Antioxidants. 
  Lucerne, Switzerland - 1/24/2002
• Protein nitration, reactive nitrogen species and function of lung allografts. 
  Florence, Italy - 9/3/2000
• Lung ischemia-reperfusion injury. 
  Toronto, ON, Canada - 5/10/2000
• Respiratory physiology of diving. 
  Toronto, ON, Canada - 5/9/2000
• Clinical implications of ROS and RNS in the lungs. 
  Toronto, ON, Canada - 5/7/2000
• Idiopathic pulmonary fibrosis. 
  Birmingham, AL - 4/12/2000
• Health and development in rural Nepal. 
  Atlanta, GA - 9/18/1999
• MnSOD in hypoxia-reoxygenation of the alveolar epithelium. 
  Cleveland, OH - 5/13/1999
• Divergent effects of hypoxia and oxidants on MnSOD expression. 
  Corfu, Greece - 6/18/1997
• Regulation of lung SOD by hypoxia and oxidants. 
  2/27/1997
• Hypoxic regulation of MnSOD activity. 
  Buenos Aires, Argentina - 4/23/1996
• Pulmonary oxygen toxicity. 
  Anaheim, CA - 4/14/1994
• Antioxidant gene regulation following oxidant stress. 
  San Francisco, CA - 5/16/1993
• Pulmonary research conference. 
  San Diego, CA - 4/5/1993
• Respiratory physiology seminar. 
  Hanover, NH - 1/10/1992
• Clinical aspects of oxidant lung injuries. 
  Birmingham, AL - 6/6/1991
• Antioxidant defenses in acute lung injury. 
  Seattle, WA - 5/24/1991
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Other

• Medicine in Shangri-La. 
  Jackson, R, AMAA Quarterly
  http://www.himalayan-healthcare.org/medinshang.pdf
  1/1/1995
• Practicing medicine in Shangri-La. 
  Jackson, R, Wilderness Medicine Newsletter
  1/1/1995