RodneyEdwinShackelfordDO

Pathology • Shreveport, LA

Molecular Genetics, Anatomic Pathology, Clinical Pathology

Assistant Professor, Pathology, Tulane University School of Medicine

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Office
1501 Kings Hwy
Shreveport, LA 71103
Phone+1 318-525-6479
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Summary

Rodney Shackelford, DO, Ph.D. is a Pathology Specialist located in Mobile, AL. With subspecialties in Molecular Genetics, Anatomic Pathology, and Clinical Pathology, Dr. Shackelford has an extensive educational background including a Ph.D. in Molecular Pathology from Duke University. He currently serves as Associate Professor of Pathology at The University of South Alabama and has similar experience in the same role at Tulane University School of Medicine. His experience is highlighted in ataxia telangiectasia, gene therapy, and ataxia. Dr. Shackelford has been recognized for his work with numerous honors and awards, and his research findings have been cited multiple times. His work is largely published in respected journals such as Biochemical and Biophysical Research Communications and Nature Reviews. Cardiology.

Education & Training

University of South Florida MorsaniResidency, Pathology-Anatomic and Clinical, 2009 - 2010
Louisiana State University School of MedicineResidency, Pathology-Anatomic and Clinical, 2003 - 2007
Des Moines University College of Osteopathic MedicineClass of 2003
Duke UniversityPh.D., Molecular Pathology, 1994
Duke UniversityPh.D., Molecular Pathology, 1994
Western Washington UniversityB.A., Biology, 1986
Western Washington UniversityB.S., Biology, minor in Chemistry, 1986
Western Washington UniversityB.A., Biology, 1986
Western Washington UniversityB.S., Biology, minor in Chemistry, 1986
Highline Community CollegeA.A., 1983
Highline Community CollegeA.A., 1983

Certifications & Licensure

LA State License 2005 - 2025
AL State License 2022 - 2024
American Board of Pathology Pathology - Anatomic/Pathology - Clinical
American Board of Pathology Pathology - Molecular Genetic

Awards, Honors, & Recognition

Albert G. Smith Resident Research Forum Award 2007
Stowell-Orbison Award Certificate of Merit United States and Canadian Academy of Pathology Meeting Poster Presentation, 2006
Granted a Special Certificate for Excelling in the Area of Psychiatry and Behavior Medicine” Des Moines University of Osteopathic Medicine, 2003
Young Investigator Award Association for Molecular Pathology, 2003-2004
Research/Publication Scholarship Des Moines University of Osteopathic Medicine, 2001
Junior Investigator Fellowship Kern Aspen Lipid Conference, 2000
Merit Scholarship Award Des Moines University of Osteopathic Medicine, 1999
Pharmacia & UpJohn Young Investigator Award American Association for Cancer Research, 1999
National Research Service Award 1995
Honor Role Western Washington University, 1985
Psy Chi Fraternity 1984
Scholarship Recipient Northwest Society for Coatings Technology, 1981
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Publications & Presentations

PubMed

Metastatic Ovarian Serous Adenocarcinoma Clinically Presenting as Inflammatory Breast Cancer.
Lingling Xian, Rachel Hunter, Emily Smith, Rasha Mohammed, Carlina Madelaire, Guillermo A Herrera, Rodney E Shackelford> ;Case Reports in Oncological Medicine. 2024 Jan 1
Pioglitazone treatment increases the cellular acid-labile and protein-bound sulfane sulfur fractions.
Mohammad Z Islam, Rodney E Shackelford> ;Biochemical and Biophysical Research Communications. 2023 Aug 30
3 citations
Methamphetamine causes cardiovascular dysfunction via cystathionine gamma lyase and hydrogen sulfide depletion.
Gopi K Kolluru, John D Glawe, Sibile Pardue, Shafiul Alam, Saranya Rajendran, Allison L Cannon, Chowdhury S Abdullah, James G Traylor, Rodney E Shackelford, Matthew D ...> ;Redox Biology. 2022 Nov 1
41 citations
Sulfide regulation of cardiovascular function in health and disease.
Gopi K Kolluru, Rodney E Shackelford, Xinggui Shen, Paari Dominic, Christopher G Kevil> ;Nature Reviews. Cardiology. 2023 Feb 1
2 citations
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction.
Mohammad Z Islam, Xinggui Shen, Sibile Pardue, Christopher G Kevil, Rodney E Shackelford> ;DNA Repair. 2022 Aug 1
20 citations
CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma.
Chun-Feng Pan, Ke Wei, Zi-Jian Ma, Yao-Zhou He, Jing-Jing Huang, Zi-Zhang Guo, Zhi-Peng Chen, Martin P Barr, Rodney E Shackelford, Yang Xia, Jun Wang> ;Translational Lung Cancer Research. 2022 Mar 1
A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder.
Rodney E Shackelford, Ekin Ozluk, Jehan Abdulsattar, Terry C Lairmore, Quyen Chu, Eric X Wei> ;Case Reports in Oncological Medicine. 2022 Jan 1
2 citations
Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation.
Rodney E. Shackelford, Yan Li, Ghali E. Ghali, Christopher G. Kevil> ;Antioxidants. 2021 Nov 17
2 citations
Ethylmalonic Encephalopathy 1 Protein Is Increased in Colorectal Adenocarcinoma.
Ekin Ozluk, Domenico Coppola, Islam Z. Mohammad, Tarif Islam, Ghali E. Ghali, Christopher G. Kevil, Rodney E. Shackelford> ;Anticancer Research. 2021 Oct 1
18 citations
Molecular Functions of Hydrogen Sulfide in Cancer.
Rodney E Shackelford, Islam Z Mohammad, Andrew T Meram, David Kim, Fawaz Alotaibi, Stavan Patel, Ghali E Ghali, Christopher G Kevil> ;Pathophysiology. 2021 Sep 20
2 citations
Primary Pulmonary Leiomyosarcoma in a Forty-Year-Old Woman.
Ekin Ozluk, Eric X. Wei, James D. Cotelingam, Rodney E. Shackelford> ;Case Reports in Oncology. 2021 Sep 1
2 citations
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Ekin Ozluk, Staven Patel, Domenico Coppola, Ghali E. Ghali, James D. Cotelingam, Christopher G. Kevil, Rodney E. Shackelford> ;Anticancer Research. 2021 Sep 1
19 citations
Hydrogen sulfide and DNA repair
Rodney E. Shackelford, Ekin Ozluk, Mohammad Z. Islam, Brian Hopper, Andrew T. Meram, Ghali E. Ghali, Christopher G. Kevil> ;Redox Biology. 2021 Jan 1
1 citations
Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein.
Dominik Dabrowski, Roberto F Silva, Michael Constantinescu, Rodney E. Shackelford, Nestor Dela Cruz, Eric X Wei> ;Case Reports in Oncological Medicine. 2020 Dec 21
4 citations
Plasmablastic Lymphoma, a Rare Entity in Bone Marrow with Unusual Immunophenotype and Challenging Differential Diagnosis.
Majd Al Shaarani, Rodney E. Shackelford, Samip Master, Glenn Mills, Yasir AlZubaidi, Ahmed Mamilly, Eric X Wei> ;Case Reports in Hematology. 2019 Sep 2
5 citations
Nicotinamide Phosphoribosyl Transferase Is Increased in Osteosarcomas and Chondrosarcomas Compared to Benign Bone and Cartilage.
Andrew T. Meram, Yasir AlZubaidi, James D. Cotelingam, Ghali E. Ghali, Liurka Lopez, Domenico Coppola, Rodney E. Shackelford> ;Anticancer Research. 2019 Apr 1
10 citations
The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations
Jie Chen, Xinggui Shen, Sibile Pardue, Andrew T. Meram, Saranya Rajendran, Ghali E. Ghali, Christopher G. Kevil, Rodney E. Shackelford> ;DNA Repair. 2019 Jan 1
27 citations
Cystathione β-Synthase Is Increased in Thyroid Malignancies.
Elba A. Turbat-Herrera, Matthew J. Kilpatrick, Jie Chen, Andrew T. Meram, James D. Cotelingam, Ghali E. Ghali, Christopher G. Kevil, Domenico Coppola, Rodney E. Shacke...> ;Anticancer Research. 2018 Nov 1
4 citations
Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Cavity Mucoepidermoid Carcinoma.
Dongsoo David Kim, Jie Chen, Andrew T. Meram, Stavan Patel, Eric X Wei, Junaid Ansari, Ghali E. Ghali, Christopher G. Kevil, Rodney E. Shackelford> ;Case Reports in Oncology. 2018 Oct 31
9 citations
Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma.
Kim Dongsoo, Jie Chen, Eric X Wei, Junaid Ansari, Andrew T. Meram, Stavan Patel, Ghali E. Ghali, Christopher G. Kevil, Rodney E. Shackelford> ;Case Reports in Oncology. 2018 Aug 27
2 citations
Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study.
Shoujun Chen, Elba A. Turbat-Herrera, Guillermo A. Herrera, Meghna Chadha, Rodney E. Shackelford, Eric X Wei> ;Ultrastructural Pathology. 2018 Jul 24
23 citations
Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.
Andrew T. Meram, Jie Chen, Stavan Patel, Dongsoo David Kim, Brett Shirley, Paul Covello, Domenico Coppola, Eric X Wei, Ghali E. Ghali, Christopher G. Kevil, Rodney E. ...> ;Anticancer Research. 2018 Jul 1
18 citations
Spontaneous tumor lysis syndrome in colon cancer: a case report and literature review.
David Sommerhalder, Amol Takalkar, Rodney E. Shackelford, Prakash Peddi> ;Clinical Case Reports. 2017 Nov 13
2 citations
Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature.
Eric X Wei, Roberto F Silva, James D. Cotelingam, Rodney E. Shackelford> ;Case Reports in Pathology. 2017 Oct 8
6 citations
γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies
Eric X Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M Azzato, Sheila A. Shurtleff, Menchu Ong, Diana M Veillon, James D. Cotelingam, Rodney E. ...> ;Case Reports in Hematology. 2017 Sep 24
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Books/Book Chapters

Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing in Hepatocellular Carcinoma.
Rodney E. Shackelford, Greg Mayhall, Shankar Japa, and Domeinico CopollaSpringer Science2014
Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing in Penile, Scrotal, and Testicular Cancer.
Nicholas A. Whitling, Sharon M. Hirsh, and Rodney E. ShackelfordSpringer Science2014
Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing in Esophageal-Gastric Cancer.
Rodney E. Shackelford, Maisoun Q. Abdelbaqi, and Domeinico CoppolaSpringer Science2014
Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing for Prostate Cancer.
Rodney E. Shackelford, Janese Trimaldi, Phillippe E. Spiess, Wade J. Sexton, Maisoun Q. Abdelbaqi, and Tian ChuangSpringer Science2014
Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing in Thyroid and Parathyroid Malignancies.
Rodney E. Shackelford, and Jason SavillSpringer Science2014
Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing in Gynecologic Malignancies.
Rodney E. Shackelford, Domeinico Coppola, and Ardeshir HakamSpringer Science2014
Molecular Diagnostics of Cancer
Chapter: Molecular-Genetic Testing in Colorectal Carcinoma.
Rodney E. Shackelford, Aejaz Nasir, Ardeshir Hakam, and Domeinico CoppolaSpringer Science2014
Methods in Molecular Biology, Edition on Hematological Malignancies
Chapter: Chapter 6: Liquid Bead Array Technology in the Detection of Common Translocations in Acute and Chronic Leukemias
Shackelford, RE, Jackson, KD, Gocke, CD2013
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Abstracts/Posters

Overexpression Of Sirt3 And Nicotinamide Phosphoribosyltransferase In Melanoma.
Kim Mayhall and Rodney E. Shackelford, College of American Pathologists Meeting, Orlando, FL, 10/13/2013
Nampt Expression Is Upregulated In Well-differentiated Thyroid Carcinoma. (Quick Shot Presentation)
X. Li, R. Shackelford, E. Kandil, 8th Annual Academic Surgical Congress, New Orleans, LA, 2/5/2013
A Gastric Adenocarcinoma With Aberrant Nicotinamide Phosphoribosyltransferase Expression Following Exposure to the Chernobyl Nuclear Accident.
Mayhall K, Ghayouri M, Shackelford R, ASCP Conference, Boston, MA, 9/18/2012
Nicotinamide Phosphoribosyltransferase Expression is Increased in Malignant Ovarian Tumors
Shackelford RE, Coppola D. Modulation, and Hakam A, College of American Pathologists Meeting, Chicago, IL, 9/26/2010
Modulation of Nicotinamide Phosphoribosyltransferase Expression in Colorectal Carcinogenesis.
Shackelford RE, Hakam A, and Coppola D, College of American Pathologists Meeting, Chicago, IL, 9/26/2010
Modulation of Nicotinamide Phosphoribosyltransferase Expression in Colorectal Carcinogenesis.
Shackelford RE, Hakam A, and Coppola D, Moffitt Cancer Center 4th Annual Fellows’ Research Symposium; University of Southern Florida Research Day (Feb 19, 2010), Tampa, FL, 5/10/2010
Nicotinamide Phosphoribosyltransferase Expression is Increased in Malignant Ovarian Tumors.
Shackelford RE, Coppola D. Modulation, and Hakam A, Moffitt Cancer Center 4th Annual Fellows’ Research Symposium; University of Southern Florida Research Day (Feb 19, 2010), Tampa, FL, 5/10/2010
Nicotinic acid increases the viability ataxia-telangiectasia cells.
Shackelford RE, Lederman H, Association for Molecular Pathology, Gaylord Texan Resort & Convention Center, Grapevine, TX, 10/29/2008
Ataxia-telangiectasia mutated gene product protects against oxidized LDL-induced cellular toxicity.
Shackelford RE, Semlitsch M, Malle E, Gemeinsame Jahrestagung, Graz, Austria, 9/21/2008
Ataxia-telangiectasia mutated gene product protects against oxidized LDL-induced cellular toxicity.
Shackelford RE, Semlitsch M, Malle E, Gemeinsame Jahrestagung, Graz, Austria, 9/21/2008
The ataxia-telangiectasia gene product is required for cellular resistance to transition metal toxicity.
Shackelford RE, Fu F, Manuszak RP, Wang S, Lowery-Nordberg M, and Chen A, United States and Canadian Academy of Pathology Meeting, San Diego, CA, 3/24/2007
Prognostic Role of EGFR in Lung Adenocarcinoma Utilizing PCR Based Screening.
Abdelbaqi M, Anga A, Shackelford R, Walter A, Mowery-Nordberg M, and Albores J, United States and Canadian Academy of Pathology Meeting, San Diego, CA, 3/24/2007
Ataxia-telangiectasia mutated gene product activity increases resistance to apergillus fumigatus gliotoxin toxicity.
Shackelford RE, Yu F, Abelbaqi M, Chen A, United States and Canadian Academy of Pathology Meeting, Atlanta, GA, 2/11/2006
Epigallocatechin gallate and iron chelators as a pharmacologic treatment for ataxia-telangiectasia.
Shackelford RE, Fu Y, Lowery-Nordberg M, and Chen A, Association for Molecular Pathology Meeting, Scottsdale, AZ, 11/11/2005
Epicatechin gallate as a treatment for ataxia-telangiectasia.
Shackelford RE, Fu Y, Lowery-Nordberg M, and Chen A, American Society for Clinical Pathology Meeting, Seattle, WA, 10/8/2005
The ataxia-telangiectasia gene product is required for genomic stability following ferric iron Exposure.
Shackelford RE, Fu Y, Manuszak RP, Sequeira A, Wang S, Glass J, Lowery-Nordberg M, and Chen P, Neuropathology Section of the United States Canadian Academy of Pathology Meeting, San Anontio, TX, 2/26/2005
Iron chelators reduce spontaneous dsDNA breaks in ataxia-telangiectasia cells.
Shackelford RE, Fu Y, Manuszak RP, Wang S, Lowery-Nordberg M, and Chen P, Barlow Symposium; Genetics Section of the Annual Association for Molecular Pathology Meeting (Nov 11, 2004), Louisiana State University Health Sciences Center, Shreveport, LA, 2/25/2005
Functional correction of A-T cells by ATM gene expression mediated by HSV amplicon vector after ionizing radiation or under oxidative stress conditions.
Manuszak R., Shackelford R, Link CJ, and Wang S, American Society of Gene Therapy, 7th Annual Meeting, 6/2/2004
Oxidized low-density low suppresses transcription factor PU.1 induction by inflammatory mediators in primary murine macrophages.
Shackelford R, United States Canadian Academy of Pathology Meeting, Vancouver, Canada, 3/16/2004
Iron chelators Increase the genomic stability of ataxia-telangiectasia Cells.
Shackelford RE, Manuszak RP, CJohnson CD, and Wang S, Genetics Section of the Annual Association for Molecular Pathology Meeting, 11/22/2003
Desferrioxamine treatment increases the genomic stability of ataxia telangiectasia Cells.
Shackelford RE, Manuszak RP, Steele TA, Link CJ, and Wang S, Basic Research Category at the 8th Annual American Medical Student Associations Poster Session, Washington, DC, 3/19/2003
In vitro and in vivo ATM gene expression mediated by HSV amplicon vector.
Manuszak RP, Shackelford RE, Cheng D, Wang X, Link, CJ Jr, Qi J, and Wang S, Stoddard Cancer Research Institute, Human Gene Therapy Research Institute, Central Iowa Health System; 5th Annual Meeting of the American Society of Gene Therapy, Des Moines, IA; Boston, MA, 6/5/2002
Recombinant ATM expression restores oxidative stress-induced responses in ataxia-telangiectasia cells.
Shackelford RE, Manuszak RP, Heinloth AN, Paules RS, Link CJ, and Wang S, 15th Annual American Federation for Aging Research Grantee Conference, NY, 4/11/2002
ATM-dependent gene expression changes after different forms of DNA damage.
Heinloth AN, Shackelford RE, Innes CL, Amin RP, Seiber SO, Kristina G. Flores, Bennett L, Bushel PR, and Paules RS, The American Society for Cancer Research, 92nd Annual Meeting, San Francisco, CA, 4/6/2002
Desferrioxamine Treatment Increases the Genomic Stability of Ataxia-Telangiectasia Cells.
Shackelford RE, Sixth Annual American Medical Student Associations Poster Session, 3/29/2001
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Lectures

Molecular Diagnostic Testing for KRAS Mutations in Colorectal Carcinoma
3/28/2014
Well-differentiated thyroid cancers.
New Orleans, LA - 2/7/2013
Pancreatic cancer, follicular lymphoma, granulosa cell tumors, poorly differentiated adenocarcinoma of the lung, and HIV-associated leukemia
6/1/2010
Metabolic Defects in ataxia-telangiectasia (A-T) Invited Lecturer
Johns Hopkins Hospital - 12/15/2008
Green tea flavonoinds, chemoprevention, and human health.
Ocean City, MD - 6/21/2008
The Biological consequences of Chernobyl: 20 years on. Guest Lecturer
Louisiana State University Health Sciences Center, Shreveport - 7/7/2006
Iron Chelators as a Pharmacologic (Guest Lecturer)
Louisiana State University Health Sciences Center, Shreveport - 4/13/2006
Epigallocatechin Gallate and Iron Chelators as a Pharmacologic Treatment for Ataxia-telangiectasia.
Seattle, WA - 10/9/2005
Ataxia-telangiectasia (Talk)
Seattle, WA - 10/9/2005
Iron Chelators as a Pharmacologic Treatment to Reduce dsDNA Breaks in ataxia-telangiectasia. (Guest Lecturer)
The Medical University of Graz, Institute of Molecular Biology and Biochemistry, Austria - 9/6/2005
The Rise of Precambrian Oxygen, ataxia-telangiectasia, and the Molecular basis of Oxidative-Stress Initiated Disease. (Guest Lecturer)
3/16/2003
Molecular Theories of the Pathogenesis of Schizophrenia. (Guest Lecturer)
12/12/2002
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Other

Online Molecular Pathology Chapter: DNA Purification
Rodney E. Shackelford
http://www.pathologyoutlines.com/
4/12/2012
Online Molecular Pathology Chapter: PCR
Rodney E. Shackelford
http://www.pathologyoutlines.com/
2/15/2011
Online Molecular Pathology Chapter: Fluorescent in situ Hybridization
Rodney E. Shackelford
http://www.pathologyoutlines.com/
2/13/2011
Online Molecular Pathology Chapter: DNA Sequencing
Rodney E. Shackelford
http://www.pathologyoutlines.com/
11/24/2010
Online Molecular Pathology Chapter: Microarray
Rodney E. Shackelford
http://www.pathologyoutlines.com/
7/3/2010
“The Health Benefits of Green Tea”
Rodney Shackelford, The Vashon Loop
1/23/2009
Newspaper column for drug education for the Polk County Medical Society
Rodney Shackelford, Des Moines Herald “House Calls” Column
11/7/2002
Studies of the Binding of Transcription Factors PU.1 and NF-kB in Murine Tissue Macrophages. (Dissertation)
Shackelford RE, Duke University Medical Center, Department of Pathology, Durham, NC
12/1/1994
Article for H+ Magazine (online): DNA Sequencing
Rodney E. Shackelford
Article for H+ Magazine (online): Synthetic Biological Life
Rodney E. Shackelford
Article for H+ Magazine (online): Caloric Restriction and Aging
Rodney E. Shackelford
Article for H+ Magazine (online): The Molecular Biology of Compassion
Rodney E. Shackelford
Article for H+ Magazine (online): Telomere Length, Disease Risk, and Current Molecular Diagnostic Testing
Rodney E. Shackelford
Article for H+ Magazine (online): Trofim Lysenko, Soviet Ideology, and Pseudo-Science
Rodney E. Shackelford
Article for H+ Magazine (online): p53
Rodney E. Shackelford
Article for H+ Magazine (online): The Polymerase Chain Reaction
Rodney E. Shackelford
Article for H+ Magazine (online): The Mitochondrial Theory of Aging
Rodney E. Shackelford
Article for H+ Magazine (online): Telomeres, Telomerase, and Aging
Rodney E. Shackelford
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Hospital Affiliations

Ochsner LSU Health Shreveport - Academic Medical CenterShreveport, Louisiana
USA Health University HospitalMobile, Alabama