RobertJosephNoveckMD

Emergency Medicine • Durham, NC

Associate Professor, Medicine, Duke University School of Medicine

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Office
200 Trent Ave.
Duke University School Of Medicine, Dcru, Dhs
Durham, NC 27710
Phone+1 919-684-1018
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Education & Training

Tulane UniversityResidency, Internal Medicine, 1982 - 1985
Louisiana State University School of Medicine in New OrleansClass of 1982

Certifications & Licensure

NC State Medical License 2009 - 2024
LA State Medical License 1982 - 2024
FL State Medical License 2014 - 2019
NJ State Medical License 2005 - 2011

Clinical Trials

Effects of CS-8080 in Healthy Volunteers Start of enrollment: 2008 Jan 01
Completed
Phase 1
Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation Start of enrollment: 2010 Dec 01
Completed
Phase 1
Study of Levotofisopam 50 mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout Start of enrollment: 2012 Jan 01
Unknown status
Phase 2
The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers Start of enrollment: 2012 Feb 01
Completed
Phase 1
A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude Start of enrollment: 2013 Sep 01
Completed
Phase 1
Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban Start of enrollment: 2013 Jul 01
Completed
Phase 1
A Double-Blind Pharmacokinetic Interaction Study Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure Start of enrollment: 2013 Sep 01
Completed
Phase 1
Variability in the Measurement of WBCT Between Blood Drawn From Indwelling Catheters and Direct Venipuncture Start of enrollment: 2014 Apr 01
Completed
Not Applicable
INC280 in Healthy Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function Start of enrollment: 2015 Jun 12
Completed
Phase 1
A Study of LY3041658 in Participants With Skin Diseases Start of enrollment: 2016 Nov 08
Completed
Phase 1
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Publications & Presentations

PubMed

1 citations
Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease
John Audley, Emily F. Gliniewicz, Kol A. Zarember, Hanna S Hong, Gal Wald, Douglas B. Kuhns, Elizabeth M. Kang, Harry L. Malech, Anthony F. Suffredini, Robert J. Novec...> ;Inflammation. 2021 Feb 1
7 citations
First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Phar...
Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy Spears, Huali Wu, Kevin M. Watt, Shruti M. Raja, ...> ;Clinical Pharmacology in Drug Development. 2021 Feb 1
10 citations
The Potential Role of the J-Tpeak Interval in Proarrhythmic Cardiac Safety: Current State of the Science From the American College of Clinical Pharmacology and the Car...
Jose Vicente, David G. Strauss, Vijay V. Upreti, Michael J. Fossler, Philip T. Sager, Robert J. Noveck> ;Journal of Clinical Pharmacology. 2019 Jul 1
1 citations
A Time of Optimism: Targeted Immunotherapeutics as the Long-Awaited Armamentaria Against the Scourge of Human Diseases
Charles Oo, Robert J. Noveck> ;Therapeutic Innovation & Regulatory Science. 2019 May 9
13 citations
A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers.
Douglas Cowart, Robert P. Venuti, Kim Lynch, Jeffrey T. Guptill, Robert J. Noveck, Shi Yin Foo> ;Journal of Clinical Pharmacology. 2019 May 1
A Time of Optimism: Targeted Immunotherapeutics as the Long-Awaited Armamentaria Against the Scourge of Human Diseases.
Oo, C.,Noveck, R. J.> ;Ther Innov Regul Sci. 2019 May 11
22 citations
Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy v...
Kent J. Weinhold, Jack F. Bukowski, Todd V. Brennan, Robert J. Noveck, Janet Staats, Liwen Lin, Linda Stempora, Constance Hammond, Ann Wouters, Christopher F. Mojcik, ...> ;Clinical Immunology. 2018 Jun 1
5 citations
Intra-Target Microdosing (ITM): A Novel Drug Development Approach Aimed at Enabling Safer and Earlier Translation of Biological Insights Into Human Testing.
Tal Burt, Robert J. Noveck, David B. MacLeod, Anita T. Layton, Malcolm Rowland, Graham Lappin> ;Clinical and Translational Science. 2017 Apr 18
6 citations
Intra-Target Microdosing - A Novel Drug Development Approach: Proof of Concept, Safety, and Feasibility Study in Humans
Tal Burt, D. C. MacLeod, K. Lee, Antoinette Santoro, D. K. Demasi, Thomas C. Hawk, Mark N. Feinglos, Malcolm Rowland, Robert J. Noveck> ;Clinical and Translational Science. 2017 Sep 1
3 citations
Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia.
Thies Schroeder, Claude A. Piantadosi, Michael J. Natoli, Julie Autmizguine, Michael Cohen-Wolkowieczs, Karyn L. Hamilton, Christopher Bell, Jelena Klawitter, Uwe Chri...> ;Clinical Pharmacology and Therapeutics. 2018 May 1
14 citations
The Burden of the "False-Negatives" in Clinical Development: Analyses of Current and Alternative Scenarios and Corrective Measures.
Tal Burt, Katherine S. Button, Howard Thom, Robert J. Noveck, Marcus R. Munafò> ;Clinical and Translational Science. 2017 Jul 4
30 citations
Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses o...
Jeffrey T. Guptill, Shruti M. Raja, Felix Boakye-Agyeman, Robert J. Noveck, Sarah Ramey, Tian Ming Tu, Daniel T. Laskowitz> ;Journal of Clinical Pharmacology. 2017 Jun 1
1 citations
The Novel Combination of Theophylline and Bambuterol as a Potential Treatment of Hypoxemia in Humans
Trond Eirik Strand, Hasse Z. Khiabani, Alina Boico, Daniel R. Radiloff, Yulin Zhao, Karyn L. Hamilton, Uwe Christians, Jelena Klawitter, Robert J. Noveck, Claude A. Pi...> ;Canadian Journal of Physiology and Pharmacology. 2017 May 3
96 citations
Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban
Jack Ansell, Sasha Bakhru, Bryan E. Laulicht, Solomon S. Steiner, Michael A. Grosso, Karen Brown, Victor Dishy, Hans Lanz, Michele Mercuri, Robert J. Noveck, James Costin> ;Thrombosis and Haemostasis. 2016 Nov 17
1 citations
Proposed Strategies for the Integration of Genomics in Primary Care.
Charles Oo, Robert J. Noveck> ;The American Journal of Medicine. 2016 Jul 1
10 citations
Intraarterial Microdosing: A Novel Drug Development Approach, Proof-of-Concept PET Study in Rats
Tal Burt, Douglas C. Rouse, Kihak Lee, Huali Wu, Anita T. Layton, Thomas C. Hawk, Douglas H. Weitzel, Bennett B. Chin, Michael Cohen-Wolkowiez, Shein-Chung Chow, Rober...> ;Journal of Nuclear Medicine. 2015 Nov 1
321 citations
Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban
Jack Ansell, Sasha Bakhru, Bryan E. Laulicht, Solomon S. Steiner, Michael A. Grosso, Karen Brown, Victor Dishy, Robert J. Noveck, James Costin> ;The New England Journal of Medicine. 2014 Nov 26
40 citations
Human endotoxin administration as an experimental model in drug development.
A F Suffredini, Robert J. Noveck> ;Clinical Pharmacology and Therapeutics. 2014 Oct 1
32 citations
Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers.
Robert J. Noveck, Erik S.G. Stroes, JoAnn Flaim, Brenda F. Baker, Steven G. Hughes, Mark J. Graham, Rosanne M. Crooke, Paul M. Ridker> ;Journal of the American Heart Association. 2014 Jul 10
9 citations
Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.
Daniel R. Radiloff, Yulin Zhao, Alina Boico, Gert Blueschke, Gregory M. Palmer, Andrew N. Fontanella, Mark W. Dewhirst, Claude A. Piantadosi, Robert J. Noveck, David I...> ;Plos One. 2014 Jun 24
7 citations
Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine.
Robert J. Noveck, Pamela S Douglas, Shein-Chung Chow, Barry Mangum, Shashidhar Kori, Donald J. Kellerman> ;Drug Design, Development and Therapy. 2013 Jul 24
157 citations
Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor.
Jeanne Mendell, Hamim Zahir, Nobuko Matsushima, Robert J. Noveck, Frank S. Lee, Shuquan Chen, George Zhang, Minggao Shi> ;American Journal of Cardiovascular Drugs. 2013 Jun 20
62 citations
Microdosing and drug development: past, present and future
Graham Lappin, Robert J. Noveck, Tal Burt> ;Expert Opinion on Drug Metabolism & Toxicology. 2013 Jun 17
32 citations
A randomized trial of the safety, pharmacokinetics and pharmacodynamics of edoxaban, an oral factor Xa inhibitor, following a switch from warfarin
Jeanne Mendell, Robert J. Noveck, Minggao Shi> ;British Journal of Clinical Pharmacology. 2013 Apr 1
26 citations
Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination.
Jeanne Mendell, Robert J. Noveck, Minggao Shi> ;Journal of Cardiovascular Pharmacology. 2012 Oct 1
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Professional Memberships

American College of Emergency Physicians - ACEP
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RobertJosephNoveckMD

Dr. Noveck is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

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