
Robert A. Lafyatis MD
Professor, Medicine, Boston University School of Medicine
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3601 Fifth AvenuePittsburgh, PA 15213
Phone+1 412-647-0943
Fax+1 412-647-4050
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Education & Training
National Institutes of Health Clinical CenterFellowship, Rheumatology, 1986 - 1989
Wake Forest University Baptist Medical CenterResidency, Internal Medicine, 1984 - 1986
Wake Forest University Baptist Medical CenterInternship, Internal Medicine, 1983 - 1984
University of Cincinnati College of MedicineClass of 1983
Certifications & Licensure
PA State Medical License 2015 - 2026
MA State Medical License 1994 - 2017
NC State Medical License 1985 - 1999
MD State Medical License 1986 - 1992
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Rheumatology
Awards, Honors, & Recognition
- Fellow (FACR) American College of Rheumatology
Clinical Trials
- Mycophenolate Mofetil in Systemic Sclerosis Start of enrollment: 2006 Mar 01
- Fresolimumab In Systemic Sclerosis Start of enrollment: 2011 Jan 01
- IL1-TRAP, Rilonacept, in Systemic Sclerosis Start of enrollment: 2011 Dec 01
Publications & Presentations
PubMed
- Suppression of interferon signaling via small-molecule modulation of TFAM.Dionisia Sideris, Husan Lee, Lyndsay Olson, Kalyan Nallaparaju, Keiichiro Okuyama
Elife. 2026-02-06 - Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.Urvashi Kaundal, Pei-Suen Tsou, Mousumi Sahu, Mengqi Huang, Steven E Boyden
Annals of the Rheumatic Diseases. 2026-02-04 - Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension.Chen-Shan Chen Woodcock, Giovanni Maroli, Hyunbum Kim, Yi Yin Tai, Ying Tang
Circulation Research. 2026-01-02
Journal Articles
- Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients with Diffuse Cutaneous Systemic SclerosisRobert Lafyatis, Yuqing Zhang, Arthritis & Rheumatology
Press Mentions
Forbius Announces the First Patient Dosed in a Phase 1b Diffuse Cutaneous Systemic Sclerosis Trial of AVID200, a Novel TGF-Beta 1 & 3 InhibitorMarch 4th, 2019
Rapid Skin Improvement Seen After Treating Systemic Sclerosis Patients with FresolimumabJune 22nd, 2015
Grant Support
- E-Box Accessibility in Myofibroblasts in Pulmonary FibrosisUNIVERSITY OF PITTSBURGH AT PITTSBURGH2025–2028
- Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic SclerosisUNIVERSITY OF PITTSBURGH AT PITTSBURGH2022–2027
- Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic SclerosisUNIVERSITY OF PITTSBURGH AT PITTSBURGH2022–2027
- Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung diseaseUNIVERSITY OF PITTSBURGH AT PITTSBURGH2024–2026
- Mapping Age-Related Changes in the LungOHIO STATE UNIVERSITY2019–2025
Professional Memberships
- Fellow
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