RodolfoMPascualMD

Pulmonology • Lexington, NC

Critical Care Medicine, Pulmonary Vascular Medicine

Associate Professor, Internal Medicine, Wake Forest University School of Medicine

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Office
4 Medical Park Dr
Lexington, NC 27292
Phone+1 336-716-2255
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Education & Training

Sidney Kimmel Medical College at Thomas Jefferson University/TJUHFellowship, Pulmonary Disease and Critical Care Medicine, 1998 - 2002
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Internal Medicine, 1994 - 1998
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1994

Certifications & Licensure

NC State Medical License 2003 - 2025
PA State Medical License 1995 - 2004
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Inpatient - Core EMR, Epic Systems Corporation, 2012

Clinical Trials

Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program Start of enrollment: 2011 Jun 01
Completed

Publications & Presentations

PubMed

20 citations
Pulmonary Rehabilitation in the Management of Chronic Lung Disease.
Sharon D. Cornelison, Rodolfo M. Pascual> ;The Medical Clinics of North America. 2019 May 1
616 citations
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N. Justice, Anoop M. Nambiar, Tamar Tchkonia, Nathan K. LeBrasseur, Rodolfo M. Pascual, Shahrukh K. Hashmi, Larissa G.P. Langhi Prata, Michal M. Masternak, Steph...> ;Ebiomedicine. 2019 Feb 1
1 citations
Effects of bronchoscopy on lung function in asthmatics
Christina Bellinger, Eugene R. Bleecker, Stephen P. Peters, Rodolfo M. Pascual, Jeffrey Krings, R. Smith, Annette T. Hastie, Wendy C. Moore> ;The Journal of Asthma. 2017 Jan 5
87 citations
Predictors of response to tiotropium versus salmeterol in asthmatic adults
Stephen P. Peters, Eugene R. Bleecker, Susan J. Kunselman, Nikolina Icitovic, Wendy C. Moore, Rodolfo M. Pascual, Bill T. Ameredes, Homer A. Boushey, William J. Calhou...> ;The Journal of Allergy and Clinical Immunology. 2013 Nov 1
187 citations
Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
Annette T. Hastie, Wendy C. Moore, Huashi Li, Brian Rector, Victor E. Ortega, Rodolfo M. Pascual, Stephen P. Peters, Deborah A. Meyers, Eugene R. Bleecker> ;The Journal of Allergy and Clinical Immunology. 2013 Jul 1
142 citations
Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized contro...
William J. Calhoun, Bill T. Ameredes, Tonya S. King, Nikolina Icitovic, Eugene R. Bleecker, Mario Castro, Reuben M. Cherniack, Vernon M. Chinchilli, Timothy J. Craig, ...> ;JAMA. 2012 Sep 12
The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma.
Hawkins GA Robinson MB Hastie AT Li X Li H Moore WC Howard TD Busse WW Erzurum SC Wenzel SE Peters SP Meyers DA Bleecker ER> ;J Allergy Clin Immunol. 2012 Aug
Asthma.
Rodolfo M Pascual, Stephen P Peters> ;The Medical Clinics of North America. 2011 Nov 1
49 citations
Safety of investigative bronchoscopy in the Severe Asthma Research Program
Wendy C. Moore, Michael D. Evans, Eugene R. Bleecker, William W. Busse, William J. Calhoun, Mario Castro, Kian Fan Chung, Serpil C. Erzurum, Douglas Curran-Everett, Ra...> ;The Journal of Allergy and Clinical Immunology. 2011 Aug 1
Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institu...
Fitzpatrick AM Teague WG Meyers DA Peters SP Li X Li H Wenzel SE Aujla S Castro M Bacharier LB Gaston BM Bleecker ER Moore WC> ;J Allergy Clin Immunol. 2011 Feb
Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma.
Fitzpatrick AM Teague WG Burwell L Brown MS Brown LA> ;Pediatr Res. 2011 Feb
53 citations
Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent
Huandong Yan, Deepak A. Deshpande, Anna M. Misior, Matthew C. Miles, Himansh Saxena, Ellen C. Riemer, Rodolfo M. Pascual, Reynold A. Panettieri, Raymond B. Penn> ;FASEB Journal. 2011 Jan 1
378 citations
Tiotropium bromide step-up therapy for adults with uncontrolled asthma
Stephen P. Peters, Susan J. Kunselman, Nikolina Icitovic, Wendy C. Moore, Rodolfo M. Pascual, Bill T. Ameredes, Homer A. Boushey, William J. Calhoun, Mario Castro, Reu...> ;The New England Journal of Medicine. 2010 Oct 28
21 citations
Update in Asthma 2009
Wendy C. Moore, Rodolfo M. Pascual> ;American Journal of Respiratory and Critical Care Medicine. 2010 Jun 1
10 citations
Pharmacogenetics of asthma.
Rodolfo M. Pascual, Eugene R. Bleecker> ;Current Opinion in Pharmacology. 2010 Jun 1
35 citations
The irreversible component of persistent asthma.
Rodolfo M. Pascual, Stephen P. Peters> ;The Journal of Allergy and Clinical Immunology. 2009 Nov 1
34 citations
Glucocorticoid- and Protein Kinase A–Dependent Transcriptome Regulation in Airway Smooth Muscle
Anna M. Misior, Deepak A. Deshpande, Matthew J. Loza, Rodolfo M. Pascual, Jason D. Hipp, Raymond B. Penn> ;American Journal of Respiratory Cell and Molecular Biology. 2009 Jul 1
37 citations
Endogenous Gs-Coupled Receptors in Smooth Muscle Exhibit Differential Susceptibility to GRK2/3-Mediated Desensitization
Kok Choi Kong, Uma Gandhi, T. J. Martin, Candace B. Anz, Huandong Yan, Anna M. Misior, Rodolfo M. Pascual, Deepak A. Deshpande, Raymond B. Penn> ;Biochemistry. 2008 Sep 2
31 citations
Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors.
Anna M. Misior, Huandong Yan, Rodolfo M. Pascual, Deepak A. Deshpande, Reynold A. Panettieri, Raymond B. Penn> ;Molecular Pharmacology. 2008 Feb 1
23 citations
PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation.
Deepak A. Deshpande, Rodolfo M. Pascual, Si-Wei Wang, Delrae M. Eckman, Ellen C. Riemer, Colin D. Funk, Raymond B. Penn> ;FASEB Journal. 2007 Aug 1
21 citations
Regulatory features of interleukin-1β-mediated prostaglandin E2 synthesis in airway smooth muscle
Rodolfo M. Pascual, Elizabeth M. Carr, Michael C. Seeds, Manhong Guo, Reynold A. Panettieri, Stephen P. Peters, Raymond B. Penn> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2006 Mar 1
63 citations
Cytokines Regulate β-2-Adrenergic Receptor Responsiveness in Airway Smooth Muscle via Multiple PKA- and EP2 Receptor-Dependent Mechanisms†
Manhong Guo, Rodolfo M. Pascual, Si-Wei Wang, Mary F. Fontana, Cathryn A. Valancius, Reynold A. Panettieri, Stephen L. Tilley, Raymond B. Penn> ;Biochemistry. 2005 Oct 25
257 citations
Airway remodeling contributes to the progressive loss of lung function in asthma: An overview
Rodolfo M. Pascual, Stephen P. Peters> ;The Journal of Allergy and Clinical Immunology. 2005 Sep 1
12 citations
Contemporary Issues in the Care of Patients With Chronic Obstructive Pulmonary Disease
Frank L. Urbano, Rodolfo M. Pascual> ;Journal of Managed Care Pharmacy. 2005 Jun 1
50 citations
Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling.
Snehal Naik, Charlotte K. Billington, Rodolfo M. Pascual, Deepak A. Deshpande, Frank P. Stefano, Trudy A. Kohout, Delrae M. Eckman, Jeffrey L. Benovic, Raymond B. Penn> ;The Journal of Biological Chemistry. 2005 Mar 11
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Hospital Affiliations

Atrium Wake Forest BaptistWinston Salem, North Carolina
Wake Forest Baptist Health-Lexington Medical CenterLexington, North Carolina
Alleghany Memorial HospitalSparta, North Carolina
High Point Medical CenterHigh Point, North Carolina