RobertWSimmsMDProfessor of Medicine

Rheumatology • Lebanon, NH

Rheumatoid Arthritis & Related, Scleroderma & Related

Professor of Medicine, Boston University

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Office
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon, NH 03756
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Education & Training

Boston University Medical CenterFellowship, Rheumatology, 1985 - 1987
Zucker School of Medicine at Hofstra/NorthwellResidency, Internal Medicine, 1980 - 1981
University of Rochester School of Medicine and DentistryClass of 1980

Certifications & Licensure

NY State Medical License 1982 - Present
NH State Medical License 2020 - 2024
VT State Medical License 2022 - 2024
MA State Medical License 1982 - 2023
ME State Medical License 2020 - 2021
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Rheumatology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2006-2014
Boston Magazine Castle Connolly, 2008-2013
Top MD Consumers Checkbook
Super Doctor SuperDoctors.com
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Clinical Trials

Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients Start of enrollment: 2005 Feb 01
Completed
Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH) Start of enrollment: 2011 Jun 24
Completed
Phase 2
Scleroderma Treatment With Autologous Transplant (STAT) Study Start of enrollment: 2011 Sep 15
Active, not recruiting
Phase 2
Safety and Tolerability of Pirfenidone in Participants With Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD) (LOTUSS) Start of enrollment: 2013 Oct 01
Completed
Phase 2
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Publications & Presentations

PubMed

7 citations
Adipose-Derived Regenerative Cell Transplantation for the Treatment of Hand Dysfunction in Systemic Sclerosis: A Randomized Clinical Trial.
Dinesh Khanna, Paul Caldron, Richard W Martin, Suzanne Kafaja, Robert Spiera, Shadi Shahouri, Ankoor Shah, Vivien Hsu, John Ervin, Robert Simms, Robyn T Domsic, Virgin...> ;Arthritis & Rheumatology. 2022 Aug 1
Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis.
Lisa M Rice, Julio C Mantero, Eric A Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W Simms, Robyn Domsic, Harrison W Farber, Robert Lafyatis> ;Arthritis Research & Therapy. 2022 May 23
2 citations
Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy.
Ankoor Shah, Jan Storek, Rob Woolson, Ashley Pinckney, Lynnette Keyes-Elstein, Paul K Wallace, Gregory D Sempowski, Peter McSweeney, Maureen D Mayes, Leslie Crofford, ...> ;Rheumatology. 2022 Oct 6
3 citations
Clinical and Molecular Findings after Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data.
Lynette Keyes-Elstein, Ashley Pinckney, Ellen Goldmuntz, Beverly Welch, Jennifer M. Franks, Viktor Martyanov, Tammara A. Wood, Leslie J. Crofford, Maureen D. Mayes, Pe...> ;Arthritis Care & Research. 2021 Sep 17
2 citations
Geographic disparity in systemic sclerosis mortality in the United States: 1999-2017.
Alicia Rodriguez-Pla, Robert W Simms> ;Journal of Scleroderma and Related Disorders. 2021 Jun 1
5 citations
A pilot study of dimethyl fumarate in pulmonary arterial hypertension associated with systemic sclerosis
Kristi Kong, Diane Koontz, Christina Morse, Eileen Roth, Robyn T. Domsic, Marc A. Simon, Eric A. Stratton, Connor Buchholz, Kimberly Tobin-Finch, Robert W. Simms, M. P...> ;Journal of Scleroderma and Related Disorders. 2021 May 28
20 citations
United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics.
J. Badlam, David B. Badesch, Eric D. Austin, Raymond L. Benza, Wendy K. Chung, Harrison W. Farber, K. Feldkircher, Adaani E. Frost, Abby Poms, Katie A. Lutz, Michael W...> ;Chest. 2021 Jan 1
27 citations
Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial
Lorinda Chung, Cathie Spino, Richard McLain, Sindhu R. Johnson, Christopher P. Denton, Jerry A. Molitor, Virginia D. Steen, Robert Lafyatis, Robert W. Simms, Suzanne K...> ;The Lancet. Rheumatology. 2020 Dec 1
Response to Mittal and Sharma Letter to the Editor
Robert Spiera, Lorinda Chung, Tracy M. Frech, Robyn T. Domsic, Vivien Hsu, Daniel E. Furst, Robert W. Simms, Maureen D. Mayes, Viktor Martyanov, Michael L. Whitfield, ...> ;Arthritis & Rheumatology. 2020 Nov 8
254 citations
Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.
Dinesh Khanna, Celia J. F. Lin, Daniel E. Furst, Jonathan G. Goldin, Grace Kim, Masataka Kuwana, Yannick Allanore, Marco Matucci-Cerinic, Oliver Distler, Yoshihito Shi...> ;The Lancet. Respiratory Medicine. 2020 Oct 1
57 citations
Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo-Controlled Trial in Adults With Systemic Sclerosis.
Robert Spiera, Laura Hummers, Lorinda Chung, Tracy M Frech, Robyn Domsic, Vivien Hsu, Daniel E Furst, Jessica Gordon, Maureen Mayes, Robert Simms, Robert Lafyatis, Vik...> ;Arthritis & Rheumatology. 2020 Aug 1
1 citations
Expert Perspectives On Clinical Challenges: Expert Perspectives: Challenges in Scleroderma.
Robert W. Simms> ;Arthritis & Rheumatology. 2020 Sep 1
137 citations
Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial
Dinesh Khanna, Cathie Spino, Sindhu R. Johnson, Lorinda Chung, Michael L. Whitfield, Christopher P. Denton, Veronica J. Berrocal, Jennifer M. Franks, Bhavan Mehta, Jer...> ;Arthritis & Rheumatology. 2020 Jan 1
90 citations
Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis
Christopher J. Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W. Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd,...> ;The Lancet. Respiratory Medicine. 2019 Mar 1
20 citations
Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.
Michael E. Johnson, Jennifer M. Franks, Guoshuai Cai, Bhaven K. Mehta, Tammara A. Wood, Kimberly Archambault, Patricia A. Pioli, Robert W. Simms, Nicole M. Orzechowski...> ;Arthritis Research & Therapy. 2019 Feb 6
18 citations
Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry.
Vivien Hsu, Lorinda Chung, Laura K. Hummers, Ami A. Shah, Robert W. Simms, Marcy B. Bolster, Faye N. Hant, Richard M. Silver, Aryeh Fischer, Monique Hinchcliff, John V...> ;The Journal of Rheumatology. 2019 Feb 1
59 citations
Long-Term Outcomes in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension From the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroder...
Kathleen D. Kolstad, Shufeng Li, Virginia D. Steen, Lorinda Chung, Marcy B. Bolster, Mary Ellen Csuka, Chris T. Derk, Robyn T. Domsic, Aryeh Fischer, Tracy M. Frech, R...> ;Chest. 2018 Oct 1
16 citations
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis
Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod R. Warburton, Kari E. Roberts, Nicholas S. Hill, Robert W. Simms, Robyn T. Domsic, Harrison W. Farber, Robert Lay...> ;Arthritis Research & Therapy. 2018 Aug 16
28 citations
Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial.
Julio C. Mantero, Nina Kishore, Jessica Ziemek, Giuseppina Stifano, Christopher Zammitti, Dinesh Khanna, Jessica K. Gordon, Robert Spiera, Yuqing Zhang, Robert W. Simm...> ;Clinical and Experimental Rheumatology. 2018 Jul 1
18 citations
Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.
Michelle Fleury, Anna C. Belkina, Elizabeth A. Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder-Cappione, Robert Lafyatis, ...> ;Arthritis & Rheumatology. 2018 Apr 1
317 citations
Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.
Keith M. Sullivan, Ellen Goldmuntz, Lynette Keyes-Elstein, Peter A. McSweeney, Ashley Pinckney, Beverly Welch, Maureen D. Mayes, Richard A. Nash, Leslie J. Crofford, B...> ;The New England Journal of Medicine. 2018 Jan 3
21 citations
Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.
Olga Y. Gorlova, Yafang Li, Ivan P. Gorlov, Jun Ying, Wei V. Chen, Shervin Assassi, John D. Reveille, Frank C. Arnett, Xiaodong Zhou, Lara Bossini-Castillo, Elena Lópe...> ;Plos One. 2018 Jan 2
72 citations
Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
T. Toyama, Agnieszka P. Looney, Brendon M. Baker, Lukasz Stawski, Paul Haines, Robert W. Simms, Aleksander D. Szymaniak, Xaralabos Varelas, Maria Trojanowska> ;The Journal of Investigative Dermatology. 2018 Jan 1
37 citations
Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82.
Robert Lafyatis, Julio C. Mantero, Jessica K. Gordon, Nina Kishore, Mary Carns, Howard C. Dittrich, Robert Spiera, Robert W. Simms, John Varga> ;The Journal of Investigative Dermatology. 2017 Dec 1
34 citations
Antisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis
Tobias Messemaker, Loubna Chadli, Guoshuai Cai, Varshna S. Goelela, M. Boonstra, Annemarie L. Dorjée, S.N. Andersen, Harald Mikkers, Peter van ‘t Hof, Hailiang Mei, Ol...> ;The Journal of Investigative Dermatology. 2017 Nov 24
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Journal Articles

Serum Biomarker for Diagnostic Evaluation of Pulmonary Arterial Hypertension in Systemic Sclerosis
Harrison W Farber, Kari Roberts, Nicholas Hill, Robyn Domsic, Robert W Simms, BioMed Central

Grant Support

Core B Clinical CoreNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
High-Dose Immunosuppressive Therapy Using Total Body IrradiationNational Center For Research Resources2007
Infusion Of Recombinant Human Relaxin In Patients W/ SclerodermaNational Center For Research Resources1999–2000
Muscle Metabolism And Muscle Fatigue In Fibromyalgia SyndromeNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1990–1991

Hospital Affiliations

Boston Medical CenterBoston, Massachusetts
Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire