RobertAWilliamsonMD

PubMed

• Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease.
  Priola SA, Ward AE, McCall SA, Trifilo M, Choi YP, Solforosi L, Williamson RA, Cruite JT, Oldstone MBA> ;J. Virol.. 2013-09-01
• Identifying key components of the PrPC-PrPSc replicative interface.
  Abalos GC, Cruite JT, Bellon A, Hemmers S, Akagi J, Mastrianni JA, Williamson RA, Solforosi L> ;J. Biol. Chem.. 2008-12-05
• Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis.
  Wadia, J. S., Schaller, M., Williamson, R. A., Dowdy, S. F.> ;PLoS One. 2008 Jan 01
• Selective incorporation of polyanionic molecules into hamster prions.
  Geoghegan JC, Valdes PA, Orem NR, Deleault NR, Williamson RA, Harris BT, Supattapone S> ;J. Biol. Chem.. 2007-12-14
• High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.
  Barron, R. M., Campbell, S. L., King, D., Bellon, A., Chapman, K. E., Williamson, R. A., Manson, J. C.> ;J Biol Chem. 2007 Dec 7
• A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo.
  Williams, J. V., Chen, Z., Cseke, G., Wright, D. W., Keefer, C. J., Tollefson, S. J., Hessell, A., Podsiad, A., Shepherd, B. E., Sanna, P. P., Burton, D. R., Crowe, J....> ;J Virol. 2007 Aug
• Toward molecular dissection of PrPC-PrPSc interactions.
  Solforosi L, Bellon A, Schaller M, Cruite JT, Abalos GC, Williamson RA> ;J. Biol. Chem.. 2007-03-09
• Pathologic prion protein is specifically recognized in situ by a novel PrP conformational antibody.
  Moroncini, G., Mangieri, M., Morbin, M., Mazzoleni, G., Ghetti, B., Gabrielli, A., Williamson, R. A., Giaccone, G., Tagliavini, F.> ;Neurobiol Dis. 2006 Sep
• Probing the conformation of the prion protein within a single amyloid fibril using a novel immunoconformational assay.
  Novitskaya, V., Makarava, N., Bellon, A., Bocharova, O. V., Bronstein, I. B., Williamson, R. A., Baskakov, I. V.> ;J Biol Chem. 2006 Jun 2
• Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation.
  Vadolas J, Nefedov M, Wardan H, Mansooriderakshan S, Voullaire L, Jamsai D, Williamson R, Ioannou PA> ;J. Biol. Chem.. 2006-03-17
• Protease-resistant prion protein amplification reconstituted with partially purified substrates and synthetic polyanions.
  Deleault NR, Geoghegan JC, Nishina K, Kascsak R, Williamson RA, Supattapone S> ;J. Biol. Chem.. 2005-07-22
• Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc.
  Moroncini, G., Kanu, N., Solforosi, L., Abalos, G., Telling, G. C., Head, M., Ironside, J., Brockes, J. P., Burton, D. R., Williamson, R. A.> ;Proc Natl Acad Sci U S A. 2004 Jul 13
• Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation.
  Yadavalli R, Guttmann RP, Seward T, Centers AP, Williamson RA, Telling GC> ;J. Biol. Chem.. 2004-05-21
• A change in the conformation of prions accompanies the emergence of a new prion strain.
  Peretz, D., Williamson, R. A., Legname, G., Matsunaga, Y., Vergara, J., Burton, D. R., DeArmond, S. J., Prusiner, S. B., Scott, M. R.> ;Neuron. 2002 Jun 13
• Neutralizing human Fab fragments against measles virus recovered by phage display.
  de Carvalho Nicacio C, Williamson RA, Parren PWHI, Lundkvist A, Burton DR, Björling E> ;J. Virol.. 2002-01-01
• Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14.
  Williamson RA, Hutton M, Vogt G, Rapti M, Knäuper V, Carr MD, Murphy G> ;J. Biol. Chem.. 2001-08-31
• Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis.
  Williamson RA, Burgoon MP, Owens GP, Ghausi O, Leclerc E, Firme L, Carlson S, Corboy J, Parren PW, Sanna PP, Gilden DH, Burton DR> ;Proc. Natl. Acad. Sci. U.S.A.. 2001-02-13
• Cloning the antibody response in humans with chronic inflammatory disease: immunopanning of subacute sclerosing panencephalitis (SSPE) brain sections with antibody pha...
  Owens GP, Williamson RA, Burgoon MP, Ghausi O, Burton DR, Gilden DH> ;J. Virol.. 2000-02-01
• Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recomb...
  Cvetkovic B, Yang B, Williamson RA, Sigmund CD> ;J. Biol. Chem.. 2000-01-14
• The effect of matrix metalloproteinase complex formation on the conformational mobility of tissue inhibitor of metalloproteinases-2 (TIMP-2).
  Williamson RA, Muskett FW, Howard MJ, Freedman RB, Carr MD> ;J. Biol. Chem.. 1999-12-24
• The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations.
  Butler GS, Hutton M, Wattam BA, Williamson RA, Knäuper V, Willenbrock F, Murphy G> ;J. Biol. Chem.. 1999-07-16
• Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines.
  Sakurai H, Williamson RA, Crowe JE, Beeler JA, Poignard P, Bastidas RB, Chanock RM, Burton DR> ;J. Virol.. 1999-04-01
• Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype.
  McDonald FJ, Yang B, Hrstka RF, Drummond HA, Tarr DE, McCray PB, Stokes JB, Welsh MJ, Williamson RA> ;Proc. Natl. Acad. Sci. U.S.A.. 1999-02-16
• Mapping the prion protein using recombinant antibodies.
  Williamson RA, Peretz D, Pinilla C, Ball H, Bastidas RB, Rozenshteyn R, Houghten RA, Prusiner SB, Burton DR> ;J. Virol.. 1998-11-01
• High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteina...
  Muskett FW, Frenkiel TA, Feeney J, Freedman RB, Carr MD, Williamson RA> ;J. Biol. Chem.. 1998-08-21
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