RohitSharmaMDPhD

PubMed

• Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
  Sharma R, Reinstadler B, Engelstad K, Skinner OS, Stackowitz E, Haller RG, Clish CB, Pierce K, Walker MA, Fryer R, Oglesbee D, Mao X, Shungu DC, Khatri A, Hirano M, De...> ;The Journal of clinical investigation.
• 575 citations
  MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
  Sneha Rath, Rohit Sharma, Rahul Gupta, Tslil Ast, Connie Chan, Timothy J. Durham, Russell P. Goodman, Zenon Grabarek, Mary E. Haas, Wendy H. W. Hung, Pallavi R. Joshi,...> ;Nucleic Acids Research. 2021 Jan 8
• 91 citations
  Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell.
  Eran Mick, Denis V. Titov, Owen S. Skinner, Rohit Sharma, Alexis A. Jourdain, Vamsi K. Mootha> ;Elife. 2020 May 28
• 85 citations
  Hepatic NADH reductive stress underlies common variation in metabolic traits
  Russell P. Goodman, Andrew L. Markhard, Hardik Shah, Rohit Sharma, Owen S. Skinner, Clary B. Clish, Amy Deik, Anupam Patgiri, Yu-Han H. Hsu, Ricard Masia, Hye Lim Noh,...> ;Nature. 2020 May 27
• 67 citations
  An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance.
  Anupam Patgiri, Owen S. Skinner, Yusuke Miyazaki, Grigorij Schleifer, Eizo Marutani, Hardik Shah, Rohit Sharma, Russell P. Goodman, Tsz-Leung To, Xiaoyan Robert Bao, F...> ;Nature Biotechnology. 2020 Jan 13
• 4 citations
  Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome
  Grigorij Schleifer, Eizo Marutani, Michele Ferrari, Rohit Sharma, Owen S. Skinner, Olga Goldberger, Robert M. H. Grange, Kathryn M. Peneyra, Rajeev Malhotra, Martin We...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2019 Feb 1
• 56 citations
  Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.
  Stephanie E. Siegmund, Hua Yang, Rohit Sharma, Martin A. Javors, Owen S. Skinner, Vamsi K. Mootha, Michio Hirano, Eric A. Schon> ;Human Molecular Genetics. 2017 Dec 1
• 28 citations
  Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.
  Nigel F. Delaney, Rohit Sharma, Laura Tadvalkar, Clary B. Clish, Ronald G. Haller, Vamsi K. Mootha> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Aug 1
• 308 citations
  Mitochondrial dysfunction remodels one-carbon metabolism in human cells
  Xiaoyan Robert Bao, Shao En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A. Thompson, Scott B. Vafai, Andrew G. Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goes...> ;Elife. 2016 Jun 16
• 20 citations
  Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma: Case Report, Literature Review, and Proposed Treatment Algorithm
  Claudia I. Chapuy, Inderneel Sahai, Rohit Sharma, Andrew X. Zhu, Olga Kozyreva> ;The Oncologist. 2016 Apr 1
• 92 citations
  A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome
  Julie Thompson Legault, Laura Strittmatter, Jessica Tardif, Rohit Sharma, Vanessa Tremblay-Vaillancourt, Chantale Aubut, Gabrielle Boucher, Clary B. Clish, Denis Cyr, ...> ;Cell Reports. 2015 Nov 3
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